Diego J Walther

Summary

Affiliation: Max Planck Institute for Molecular Genetics
Country: Germany

Publications

  1. ncbi request reprint Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release
    Diego J Walther
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
    Cell 115:851-62. 2003
  2. ncbi request reprint Serotonin regulates mammary gland development via an autocrine-paracrine loop
    Manabu Matsuda
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45221, USA
    Dev Cell 6:193-203. 2004
  3. ncbi request reprint Platelet-derived serotonin mediates liver regeneration
    Mickael Lesurtel
    Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
    Science 312:104-7. 2006
  4. pmc Alternative splicing and extensive RNA editing of human TPH2 transcripts
    Maik Grohmann
    Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 5:e8956. 2010
  5. pmc Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation
    Nils Paulmann
    Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS Biol 7:e1000229. 2009
  6. pmc Development of a novel cell-based assay system EPISSAY for screening epigenetic drugs and liposome formulated decitabine
    Sue Ping Lim
    Cancer Therapeutics Laboratory, Centre for Personalized Cancer Medicine, The University of Adelaide, Adelaide, South Australia, Australia
    BMC Cancer 13:113. 2013
  7. doi request reprint Novel roles for biogenic monoamines: from monoamines in transglutaminase-mediated post-translational protein modification to monoaminylation deregulation diseases
    Diego J Walther
    Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    FEBS J 278:4740-55. 2011
  8. pmc Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling
    Jakob Vowinckel
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    FEBS Lett 586:3819-24. 2012
  9. ncbi request reprint Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons
    Kathrin Scheuch
    Laboratory of Molecular Psychiatry, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, Berlin, Germany
    Biol Psychiatry 62:1288-94. 2007
  10. pmc A mammalianized synthetic nitroreductase gene for high-level expression
    Maik Grohmann
    Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    BMC Cancer 9:301. 2009

Collaborators

  • Maik Grohmann
  • Jakob Vowinckel
  • Michael Bader
  • J Priller
  • Stefan Roepcke
  • Heidemarie Neitzel
  • Markus Ralser
  • Natalia Alenina
  • Markus Höltje
  • Julia Kirchheiner
  • Jörg Peter Voigt
  • P Zill
  • Christian Gachet
  • R Jahn
  • Claus Zabel
  • Wanjin Hong
  • Shigeo Takamori
  • Pierre Alain Clavien
  • Jens Uwe Peter
  • Irene Brunk
  • Sandra Winter
  • Sue Ping Lim
  • Marc Trimborn
  • Nils Paulmann
  • Kathrin Scheuch
  • Ian Morecroft
  • Mickael Lesurtel
  • Claudia Zahn
  • Nurgul Carkaci-Salli
  • Gudrun Ahnert-Hilger
  • Manabu Matsuda
  • Rachel J Suetani
  • Yamini Akkamsetty
  • Paul M Neilsen
  • Kristen Ho
  • David F Callen
  • Wen Wang
  • Raman Kumar
  • Clive Prestidge
  • Jean Nowak
  • Charlotte Poehlmann
  • Joachim Klose
  • Andreas Busche
  • Mahdi Ghani
  • Susanne Mueller
  • Veronica Esquitino
  • Véronique Dutrannoy
  • Monika Dopatka
  • Ioannis Gavvovidis
  • Andreas W Kuss
  • Stefanie Nowak
  • Karl Sperling
  • Hans Hilger Ropers
  • Franziska Meyer
  • Detlev Schindler
  • Masoud Garshasbi
  • Heidrun Fink
  • Bettina Bert
  • Masa Skelin
  • Marjan Rupnik
  • Marko Jevsek
  • Silke Stahlberg
  • Lynn Loughlin
  • Marion Lautenschlager
  • Yvonne Dempsie
  • Margaret Nilsen
  • Katarina Kotnik
  • Andreas Heinz
  • Margaret R MacLean
  • Christian Blex
  • Matthew K Martz
  • Lei Lu
  • Ingrid Pahner
  • Boris Aleil
  • Angela Hommel
  • Ugur Salli
  • John M Flanagan
  • Kent E Vrana
  • Hans Georg Joost
  • Sivaramakrishna Rachakonda
  • Wolfram Jochum
  • Simone Florian
  • Yinghua Tian
  • Rolf Graf
  • Annette Schurmann
  • Meisheng Jiang
  • Lutz Birnbaumer
  • Kathryn M Nieport
  • Zhaoyuan Hou
  • Meenakshi Mistry

Detail Information

Publications21

  1. ncbi request reprint Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release
    Diego J Walther
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
    Cell 115:851-62. 2003
    ..Our data provides evidence for a receptor-independent signaling mechanism, termed herein as "serotonylation," which leads to alpha-granule exocytosis from platelets...
  2. ncbi request reprint Serotonin regulates mammary gland development via an autocrine-paracrine loop
    Manabu Matsuda
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45221, USA
    Dev Cell 6:193-203. 2004
    ..Thus, autocrine-paracrine serotonin signaling is an important regulator of mammary homeostasis and early involution...
  3. ncbi request reprint Platelet-derived serotonin mediates liver regeneration
    Mickael Lesurtel
    Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
    Science 312:104-7. 2006
    ..This failure of regeneration was rescued by reloading serotonin-free platelets with a serotonin precursor molecule. These results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration...
  4. pmc Alternative splicing and extensive RNA editing of human TPH2 transcripts
    Maik Grohmann
    Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 5:e8956. 2010
    ..Finally, we present molecular and large-scale linkage data evidencing that deregulated alternative splicing and RNA editing is involved in the etiology of psychiatric diseases, such as suicidal behaviour...
  5. pmc Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation
    Nils Paulmann
    Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS Biol 7:e1000229. 2009
    ....
  6. pmc Development of a novel cell-based assay system EPISSAY for screening epigenetic drugs and liposome formulated decitabine
    Sue Ping Lim
    Cancer Therapeutics Laboratory, Centre for Personalized Cancer Medicine, The University of Adelaide, Adelaide, South Australia, Australia
    BMC Cancer 13:113. 2013
    ..Here, we describe a cell-based assay system for screening gene reactivation...
  7. doi request reprint Novel roles for biogenic monoamines: from monoamines in transglutaminase-mediated post-translational protein modification to monoaminylation deregulation diseases
    Diego J Walther
    Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    FEBS J 278:4740-55. 2011
    ..Furthermore, the potential regulatory roles of protein monoaminylation in small GTPase, heterotrimeric G-protein and lipid signaling, as well as in modulating metabolic enzymes and nuclear processes, are critically assessed...
  8. pmc Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling
    Jakob Vowinckel
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    FEBS Lett 586:3819-24. 2012
    ..Protein αmonoaminylations, thus including histaminylation, serotonylation, dopaminylation and norepinephrinylation, hence emerge as a novel class of regulatory PTMs...
  9. ncbi request reprint Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons
    Kathrin Scheuch
    Laboratory of Molecular Psychiatry, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, Berlin, Germany
    Biol Psychiatry 62:1288-94. 2007
    ..Although dysfunction of 5-HT neurotransmission has been implicated in a variety of neuropsychiatric conditions, the human TPH2 promoter has not been characterized in vitro...
  10. pmc A mammalianized synthetic nitroreductase gene for high-level expression
    Maik Grohmann
    Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    BMC Cancer 9:301. 2009
    ..This metabolite causes apoptotic cell death by DNA interstrand crosslinking. Enhancing the enzymatic NTR activity for CB1954 should improve the therapeutical potential of this enzyme-prodrug combination in cancer gene therapy...
  11. ncbi request reprint Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase
    Jens Uwe Peter
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195, Berlin, Germany
    Mol Cell Biochem 295:205-15. 2007
    ..Therefore, this Tph1-specific miniribozyme may provide a novel and effective form of gene therapy that may be applicable to a variety of thrombotic diseases...
  12. pmc Establishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 function
    Marc Trimborn
    Institute for Medical Genetics, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 5:e9242. 2010
    ..To the best of our knowledge this represents the first mammalian transgenic model displaying a defect in mitotic chromosome condensation and is also the first mouse model for impaired Mcph1-function...
  13. pmc A tandem sequence motif acts as a distance-dependent enhancer in a set of genes involved in translation by binding the proteins NonO and SFPQ
    Stefan Roepcke
    Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    BMC Genomics 12:624. 2011
    ..In this work we sought to identify additional genes and LTSM-binding proteins to elucidate potential regulatory mechanisms...
  14. ncbi request reprint A unique central tryptophan hydroxylase isoform
    Diego J Walther
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Strasse 10, D 13092 Berlin Buch, Germany
    Biochem Pharmacol 66:1673-80. 2003
    ..In fact, there are two serotonin systems in vertebrates, independently regulated and with distinct functions...
  15. ncbi request reprint Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension
    Ian Morecroft
    Division of Neuroscience and Biomedical Systems, Faculty of Biomedical and Life Sciences, Glasgow University, Glasgow, Scotland
    Hypertension 49:232-6. 2007
    ..In addition, the results suggest that, in mice, serotonin has differential effects on the pulmonary vasculature and right ventricular hypertrophy...
  16. ncbi request reprint Synthesis of serotonin by a second tryptophan hydroxylase isoform
    Diego J Walther
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Strasse 10, D 13092 Berlin Buch, Germany
    Science 299:76. 2003
  17. ncbi request reprint Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells
    Claudia Zahn
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Mol Membr Biol 23:475-85. 2006
    ..These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi...
  18. ncbi request reprint The first luminal domain of vesicular monoamine transporters mediates G-protein-dependent regulation of transmitter uptake
    Irene Brunk
    Functional Cell Biology, Centre for Anatomy, Charite Universitatsmedizin Berlin, Philippstrasse 12, D 10115 Berlin, Germany
    J Biol Chem 281:33373-85. 2006
    ..The first luminal loop of VMATs may represent a G-protein-coupled receptor that adapts vesicular filling...
  19. ncbi request reprint Functional domains of human tryptophan hydroxylase 2 (hTPH2)
    Nurgul Carkaci-Salli
    Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania 17033 2360, USA
    J Biol Chem 281:28105-12. 2006
    ..These data identify the NH(2)-terminal regulatory domain as the source of hTPH2 instability and reduced solubility...
  20. ncbi request reprint Galphao2 regulates vesicular glutamate transporter activity by changing its chloride dependence
    Sandra Winter
    AG Funktionelle Zellbiologie, Centrum für Anatomie, Charite Universitatsmedizin Berlin, D 10115 Berlin, Germany
    J Neurosci 25:4672-80. 2005
    ..Thus, Galpha(o2) acts on a putative regulatory chloride binding domain that appears to modulate transport activity of vesicular glutamate transporters...
  21. ncbi request reprint 7-Hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumors
    Diego J Walther
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Cancer 94:3135-40. 2002
    ..Therefore, there is still a need for more specific and potent chemotherapeutic agents in the fight against serotonin-producing tumors...