Hauke B Werner

Summary

Affiliation: Max Planck Institute for Experimental Medicine
Country: Germany

Publications

  1. doi request reprint A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system
    Hauke B Werner
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Glia 61:567-86. 2013
  2. pmc Proteolipid protein is required for transport of sirtuin 2 into CNS myelin
    Hauke B Werner
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Goettingen, Germany
    J Neurosci 27:7717-30. 2007
  3. doi request reprint The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia
    Anke Schardt
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    J Neurosci Res 87:3465-79. 2009
  4. doi request reprint Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection
    Wiebke Mobius
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Neuron Glia Biol 4:111-27. 2008
  5. doi request reprint Systematic approaches to central nervous system myelin
    Patricia de Monasterio-Schrader
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann Rein Str 3, 37075, Gottingen, Germany
    Cell Mol Life Sci 69:2879-94. 2012
  6. pmc Myelin proteomics: molecular anatomy of an insulating sheath
    Olaf Jahn
    Proteomics Group, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Mol Neurobiol 40:55-72. 2009
  7. ncbi request reprint Molecular evolution of myelin basic protein, an abundant structural myelin component
    Schanila Nawaz
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Glia 61:1364-77. 2013
  8. doi request reprint Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium
    Schanila Nawaz
    Max Planck Institute of Experimental Medicine, University of Gottingen, D 37075 Gottingen, Germany
    J Neurosci 29:4794-807. 2009
  9. ncbi request reprint Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes
    Celia M Kassmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Nat Genet 39:969-76. 2007

Collaborators

Detail Information

Publications9

  1. doi request reprint A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system
    Hauke B Werner
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Glia 61:567-86. 2013
    ..However, M6B is not efficiently sorted into mature myelin, in which it is 200-fold less abundant than PLP. Thus, only PLP contributes to the high cholesterol content of myelin by association and co-transport...
  2. pmc Proteolipid protein is required for transport of sirtuin 2 into CNS myelin
    Hauke B Werner
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Goettingen, Germany
    J Neurosci 27:7717-30. 2007
    ..Because normal SIRT2 activity is controlled by the NAD+/NADH ratio, its function may be coupled to the axo-glial metabolism and the long-term support of axons by oligodendrocytes...
  3. doi request reprint The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia
    Anke Schardt
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    J Neurosci Res 87:3465-79. 2009
    ..We suggest that Rab3A may regulate SNAP-29-mediated membrane fusion during myelination...
  4. doi request reprint Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection
    Wiebke Mobius
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Neuron Glia Biol 4:111-27. 2008
    ..We suggest that the molecular shift from P0 to PLP also correlates with the concentration of adhesive forces at the radial component, and that the new balance between membrane adhesion and dynamics was favorable for CNS myelination...
  5. doi request reprint Systematic approaches to central nervous system myelin
    Patricia de Monasterio-Schrader
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann Rein Str 3, 37075, Gottingen, Germany
    Cell Mol Life Sci 69:2879-94. 2012
    ..Systematic approaches to oligodendrocytes and myelin thus provide valuable resources for the molecular dissection of developmental myelination, glia-axonal interactions, leukodystrophies, and demyelinating diseases...
  6. pmc Myelin proteomics: molecular anatomy of an insulating sheath
    Olaf Jahn
    Proteomics Group, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Mol Neurobiol 40:55-72. 2009
    ....
  7. ncbi request reprint Molecular evolution of myelin basic protein, an abundant structural myelin component
    Schanila Nawaz
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Glia 61:1364-77. 2013
    ..We propose that the PIP₂-binding function of MBP is evolutionarily old and that its emergence in ancient gnathostomata provided glial cells with the competence to myelinate...
  8. doi request reprint Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium
    Schanila Nawaz
    Max Planck Institute of Experimental Medicine, University of Gottingen, D 37075 Gottingen, Germany
    J Neurosci 29:4794-807. 2009
    ..Together, these results establish that PIP2 is an essential determinant for stable membrane binding of MBP and provide a novel link between glial phosphoinositol metabolism and MBP function in development and disease...
  9. ncbi request reprint Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes
    Celia M Kassmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Nat Genet 39:969-76. 2007
    ..We conclude that peroxisomes provide oligodendrocytes with an essential neuroprotective function against axon degeneration and neuroinflammation, which is relevant for human demyelinating diseases...