Research Topics
| Diego J WaltherSummaryAffiliation: Max Planck Institute for Molecular Genetics Country: Germany Publications
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Detail Information
Publications
Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule releaseDiego J Walther
Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
Cell 115:851-62. 2003..Our data provides evidence for a receptor-independent signaling mechanism, termed herein as "serotonylation," which leads to alpha-granule exocytosis from platelets...- Serotonin regulates mammary gland development via an autocrine-paracrine loopManabu Matsuda
Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45221, USA
Dev Cell 6:193-203. 2004..Thus, autocrine-paracrine serotonin signaling is an important regulator of mammary homeostasis and early involution... - Platelet-derived serotonin mediates liver regenerationMickael Lesurtel
Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
Science 312:104-7. 2006..This failure of regeneration was rescued by reloading serotonin-free platelets with a serotonin precursor molecule. These results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration... 
Novel roles for biogenic monoamines: from monoamines in transglutaminase-mediated post-translational protein modification to monoaminylation deregulation diseasesDiego J Walther
Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
FEBS J 278:4740-55. 2011..Furthermore, the potential regulatory roles of protein monoaminylation in small GTPase, heterotrimeric G-protein and lipid signaling, as well as in modulating metabolic enzymes and nuclear processes, are critically assessed...- Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signalingJakob Vowinckel
Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany Cambridge Systems Biology Centre and Dept of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK Electronic address
FEBS Lett 586:3819-24. 2012.... 
Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylationNils Paulmann
Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
PLoS Biol 7:e1000229. 2009....- A mammalianized synthetic nitroreductase gene for high-level expressionMaik Grohmann
Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
BMC Cancer 9:301. 2009..This metabolite causes apoptotic cell death by DNA interstrand crosslinking. Enhancing the enzymatic NTR activity for CB1954 should improve the therapeutical potential of this enzyme-prodrug combination in cancer gene therapy... - Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neuronsKathrin Scheuch
Laboratory of Molecular Psychiatry, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, Berlin, Germany
Biol Psychiatry 62:1288-94. 2007..Although dysfunction of 5-HT neurotransmission has been implicated in a variety of neuropsychiatric conditions, the human TPH2 promoter has not been characterized in vitro... - Alternative splicing and extensive RNA editing of human TPH2 transcriptsMaik Grohmann
Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
PLoS ONE 5:e8956. 2010..Finally, we present molecular and large-scale linkage data evidencing that deregulated alternative splicing and RNA editing is involved in the etiology of psychiatric diseases, such as suicidal behaviour... - Establishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 functionMarc Trimborn
Institute for Medical Genetics, Charite Universitatsmedizin Berlin, Berlin, Germany
PLoS ONE 5:e9242. 2010..To the best of our knowledge this represents the first mammalian transgenic model displaying a defect in mitotic chromosome condensation and is also the first mouse model for impaired Mcph1-function... - Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylaseJens Uwe Peter
Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195, Berlin, Germany
Mol Cell Biochem 295:205-15. 2007..Therefore, this Tph1-specific miniribozyme may provide a novel and effective form of gene therapy that may be applicable to a variety of thrombotic diseases... - A tandem sequence motif acts as a distance-dependent enhancer in a set of genes involved in translation by binding the proteins NonO and SFPQStefan Roepcke
Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
BMC Genomics 12:624. 2011..In this work we sought to identify additional genes and LTSM-binding proteins to elucidate potential regulatory mechanisms... - Synthesis of serotonin by a second tryptophan hydroxylase isoformDiego J Walther
, , D-13092 Berlin-Buch, Germany
Science 299:76. 2003 - Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertensionIan Morecroft
Division of Neuroscience and Biomedical Systems, Faculty of Biomedical and Life Sciences, Glasgow University, Glasgow, Scotland
Hypertension 49:232-6. 2007..In addition, the results suggest that, in mice, serotonin has differential effects on the pulmonary vasculature and right ventricular hypertrophy... - A unique central tryptophan hydroxylase isoformDiego J Walther
Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Strasse 10, D 13092 Berlin Buch, Germany
Biochem Pharmacol 66:1673-80. 2003..In fact, there are two serotonin systems in vertebrates, independently regulated and with distinct functions... - Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cellsClaudia Zahn
Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
Mol Membr Biol 23:475-85. 2006..These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi... - The first luminal domain of vesicular monoamine transporters mediates G-protein-dependent regulation of transmitter uptakeIrene Brunk
Functional Cell Biology, Centre for Anatomy, Charite Universitatsmedizin Berlin, Philippstrasse 12, D 10115 Berlin, Germany
J Biol Chem 281:33373-85. 2006..The first luminal loop of VMATs may represent a G-protein-coupled receptor that adapts vesicular filling... - Functional domains of human tryptophan hydroxylase 2 (hTPH2)Nurgul Carkaci-Salli
Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania 17033 2360, USA
J Biol Chem 281:28105-12. 2006..These data identify the NH(2)-terminal regulatory domain as the source of hTPH2 instability and reduced solubility... - Galphao2 regulates vesicular glutamate transporter activity by changing its chloride dependenceSandra Winter
AG Funktionelle Zellbiologie, Centrum für Anatomie, Charite Universitatsmedizin Berlin, D 10115 Berlin, Germany
J Neurosci 25:4672-80. 2005..Thus, Galpha(o2) acts on a putative regulatory chloride binding domain that appears to modulate transport activity of vesicular glutamate transporters... - 7-Hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumorsDiego J Walther
Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
Cancer 94:3135-40. 2002..Therefore, there is still a need for more specific and potent chemotherapeutic agents in the fight against serotonin-producing tumors...