E E Wanker

Summary

Affiliation: Max Planck Institute for Molecular Genetics
Country: Germany

Publications

  1. ncbi request reprint Protein aggregation in Huntington's and Parkinson's disease: implications for therapy
    E E Wanker
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, D 14195, Berlin, Germany
    Mol Med Today 6:387-91. 2000
  2. pmc Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation
    S Waelter
    Max Planck Institut fur Molekulare Genetik, D 14195 Berlin Dahlem, Germany
    Mol Biol Cell 12:1393-407. 2001
  3. ncbi request reprint SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates
    A Sittler
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Mol Cell 2:427-36. 1998
  4. ncbi request reprint The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis
    S Waelter
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, D 14195 Berlin Dahlem, Germany
    Hum Mol Genet 10:1807-17. 2001
  5. ncbi request reprint Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease
    A Sittler
    , Ihnestrasse 73, D-14195 Berlin, Germany
    Hum Mol Genet 10:1307-15. 2001
  6. ncbi request reprint Huntingtin interacts with the receptor sorting family protein GASP2
    S C Horn
    Department of Neuroproteomics, Max Delbrück Centrum for Molecular Medicine MDC, Berlin, Germany
    J Neural Transm 113:1081-90. 2006
  7. ncbi request reprint Ataxin-3 is transported into the nucleus and associates with the nuclear matrix
    D Tait
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, D 14195 Berlin Dahlem, Germany
    Hum Mol Genet 7:991-7. 1998
  8. ncbi request reprint Characterization of the mouse Src homology 3 domain gene Sh3d2c on Chr 7 demonstrates coexpression with huntingtin in the brain and identifies the processed pseudogene Sh3d2c-ps1 on Chr 2
    U Zechner
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, Berlin Dahlem, D14195, Germany
    Genomics 54:505-10. 1998
  9. ncbi request reprint HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
    E E Wanker
    Max Planck Institut fur Molekulare Genetik, Berlin Dahlem, Germany
    Hum Mol Genet 6:487-95. 1997
  10. ncbi request reprint Localization of the human HIP1 gene close to the elastin (ELN) locus on 7q11.23
    N Wedemeyer
    Max Planck Institut fur Molekulare Genetik, Berlin, Dahlem, Germany
    Genomics 46:313-5. 1997

Collaborators

  • S Walter
  • G P Bates
  • H Himmelbauer
  • U Fischer
  • T Haaf
  • E Nordhoff
  • F U Hartl
  • J Priller
  • H Lehrach
  • A Sittler
  • S Waelter
  • S A Kunde
  • E Scherzinger
  • R Lurz
  • S C Horn
  • N Wedemeyer
  • H Goehler
  • G Lueder
  • A Grimme
  • L Musante
  • V M Kalscheuer
  • E Muller
  • R Hasenbank
  • M Lalowski
  • A Dröge
  • D Tait
  • U Zechner
  • U Stelzl
  • K Sathasivam
  • C Gauss
  • M K Hayer-Hartl
  • A Boeddrich
  • H Eickhoff
  • S Santi
  • A Ognibene
  • M Hemberger
  • M Riccio
  • S Scheel
  • M Hopp
  • R Fundele
  • N M Maraldi
  • R Peoples
  • U Francke

Detail Information

Publications11

  1. ncbi request reprint Protein aggregation in Huntington's and Parkinson's disease: implications for therapy
    E E Wanker
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, D 14195, Berlin, Germany
    Mol Med Today 6:387-91. 2000
    ..Therefore, a detailed understanding of the molecular mechanisms of protein aggregation and its effects on neuronal cell death could open new opportunities for therapy...
  2. pmc Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation
    S Waelter
    Max Planck Institut fur Molekulare Genetik, D 14195 Berlin Dahlem, Germany
    Mol Biol Cell 12:1393-407. 2001
    ..Together these findings support the hypothesis that the ATP-dependent ubiquitin-proteasome system is a potential target for therapeutic interventions in glutamine repeat disorders...
  3. ncbi request reprint SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates
    A Sittler
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Mol Cell 2:427-36. 1998
    ..The characteristics of the interaction between SH3GL3 and huntingtin and the colocalization of the two proteins suggest that SH3GL3 could be involved in the selective neuronal cell death in HD...
  4. ncbi request reprint The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis
    S Waelter
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, D 14195 Berlin Dahlem, Germany
    Hum Mol Genet 10:1807-17. 2001
    ....
  5. ncbi request reprint Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease
    A Sittler
    , Ihnestrasse 73, D-14195 Berlin, Germany
    Hum Mol Genet 10:1307-15. 2001
    ..These findings may provide the basis for the development of a novel pharmacotherapy for HD and related glutamine repeat disorders...
  6. ncbi request reprint Huntingtin interacts with the receptor sorting family protein GASP2
    S C Horn
    Department of Neuroproteomics, Max Delbrück Centrum for Molecular Medicine MDC, Berlin, Germany
    J Neural Transm 113:1081-90. 2006
    ..As the GASP protein family plays a role in G protein-coupled receptor sorting, our data suggest that htt might influence receptor trafficking via the interaction with GASP2...
  7. ncbi request reprint Ataxin-3 is transported into the nucleus and associates with the nuclear matrix
    D Tait
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, D 14195 Berlin Dahlem, Germany
    Hum Mol Genet 7:991-7. 1998
    ..Our results taken together with the finding of a nuclear localization signal in ataxin-3 indicate that the ataxin-3 protein per se translocates to the nucleus and that an expanded glutamine repeat is not essential for this transport...
  8. ncbi request reprint Characterization of the mouse Src homology 3 domain gene Sh3d2c on Chr 7 demonstrates coexpression with huntingtin in the brain and identifies the processed pseudogene Sh3d2c-ps1 on Chr 2
    U Zechner
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, Berlin Dahlem, D14195, Germany
    Genomics 54:505-10. 1998
    ..Because huntingtin and Sh3d2c are coexpressed in most regions of the brain, it can be speculated that there is a link between the association of huntingtin/Sh3d2c and the pathogenesis of Huntington disease...
  9. ncbi request reprint HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
    E E Wanker
    Max Planck Institut fur Molekulare Genetik, Berlin Dahlem, Germany
    Hum Mol Genet 6:487-95. 1997
    ..HIP-I and huntingtin behave almost identically during subcellular fractionation and both proteins are enriched in the membrane containing fractions...
  10. ncbi request reprint Localization of the human HIP1 gene close to the elastin (ELN) locus on 7q11.23
    N Wedemeyer
    Max Planck Institut fur Molekulare Genetik, Berlin, Dahlem, Germany
    Genomics 46:313-5. 1997
  11. doi request reprint The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules
    S A Kunde
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
    Hum Mol Genet 20:4916-31. 2011
    ....