Alexandra Wigger

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. ncbi request reprint Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin
    Alexandra Wigger
    Max Planck Institute of Psychiatry, Behavioural Neuroendocrinology, Munich, Germany
    Neuropsychopharmacology 29:1-14. 2004
  2. ncbi request reprint Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety
    Chris Murgatroyd
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 24:7762-70. 2004
  3. ncbi request reprint Genetic predisposition to anxiety-related behavior determines coping style, neuroendocrine responses, and neuronal activation during social defeat
    Elisabeth Frank
    Max Planck Institute of Psychiatry, Munich, Germany
    Behav Neurosci 120:60-71. 2006
  4. ncbi request reprint Viral vector-mediated gene transfer of the vole V1a vasopressin receptor in the rat septum: improved social discrimination and active social behaviour
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    Eur J Neurosci 18:403-11. 2003
  5. ncbi request reprint Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 28:235-43. 2003
  6. ncbi request reprint High vs low anxiety-related behavior rats: an animal model of extremes in trait anxiety
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Munich, Germany
    Behav Genet 32:301-14. 2002
  7. ncbi request reprint Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders
    Martin E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
    Neuropsychopharmacology 26:94-105. 2002
  8. ncbi request reprint High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats
    Raffael Kalisch
    NMR Study Group, Max Planck Institute of Psychiatry, Munich, Germany
    Neuroimage 23:382-91. 2004
  9. ncbi request reprint The CRH1 receptor antagonist R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety
    Marike Lancel
    Max Planck Institute of Psychiatry, Section Neurophysiology, Kraepelinstr 2 10, D 80804, Munich, Germany
    J Psychiatr Res 36:197-208. 2002
  10. ncbi request reprint Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior
    Markus S H Henniger
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 26:729-36. 2002

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin
    Alexandra Wigger
    Max Planck Institute of Psychiatry, Behavioural Neuroendocrinology, Munich, Germany
    Neuropsychopharmacology 29:1-14. 2004
    ....
  2. ncbi request reprint Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety
    Chris Murgatroyd
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 24:7762-70. 2004
    ..Taken together, our results demonstrate a role for an AVP gene polymorphism and CBF-A in elevated AVP expression in the PVN of HAB rats likely to contribute to their behavioral and neuroendocrine phenotype...
  3. ncbi request reprint Genetic predisposition to anxiety-related behavior determines coping style, neuroendocrine responses, and neuronal activation during social defeat
    Elisabeth Frank
    Max Planck Institute of Psychiatry, Munich, Germany
    Behav Neurosci 120:60-71. 2006
    ..In the latter, Fos expression upon SD was enhanced in the amygdala and hypothalamic areas compared with LABs, whereas it was diminished in prefrontal and brainstem areas...
  4. ncbi request reprint Viral vector-mediated gene transfer of the vole V1a vasopressin receptor in the rat septum: improved social discrimination and active social behaviour
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    Eur J Neurosci 18:403-11. 2003
    ..Viral vector-mediated gene transfer provides a valuable tool for studies on the role of localized gene expression on behavioural parameters...
  5. ncbi request reprint Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 28:235-43. 2003
    ..This novel mechanism of action of paroxetine on vasopressin gene regulation renders vasopressinergic neuronal circuits a promising target for the development of more causal antidepressant treatment strategies...
  6. ncbi request reprint High vs low anxiety-related behavior rats: an animal model of extremes in trait anxiety
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Munich, Germany
    Behav Genet 32:301-14. 2002
    ..HAB/LAB rats are thus proving to be a unique animal model to identify and characterize neurobiological, neuroendocrine, and genetic correlates of trait anxiety, and perhaps depression, in humans...
  7. ncbi request reprint Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders
    Martin E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
    Neuropsychopharmacology 26:94-105. 2002
    ....
  8. ncbi request reprint High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats
    Raffael Kalisch
    NMR Study Group, Max Planck Institute of Psychiatry, Munich, Germany
    Neuroimage 23:382-91. 2004
    ..In the context of an anxiety-inhibiting role of the dmPFC, we propose that failure to sufficiently activate this region in stressful situations may contribute to high trait anxiety...
  9. ncbi request reprint The CRH1 receptor antagonist R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety
    Marike Lancel
    Max Planck Institute of Psychiatry, Section Neurophysiology, Kraepelinstr 2 10, D 80804, Munich, Germany
    J Psychiatr Res 36:197-208. 2002
    ..e. CRH hypersecretion) condition only...
  10. ncbi request reprint Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior
    Markus S H Henniger
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 26:729-36. 2002
    ..It is concluded that, although such a relationship might exist in some individuals, increased levels of inborn anxiety and alcohol consumption are not necessarily related...
  11. ncbi request reprint Anxiety and hippocampus volume in the rat
    Raffael Kalisch
    NMR Study Group, Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 31:925-32. 2006
    ....
  12. ncbi request reprint Altered brain activation pattern associated with drug-induced attenuation of enhanced depression-like behavior in rats bred for high anxiety
    Patrik Muigg
    Department of Pharmacology and Toxicology, University of Innsbruck, Innsbruck, Austria
    Biol Psychiatry 61:782-96. 2007
    ..The aim of the present study was to identify neuronal substrates underlying this treatment response in HABs...
  13. ncbi request reprint Airjet and FG-7142-induced Fos expression differs in rats selectively bred for high and low anxiety-related behavior
    Peter Salchner
    Department of Pharmacology and Toxicology, Institute of Pharmacy and Center of Molecular Biosciences Innsbruck, University of Innsbruck, Peter Mayr Strasse 1, A 6020 Innsbruck, Austria
    Neuropharmacology 50:1048-58. 2006
    ....
  14. ncbi request reprint Neurobiological correlates of high (HAB) versus low anxiety-related behavior (LAB): differential Fos expression in HAB and LAB rats
    Nicolas Salome
    Laboratoire de Stress Périnatal, Universite de Lille 1, Villeneuve d Ascq, France
    Biol Psychiatry 55:715-23. 2004
    ..Two Wistar rat lines selectively bred for either high (HAB) or low (LAB) anxiety-related behavior were used to identify neurobiological correlates of trait anxiety...
  15. ncbi request reprint Reliability of high and low anxiety-related behaviour: influence of laboratory environment and multifactorial analysis
    Nicolas Salome
    Laboratoire de Neurosciences du Comportement, Universite de Lille 1, SN4, 59655 Villeneuve d Ascq cedex, France
    Behav Brain Res 136:227-37. 2002
    ..Finally, the principal component analysis again confirmed that the selection of HAB and LAB rats is based on anxiety-related behaviour rather than locomotor activity...
  16. ncbi request reprint Decreased sensitivity to thermal pain in rats bred for high anxiety-related behaviour is attenuated by citalopram or diazepam treatment
    Thomas Jochum
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07743 Jena, Federal Republic of Germany
    Behav Brain Res 183:18-24. 2007
    ....