Research Topics
| Theodor W MaySummaryCountry: Germany Publications
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Detail Information
Publications
Serum concentrations of topiramate in patients with epilepsy: influence of dose, age, and comedicationTheodor W May
Department of Biochemistry, Gesellschaft für Epilepsieforschung, Maraweg 13, D 33546 Bielefeld, Germany
Ther Drug Monit 24:366-74. 2002..Comedication and age should be considered in adjusting topiramate dosage. Determination of topiramate serum concentrations may be useful, especially when enzyme-inducing drugs are withdrawn or added...- The efficacy of an educational treatment program for patients with epilepsy (MOSES): results of a controlled, randomized study. Modular Service Package EpilepsyTheodor W May
Gesellschaft für Epilepsieforschung, Bielefeld, Germany
Epilepsia 43:539-49. 2002..The program intends to improve patients' coping with the disease, to strengthen self-esteem, and to support patients to become experts in managing their epilepsy... - Is sudden unexplained death in adult epileptic patients associated with geomagnetic disturbances at the day of death or the 4 days before?Ralf Schnabel
Institute of Neuropathology, Ludwig Maximilians Universitiy of Munich, Thalkirchner Strasse 36, D 80337 München, Germany
Neurosci Lett 329:261-4. 2002..1 versus 3.9%) or the 4 days before (5.1 versus 11.8%) (Fisher test; P>0.2). Consequently, the current data did not support the hypothesis that geomagnetic activities may act as a relevant risk factor for SUDEP... - Serum concentrations of Levetiracetam in epileptic patients: the influence of dose and co-medicationTheodor W May
Department of Biochemistry, Gesellschaft für Epilepsieforschung, Bielefeld, Germany
Ther Drug Monit 25:690-9. 2003..g., phenytoin, carbamazepine) can moderately decrease LEV serum concentrations (by 20-30%). However, our observations should be confirmed by prospective pharmacokinetic studies... 
Concentrations of stiripentol in children and adults with epilepsy: the influence of dose, age, and comedicationTheodor W May
Pharmacological Laboratory, Society for Epilepsy Research, Bielefeld, Germany
Ther Drug Monit 34:390-7. 2012....- Serum concentrations of rufinamide in children and adults with epilepsy: the influence of dose, age, and comedicationTheodor W May
Pharmacological Laboratory, Society for Epilepsy Research, Bielefeld, Germany
Ther Drug Monit 33:214-21. 2011..Our data indicate that oxcarbazepine and, especially, methsuximide decrease RUF concentrations as well. Therapeutic drug monitoring might be helpful because RUF concentrations differ markedly in patients on comparable RUF doses... - Serum concentrations of pregabalin in patients with epilepsy: the influence of dose, age, and comedicationTheodor W May
Pharmacological Laboratory, Society for Epilepsy Research, Bielefeld, Germany
Ther Drug Monit 29:789-94. 2007..Further studies should clarify the effect of age and interactions on PGB concentrations... - Are geomagnetic disturbances a risk factor for the sudden unexplained death of epileptic children?Ralf Schnabel
Institut für Neuropathologie, Ludwig Maximilians Universitat Munchen, Thalkirchner Strasse 36, D 80337 Munich, Germany
Int J Biometeorol 48:20-4. 2003..7%) from the KCD group (23.8%) ( P > 0.2, Fisher test). The results do not support the hypothesis that geomagnetic disturbances are a risk factor for the sudden unexplained death of epileptic children... - Does lamotrigine influence valproate concentrations?Mihaela Irina Mataringa
Epilepsy Center Bethel, Klinik Mara, Bielefeld, Germany
Ther Drug Monit 24:631-6. 2002..It did not. Thus, the authors conclude that the effect of LTG on VPA concentrations is not of clinical relevance... - Clinical pharmacokinetics of oxcarbazepineTheodor W May
Department of Biochemistry, Epilepsy Research Foundation, Bielefeld, Germany
Clin Pharmacokinet 42:1023-42. 2003..A mean therapeutic range of 15-35 mg/L for MHD seems to be appropriate. However, more systematic studies exploring the concentration-effect relationship are required... - Topiramate overdose: a case report of a patient with extremely high topiramate serum concentrations and nonconvulsive status epilepticusChristian Brandt
Bethel Epilepsy Centre, Department of General Epileptology, Bielefeld, Germany
Epilepsia 51:1090-3. 2010..6 microg/ml. To our knowledge, this is the first report of a patient who survived such a high TPM concentration. The case indicates that nonconvulsive status epilepticus could be a manifestation of TPM intoxication... - Ictal autoscopic phenomena and near death experiences: a study of five patients with ictal autoscopiesRobert Hoepner
Bethel Epilepsy Centre, Mara Hospital, Maraweg 17 21, 33617, Bielefeld, Germany
J Neurol 260:742-9. 2013..Therefore, a malfunction of this brain region might also be involved in near death experiences of other origins especially during states which could cause a near death experience and a cerebral excitability... - Topiramate: a prospective study on the relationship between concentration, dosage and adverse events in epileptic patients on combination therapyWalter Fröscher
Department of Neurology and Epileptology, the Epilepsy Center Bodensee, Die Weissenau, Germany
Epileptic Disord 7:237-48. 2005..The goal of the study was to investigate the relationship between the occurrence of adverse events due to TPM and its serum concentration or dosage, respectively... - E-learning courses in epilepsy--concept, evaluation, and experience with the e-learning course "genetics of epilepsies"Verena Hézser V Wehrs
European Epilepsy Academy e V, Bielefeld EUREPA, Germany
Epilepsia 48:872-9. 2007..To evaluate the efficacy of the e-learning course "Genetics of Epilepsies" and to assess the experiences of the participants and e-moderators with this new approach... - Experience with generic drugs in epilepsy patients: an electronic survey of members of the German, Austrian and Swiss branches of the ILAEGunter Kramer
Epilepsia 48:609-11. 2007 - Perioral reflex myoclonias: a controlled study in patients with JME and focal epilepsiesThomas A Mayer
Kleinwachau Saxonian Epilepsy Centre Radeberg, Radeberg, Germany
Epilepsia 47:1059-67. 2006..PORMs remain often undiagnosed because the patients are not aware that these are epileptic seizures and fail to report them. Their semiology is not fundamentally different in various epileptic syndromes... - Comparison of brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with intractable epilepsyBernhard Rambeck
Biochemical Laboratory of the Epilepsy Research Foundation, , Germany
Epilepsia 47:681-94. 2006..Instead, the present study illustrates the methodologic difficulties involved in performing IOMD studies in patients and may thus be helpful for future approaches aimed at elucidating the role of multidrug transporters in epilepsy...