Aristoteles A N Giagounidis

Summary

Affiliation: Medizinische Klinik II
Country: Germany

Publications

  1. ncbi request reprint Biological and prognostic significance of chromosome 5q deletions in myeloid malignancies
    Aristoteles A N Giagounidis
    St Johannes Hospital, Medizinische Klinik II, Duisburg, Germany
    Clin Cancer Res 12:5-10. 2006
  2. pmc Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes
    Aristoteles Giagounidis
    Marienhospital Düsseldorf, Dusseldorf, Germany
    Ann Hematol 93:1-11. 2014
  3. ncbi request reprint The 5q- syndrome
    A A N Giagounidis
    St Johannes Hospital, Medizinische Klinik II, Duisburg, Germany
    Hematology 9:271-7. 2004
  4. ncbi request reprint Prognosis of patients with del(5q) MDS and complex karyotype and the possible role of lenalidomide in this patient subgroup
    A A N Giagounidis
    Medizinische Klinik II, St Johannes Hospital, An der Abtei 7 11, 47166, Duisburg, and Klinik für Hämatologie, Onkologie und klinische Immunologie, Heinrich Heine Universitat Dusseldorf, Germany
    Ann Hematol 84:569-71. 2005
  5. ncbi request reprint Autoimmune disorders in two patients with myelodysplastic syndrome and 5q deletion
    A A N Giagounidis
    Medizinische Klinik II, St Johannes Hospital, Duisburg, Deutschland
    Acta Haematol 113:146-9. 2005
  6. ncbi request reprint Treatment of myelodysplastic syndrome with isolated del(5q) including bands q31-q33 with a combination of all-trans-retinoic acid and tocopherol-alpha: a phase II study
    Aristoteles A N Giagounidis
    St Johannes Hospital, Medizinische Klinik II, An der Abtei 7 11, 47166, Duisburg, Germany
    Ann Hematol 84:389-94. 2005
  7. ncbi request reprint Early plasmacytoid dendritic cell leukemia/lymphoma coexpressing myeloid antigenes
    A A N Giagounidis
    St Johannes Hospital, Medizinische Klinik II, An der Abtei 7 11, 47166, Duisburg, Germany
    Ann Hematol 83:716-21. 2004
  8. pmc Practical recommendations on the use of lenalidomide in the management of myelodysplastic syndromes
    Aristoteles Giagounidis
    St Johannes Hospital, Medizinische Klinik II, An der Abtei 7 11, 47166 Duisburg, Germany
    Ann Hematol 87:345-52. 2008
  9. ncbi request reprint Clinical, morphological, cytogenetic, and prognostic features of patients with myelodysplastic syndromes and del(5q) including band q31
    A A N Giagounidis
    St Johannes Hospital, Medizinische Klinik II, Duisburg, Germany
    Leukemia 18:113-9. 2004
  10. pmc Lenalidomide in the context of complex karyotype or interrupted treatment: case reviews of del(5q)MDS patients with unexpected responses
    Aristoteles A N Giagounidis
    Medizinsche Klinik II, St Johannes Hospital, An der Abtei 7 11, Duisburg, Germany
    Ann Hematol 86:133-7. 2007

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Biological and prognostic significance of chromosome 5q deletions in myeloid malignancies
    Aristoteles A N Giagounidis
    St Johannes Hospital, Medizinische Klinik II, Duisburg, Germany
    Clin Cancer Res 12:5-10. 2006
    ..The data provide important new insights into the pathobiology of 5q chromosomal deletions in myeloid malignancies...
  2. pmc Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes
    Aristoteles Giagounidis
    Marienhospital Düsseldorf, Dusseldorf, Germany
    Ann Hematol 93:1-11. 2014
    ..In addition, we discuss how improved understanding of the mechanism of disease will facilitate clinicians' ability to predict/monitor response and identify patients at risk of relapse...
  3. ncbi request reprint The 5q- syndrome
    A A N Giagounidis
    St Johannes Hospital, Medizinische Klinik II, Duisburg, Germany
    Hematology 9:271-7. 2004
    ..The most promising therapeutic approach is the novel thalidomide analogue CC5013 that is currently evaluated in an international phase II study...
  4. ncbi request reprint Prognosis of patients with del(5q) MDS and complex karyotype and the possible role of lenalidomide in this patient subgroup
    A A N Giagounidis
    Medizinische Klinik II, St Johannes Hospital, An der Abtei 7 11, 47166, Duisburg, and Klinik für Hämatologie, Onkologie und klinische Immunologie, Heinrich Heine Universitat Dusseldorf, Germany
    Ann Hematol 84:569-71. 2005
    ....
  5. ncbi request reprint Autoimmune disorders in two patients with myelodysplastic syndrome and 5q deletion
    A A N Giagounidis
    Medizinische Klinik II, St Johannes Hospital, Duisburg, Deutschland
    Acta Haematol 113:146-9. 2005
    ..Contrary to previous reports on autoimmune disorders in MDS mentioning improvements of hematological function in response to steroid administration, neither of our patients had a hematological improvement under corticosteroids...
  6. ncbi request reprint Treatment of myelodysplastic syndrome with isolated del(5q) including bands q31-q33 with a combination of all-trans-retinoic acid and tocopherol-alpha: a phase II study
    Aristoteles A N Giagounidis
    St Johannes Hospital, Medizinische Klinik II, An der Abtei 7 11, 47166, Duisburg, Germany
    Ann Hematol 84:389-94. 2005
    ..Based on these results, the combination of ATRA and tocopherol-alpha is not recommended for the treatment of del(5q) MDS...
  7. ncbi request reprint Early plasmacytoid dendritic cell leukemia/lymphoma coexpressing myeloid antigenes
    A A N Giagounidis
    St Johannes Hospital, Medizinische Klinik II, An der Abtei 7 11, 47166, Duisburg, Germany
    Ann Hematol 83:716-21. 2004
    ..Although patients usually have an ominous prognosis, with only 25% living more than 24 months, our patient is alive after 30+ months and has again achieved complete remission after the last chemotherapy...
  8. pmc Practical recommendations on the use of lenalidomide in the management of myelodysplastic syndromes
    Aristoteles Giagounidis
    St Johannes Hospital, Medizinische Klinik II, An der Abtei 7 11, 47166 Duisburg, Germany
    Ann Hematol 87:345-52. 2008
    ....
  9. ncbi request reprint Clinical, morphological, cytogenetic, and prognostic features of patients with myelodysplastic syndromes and del(5q) including band q31
    A A N Giagounidis
    St Johannes Hospital, Medizinische Klinik II, Duisburg, Germany
    Leukemia 18:113-9. 2004
    ..Our data support the current definition of a separate entity of MDS with del(5q) that has been suggested by the World Health Organization...
  10. pmc Lenalidomide in the context of complex karyotype or interrupted treatment: case reviews of del(5q)MDS patients with unexpected responses
    Aristoteles A N Giagounidis
    Medizinsche Klinik II, St Johannes Hospital, An der Abtei 7 11, Duisburg, Germany
    Ann Hematol 86:133-7. 2007
    ..These clinical observations illustrate the heterogeneity of del(5q)MDS pathogenesis and the diversity of lenalidomide responses within this patient subset...
  11. pmc A European survey on the detection and management of iron overload in transfusion-dependent patients with MDS
    Aristoteles Giagounidis
    Medizinische Klinik II, St Johannes Hospital, An der Abtei 7 11, 47166, Duisburg, Germany
    Ann Hematol 90:667-73. 2011
    ..The views of these experienced MDS physicians reflect available international MDS treatment guidelines...
  12. doi request reprint Lenalidomide for del(5q) and non-del(5q) myelodysplastic syndromes
    Aristoteles A N Giagounidis
    Department of Hematology, Oncology, and Palliative Care, Marienhospital Düsseldorf, Dusseldorf, Germany
    Semin Hematol 49:312-22. 2012
    ..This article will also discuss combination strategies with lenalidomide in higher risk disease...
  13. pmc Lenalidomide: a brief review of its therapeutic potential in myelodysplastic syndromes
    Aristoteles A N Giagounidis
    Medizinische Klinik II, St Johannes Hospital Duisburg, Germany
    Ther Clin Risk Manag 3:553-62. 2007
    ..Combination therapies with cytokines, demethylating agents, tyrosine kinase inhibitors, or chemotherapy are being investigated and may show additional benefit in both low- and high risk MDS...
  14. ncbi request reprint The 5q- syndrome
    Aristoteles A N Giagounidis
    St Johannes Hospital, Duisburg, Germany
    Cancer Treat Res 142:133-48. 2008
  15. ncbi request reprint BCR-ABL gene amplification and overexpression in a patient with chronic myeloid leukemia treated with imatinib
    Dorothea Gadzicki
    Institute of Cell and Molecular Pathology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Cancer Genet Cytogenet 159:164-7. 2005
    ..We give further evidence that the genomic BCR-ABL amplification results in an increased level of BCR-ABL transcript linking two potent mechanisms of resistance against imatinib treatment...
  16. ncbi request reprint Clinicopathologic correlations of genomic gains and losses in follicular lymphoma
    Andreas Viardot
    Abteilung Innere Medizin III, Pathologie, and Biometrie und Medizinische Dokumentation, Universitat Ulm, Germany
    J Clin Oncol 20:4523-30. 2002
    ..To evaluate the clinical relevance of genomic aberrations in follicular lymphomas (FLs)...
  17. ncbi request reprint Morphologic dysplasia in de novo acute myeloid leukemia (AML) is related to unfavorable cytogenetics but has no independent prognostic relevance under the conditions of intensive induction therapy: results of a multiparameter analysis from the German AML
    Torsten Haferlach
    Department of Medicine III, Ludwig Maximilians University, Grosshadern, Munich, Germany
    J Clin Oncol 21:256-65. 2003
    ..We also assessed the clinical significance of the recently introduced World Health Organization (WHO) classification for AML, which proposed dysplasia as a new parameter for classification...
  18. ncbi request reprint Fluorescence in situ hybridization reveals closely correlated results in cytological and histological specimens of hematological neoplasias compared to conventional cytogenetics
    Heidrun Gerr
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Pathobiology 73:271-9. 2006
    ..However, up to now, there has been no study comparing two main sources of diagnostic material, i.e. bone marrow aspirates and trephine biopsies. We therefore analyzed these materials by FISH in comparison with CBA...
  19. ncbi request reprint MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML
    Michael Heuser
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
    Blood 110:1639-47. 2007
    ..MN1 is a unique oncogene in hematopoiesis that both promotes proliferation/self-renewal and blocks differentiation, and may become useful as a predictive marker in AML treatment...
  20. ncbi request reprint Promoter methylation of PARG1, a novel candidate tumor suppressor gene in mantle-cell lymphomas
    Tim Ripperger
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Haematologica 92:460-8. 2007
    ..The identification of inactivated tumor suppressor genes contributing to the development of MCL may lead to further elucidation of the biology of this disease and help to identify novel targets for therapy...
  21. ncbi request reprint Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials
    Elke Will
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Mol Ther 15:782-91. 2007
    ....
  22. ncbi request reprint High interleukin-15 expression characterizes childhood acute lymphoblastic leukemia with involvement of the CNS
    Gunnar Cario
    Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany
    J Clin Oncol 25:4813-20. 2007
    ....
  23. pmc Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice
    Sonja Schaetzlein
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, 30625 Hanover, Germany
    Cell 130:863-77. 2007
    ..Together, these studies provide evidence that EXO1 contributes to DNA damage signal induction in mammalian cells, and deletion of Exo1 can prolong survival in the context of telomere dysfunction...
  24. ncbi request reprint Mesenteric chloroma with t(16;16) followed by acute myelomonocytic leukemia with clonal evolution
    Gudrun Göhring
    Cancer Genet Cytogenet 179:162-4. 2007
  25. doi request reprint Copy number alterations in childhood acute lymphoblastic leukemia and their association with minimal residual disease
    Doris Steinemann
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Genes Chromosomes Cancer 47:471-80. 2008
    ..This article contains supplementary material available via the Internet at http://www.interscience.wiley.com/jpages/1045-2257/suppmat...
  26. doi request reprint Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
    Richard F Schlenk
    University Hospital of Ulm, Ulm, Germany
    N Engl J Med 358:1909-18. 2008
    ..We evaluated the associations of these mutations with clinical outcomes in patients...
  27. ncbi request reprint Assessment of differentiation and progression of hepatic tumors using array-based comparative genomic hybridization
    Doris Steinemann
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Clin Gastroenterol Hepatol 4:1283-91. 2006
    ....
  28. ncbi request reprint High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics
    Michael Heuser
    British Columbia Cancer Research Centre, 675 West 10th Ave, Vancouver, BC, Canada
    Blood 108:3898-905. 2006
    ..In conclusion, our data suggest MN1 overexpression as a new prognostic marker in AML with normal cytogenetics...
  29. ncbi request reprint Quantitative microsatellite analysis to delineate the commonly deleted region 1p22.3 in mantle cell lymphomas
    Asha Balakrishnan
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Genes Chromosomes Cancer 45:883-92. 2006
    ..Two hotspots with copy number losses were detected at chromosomal localizations 85.4 and 86.6 Mb encompassing BCL10 and CLCA2. Both the genes seem to be attractive candidates to study tumor suppressor function in MCL...
  30. ncbi request reprint Interphase FISH assays for the detection of translocations with breakpoints in immunoglobulin light chain loci
    Jose I Martin-Subero
    Institute of Human Genetics, University Hospital Kiel, Germany
    Int J Cancer 98:470-4. 2002
    ..Other translocation partners were 2p13-14, 4q13 and 16p12. Our results show that these FISH assays provide flexible, simple and reliable tools in the diagnosis and characterization of genetic changes in B-cell malignancies...
  31. ncbi request reprint Simultaneous fluorescence immunophenotyping and FISH on tumor cells
    Yanming Zhang
    Department of Medicine, Section of Hematology Oncology, University of Chicago, Chicago, IL, USA
    Methods Mol Biol 204:379-90. 2002
  32. ncbi request reprint Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma
    Undraga Schagdarsurengin
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Oncogene 22:1866-71. 2003
    ..Thus, RASSF1A hypermethylation could be useful as a marker of malignancy and to distinguish between the distinct forms of highly differentiated liver neoplasm...
  33. ncbi request reprint Identification of candidate tumor-suppressor genes in 6q27 by combined deletion mapping and electronic expression profiling in lymphoid neoplasms
    Doris Steinemann
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Genes Chromosomes Cancer 37:421-6. 2003
    ..Furthermore, epigenetic studies in these nine and an additional 48 lymphomas did not show altered methylation of the PDCD2 locus in these tumors. Possibly haploinsufficiency is effectual in accelerating tumor progression...
  34. ncbi request reprint Interphase cytogenetic characterization of aberrations in the long arm of chromosome 1 in B-cell lymphoid malignancies
    Lihong Weng
    Cancer Genet Cytogenet 144:83-4. 2003
  35. pmc Induction of aneuploidy by increasing chromosomal instability during dedifferentiation of hepatocellular carcinoma
    Ludwig Wilkens
    Institutes of Cell and Molecular Pathology and Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 101:1309-14. 2004
    ..In conclusion, CIN may induce a stepwise increase of aneuploidy in HCC that is mirrored by the morphological dedifferentiation of tumor cells...
  36. ncbi request reprint Tumor cells escape suicide gene therapy by genetic and epigenetic instability
    Oliver Frank
    Department of Cell and Virus Genetics, Heinrich Pette Institute, Hamburg, Germany
    Blood 104:3543-9. 2004
    ..Considering the mechanisms of escape identified here, the proactive use of suicide genes to prevent complications of insertional mutagenesis may still be efficient...
  37. ncbi request reprint Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia
    Gunnar Cario
    Department of Pediatric Hematology and Oncology, Institute for Cell and Molecular Pathology, Hannover Medical School, Germany
    Blood 105:821-6. 2005
    ..Because treatment response could be predicted with high accuracy, gene expression profiling could become a clinically relevant tool for treatment stratification in the early course of childhood ALL...
  38. ncbi request reprint Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking
    Olga Kustikova
    Bone Marrow Transplantation, University Hospital Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany
    Science 308:1171-4. 2005
    ..Transcriptional dysregulation occurred in all 12 insertion sites analyzed. These findings have major implications for diagnostic gene marking and the discovery of genes regulating stem cell turnover...
  39. ncbi request reprint Filgrastim-mobilized peripheral blood progenitor cells versus bone marrow transplantation for treating leukemia: 3-year results from the EBMT randomized trial
    Norbert Schmitz
    Department of Hematology, AK St Georg, Lohmuehlenstrasse 5, 20099 Hamburg, Germany
    Haematologica 90:643-8. 2005
    ....
  40. ncbi request reprint Standardised fluorescence in situ hybridisation in cytological and histological specimens
    Ludwig Wilkens
    Institute of Cell and Molecular Pathology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Virchows Arch 447:586-92. 2005
    ..The protocol shown here is easy to perform and can be used with cytological and histological specimens. Moreover, with "hands on" time of less than 2 h, FISH can also be used for daily routine purposes...
  41. ncbi request reprint Hypermethylation of the suppressor of cytokine signalling-1 (SOCS-1) in myelodysplastic syndrome
    Kai Brakensiek
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Br J Haematol 130:209-17. 2005
    ....
  42. ncbi request reprint Cytogenetic characterization of a BCR-ABL transduced mouse cell line
    Cornelia Rudolph
    Institute of Cell and Molecular Pathology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Cancer Genet Cytogenet 161:51-6. 2005
    ....
  43. ncbi request reprint Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma
    Ruben R Plentz
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Germany
    Hepatology 42:522-6. 2005
    ..In conclusion, our study gives direct evidence that telomere shortening is linked to a specific genetic alteration characteristic for human HCC...
  44. ncbi request reprint Gene-expression profiles and their association with drug resistance in adult acute myeloid leukemia
    Michael Heuser
    Department of Hematology, Hemostaseology and Oncology, Hannover Medical School, Hannover, Germany
    Haematologica 90:1484-92. 2005
    ..We investigated whether resistance to chemotherapy be represented by gene-expression profiles, and which genes are associated with resistance...
  45. ncbi request reprint Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma
    Jose I Martin-Subero
    Institute of Human Genetics, University Hospital Kiel, Germany
    Blood 99:1474-7. 2002
    ..These data indicate that REL rather than BCL11A may be the target of the 2p13 alterations in cHL...