T C Wetter

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. ncbi request reprint Sleep and periodic leg movement patterns in drug-free patients with Parkinson's disease and multiple system atrophy
    T C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    Sleep 23:361-7. 2000
  2. ncbi request reprint Increased alpha activity in REM sleep in de novo patients with Parkinson's disease
    T C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    Mov Disord 16:928-33. 2001
  3. ncbi request reprint Restless legs syndrome probably induced by risperidone treatment
    T C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacopsychiatry 35:109-11. 2002
  4. ncbi request reprint Restless legs syndrome: a review for the renal care professionals
    T C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    EDTNA ERCA J 27:42-6. 2001
  5. ncbi request reprint Current treatment options for restless legs syndrome
    Thomas C Wetter
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    Expert Opin Pharmacother 4:1727-38. 2003
  6. ncbi request reprint An automatic method for scoring leg movements in polygraphic sleep recordings and its validity in comparison to visual scoring
    Thomas C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    Sleep 27:324-8. 2004
  7. ncbi request reprint Effect of the GABAA agonist gaboxadol on nocturnal sleep and hormone secretion in healthy elderly subjects
    M Lancel
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Am J Physiol Endocrinol Metab 281:E130-7. 2001
  8. ncbi request reprint Clinical characteristics and frequency of the hereditary restless legs syndrome in a population of 300 patients
    J Winkelmann
    Max Planck Institute of Psychiatry, Section of Neurology, Munich, Germany
    Sleep 23:597-602. 2000
  9. ncbi request reprint Reduced NAA in the thalamus and altered membrane and glial metabolism in schizophrenic patients detected by 1H-MRS and tissue segmentation
    D P Auer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804, Munchen, Germany
    Schizophr Res 52:87-99. 2001
  10. doi request reprint The neural correlates and temporal sequence of the relationship between shock exposure, disturbed sleep and impaired consolidation of fear extinction
    V I Spoormaker
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    J Psychiatr Res 44:1121-8. 2010

Detail Information

Publications35

  1. ncbi request reprint Sleep and periodic leg movement patterns in drug-free patients with Parkinson's disease and multiple system atrophy
    T C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    Sleep 23:361-7. 2000
    ..To assess and compare polygraphic sleep measures and periodic leg movement (PLM) patterns in untreated patients with mild to moderate Parkinson's disease (PD), multiple system atrophy (MSA) and healthy age-matched controls...
  2. ncbi request reprint Increased alpha activity in REM sleep in de novo patients with Parkinson's disease
    T C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    Mov Disord 16:928-33. 2001
    ..The analysis of the temporal dynamics of the observed changes suggests a dysregulation of the REM sleep homeostasis in the patients with PD...
  3. ncbi request reprint Restless legs syndrome probably induced by risperidone treatment
    T C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacopsychiatry 35:109-11. 2002
    ..Restless legs syndrome (RLS), which shares some clinical features with akathisia, is a distinct movement and sleep disorder that may be induced by various drugs that act on the CNS...
  4. ncbi request reprint Restless legs syndrome: a review for the renal care professionals
    T C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    EDTNA ERCA J 27:42-6. 2001
    ..Alternative medications are opioids and benzodiazepines. In secondary restless legs syndrome the underlying illness should be treated first, but dopaminergic drugs may also be helpful...
  5. ncbi request reprint Current treatment options for restless legs syndrome
    Thomas C Wetter
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    Expert Opin Pharmacother 4:1727-38. 2003
    ..In secondary RLS, the underlying illness should first be treated, although dopaminergic drugs may also be helpful...
  6. ncbi request reprint An automatic method for scoring leg movements in polygraphic sleep recordings and its validity in comparison to visual scoring
    Thomas C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    Sleep 27:324-8. 2004
    ..The study presents an automatic method for scoring leg movements in polysomnographic recordings and describes an empirical investigation of its validity...
  7. ncbi request reprint Effect of the GABAA agonist gaboxadol on nocturnal sleep and hormone secretion in healthy elderly subjects
    M Lancel
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Am J Physiol Endocrinol Metab 281:E130-7. 2001
    ....
  8. ncbi request reprint Clinical characteristics and frequency of the hereditary restless legs syndrome in a population of 300 patients
    J Winkelmann
    Max Planck Institute of Psychiatry, Section of Neurology, Munich, Germany
    Sleep 23:597-602. 2000
    ..1% vs. 2.6%, p < 0.05). Our study shows that patients with hereditary RLS may experience an earlier onset of the disease. Hereditary and non-hereditary RLS present with similiar clinical signs and symptoms...
  9. ncbi request reprint Reduced NAA in the thalamus and altered membrane and glial metabolism in schizophrenic patients detected by 1H-MRS and tissue segmentation
    D P Auer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804, Munchen, Germany
    Schizophr Res 52:87-99. 2001
    ..In addition, we demonstrate the need to correct metabolite concentrations for regional tissue composition in studies employing patients with altered brain morphology...
  10. doi request reprint The neural correlates and temporal sequence of the relationship between shock exposure, disturbed sleep and impaired consolidation of fear extinction
    V I Spoormaker
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    J Psychiatr Res 44:1121-8. 2010
    ..These findings help understand the neurobiological basis and the temporal sequence of the relationship between shock exposure, disturbed sleep and impaired consolidation of extinction, as observed in PTSD...
  11. ncbi request reprint Polysomnographic measures in Parkinson's disease: a comparison between patients with and without REM sleep disturbances
    T C Wetter
    Max Planck Institute of Psychiatry, Munich, Federal Republic of Germany
    Wien Klin Wochenschr 113:249-53. 2001
    ..To assess the frequency of rapid eye movement (REM) sleep abnormalities in Parkinson's disease (PD) patients and compare polygraphic sleep measures in those with and without REM sleep disturbances...
  12. ncbi request reprint The GABA uptake inhibitor tiagabine promotes slow wave sleep in normal elderly subjects
    S Mathias
    Max Planck Institute of Psychiatry, Munich, Germany
    Neurobiol Aging 22:247-53. 2001
    ....
  13. ncbi request reprint Decreased corticotropin-releasing hormone (CRH) concentrations in the cerebrospinal fluid of eucortisolemic suicide attempters
    J Brunner
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804, Munich, Germany
    J Psychiatr Res 35:1-9. 2001
    ..non-attempters. Further studies with more homogeneous samples, drug-free patients and with simultaneous assessment of various parameters of the HPA system are warranted...
  14. ncbi request reprint Effect of sleep deprivation on motor performance in patients with Parkinson's disease
    B Hogl
    Max Planck Institute of Psychiatry, Neurology Department, Munich, Germany
    Mov Disord 16:616-21. 2001
    ..However, the results indicate that different response types to sleep deprivation may exist and that a subgroup of patients could benefit from partial sleep deprivation...
  15. ncbi request reprint Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome
    I Eisensehr
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    Neurology 57:1307-9. 2001
    ..The authors conclude that striatal dopamine transporter and receptor density is normal in drug-naive and levodopa-treated patients with RLS...
  16. ncbi request reprint Gray matter-changes and correlates of disease severity in schizophrenia: a statistical parametric mapping study
    M Wilke
    NMR, Suicide study group, Max Planck-Institute of Psychiatry, Kraepelinstrasse 10, Munich, 80804, Germany
    Neuroimage 13:814-24. 2001
    ..These findings may be of potentially large importance for both the future interpretation and design of neuroimaging studies in schizophrenia and the further elucidation of possible pathophysiological processes occurring in this disease...
  17. ncbi request reprint Brain activation and hypothalamic functional connectivity during human non-rapid eye movement sleep: an EEG/fMRI study
    C Kaufmann
    Max Planck Institute of Psychiatry, Munich, Germany
    Brain 129:655-67. 2006
    ..We describe a specific pattern of decreased brain activity during sleep and suggest that this pattern must be synchronized for establishing and maintaining sleep...
  18. ncbi request reprint Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans
    Katja Held
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    Pharmacopsychiatry 35:135-43. 2002
    ..The similarities of the effect of Mg(2+) and that of the related electrolyte Li+ furthermore supports the possible efficacy of Mg(2+) as a mood stabilizer...
  19. ncbi request reprint The influence of different definition criteria on the PLM index
    Stephany Fulda
    Max Planck Institute of Psychiatry, Munich, Germany
    Sleep Med 8:484-90. 2007
    ..We investigated to what extent changes in PLM criteria for leg movement duration, intermovement interval and combination of bilateral leg movements (LM) influence the PLM index...
  20. ncbi request reprint Where dopamine meets opioids: a meta-analysis of the placebo effect in restless legs syndrome treatment studies
    Stephany Fulda
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    Brain 131:902-17. 2008
    ..This meta-analysis yields several implications for the planning of both clinical RLS treatment studies and basic research programs...
  21. ncbi request reprint Plasma levels of tumor necrosis factor alpha and soluble tumor necrosis factor receptors in patients with narcolepsy
    Hubertus Himmerich
    Max Planck Institute of Psychiatry, Munich, Germany
    Arch Intern Med 166:1739-43. 2006
    ..Recent studies suggest that the immune system might play a pathogenic role pointing to a possible involvement of inflammatory cytokines...
  22. ncbi request reprint Successful treatment of tardive lingual dystonia with botulinum toxin: case report and review of the literature
    Johannes M H Hennings
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 32:1167-71. 2008
    ..A review of the literature that is part of this article adverts BTX-A injection as a potential beneficial approach of various kinds of TD...
  23. ncbi request reprint Rapid eye movement-related brain activation in human sleep: a functional magnetic resonance imaging study
    Renate Wehrle
    Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
    Neuroreport 16:853-7. 2005
    ..Studying intact neuronal networks underlying sleep regulation is no longer confined to animal models, but has been shown to be feasible in humans by a combined functional magnetic resonance imaging and electroencephalograph approach...
  24. ncbi request reprint Functional MRI during sleep: BOLD signal decreases and their electrophysiological correlates
    Michael Czisch
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 Munich, Germany
    Eur J Neurosci 20:566-74. 2004
    ..This sleep stage-dependent deactivation might serve to protect the brain from arousing stimuli, particularly during the light phases of sleep shortly after sleep onset...
  25. ncbi request reprint Altered processing of acoustic stimuli during sleep: reduced auditory activation and visual deactivation detected by a combined fMRI/EEG study
    Michael Czisch
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Neuroimage 16:251-8. 2002
    ....
  26. ncbi request reprint The effect of cabergoline on sleep, periodic leg movements in sleep, and early morning motor function in patients with Parkinson's disease
    Birgit Hogl
    Max Planck Institute of Psychiatry, Department of Neurology, Munich, Germany
    Neuropsychopharmacology 28:1866-70. 2003
    ..Cabergoline slightly fragmented sleep, without altering its total amount. The functional significance of this finding is uncertain. The subjective quality of sleep improved, and periodic limb movements in sleep decreased...
  27. ncbi request reprint Microstructure of the non-rapid eye movement sleep electroencephalogram in patients with newly diagnosed Parkinson's disease: effects of dopaminergic treatment
    Hans Brunner
    Max Planck Institute of Psychiatry, Munich, Germany
    Mov Disord 17:928-33. 2002
    ..It is suggested that Parkinson's disease as well as the application of dopaminergic drugs exerts a desynchronizing effect on the sleep EEG that is reflected in a disruption of sleep continuity...
  28. ncbi request reprint One-year treatment with standard and sustained-release levodopa: appropriate long-term treatment of restless legs syndrome?
    Claudia Trenkwalder
    Max Planck Institute of Psychiatry, Munich, Germany
    Mov Disord 18:1184-9. 2003
    ....
  29. ncbi request reprint Functional neuroimaging studies in restless legs syndrome
    Thomas C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    Sleep Med 5:401-6. 2004
    ..Further investigations, especially at night when RLS symptoms are most pronounced, will lead to a better understanding of the mechanisms underlying RLS...
  30. ncbi request reprint Dopamine agonists for the treatment of restless legs syndrome
    Stephany Fulda
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    Expert Opin Pharmacother 6:2655-66. 2005
    ..In May 2005, the first dopamine agonist, ropinirole, was approved by the FDA. This review discusses treatment studies of dopamine agonists in patients with restless legs syndrome and focuses on long-term treatment with dopamine agonists...
  31. ncbi request reprint Clinical trials in restless legs syndrome--recommendations of the European RLS Study Group (EURLSSG)
    Claudia Trenkwalder
    Paracelsus Elena Hospital, Center of Parkinsonism and Movement Disorders, Klinikstr 16, 34128 Kassel, Germany
    Mov Disord 22:S495-504. 2007
    ..The aim of these recommendations is to support research groups or pharmaceutical companies in the design of optimized study protocols...
  32. ncbi request reprint Is daytime sleepiness a neglected problem in patients with restless legs syndrome?
    Stephany Fulda
    Max Planck Institute of Psychiatry, Munich, Germany
    Mov Disord 22:S409-13. 2007
    ..Summarizing 26 studies that assessed sleepiness by means of the Epworth Sleepiness Scale (ESS) in untreated subjects with idiopathic RLS, we found that 20 to 25% of subjects are at an increased risk for daytime sleepiness...
  33. ncbi request reprint Endocrine rhythms in patients with restless legs syndrome
    Thomas C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neurol 249:146-51. 2002
    ..9 +/- 17.1) compared with the controls (12.0 +/- 9.2; p < 0.05). It is suggested that a possible dysfunction of the dopaminergic system in RLS does not affect the release of prolactin and hGH from the pituitary gland...
  34. ncbi request reprint Emerging drugs for restless legs syndrome
    Stephany Fulda
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    Expert Opin Emerg Drugs 10:537-52. 2005
    ..Ropinirole is the first dopamine agonist that has been approved by the FDA in May 2005. In addition, several promising new therapies with nondopamine profiles are under development for RLS...
  35. ncbi request reprint Functional microstates within human REM sleep: first evidence from fMRI of a thalamocortical network specific for phasic REM periods
    Renate Wehrle
    Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
    Eur J Neurosci 25:863-71. 2007
    ..Thus, REM sleep has to be subdivided into tonic REM sleep with residual alertness, and phasic REM sleep with the brain acting as a functionally isolated and closed intrinsic loop...