Research Topics
| Aristoteles A N GiagounidisSummaryAffiliation: Medizinische Klinik II Country: Germany Publications
| Collaborators
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Detail Information
Publications
The 5q- syndromeA A N Giagounidis
St Johannes Hospital, Medizinische Klinik II, Duisburg, Germany
Hematology 9:271-7. 2004..The most promising therapeutic approach is the novel thalidomide analogue CC5013 that is currently evaluated in an international phase II study...- Prognosis of patients with del(5q) MDS and complex karyotype and the possible role of lenalidomide in this patient subgroupA A N Giagounidis
Medizinische Klinik II, St Johannes Hospital, An der Abtei 7 11, 47166, Duisburg, and Klinik für Hämatologie, Onkologie und klinische Immunologie, Heinrich Heine Universitat Dusseldorf, Germany
Ann Hematol 84:569-71. 2005.... - Autoimmune disorders in two patients with myelodysplastic syndrome and 5q deletionA A N Giagounidis
Medizinische Klinik II, St Johannes Hospital, Duisburg, Deutschland
Acta Haematol 113:146-9. 2005..Contrary to previous reports on autoimmune disorders in MDS mentioning improvements of hematological function in response to steroid administration, neither of our patients had a hematological improvement under corticosteroids... - Treatment of myelodysplastic syndrome with isolated del(5q) including bands q31-q33 with a combination of all-trans-retinoic acid and tocopherol-alpha: a phase II studyAristoteles A N Giagounidis
St Johannes Hospital, Medizinische Klinik II, An der Abtei 7 11, 47166, Duisburg, Germany
Ann Hematol 84:389-94. 2005..Based on these results, the combination of ATRA and tocopherol-alpha is not recommended for the treatment of del(5q) MDS... 
A European survey on the detection and management of iron overload in transfusion-dependent patients with MDSAristoteles Giagounidis
Medizinische Klinik II, St Johannes Hospital, An der Abtei 7 11, 47166, Duisburg, Germany
Ann Hematol 90:667-73. 2011..The views of these experienced MDS physicians reflect available international MDS treatment guidelines...- Early plasmacytoid dendritic cell leukemia/lymphoma coexpressing myeloid antigenesA A N Giagounidis
St Johannes Hospital, Medizinische Klinik II, An der Abtei 7 11, 47166, Duisburg, Germany
Ann Hematol 83:716-21. 2004..Although patients usually have an ominous prognosis, with only 25% living more than 24 months, our patient is alive after 30+ months and has again achieved complete remission after the last chemotherapy... 
Lenalidomide in the context of complex karyotype or interrupted treatment: case reviews of del(5q)MDS patients with unexpected responsesAristoteles A N Giagounidis
Medizinsche Klinik II, St Johannes Hospital, An der Abtei 7 11, Duisburg, Germany
Ann Hematol 86:133-7. 2007..These clinical observations illustrate the heterogeneity of del(5q)MDS pathogenesis and the diversity of lenalidomide responses within this patient subset...- Clinical, morphological, cytogenetic, and prognostic features of patients with myelodysplastic syndromes and del(5q) including band q31A A N Giagounidis
St Johannes Hospital, Medizinische Klinik II, Duisburg, Germany
Leukemia 18:113-9. 2004..Our data support the current definition of a separate entity of MDS with del(5q) that has been suggested by the World Health Organization... - Practical recommendations on the use of lenalidomide in the management of myelodysplastic syndromesAristoteles Giagounidis
St Johannes Hospital, Medizinische Klinik II, An der Abtei 7 11, 47166 Duisburg, Germany
Ann Hematol 87:345-52. 2008.... - Biological and prognostic significance of chromosome 5q deletions in myeloid malignanciesAristoteles A N Giagounidis
St Johannes Hospital, Medizinische Klinik II, Duisburg, Germany
Clin Cancer Res 12:5-10. 2006..The data provide important new insights into the pathobiology of 5q chromosomal deletions in myeloid malignancies... - Lenalidomide: a brief review of its therapeutic potential in myelodysplastic syndromesAristoteles A N Giagounidis
Medizinische Klinik II, St Johannes Hospital Duisburg, Germany
Ther Clin Risk Manag 3:553-62. 2007..Combination therapies with cytokines, demethylating agents, tyrosine kinase inhibitors, or chemotherapy are being investigated and may show additional benefit in both low- and high risk MDS... - The 5q- syndromeAristoteles A N Giagounidis
St. Johannes Hospital, Duisburg, Germany
Cancer Treat Res 142:133-48. 2008 - BCR-ABL gene amplification and overexpression in a patient with chronic myeloid leukemia treated with imatinibDorothea Gadzicki
Institute of Cell and Molecular Pathology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
Cancer Genet Cytogenet 159:164-7. 2005..We give further evidence that the genomic BCR-ABL amplification results in an increased level of BCR-ABL transcript linking two potent mechanisms of resistance against imatinib treatment... - Clinicopathologic correlations of genomic gains and losses in follicular lymphomaAndreas Viardot
Abteilung Innere Medizin III, Pathologie, and Biometrie und Medizinische Dokumentation, , Germany
J Clin Oncol 20:4523-30. 2002..6). CONCLUSION: These data indicate that genomic aberrations may contribute significantly to risk assessment in patients with FL, the majority of whom are included in low-risk groups using established clinical prognostic scores... - Morphologic dysplasia in de novo acute myeloid leukemia (AML) is related to unfavorable cytogenetics but has no independent prognostic relevance under the conditions of intensive induction therapy: results of a multiparameter analysis from the German AML Torsten Haferlach
Department of Medicine III, Ludwig Maximilians University, Grosshadern, Munich, Germany
J Clin Oncol 21:256-65. 2003..We also assessed the clinical significance of the recently introduced World Health Organization (WHO) classification for AML, which proposed dysplasia as a new parameter for classification... - Fluorescence in situ hybridization reveals closely correlated results in cytological and histological specimens of hematological neoplasias compared to conventional cytogeneticsHeidrun Gerr
Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
Pathobiology 73:271-9. 2006..Therefore, the use of biopsy sections for the routine FISH examination of chromosomal abnormalities is a valid method... - MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AMLMichael Heuser
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
Blood 110:1639-47. 2007..MN1 is a unique oncogene in hematopoiesis that both promotes proliferation/self-renewal and blocks differentiation, and may become useful as a predictive marker in AML treatment... - Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trialsElke Will
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Mol Ther 15:782-91. 2007.... - Assessment of differentiation and progression of hepatic tumors using array-based comparative genomic hybridizationDoris Steinemann
Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
Clin Gastroenterol Hepatol 4:1283-91. 2006..001 and <.005, respectively). CONCLUSIONS: The increased chromosomal instability during dedifferentiation of HCC leads to an accumulation of structural chromosomal aberrations and losses and gains of defined chromosome regions... - Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional miceSonja Schaetzlein
Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, 30625 Hanover, Germany
Cell 130:863-77. 2007..Together, these studies provide evidence that EXO1 contributes to DNA damage signal induction in mammalian cells, and deletion of Exo1 can prolong survival in the context of telomere dysfunction... - Promoter methylation of PARG1, a novel candidate tumor suppressor gene in mantle-cell lymphomasTim Ripperger
Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
Haematologica 92:460-8. 2007..The identification of inactivated tumor suppressor genes contributing to the development of MCL may lead to further elucidation of the biology of this disease and help to identify novel targets for therapy... - High interleukin-15 expression characterizes childhood acute lymphoblastic leukemia with involvement of the CNSGunnar Cario
Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany
J Clin Oncol 25:4813-20. 2007.... - Mesenteric chloroma with t(16;16) followed by acute myelomonocytic leukemia with clonal evolutionGudrun Göhring
Cancer Genet Cytogenet 179:162-4. 2007 - Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinomaUndraga Schagdarsurengin
, , Halle/Saale, Germany
Oncogene 22:1866-71. 2003..Thus, RASSF1A hypermethylation could be useful as a marker of malignancy and to distinguish between the distinct forms of highly differentiated liver neoplasm... 
Copy number alterations in childhood acute lymphoblastic leukemia and their association with minimal residual diseaseDoris Steinemann
Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
Genes Chromosomes Cancer 47:471-80. 2008..This article contains supplementary material available via the Internet at http://www.interscience.wiley.com/jpages/1045-2257/suppmat...- Mutations and treatment outcome in cytogenetically normal acute myeloid leukemiaRichard F Schlenk
University Hospital of Ulm, Ulm, Germany
N Engl J Med 358:1909-18. 2008..We evaluated the associations of these mutations with clinical outcomes in patients... - High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogeneticsMichael Heuser
British Columbia Cancer Research Centre, 675 West 10th Ave, Vancouver, BC, Canada
Blood 108:3898-905. 2006..In conclusion, our data suggest MN1 overexpression as a new prognostic marker in AML with normal cytogenetics... - Quantitative microsatellite analysis to delineate the commonly deleted region 1p22.3 in mantle cell lymphomasAsha Balakrishnan
Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
Genes Chromosomes Cancer 45:883-92. 2006..Two hotspots with copy number losses were detected at chromosomal localizations 85.4 and 86.6 Mb encompassing BCL10 and CLCA2. Both the genes seem to be attractive candidates to study tumor suppressor function in MCL... - Interphase FISH assays for the detection of translocations with breakpoints in immunoglobulin light chain lociJose I Martin-Subero
Institute of Human Genetics, University Hospital Kiel, Germany
Int J Cancer 98:470-4. 2002..Other translocation partners were 2p13-14, 4q13 and 16p12. Our results show that these FISH assays provide flexible, simple and reliable tools in the diagnosis and characterization of genetic changes in B-cell malignancies... - Simultaneous fluorescence immunophenotyping and FISH on tumor cellsYanming Zhang
Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA
Methods Mol Biol 204:379-90. 2002 - Identification of candidate tumor-suppressor genes in 6q27 by combined deletion mapping and electronic expression profiling in lymphoid neoplasmsDoris Steinemann
Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
Genes Chromosomes Cancer 37:421-6. 2003..Furthermore, epigenetic studies in these nine and an additional 48 lymphomas did not show altered methylation of the PDCD2 locus in these tumors. Possibly haploinsufficiency is effectual in accelerating tumor progression... - Interphase cytogenetic characterization of aberrations in the long arm of chromosome 1 in B-cell lymphoid malignanciesLihong Weng
Cancer Genet Cytogenet 144:83-4. 2003 - Induction of aneuploidy by increasing chromosomal instability during dedifferentiation of hepatocellular carcinomaLudwig Wilkens
Institutes of Cell and Molecular Pathology and Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
Proc Natl Acad Sci U S A 101:1309-14. 2004..In conclusion, CIN may induce a stepwise increase of aneuploidy in HCC that is mirrored by the morphological dedifferentiation of tumor cells... - Tumor cells escape suicide gene therapy by genetic and epigenetic instabilityOliver Frank
Department of Cell and Virus Genetics, Heinrich-Pette-Institute, Hamburg, Germany
Blood 104:3543-9. 2004..Considering the mechanisms of escape identified here, the proactive use of suicide genes to prevent complications of insertional mutagenesis may still be efficient... - Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemiaGunnar Cario
Department of Pediatric Hematology and Oncology, Institute for Cell and Molecular Pathology, Hannover Medical School, Germany
Blood 105:821-6. 2005..Because treatment response could be predicted with high accuracy, gene expression profiling could become a clinically relevant tool for treatment stratification in the early course of childhood ALL... - Clonal dominance of hematopoietic stem cells triggered by retroviral gene markingOlga Kustikova
Bone Marrow Transplantation, University Hospital Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany
Science 308:1171-4. 2005..Transcriptional dysregulation occurred in all 12 insertion sites analyzed. These findings have major implications for diagnostic gene marking and the discovery of genes regulating stem cell turnover... - Filgrastim-mobilized peripheral blood progenitor cells versus bone marrow transplantation for treating leukemia: 3-year results from the EBMT randomized trialNorbert Schmitz
Department of Hematology, AK St Georg, Lohmuehlenstrasse 5, 20099 Hamburg, Germany
Haematologica 90:643-8. 2005.... - Standardised fluorescence in situ hybridisation in cytological and histological specimensLudwig Wilkens
Institute of Cell and Molecular Pathology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
Virchows Arch 447:586-92. 2005..The protocol shown here is easy to perform and can be used with cytological and histological specimens. Moreover, with "hands on" time of less than 2 h, FISH can also be used for daily routine purposes... - Hypermethylation of the suppressor of cytokine signalling-1 (SOCS-1) in myelodysplastic syndromeKai Brakensiek
Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
Br J Haematol 130:209-17. 2005.... - Cytogenetic characterization of a BCR-ABL transduced mouse cell lineCornelia Rudolph
Institute of Cell and Molecular Pathology, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany
Cancer Genet Cytogenet 161:51-6. 2005.... - Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinomaRuben R Plentz
Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Germany
Hepatology 42:522-6. 2005..In conclusion, our study gives direct evidence that telomere shortening is linked to a specific genetic alteration characteristic for human HCC... - Gene-expression profiles and their association with drug resistance in adult acute myeloid leukemiaMichael Heuser
Department of Hematology, Hemostaseology and Oncology, Hannover Medical School, Hannover, Germany
Haematologica 90:1484-92. 2005..006). INTERPRETATION AND CONCLUSIONS: Resistance to chemotherapy in AML can be identified by gene-expression profiling before treatment and seems to be mediated by a transcriptional program active in hematopoietic stem/progenitor cells... - Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphomaJose I Martin-Subero
Institute of Human Genetics, University Hospital Kiel, Germany
Blood 99:1474-7. 2002..These data indicate that REL rather than BCL11A may be the target of the 2p13 alterations in cHL...