Hans Ulrich Wittchen

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. ncbi request reprint Generalized anxiety disorder: nature and course
    H U Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden, Germany
    J Clin Psychiatry 62:15-9; discussion 20-1. 2001
  2. doi request reprint A typology of cannabis-related problems among individuals with repeated illegal drug use in the first three decades of life: Evidence for heterogeneity and different treatment needs
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Chemnitzer Str 46, D 01187 Dresden, Germany
    Drug Alcohol Depend 102:151-7. 2009
  3. ncbi request reprint Prevalence, recognition and management of depression in primary care in Germany: the Depression 2000 study
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy and Technical University of Dresden, Dresden, Germany
    Hum Psychopharmacol 17:S1-11. 2002
  4. ncbi request reprint Generalized anxiety and depression in primary care: prevalence, recognition, and management
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden, Germany
    J Clin Psychiatry 63:24-34. 2002
  5. ncbi request reprint Trauma and PTSD - an overlooked pathogenic pathway for premenstrual dysphoric disorder?
    H U Wittchen
    Technical University of Dresden, Institute of Clinical Psychology and Psychotherapy, Dresden, Germany
    Arch Womens Ment Health 6:293-7. 2003
  6. ncbi request reprint Size and burden of mental disorders in Europe--a critical review and appraisal of 27 studies
    Hans Ulrich Wittchen
    Clinical Psychology and Psychotherapy, Technical University of Dresden, Dresden, Germany
    Eur Neuropsychopharmacol 15:357-76. 2005
  7. ncbi request reprint Prevalence and recognition of depressive syndromes in German primary care settings: poorly recognized and treated?
    H U Wittchen
    Department of Clinical Psychology and Epidemiology, Max Planck Institute of Psychiatry, Munich, Germany
    Int Clin Psychopharmacol 16:121-35. 2001
  8. ncbi request reprint Disabilities and quality of life in pure and comorbid generalized anxiety disorder and major depression in a national survey
    H U Wittchen
    Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology Unit, Munich, Germany
    Int Clin Psychopharmacol 15:319-28. 2000
  9. ncbi request reprint The many faces of social anxiety disorder
    H U Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden, Munich, Germany
    Int Clin Psychopharmacol 15:S7-12. 2000
  10. doi request reprint Heterogeneity of DSM-IV major depressive disorder as a consequence of subthreshold bipolarity
    Petra Zimmermann
    Molecular Psychology Unit, Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    Arch Gen Psychiatry 66:1341-52. 2009

Detail Information

Publications126 found, 100 shown here

  1. ncbi request reprint Generalized anxiety disorder: nature and course
    H U Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden, Germany
    J Clin Psychiatry 62:15-9; discussion 20-1. 2001
    ..GAD is frequently associated with comorbid depression and other anxiety and somatoform disorders. Significant GAD-specific disability occurs even when comorbidity is not present...
  2. doi request reprint A typology of cannabis-related problems among individuals with repeated illegal drug use in the first three decades of life: Evidence for heterogeneity and different treatment needs
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Chemnitzer Str 46, D 01187 Dresden, Germany
    Drug Alcohol Depend 102:151-7. 2009
    ..Cannabis use (CU) and disorders (CUD) are highly prevalent among adolescents and young adults. We aim to identify clinically meaningful latent classes of users of cannabis and other illegal substances with distinct problem profiles...
  3. ncbi request reprint Prevalence, recognition and management of depression in primary care in Germany: the Depression 2000 study
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy and Technical University of Dresden, Dresden, Germany
    Hum Psychopharmacol 17:S1-11. 2002
    ..It remains of continued prime importance to educate primary care doctors to better recognise depression in order to increase the patients' chances of receiving appropriate treatment...
  4. ncbi request reprint Generalized anxiety and depression in primary care: prevalence, recognition, and management
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden, Germany
    J Clin Psychiatry 63:24-34. 2002
    ....
  5. ncbi request reprint Trauma and PTSD - an overlooked pathogenic pathway for premenstrual dysphoric disorder?
    H U Wittchen
    Technical University of Dresden, Institute of Clinical Psychology and Psychotherapy, Dresden, Germany
    Arch Womens Ment Health 6:293-7. 2003
    ..A recent epidemiological analysis on premenstrual dysphoric disorder (PMDD) in the community revealed increased rates of DSM-IV posttraumatic stress disorder (PTSD) among women suffering from PMDD...
  6. ncbi request reprint Size and burden of mental disorders in Europe--a critical review and appraisal of 27 studies
    Hans Ulrich Wittchen
    Clinical Psychology and Psychotherapy, Technical University of Dresden, Dresden, Germany
    Eur Neuropsychopharmacol 15:357-76. 2005
    ..These needs are most pronounced for the new EU member states as well as more generally for adolescent and older populations...
  7. ncbi request reprint Prevalence and recognition of depressive syndromes in German primary care settings: poorly recognized and treated?
    H U Wittchen
    Department of Clinical Psychology and Epidemiology, Max Planck Institute of Psychiatry, Munich, Germany
    Int Clin Psychopharmacol 16:121-35. 2001
    ....
  8. ncbi request reprint Disabilities and quality of life in pure and comorbid generalized anxiety disorder and major depression in a national survey
    H U Wittchen
    Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology Unit, Munich, Germany
    Int Clin Psychopharmacol 15:319-28. 2000
    ..The impairment outcomes for GAD were comparable in size to those for MDD. These findings underline the significance of this disorder from a clinical and social perspective and provide support for the independent diagnostic status of GAD...
  9. ncbi request reprint The many faces of social anxiety disorder
    H U Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden, Munich, Germany
    Int Clin Psychopharmacol 15:S7-12. 2000
    ....
  10. doi request reprint Heterogeneity of DSM-IV major depressive disorder as a consequence of subthreshold bipolarity
    Petra Zimmermann
    Molecular Psychology Unit, Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    Arch Gen Psychiatry 66:1341-52. 2009
    ..There is growing evidence that major depressive disorder (MDD) might be overdiagnosed at the expense of bipolar disorder (BPD)...
  11. ncbi request reprint Panic attack as a risk factor for severe psychopathology
    Renee D Goodwin
    Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
    Am J Psychiatry 161:2207-14. 2004
    ..The purpose of the study was to examine the relationship between panic attack and the onset of specific mental disorders and severe psychopathology across the diagnostic spectrum among adolescents and young adults...
  12. ncbi request reprint Incidence of social anxiety disorder and the consistent risk for secondary depression in the first three decades of life
    Katja Beesdo
    Institute of Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Germany
    Arch Gen Psychiatry 64:903-12. 2007
    ....
  13. doi request reprint Frequency of dementia, depression, and other neuropsychiatric symptoms in 1,449 outpatients with Parkinson's disease
    Oliver Riedel
    Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden, Chemnitzer Strasse 46, Dresden, Germany
    J Neurol 257:1073-82. 2010
    ..PD outpatients are at an increased risk for all neuropsychiatric conditions, increasing with PD severity but not with age or age of onset (except dementia), revealing challenging symptom patterns...
  14. ncbi request reprint Risk factors for premenstrual dysphoric disorder in a community sample of young women: the role of traumatic events and posttraumatic stress disorder
    Axel Perkonigg
    Technical University of Dresden, Institute of Clinical Psychology and Psychotherapy, Dresden, Germany
    J Clin Psychiatry 65:1314-22. 2004
    ....
  15. doi request reprint Pain associated with specific anxiety and depressive disorders in a nationally representative population sample
    Katja Beesdo
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Chemnitzer Str 46, 01187, Dresden, Germany
    Soc Psychiatry Psychiatr Epidemiol 45:89-104. 2010
    ....
  16. ncbi request reprint [Prevalence, drug treatment and metabolic control of diabetes mellitus in primary care]
    David Pittrow
    Institut fur Klinische Pharmakologie, Forschungsverbund Public Health, Technische Universitat Dresden, Dresden, Germany
    Med Klin (Munich) 101:635-44. 2006
    ....
  17. ncbi request reprint Longitudinal course of posttraumatic stress disorder and posttraumatic stress disorder symptoms in a community sample of adolescents and young adults
    Axel Perkonigg
    Clinical Psychology and Epidemiology Department, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Am J Psychiatry 162:1320-7. 2005
    ..The authors examined determinants of remission and chronicity of PTSD and associations with other disorders in a prospective community sample...
  18. doi request reprint The relevance of age at first alcohol and nicotine use for initiation of cannabis use and progression to cannabis use disorders
    Silke Behrendt
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Chemnitzer Str 46, D 01187 Dresden, Germany
    Drug Alcohol Depend 123:48-56. 2012
    ..However, the cross-substance relationship between a younger age at onset of alcohol use (AU) and nicotine use (NU) and the risk of cannabis use disorders (CUD) in adolescence and early adulthood remains unclear...
  19. doi request reprint The structure of mental disorders re-examined: is it developmentally stable and robust against additions?
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Dresden, Germany
    Int J Methods Psychiatr Res 18:189-203. 2009
    ..However, again, there is little consistency in findings when different age groups or different diagnoses are considered. Our findings suggest that psychopathology cannot be reduced to any simple structure...
  20. doi request reprint Incidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder
    Katja Beesdo
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Chemnitzer St 46, 01187 Dresden, Germany
    Arch Gen Psychiatry 67:47-57. 2010
    ..Controversy surrounds the diagnostic categorization of generalized anxiety disorder (GAD)...
  21. ncbi request reprint Pathways into ecstasy use: the role of prior cannabis use and ecstasy availability
    Petra Zimmermann
    Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology, Kraepelinstrasse 2, 80804 Munich, Germany
    Drug Alcohol Depend 79:331-41. 2005
    ..To explore the role of cannabis use for the availability of ecstasy as a potential pathway to subsequent first ecstasy use...
  22. ncbi request reprint Maternal suicidality and risk of suicidality in offspring: findings from a community study
    Roselind Lieb
    Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology Unit, Kraepelinstr 2, 80804 München, Germany
    Am J Psychiatry 162:1665-71. 2005
    ..This study evaluated the associations between suicidal ideation and suicide attempts in mothers and various aspects of suicidality in their offspring in a representative community sample...
  23. ncbi request reprint Estimating the prevalence of mental and somatic disorders in the community: aims and methods of the German National Health Interview and Examination Survey
    Frank Jacobi
    Institute of Clinical Psychology and Psychotherapy, Unit, Technical University of Dresden, Germany
    Int J Methods Psychiatr Res 11:1-18. 2002
    ..Overall, the GHS core survey and its mental health supplement provide the mental health research community with complex data that allow for high-quality analysis of mental disorders and associations with somatic disorders...
  24. ncbi request reprint What characteristics of primary anxiety disorders predict subsequent major depressive disorder?
    Antje Bittner
    Department of Clinical Psychology and Psychotherapy, Technical University Dresden, Dresden, Germany
    J Clin Psychiatry 65:618-26, quiz 730. 2004
    ....
  25. doi request reprint Occurrence risk and structure of depression in Parkinson disease with and without dementia: results from the GEPAD Study
    Oliver Riedel
    Technische Universitaet Dresden, Institute of Clinical Psychology and Psychotherapy, Dresden, Germany
    J Geriatr Psychiatry Neurol 23:27-34. 2010
    ....
  26. ncbi request reprint Smoking increases the risk of panic: findings from a prospective community study
    Barbara Isensee
    Clinical Psychology and Epidemiology Unit, Max Planck Institute of Psychiatry, Munich, Germany
    Arch Gen Psychiatry 60:692-700. 2003
    ..We examined prospectively determined bidirectional associations between smoking and panic and other anxiety disorders and their temporal ordering of onset in a representative community sample of adolescents and young adults...
  27. doi request reprint Agoraphobia and panic. Prospective-longitudinal relations suggest a rethinking of diagnostic concepts
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Dresden, Germany
    Psychother Psychosom 77:147-57. 2008
    ..The aim of the current study is to prospectively examine the 10-year natural course of PA, PD and AG in the first three decades of life, their stability and their reciprocal transitions...
  28. doi request reprint The structure of common mental disorders: a replication study in a community sample of adolescents and young adults
    Katja Beesdo-Baum
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Dresden, Germany
    Int J Methods Psychiatr Res 18:204-20. 2009
    ....
  29. ncbi request reprint Substance use and substance use disorders in a community sample of adolescents and young adults: incidence, age effects and patterns of use
    Axel Perkonigg
    Department of Clinical Psychology and Psychotherapy, Dresden University of Technology, Dresden, Germany
    Eur Addict Res 12:187-96. 2006
    ..Patterns of onset, cohort trends, and use of various substance classes are also analyzed...
  30. doi request reprint Social fear and social phobia types among community youth: differential clinical features and vulnerability factors
    Susanne Knappe
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Dresden, Germany
    J Psychiatr Res 45:111-20. 2011
    ....
  31. doi request reprint The diagnostic threshold of generalized anxiety disorder in the community: a developmental perspective
    Katja Beesdo-Baum
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Chemnitzer Street 46, 01187 Dresden, Germany
    J Psychiatr Res 45:962-72. 2011
    ..Developmental aspects require stronger consideration in future diagnostic systems...
  32. doi request reprint Clock drawing test: is it useful for dementia screening in patients having Parkinson disease with and without depression?
    Oliver Riedel
    Technische Universitaet Dresden, Institute of Clinical Psychology and Psychotherapy, Germany
    J Geriatr Psychiatry Neurol 26:151-7. 2013
    ..Our results indicate that CDT is a suitable screening instrument in patients with PD, but test results from patients with depression warrant careful consideration. ..
  33. ncbi request reprint Where have they been? Service use of regular substance users with and without abuse and dependence
    Axel Perkonigg
    Technische Universitat Dresden, Dresden, Germany
    Soc Psychiatry Psychiatr Epidemiol 41:470-9. 2006
    ..To present lifetime rates of service use for psychological and substance use related problems among regular substance users and to examine factors associated with service use...
  34. ncbi request reprint DSM-IV pain disorder in the general population. An exploration of the structure and threshold of medically unexplained pain symptoms
    Christine Frohlich
    Technische Universitat Dresden, Institute of Clinical Psychology and Psychotherapy, Dresden, Germany
    Eur Arch Psychiatry Clin Neurosci 256:187-96. 2006
    ..Despite an abundance of questionnaire data, the prevalence of clinically significant and medically unexplained pain syndromes in the general population has rarely been examined with a rigid personal-interview methodology...
  35. doi request reprint Psychometric properties of the dimensional anxiety scales for DSM-V in an unselected sample of German treatment seeking patients
    Katja Beesdo-Baum
    Institute of Clinical Psychology and Psychotherapy, Tech nische Universitaet Dresden, Germany
    Depress Anxiety 29:1014-24. 2012
    ..These scales use a common template to assess core constructs of fear and anxiety...
  36. doi request reprint Depression does not affect the treatment outcome of CBT for panic and agoraphobia: results from a multicenter randomized trial
    Angela Emmrich
    Institute of Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Dresden, Germany
    Psychother Psychosom 81:161-72. 2012
    ....
  37. doi request reprint The role of parental psychopathology and family environment for social phobia in the first three decades of life
    Susanne Knappe
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Dresden, Germany
    Depress Anxiety 26:363-70. 2009
    ..To examine the role of parental psychopathology and family environment for the risk of social phobia (SP) in offspring from childhood to early adulthood, encompassing the high risk period for SP...
  38. doi request reprint Maternal anxiety disorders prior to conception, psychopathology during pregnancy and early infants' development: a prospective-longitudinal study
    Julia Martini
    Institute of Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Chemnitzer Straße 46, 01187, Dresden, Germany
    Arch Womens Ment Health 16:549-60. 2013
    ..Results are expected to provide new insights into mechanisms of familial transmission and clues for targeted prevention and early intervention. ..
  39. pmc Traumatic experiences and posttraumatic stress disorder in soldiers following deployment abroad: how big is the hidden problem?
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy and Center of Clinical Epidemiology and Longitudinal Studies, Technische Universitat Dresden, Dresden, Germany
    Dtsch Arztebl Int 109:559-68. 2012
    ..Little is known about the frequency of traumatic event exposure and the development of post-traumatic stress disorder (PTSD) among German soldiers serving in Afghanistan...
  40. ncbi request reprint Aims, design and methods of the Smoking and Nicotine Dependence Awareness and Screening (SNICAS) study
    Stephan Muehlig
    Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden, Dresden, Germany
    Int J Methods Psychiatr Res 12:208-28. 2003
    ..This paper provides an overview of the design and methods of the study, informs about sampling and response rates, and examines whether the study sample could be considered representative of German primary care doctors...
  41. doi request reprint Low testosterone levels predict all-cause mortality and cardiovascular events in women: a prospective cohort study in German primary care patients
    Caroline Sievers
    Department of Endocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, Germany
    Eur J Endocrinol 163:699-708. 2010
    ..The objective was to determine whether baseline testosterone levels in women are associated with future overall or CV morbidity and mortality...
  42. doi request reprint Binary regression: total gain in positive and negative predictive values
    Jens Klotsche
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Chemnitzer Strasse 46, 01187 Dresden, Germany
    Biom J 54:808-23. 2012
    ..Both measures provide a useful tool for assessing the performance or accuracy of a set of predictor variables for the prediction of a binary outcome. This concept is a tool for evaluating the optimal prediction model in future research...
  43. ncbi request reprint How prevalent is smoking and nicotine dependence in primary care in Germany?
    Eva Hoch
    Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology, Munich, Germany
    Addiction 99:1586-98. 2004
    ....
  44. ncbi request reprint Cannabis use and cannabis use disorders and their relationship to mental disorders: a 10-year prospective-longitudinal community study in adolescents
    Hans Ulrich Wittchen
    Clinical Psychology and Psychotherapy, Technical University Dresden, D 01187 Dresden, Germany
    Drug Alcohol Depend 88:S60-70. 2007
    ..Whereas the role of externalizing disorders is relatively well established in predicting the onset of cannabis use (CU) or cannabis use disorder (CUD), the status of anxiety and mood disorders in predicting CU and CUD remains controversial...
  45. ncbi request reprint Parental major depression and the risk of depression and other mental disorders in offspring: a prospective-longitudinal community study
    Roselind Lieb
    Clinical Psychology and Epidemiology Unit, Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
    Arch Gen Psychiatry 59:365-74. 2002
    ..This article examines associations between DSM-IV depressive disorders, their natural course, other psychopathology, and parental major depression in a community sample of adolescents and young adults...
  46. ncbi request reprint Effects of ethanol administration and induction of anxiety-related affective states on the acoustic startle reflex in sons of alcohol-dependent fathers
    Ulrich Zimmermann
    Max Planck Institute of Psychiatry, Munich, Germany
    Alcohol Clin Exp Res 28:424-32. 2004
    ..This study used the startle reflex to investigate whether increased reactivity to stimuli inducing fear or related affective states might be one mechanism by which a family genetic risk promotes the development of alcohol use disorders...
  47. ncbi request reprint Childhood separation anxiety and the risk of subsequent psychopathology: Results from a community study
    Tanja M Brückl
    Department of Clinical Psychology and Epidemiology, Max Planck Institute of Psychiatry, Munich, Germany
    Psychother Psychosom 76:47-56. 2007
    ..To examine the association between separation anxiety disorder (SAD) and mental disorders in a community sample and to evaluate whether separation anxiety is specifically related to panic disorder with and without agoraphobia...
  48. doi request reprint Prevalence, incidence and determinants of PTSD and other mental disorders: design and methods of the PID-PTSD+3 study
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Germany
    Int J Methods Psychiatr Res 21:98-116. 2012
    ..We expect the findings to advance our understanding of a wide spectrum of adverse mental health outcomes beyond PTSD...
  49. ncbi request reprint Depressive episodes--evidence for a causal role of primary anxiety disorders?
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Dresden University of Technology, Chemnitzerstrasse 46, 01187 Dresden, Germany
    Eur Psychiatry 18:384-93. 2003
    ..The goal of this paper is to review recent literature, summarize implications of previous findings, and suggest directions for future research regarding preventive and intervention strategies...
  50. ncbi request reprint The interplay of familial depression liability and adverse events in predicting the first onset of depression during a 10-year follow-up
    Petra Zimmermann
    Molecular Psychology Unit, Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 63:406-14. 2008
    ....
  51. ncbi request reprint Frequency of albuminuria in primary care: a cross-sectional study
    Peter Bramlage
    Institute for Clinical Pharmacology, Medical Faculty, Technical University of Dresden, Dresden, Germany
    Eur J Cardiovasc Prev Rehabil 14:107-13. 2007
    ....
  52. ncbi request reprint Hypertension in overweight and obese primary care patients is highly prevalent and poorly controlled
    Peter Bramlage
    Institute of Clinical Pharmacology, Institute of Clinical Psychology and Psychotherapy, Technical University, Dresden
    Am J Hypertens 17:904-10. 2004
    ..The objective of this study was to assess the prevalence of hypertension and the diagnosis, treatment status, and control rates of hypertension in obese patients as compared to patients with normal weight...
  53. ncbi request reprint Clinical characteristics of major depressive disorder run in families--a community study of 933 mothers and their children
    Andrea Schreier
    Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology Unit, Kraepelinstrasse 2, 80804 Munich, Germany
    J Psychiatr Res 40:283-92. 2006
    ..Severe and melancholic MDD reveal a considerable high degree of familiar aggregation making the search for mechanisms involved in the familiar transmission of these forms of MDD particularly promising...
  54. ncbi request reprint Parental depression and depression in offspring: evidence for familial characteristics and subtypes?
    Roselind Lieb
    Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology, Kraepelinstrasse 2, 80804, Munich, Germany
    J Psychiatr Res 36:237-46. 2002
    ..Our findings suggest that clinical features of major depression may indicate familial subtypes of the disorder, most evident for recurrence and impairment...
  55. ncbi request reprint What predicts incident use of cannabis and progression to abuse and dependence? A 4-year prospective examination of risk factors in a community sample of adolescents and young adults
    Kirsten von Sydow
    Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology, Kraepelinstrasse 2, D 80804 Munich, Germany
    Drug Alcohol Depend 68:49-64. 2002
    ..To determine risk factors of incident onset of use, abuse and dependence of cannabis in a community sample of adolescents and young adults...
  56. doi request reprint Criminal behavior in opioid-dependent patients before and during maintenance therapy: 6-year follow-up of a nationally representative cohort sample
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Forensic Sci 57:1524-30. 2012
    ..Maintenance therapy is effective in the reduction in both narcotics-related and acquisition crime...
  57. doi request reprint Re-examining the differential familial liability of agoraphobia and panic disorder
    Susanne Knappe
    Institute of Clinical Psychology and Psychotherapy, Tech nische Universitaet, Dresden, Germany
    Depress Anxiety 29:931-8. 2012
    ..Convincing evidence for either position notably requires considering also other anxiety disorders to establish the position of AG relative to the panic/anxiety spectrum...
  58. doi request reprint Anxiety disorders before birth and self-perceived distress during pregnancy: associations with maternal depression and obstetric, neonatal and early childhood outcomes
    Julia Martini
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet, Dresden, Germany
    Early Hum Dev 86:305-10. 2010
    ..However, studies considering the effect of DSM-IV anxiety disorders beyond maternal self-perceived distress during pregnancy and its timing are lacking...
  59. ncbi request reprint Estimating causal effects from observational data with a model for multiple bias
    Michael Hofler
    Institute of Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Chemnitzer Strasse 46a, 01187 Dresden, Germany
    Int J Methods Psychiatr Res 16:77-87. 2007
    ..Multiple bias modelling, if properly used, reveals the necessity for a better understanding of bias, suggesting a need to conduct larger and more adequate validation studies on instruments that are used to diagnose mental disorders...
  60. ncbi request reprint Calculating control variables with age at onset data to adjust for conditions prior to exposure
    Michael Hofler
    Clinical Psychology and Epidemiology, Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 München, Germany
    Soc Psychiatry Psychiatr Epidemiol 40:731-6. 2005
    ..On the other hand, adjustment for such variables can also be a source of underestimation because such variables may be the causal consequence of X and part of the mechanism that leads from X to Y...
  61. ncbi request reprint Dependence symptoms in young cannabis users? A prospective epidemiological study
    Agnes Nocon
    Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 40:394-403. 2006
    ..To examine prospectively over a period of 4 years the profile of cannabis dependence and the risk of specific dependence criteria in a community sample of adolescents...
  62. doi request reprint Risk and speed of transitions to first alcohol dependence symptoms in adolescents: a 10-year longitudinal community study in Germany
    Silke Behrendt
    Institute of Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Germany
    Addiction 103:1638-47. 2008
    ..It is unclear whether early onset of AU is associated with the speed of transition to first AD symptoms and whether specific first AD symptoms and their timing are associated with AD...
  63. doi request reprint (Don't) panic in the scanner! How panic patients with agoraphobia experience a functional magnetic resonance imaging session
    Ulrike Lueken
    Institute of Clinical Psychology and Psychotherapy, Department of Psychology, Technische Universitat Dresden, Dresden, Germany
    Eur Neuropsychopharmacol 21:516-25. 2011
    ..Future studies are needed to investigate the relationship between self-reported distress and fMRI data in patient groups that are subject to neuroimaging research...
  64. doi request reprint Posttraumatic stress disorder and obesity: evidence for a risk association
    Axel Perkonigg
    Department of Clinical Psychology and Psychotherapy, Technical University of Dresden, Dresden, Germany
    Am J Prev Med 36:1-8. 2009
    ..The aim of this study was to examine prospective longitudinal associations between PTSD and obesity in a community sample...
  65. ncbi request reprint Maternal smoking and smoking in adolescents: a prospective community study of adolescents and their mothers
    Roselind Lieb
    Clinical Psychology and Epidemiology Unit, Max Planck Institute of Psychiatry, Munich, Germany
    Eur Addict Res 9:120-30. 2003
    ..Our findings show that maternal smoking predicts escalation of smoking, development of nicotine dependence, and stability of smoking behavior in children. Implications for specific intervention and prevention efforts are discussed...
  66. doi request reprint Prediction of incident diabetes mellitus by baseline IGF1 levels
    Harald Jorn Schneider
    Medizinische Klinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Eur J Endocrinol 164:223-9. 2011
    ..We hypothesized that both low- and high-IGF1 levels increase the risk of diabetes and aimed to assess the role of IGF1 in the risk of developing diabetes in a large prospective study...
  67. doi request reprint Trajectory classes of decline in health-related quality of life in Parkinson's disease: a pilot study
    Jens Klotsche
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Dresden, Germany
    Value Health 14:329-38. 2011
    ..To analyze the change in health-related quality-of-life (HRQoL) in patients with Parkinson's disease (PD) and to identify different classes of HRQoL decline...
  68. ncbi request reprint Psychometric properties of the Retrospective Self Report of Inhibition (RSRI) in a representative German sample
    Heike Rohrbacher
    Institute of Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Chemnitzer Strasse 46, Dresden, Germany
    Int J Methods Psychiatr Res 17:80-8. 2008
    ..The psychometric properties of the German RSRI were found to be comparable to those of the English version. The applicability of this questionnaire in German-speaking countries is therefore recommended for adolescents and young adults...
  69. doi request reprint Characterizing the association between parenting and adolescent social phobia
    Susanne Knappe
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Germany
    J Anxiety Disord 26:608-16. 2012
    ..paternal contributions, putative predictors of unfavorable parenting behaviors and its specificity for SP are warranted to delineate targeted prevention and intervention strategies...
  70. ncbi request reprint Association chain graphs: modelling etiological pathways
    Michael Hofler
    Technical University Dresden, Institute of Clinical Psychology and Psychotherapy, Dresden, Germany
    Int J Methods Psychiatr Res 12:77-84. 2003
    ..With this new type of graph, more specific information can be displayed whenever the data are essentially described only with statistical main- and two-way interaction effects...
  71. doi request reprint Anxiety disorders in mothers and their children: prospective longitudinal community study
    Andrea Schreier
    Max Planck Institute of Psychiatry, Munich, Germany
    Br J Psychiatry 192:308-9. 2008
    ..These results suggest that the type of maternal anxiety disorder and its severity of manifestation contribute to mother-offspring aggregation of anxiety...
  72. ncbi request reprint The short- and long-term effect of duloxetine on painful physical symptoms in patients with generalized anxiety disorder: results from three clinical trials
    Katja Beesdo
    Technische Universitaet Dresden, Institute of Clinical Psychology and Psychotherapy, Dresden, Germany
    J Anxiety Disord 23:1064-71. 2009
    ..02). In conclusion, duloxetine was efficacious in the short- and long-term treatment of PPS, which are common in GAD patients...
  73. doi request reprint Association between generalized anxiety levels and pain in a community sample: evidence for diagnostic specificity
    Katja Beesdo
    Institute of Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Chemnitzer Str 46, 01187 Dresden, Germany
    J Anxiety Disord 23:684-93. 2009
    ..It is unclear whether generalized anxiety disorder (GAD) has a specific relationship to pain syndromes, going beyond the established association of pain with anxiety syndromes in general...
  74. ncbi request reprint The natural course of DSM-IV somatoform disorders and syndromes among adolescents and young adults: a prospective-longitudinal community study
    Roselind Lieb
    Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology Unit, Kraepelinstr 2, Munich, Germany
    Eur Psychiatry 17:321-31. 2002
    ..Although somatoform disorders are assumed to be chronic clinical conditions, epidemiological knowledge on their natural course based on representative samples is not available...
  75. doi request reprint The natural course of cannabis use, abuse and dependence during the first decades of life
    Axel Perkonigg
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Germany
    Addiction 103:439-49; discussion 450-1. 2008
    ..The current study estimated rates and risk factors associated with stability and variation in cannabis use patterns, cannabis abuse and cannabis dependence in a community sample over a 10-year period...
  76. ncbi request reprint High cholesterol, triglycerides, and body-mass index in suicide attempters
    Jurgen Brunner
    Max Planck Institute of Psychiatry, Munich, Germany
    Arch Suicide Res 10:1-9. 2006
    ..The results of this study are compatible with two recent epidemiological cohort studies showing a positive association between cholesterol and completed suicide...
  77. ncbi request reprint Accuracy of anthropometric indicators of obesity to predict cardiovascular risk
    Harald J Schneider
    Institute of Clinical Psychology and Psychotherapy, Technical University, Dresden, Germany
    J Clin Endocrinol Metab 92:589-94. 2007
    ..However, more recently, waist to hip ratio (WHR) or waist circumference (WC) as more sensitive measures for visceral obesity have been proposed to be more indicative of cardiovascular risk...
  78. ncbi request reprint One-year mortality rates of patients receiving methadone and buprenorphine maintenance therapy: a nationally representative cohort study in 2694 patients
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Clin Psychopharmacol 26:657-60. 2006
    ..Taking into account the high comorbidity of opioid dependent patients and the severity of dependence, the mortality rate of approximately 1% confirms that maintenance treatment could be regarded as a fairly safe treatment...
  79. doi request reprint How specific is specific phobia? Different neural response patterns in two subtypes of specific phobia
    Ulrike Lueken
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, 01187 Dresden, Germany
    Neuroimage 56:363-72. 2011
    ..If replicated, results could contribute to a better understanding of underlying neurobiological mechanisms of specific phobia and their respective classification...
  80. ncbi request reprint Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers
    Ulrich Zimmermann
    Max Planck Institute of Psychiatry, Kraepelinstrasse, Munich, Germany
    Neuropsychopharmacology 29:1156-65. 2004
    ....
  81. doi request reprint Cognitive impairment in 873 patients with idiopathic Parkinson's disease. Results from the German Study on Epidemiology of Parkinson's Disease with Dementia (GEPAD)
    Oliver Riedel
    Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden, Chemnitzer Strasse 46, Dresden, Germany
    J Neurol 255:255-64. 2008
    ..Prevalence estimates of these complications are quite variable and are lacking for the outpatient care sector...
  82. pmc Associations of familial risk factors with social fears and social phobia: evidence for the continuum hypothesis in social anxiety disorder?
    Susanne Knappe
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Chemnitzer Str 46, 01187 Dresden, Germany
    J Neural Transm 116:639-48. 2009
    ..Parental psychopathology and negative parental styles may be used defining high-risk groups to assign individuals with already subthreshold conditions of SAD to early intervention programs...
  83. doi request reprint Is moderate substance use associated with altered executive functioning in a population-based sample of young adults?
    Michaela Piechatzek
    Ludwig Maximilian University, Munich, Germany
    Hum Psychopharmacol 24:650-65. 2009
    ..Though, the majority of users are not involved in heavy use. This study investigates the association between moderate use and cognition in a population-based sample...
  84. ncbi request reprint Mania, hypomania, and suicidality: findings from a prospective community study
    Thomas Bronisch
    Max Planck Institute of Psychiatry, Munich, Germany
    Arch Suicide Res 9:267-78. 2005
    ..5). No associations could be found between prior mania/hypo-mania and incident suicide attempts. The prospective analyses revealed a remarkable relationship between preexisting mania and increased risk for subsequent suicidal ideation...
  85. ncbi request reprint Prevalence of low male testosterone levels in primary care in Germany: cross-sectional results from the DETECT study
    Harald Jorn Schneider
    Medizinische Klinik, Ludwig Maximilian University, Innenstadt, Munich, Germany
    Clin Endocrinol (Oxf) 70:446-54. 2009
    ....
  86. doi request reprint Do parental psychopathology and unfavorable family environment predict the persistence of social phobia?
    Susanne Knappe
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Chemnitzer Str 46, 01187 Dresden, Germany
    J Anxiety Disord 23:986-94. 2009
    ..Predictors for SP persistence differ from those predicting SP onset. Unfavorable family environment alone and in interaction with parental disorders predict higher SP persistence...
  87. ncbi request reprint Generalized anxiety disorder: prevalence, burden, and cost to society
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden, Germany
    Depress Anxiety 16:162-71. 2002
    ....
  88. pmc A novel nonparametric approach for estimating cut-offs in continuous risk indicators with application to diabetes epidemiology
    Jens Klotsche
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Germany
    BMC Med Res Methodol 9:63. 2009
    ..The cut-off corresponding to the Youden-Index is often applied in epidemiology and biomedical literature for dichotomizing a continuous risk indicator...
  89. ncbi request reprint Use, abuse and dependence of ecstasy and related drugs in adolescents and young adults-a transient phenomenon? Results from a longitudinal community study
    Kirsten von Sydow
    Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology, Kraepelinstrasse 2, 80804, Munich, Germany
    Drug Alcohol Depend 66:147-59. 2002
    ..To determine incidence and patterns of natural course of ecstasy/stimulant/hallucinogen (ESH) use and disorders as well as cohort effects in a community sample of adolescents and young adults...
  90. ncbi request reprint The use of weights to account for non-response and drop-out
    Michael Hofler
    Max Planck Institut of Psychiatry, Clinical Psychology and Epidemiology, Kraepelinstr 2 10, 80804, Munchen, Germany
    Soc Psychiatry Psychiatr Epidemiol 40:291-9. 2005
    ..Non-participation and drop-out may introduce a bias whose magnitude depends on how strongly its determinants are related to the respective parameter of interest...
  91. ncbi request reprint Prevalence of mental disorders in acromegaly: a cross-sectional study in 81 acromegalic patients
    Caroline Sievers
    Departments of Endocrinology and Molecular Psychology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, Germany
    Clin Endocrinol (Oxf) 71:691-701. 2009
    ....
  92. doi request reprint [Cardiovascular risk assessment by primary-care physicians in Germany and its lack of agreement with the Established Risk Scores (DETECT)]
    Sigmund Silber
    Kardiologische Praxis und Praxisklinik, Akademische Lehrpraxis der Ludwig Maximilians Universität München, Am Isarkanal 36, Munich, Germany
    Med Klin (Munich) 103:638-45. 2008
    ..The concordance of several cardiovascular risk scores (PROCAM Score, Framingham Score and ESC Score) and its agreement with the treating physicians' risk assessment is unclear...
  93. doi request reprint Feasibility and outcome of substitution treatment of heroin-dependent patients in specialized substitution centers and primary care facilities in Germany: a naturalistic study in 2694 patients
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Chemnitzerstrasse 46, 01187 Dresden, Germany
    Drug Alcohol Depend 95:245-57. 2008
    ..Despite many short-term studies, little is known about the long-term (12-month) effects of these treatments in different settings, i.e. primary care-based (PMC) and specialized substitution centers (SSCs)...
  94. doi request reprint The position of anxiety disorders in structural models of mental disorders
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Department of Psychology, Technische Universita t Dresden, Chemnitzer Strasse 46, D 01187 Dresden, Germany
    Psychiatr Clin North Am 32:465-81. 2009
    ..Extant results are not stable enough to form the basis of clinical diagnostic classification systems such as DSM and the International Classification of Diseases...
  95. doi request reprint Women-specific mental disorders in DSM-V: are we failing again?
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Department of Psychology, Technische Universitat Dresden, Chemnitzer Str 46, 01187 Dresden, Germany
    Arch Womens Ment Health 13:51-5. 2010
    ....
  96. ncbi request reprint Natural course and burden of bipolar disorders
    Hans Ulrich Wittchen
    Technical University of Dresden, Institute of Clinical Psychology and Psychotherapy D 01062 Dresden, Germany
    Int J Neuropsychopharmacol 6:145-54. 2003
    ..iii) The value of both types of studies might be enhanced, if beyond the use of standardized diagnostic interview, special attempts are made to use prospective life- and episode-charting methods for bipolar illnesses...
  97. ncbi request reprint Posttraumatic stress disorder: diagnostic and epidemiological perspectives
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Dresden, Germany
    CNS Spectr 14:5-12. 2009
    ..A further exploitation of the existing data, and an improvement of existing epidemiological methods, strategies, and assessments are likely to substantially contribute to the clarification of unresolved diagnostic issues...
  98. ncbi request reprint Differential familial liability of panic disorder and agoraphobia
    A Nocon
    Research Group of Molecular Psychology, Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology, Munich, Germany
    Depress Anxiety 25:422-34. 2008
    ..We confirmed and expanded previous results from clinical samples that comorbid PD and AG aggregate in families. AG without PD is not familial, but it might enhance the familial transmission of PD...
  99. ncbi request reprint Cardiovascular risk factors in primary care: methods and baseline prevalence rates--the DETECT program
    H U Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden, Germany
    Curr Med Res Opin 21:619-30. 2005
    ....
  100. ncbi request reprint What are the high risk periods for incident substance use and transitions to abuse and dependence? Implications for early intervention and prevention
    H U Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Chemnitzer Str 46, D 01187 Dresden, Germany
    Int J Methods Psychiatr Res 17:S16-29. 2008
    ..It is the aim of this paper to describe the high density incidence and transition periods of SU and SUD for alcohol, nicotine, cannabis and other illicit drugs for young males and females...