Dietmar Vestweber

Summary

Affiliation: Max Planck Institute for Molecular Biomedicine
Country: Germany

Publications

  1. doi request reprint Relevance of endothelial junctions in leukocyte extravasation and vascular permeability
    Dietmar Vestweber
    Max Planck Institute of Molecular Biomedicine, Munster, Germany
    Ann N Y Acad Sci 1257:184-92. 2012
  2. ncbi request reprint Adhesion and signaling molecules controlling the transmigration of leukocytes through endothelium
    Dietmar Vestweber
    Max Planck Institute of Molecular Biomedicine, Munster, Germany
    Immunol Rev 218:178-96. 2007
  3. ncbi request reprint VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation
    Dietmar Vestweber
    Max Planck Institute of Molecular Biomedicine, Röntgenstr 20, D 48149 Munster, Germany
    Arterioscler Thromb Vasc Biol 28:223-32. 2008
  4. doi request reprint A new player in lymphocyte homing
    Dietmar Vestweber
    Department of Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, D 48149 Munster, Germany
    Nat Immunol 9:347-8. 2008
  5. doi request reprint Control of endothelial barrier function by regulating vascular endothelial-cadherin
    Dietmar Vestweber
    Max Planck Institute of Molecular Biomedicine, Munster, Germany
    Curr Opin Hematol 17:230-6. 2010
  6. doi request reprint Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player
    Dietmar Vestweber
    Max Planck Institute of Molecular Biomedicine, Röntgenstrasse 20, Munster, Germany
    Trends Cell Biol 19:8-15. 2009
  7. pmc A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells
    Sandra Iden
    Institute of Medical Biochemistry, ZMBE, University of Munster, Von Esmarch Str 56, D 48149 Munster, Germany
    EMBO Rep 7:1239-46. 2006
  8. pmc VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF
    Astrid F Nottebaum
    Max Planck Institute of Molecular Biomedicine, Munster, Germany
    J Exp Med 205:2929-45. 2008
  9. doi request reprint CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis
    M Gabriele Bixel
    Max Planck Institute of Molecular Biomedicine, Roentgenstrasse 20, Munster, Germany
    Blood 116:1172-84. 2010
  10. pmc VE-PTP controls blood vessel development by balancing Tie-2 activity
    Mark Winderlich
    Max Planck Institute of Molecular Biomedicine, D 48149 Munster, Germany
    J Cell Biol 185:657-71. 2009

Detail Information

Publications72

  1. doi request reprint Relevance of endothelial junctions in leukocyte extravasation and vascular permeability
    Dietmar Vestweber
    Max Planck Institute of Molecular Biomedicine, Munster, Germany
    Ann N Y Acad Sci 1257:184-92. 2012
    ..In addition, recent progress has improved our understanding of the molecular mechanisms that regulate junctional stability, the opening of endothelial junctions during leukocyte extravasation, and the induction of vascular permeability...
  2. ncbi request reprint Adhesion and signaling molecules controlling the transmigration of leukocytes through endothelium
    Dietmar Vestweber
    Max Planck Institute of Molecular Biomedicine, Munster, Germany
    Immunol Rev 218:178-96. 2007
    ..The various molecular players and the functional steps involved in diapedesis are discussed...
  3. ncbi request reprint VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation
    Dietmar Vestweber
    Max Planck Institute of Molecular Biomedicine, Röntgenstr 20, D 48149 Munster, Germany
    Arterioscler Thromb Vasc Biol 28:223-32. 2008
    ..This review will focus on recent new developments in understanding the role of VE-cadherin in controlling endothelial cell contacts and influencing endothelial cell behavior by various outside-in signaling processes...
  4. doi request reprint A new player in lymphocyte homing
    Dietmar Vestweber
    Department of Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, D 48149 Munster, Germany
    Nat Immunol 9:347-8. 2008
  5. doi request reprint Control of endothelial barrier function by regulating vascular endothelial-cadherin
    Dietmar Vestweber
    Max Planck Institute of Molecular Biomedicine, Munster, Germany
    Curr Opin Hematol 17:230-6. 2010
    ..The endothelial barrier also controls the entry of leukocytes into tissue and it is believed that leukocytes target endothelial cell contacts to reach sites of inflammation...
  6. doi request reprint Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player
    Dietmar Vestweber
    Max Planck Institute of Molecular Biomedicine, Röntgenstrasse 20, Munster, Germany
    Trends Cell Biol 19:8-15. 2009
    ..Here, we focus on recent results showing how leukocytes and angiogenic factors regulate endothelial junctions...
  7. pmc A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells
    Sandra Iden
    Institute of Medical Biochemistry, ZMBE, University of Munster, Von Esmarch Str 56, D 48149 Munster, Germany
    EMBO Rep 7:1239-46. 2006
    ..They also point to a direct role of a cadherin in the regulation of cell polarity in vertebrates...
  8. pmc VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF
    Astrid F Nottebaum
    Max Planck Institute of Molecular Biomedicine, Munster, Germany
    J Exp Med 205:2929-45. 2008
    ..In conclusion, leukocytes interacting with endothelial cells rapidly dissociate VE-PTP from VE-cadherin, weakening endothelial cell contacts via a mechanism that requires plakoglobin but not beta-catenin...
  9. doi request reprint CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis
    M Gabriele Bixel
    Max Planck Institute of Molecular Biomedicine, Roentgenstrasse 20, Munster, Germany
    Blood 116:1172-84. 2010
    ..We conclude that CD99 and CD99L2 act independently of PECAM-1 in leukocyte extravasation and cooperate in an independent way to help neutrophils overcome the endothelial basement membrane...
  10. pmc VE-PTP controls blood vessel development by balancing Tie-2 activity
    Mark Winderlich
    Max Planck Institute of Molecular Biomedicine, D 48149 Munster, Germany
    J Cell Biol 185:657-71. 2009
    ..We conclude that VE-PTP is required to balance Tie-2 activity and endothelial cell proliferation, thereby controlling blood vessel development and vessel size...
  11. pmc Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo
    Andre Broermann
    Max Planck Institute for Molecular Biomedicine, D 48149 Munster, Germany
    J Exp Med 208:2393-401. 2011
    ..We conclude that the dissociation of VE-PTP from VE-cadherin is indeed required in vivo for the opening of endothelial cell contacts during induction of vascular permeability and leukocyte extravasation...
  12. ncbi request reprint A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo
    M Gabriele Bixel
    Institute of Cell Biology, Zentrum für Molekularbiologie der Entzündung ZMBE, Interdisziplinäres Klinisches Forschungszentrum Münster, University of Munster, Munster, Germany
    Blood 109:5327-36. 2007
    ..Our results establish CD99L2 as a new endothelial surface protein involved in neutrophil extravasation. In addition, this is the first evidence for a role of CD99 and CD99L2 in the process of leukocyte diapedesis in vivo...
  13. pmc Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability
    Dörte Schulte
    Department of Vascular Cell Biology, Max Planck Institute of Molecular Biomedicine, Munster, Germany
    EMBO J 30:4157-70. 2011
    ..Furthermore, in these tissues, plasticity of the VE-cadherin-catenin complex is central for the leukocyte diapedesis mechanism...
  14. ncbi request reprint Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development
    Sebastian Baumer
    Max Planck Institute of Molecular Biomedicine, D 48149 Munster, Germany
    Blood 107:4754-62. 2006
    ..No signs for enhanced endothelial apoptosis or proliferation were observed. Thus, the activity of VE-PTP is not required for the initial formation of blood vessels, yet it is essential for their maintenance and remodeling...
  15. doi request reprint Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo
    Ruth Seelige
    Max Planck Institute for Molecular Biomedicine, D48149 Munster, Germany
    J Immunol 190:892-6. 2013
    ..We conclude that CD99L2 is an essential endothelial Ag for leukocyte extravasation, which does not require homophilic interactions with CD99L2 on leukocytes...
  16. ncbi request reprint Mouse CD99 participates in T-cell recruitment into inflamed skin
    Gabriele Bixel
    Max Planck Institute of Molecular Biomedicine, Von Esmarch Str 56, D 48149 Munster, Germany
    Blood 104:3205-13. 2004
    ..We conclude that mouse CD99 participates in the TEM of lymphocytes and in their recruitment to inflamed skin in vivo. This establishes CD99 as a valid target for interference with cutaneous inflammatory processes...
  17. doi request reprint von Willebrand factor promotes leukocyte extravasation
    Björn Petri
    Max Planck Institute for Molecular Biomedicine, Munster, Germany
    Blood 116:4712-9. 2010
    ..This step could be related to leukocyte diapedesis facilitated by destabilization of the endothelial barrier...
  18. ncbi request reprint Migration of immature mouse DC across resting endothelium is mediated by ICAM-2 but independent of beta2-integrins and murine DC-SIGN homologues
    Klaus Wethmar
    Max Planck Institute for Molecular Biomedicine, Munster, Germany, and Institute of Cell Biology, ZMBE, University of Munster, Munster, Germany
    Eur J Immunol 36:2781-94. 2006
    ..Taken together, this study shows that ICAM-2 strongly supports transmigration of immature DC across resting endothelium by interacting with ligands that are distinct from beta2-integrins and DC-SIGN homologues...
  19. doi request reprint Role of the heparan sulfate proteoglycan syndecan-1 (CD138) in delayed-type hypersensitivity
    Behzad Kharabi Masouleh
    Department of Gynecology and Obstetrics, Medical Center, University of Munster, Munster, Germany
    J Immunol 182:4985-93. 2009
    ..Collectively, our results show an important role of syndecan-1 in the contact DTH reaction, identifying syndecan-1 as a novel target in anti-inflammatory therapy...
  20. pmc Association of Csk to VE-cadherin and inhibition of cell proliferation
    Ulf Baumeister
    Institute of Cell Biology, ZMBE, University of Munster, Munster, Germany
    EMBO J 24:1686-95. 2005
    ..Our results suggest that the phosphorylated tyrosine residue 685 of VE-cadherin and probably the binding of Csk to this site are involved in inhibition of cell growth triggered by cell density...
  21. doi request reprint How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin
    Matthias Vockel
    Max Planck Institute for Molecular Biomedicine, Munster, Germany
    Blood 122:2512-22. 2013
    ..We suggest that lymphocyte binding to vascular cell adhesion molecule 1 triggers a signaling process that enables a VE-PTP substrate to dissociate VE-PTP from VE-cadherin, thereby facilitating efficient transmigration. ..
  22. doi request reprint Spatial regulation of VEGF receptor endocytosis in angiogenesis
    Masanori Nakayama
    Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Muenster, Faculty of Medicine, D 48149 Muenster, Germany
    Nat Cell Biol 15:249-60. 2013
    ..Our work uncovers how vessel growth is dynamically controlled by local VEGF receptor endocytosis and the activity of cell polarity proteins...
  23. ncbi request reprint Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo
    Stephan Seeliger
    Department of Pediatrics, University of Munster, Munster, Germany
    FASEB J 17:1871-85. 2003
    ..Thus, PAR-2 may be a beneficial therapeutic target for the treatment of inflammatory skin diseases...
  24. ncbi request reprint Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B
    Jörg Buddenkotte
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    J Invest Dermatol 124:38-45. 2005
    ..Thus, PAR2 may play an important regulatory role of human KTC during inflammation and immune response...
  25. pmc Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo
    Michael Schnoor
    Max Planck Institute for Molecular Biomedicine, D 48149 Munster, Germany
    J Exp Med 208:1721-35. 2011
    ..Our results represent the first physiological evidence that cortactin is crucial for orchestrating the molecular events leading to proper endothelial barrier function and leukocyte recruitment in vivo...
  26. ncbi request reprint Junctional adhesion molecule-a participates in the formation of apico-basal polarity through different domains
    Daniela Rehder
    Institute of Cell Biology, ZMBE, University of Munster, D 48149 Munster, Germany
    Exp Cell Res 312:3389-403. 2006
    ..Together our findings suggest an important role for JAM-A in the development of apico-basal polarity in epithelial cells and identify regions in JAM-A which are critical for this role...
  27. ncbi request reprint The alpha (1,3)-fucosyltransferase Fuc-TIV, but not Fuc-TVII, generates sialyl Lewis X-like epitopes preferentially on glycolipids
    Min Chuan Huang
    Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster and the Max Planck Institute of Vascular Biology, D 48149 Munster, Germany
    J Biol Chem 277:47786-95. 2002
    ..Interestingly, the non-catalytic portion of Fuc-TIV in a Fuc-TIV/VII chimeric enzyme mediated the specificity for glycolipid substrates...
  28. ncbi request reprint Lymphocyte trafficking through blood and lymphatic vessels: more than just selectins, chemokines and integrins
    Dietmar Vestweber
    Max Planck Institute of Vascular Biology and Institute of Cell Biology, ZMBE, University of Munster, Munster, Germany
    Eur J Immunol 33:1361-4. 2003
  29. doi request reprint Leukocyte integrin activation and deactivation: novel mechanisms of balancing inflammation
    Alexander Zarbock
    Department of Anesthesiology and Intensive Care Medicine, University of Munster, Albert Schweitzer Strasse 33, Munster, Germany
    J Mol Med (Berl) 90:353-9. 2012
    ..Further investigation of this new mechanism may allow providing new approaches for the development of the next generation of anti-inflammatory drugs...
  30. pmc ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability
    Frank Wegmann
    Max Planck Institute for Molecular Biomedicine and Institute of Cell Biology, University of Munster, D 48149 Munster, Germany
    J Exp Med 203:1671-7. 2006
    ..Collectively, ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts...
  31. pmc VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts
    Roman Nawroth
    Max Planck Institute for Vascular Biology, D 48149 Munster, Germany
    EMBO J 21:4885-95. 2002
    ..Thus, VE-PTP is a transmembrane binding partner of VE-cadherin that associates through an extracellular domain and reduces the tyrosine phosphorylation of VE-cadherin and cell layer permeability independently of its enzymatic activity...
  32. ncbi request reprint Leukocyte adhesion deficiency II: therapy and genetic defect
    Martin K Wild
    Institut fur Zellbiologie, Zentrum fur Molekularbiologie der Entzundung, Universitat Munster, Munster, Germany
    Cells Tissues Organs 172:161-73. 2002
    ..Thus, LAD II represents the first developmental and immune defect that is based on a malfunctioning nucleotide sugar transporter...
  33. doi request reprint Blocking von Willebrand factor for treatment of cutaneous inflammation
    Carina Hillgruber
    1 Department of Dermatology, University Hospital of Munster, Munster, Germany 2 Interdisciplinary Center for Clinical Research IZKF, University of Munster, Munster, Germany
    J Invest Dermatol 134:77-86. 2014
    ..Of particular importance, anti-VWF treatment was effective both in prophylactic and therapeutic administration. Thus, VWF represents a promising target for the treatment of cutaneous inflammation, e.g., leukocytoclastic vasculitis. ..
  34. ncbi request reprint Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1
    Gunther G Pendl
    Institute of Cell Biology, ZMBE, University of Munster, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Blood 99:946-56. 2002
    ..Thus, fucosylated ligands of the endothelial selectins, determined in part by Fuc-TIV, and independent of PSGL-1, are required for extravasation of DCs into sites of cutaneous inflammation...
  35. ncbi request reprint Ultraviolet radiation-induced regulatory T cells not only inhibit the induction but can suppress the effector phase of contact hypersensitivity
    Agatha Schwarz
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Von Esmarchstrasse 58, D 48149 Munster, Germany
    J Immunol 172:1036-43. 2004
    ..v. injection, because they obviously do not migrate into the skin...
  36. ncbi request reprint Characterization of the inflammatory infiltrate and expression of endothelial cell adhesion molecules in lupus erythematosus tumidus
    Annegret Kuhn
    Institute of Cell Biology, ZMBE, Westfalische Wilhelms University, Munster, Germany
    Arch Dermatol Res 294:6-13. 2002
    ..Furthermore, expression of endothelial cell adhesion molecules was equally upregulated in LET compared with the expression in DLE and SCLE, suggesting a similar immunopathomechanism of these subtypes of CLE...
  37. doi request reprint Novel insights into leukocyte extravasation
    Dietmar Vestweber
    Department of Vascular Cell Biology, Max Planck Institute of Molecular Biomedicine, Munster, North Rhine Westphalia, Germany
    Curr Opin Hematol 19:212-7. 2012
    ..This review will highlight recent findings that define new regulatory mechanisms and novel activities in the process of leukocyte docking to the endothelium and diapedesis of leukocytes through the endothelial barrier of the vessel wall...
  38. pmc Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo
    Steffen Massberg
    Deutsches Herzzentrum and Medizinische Klinik, Technical University of Munich, D 80636 Munich, Germany
    J Exp Med 203:1221-33. 2006
    ..These findings establish the platelet as a major player in the initiation of vascular remodeling, a process of fundamental importance for vascular repair and pathological remodeling after vascular injury...
  39. doi request reprint Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node
    Friederike Pfeiffer
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Eur J Immunol 38:2142-55. 2008
    ....
  40. ncbi request reprint Junctional adhesion molecules (JAMs): more molecules with dual functions?
    Klaus Ebnet
    Institute of Cell Biology, ZMBE, University of Munster, 48149 Munster, Germany
    J Cell Sci 117:19-29. 2004
    ....
  41. ncbi request reprint PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrin
    Yoshio Katayama
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1079, New York, NY 10029
    Blood 102:2060-7. 2003
    ..Our results thus underscore a major difference between mature myeloid cells and immature stem/progenitor cells in that E-selectin ligands cooperate with alpha4 integrin rather than P-selectin ligands...
  42. ncbi request reprint Regulation of endothelial cell contacts during leukocyte extravasation
    Dietmar Vestweber
    Max Planck Institute of Vascular Biology, Institute of Cell Biology, ZMBE University of Münster, Von Esmarch Strasse 56, D 48149 Muenster, Germany
    Curr Opin Cell Biol 14:587-93. 2002
    ..Progress has been made in identifying novel membrane proteins at endothelial cell contacts as well as novel mechanisms that control interendothelial adhesiveness and transendothelial migration of leukocytes...
  43. pmc Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration
    Patric Turowski
    Division of Cell Biology, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    J Cell Sci 121:29-37. 2008
    ..Taken together, these results demonstrate that phosphorylation of adherens junctions constitutes a molecular endpoint of lymphocyte-induced vascular EC signaling and may be exploited as a new target of anti-inflammatory therapies...
  44. ncbi request reprint Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro
    Jennifer R Allport
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Leukoc Biol 71:821-8. 2002
    ..These results indicate that although neutrophil proteases may play a role in the acute inflammatory response, neutrophil elastase or MMP-9 is not essential for neutrophil transendothelial migration in this murine system...
  45. pmc Leukocyte rolling is exclusively mediated by P-selectinin colonic venules
    Ming Xiu Wan
    Department of Surgery, Malmo University Hospital, Lund University, 20502 Malmo, Sweden
    Br J Pharmacol 135:1749-56. 2002
    ..Thus, these findings suggest that P-selectin may be a key target to reduce pathological recruitment of inflammatory cells in the colon...
  46. ncbi request reprint A transmembrane tight junction protein selectively expressed on endothelial cells and platelets
    Ines Nasdala
    Institute of Cell Biology, ZMBE, University of Munster, 48149 Munster, Germany
    J Biol Chem 277:16294-303. 2002
    ..The 1G8 antigen supports homophilic interactions on transfected Chinese hamster ovary cells. Based on the similarity to the JAM molecules, it is plausible that the 1G8 antigen might be involved in interendothelial cell adhesion...
  47. ncbi request reprint Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors
    Laura Piccio
    Department of Pathology, University of Verona, Verona, Italy
    J Immunol 168:1940-9. 2002
    ..In conclusion, our data unveils the molecular mechanisms controlling the recruitment of autoreactive lymphocytes in inflamed cerebral vessels and suggest new insights into the pathogenesis of autoimmune inflammatory diseases of the CNS...
  48. pmc Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation
    David Frommhold
    Children s Hospital, University of Heidelberg, 69120 Heidelberg, Germany
    J Exp Med 205:1435-46. 2008
    ..Collectively, we provide substantial evidence that sialylation by ST3Gal-IV significantly contributes to CXCR2-mediated leukocyte adhesion during inflammation in vivo...
  49. pmc Functionally specialized junctions between endothelial cells of lymphatic vessels
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 204:2349-62. 2007
    ..Our findings suggest that fluid enters throughout initial lymphatics via openings between buttons, which open and close without disrupting junctional integrity, but most leukocytes enter the proximal half of initial lymphatics...
  50. ncbi request reprint Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts
    Frank Wegmann
    Institute of Cell Biology, ZMBE, University of Muenster, 48149 Muenster, Germany
    Exp Cell Res 300:121-33. 2004
    ..In CHO cells, recruitment of MAGI-1 to cell contacts required the presence of ESAM. Hence, ESAM may be involved in anchoring MAGI-1 at endothelial tight junctions...
  51. pmc Nano-surgery at the leukocyte-endothelial docking site
    Christoph Riethmuller
    Institute of Physiology II, University of Munster, Robert Koch Strasse 27 b, 48149 Munster, Germany
    Pflugers Arch 456:71-81. 2008
    ..Moreover, there were no cases of phagocytotic engulfment, but instead the formation of a transmigratory channel could be observed...
  52. ncbi request reprint P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice
    Britta Engelhardt
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    J Immunol 175:1267-75. 2005
    ..Taken together, our findings demonstrate that PSGL-1 is not required for the pathogenesis of EAE...
  53. ncbi request reprint Platelet-induced differentiation of endothelial progenitor cells
    Harald F Langer
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 33:136-43. 2007
    ..The described interaction of EPCs with platelets represents a novel mechanism of vascular remodeling and healing of endothelial lesions...
  54. ncbi request reprint Synthetic glycopeptides from the E-selectin ligand 1 with varied sialyl Lewis(x) structure as cell-adhesion inhibitors of E-selectin
    Christian Filser
    Institut fur Organische Chemie, Johannes Gutenberg Universitat Mainz, Duesbergweg 10 14, 55128 Mainz, Germany
    Angew Chem Int Ed Engl 46:2108-11. 2007
  55. ncbi request reprint Cell-matrix interactions during development and apoptosis of the mouse mammary gland in vivo
    Janine M Prince
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester, United Kingdom
    Dev Dyn 223:497-516. 2002
    ..This finding may provide a novel dynamic mechanism for inhibiting the transduction of extracellular matrix survival signals, thereby contributing to the onset of apoptosis in a developmental context in vivo...
  56. pmc Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope
    Ulrike Samulowitz
    Institute of Cell Biology, ZMBE, University of Munster, Germany
    Am J Pathol 160:1669-81. 2002
    ..We conclude that human and mouse endomucin are endothelial sialomucins with the potential to function as L-selectin ligands...
  57. ncbi request reprint Adherent platelets recruit and induce differentiation of murine embryonic endothelial progenitor cells to mature endothelial cells in vitro
    Harald Langer
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Germany
    Circ Res 98:e2-10. 2006
    ..We conclude that platelets may play a critical part in the capture and subsequent differentiation of murine eEPCs at sites of vascular lesions, revealing a possible new role of platelets in neoendothelization after vascular injury...
  58. ncbi request reprint Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44
    Andres Hidalgo
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunity 26:477-89. 2007
    ..These results suggest distinct and dynamic contributions of these three glycoproteins in selectin-mediated neutrophil adhesion and signaling...
  59. ncbi request reprint Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction
    Davy Vanhoutte
    Experimental and Molecular Cardiology CARIM, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Circulation 115:475-82. 2007
    ..The present study investigated whether Synd1 may also regulate cardiac inflammation, matrix remodeling, and function after myocardial infarction (MI)...
  60. doi request reprint Vascular endothelial cadherin promotes breast cancer progression via transforming growth factor beta signaling
    Myriam Labelle
    Institute of Pathology, University of Dresden, Dresden, Germany
    Cancer Res 68:1388-97. 2008
    ..Our findings may have important implications for the clinical application of anti-VE-cadherin strategies...
  61. ncbi request reprint In vitro cellular handling and in vivo targeting of E-selectin-directed immunoconjugates and immunoliposomes used for drug delivery to inflamed endothelium
    Maaike Everts
    Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration, Groningen, The Netherlands
    Pharm Res 20:64-72. 2003
    ....
  62. ncbi request reprint E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice
    Axinia Döring
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    J Immunol 179:8470-9. 2007
    ..Thus, E- and P-selectin are not required for leukocyte recruitment across the BBB and the development of EAE in C57BL/6 and in SJL mice...
  63. ncbi request reprint A down-regulatable E-selectin ligand is functionally important for PSGL-1-independent leukocyte-endothelial cell interactions
    Renata C O Zanardo
    Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1
    Blood 104:3766-73. 2004
    ..In conclusion, E-selectin mediates PSGL-1-dependent and independent rolling and the latter can be down-regulated by systemic activation and can replace PSGL-1 to support the development of inflammation...
  64. doi request reprint Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts
    Pipsa Saharinen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
    Nat Cell Biol 10:527-37. 2008
    ..This novel type of cellular microenvironment-dependent receptor tyrosine kinase activation may explain some of the effects of angiopoietins in angiogenesis and vessel stabilization...
  65. ncbi request reprint Detection of a hypersialylated beta1 integrin endogenously expressed in the human astrocytoma cell line A172
    Petr Bartik
    Département de Pharmacologie et Physicochimie, UMR 7175 CNRS, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, BP 60024, 67401 Illkirch, France
    Int J Oncol 32:1021-31. 2008
    ..In addition, beta1-A172 cells exhibited increased matrix dependence for normal cell cycling. Collectively, the data add new evidence for the role of beta1 glycosylation/sialylation in the regulation of integrin functions...
  66. doi request reprint Vaccination against CD99 inhibits atherogenesis in low-density lipoprotein receptor-deficient mice
    Eva J A van Wanrooij
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, PO Box 9502, 2300 RA Leiden, The Netherlands
    Cardiovasc Res 78:590-6. 2008
    ..The aim of the present study is to show the role of CD99 in atherosclerosis using a CD99 vaccination protocol to block the function of CD99 during atherosclerosis...
  67. ncbi request reprint Interleukin-6 is a direct mediator of T cell migration
    Manuela Weissenbach
    Department of Biochemistry, RWTH Aachen, Aachen, Germany
    Eur J Immunol 34:2895-906. 2004
    ..Selective activation of the JAK/STAT or the MAPK cascade by mutated receptor proteins shows a crucial role of IL-6-initiated SH2 domain-containing tyrosine phosphatase 2/MAPK activity for migration...
  68. doi request reprint A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis
    Steven Clasper
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    Cancer Res 68:7293-303. 2008
    ..These findings reveal a remarkable degree of phenotypic plasticity in cancer lymphatics and provide new insight into the processes of lymphatic invasion and lymph node metastasis...
  69. ncbi request reprint Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II
    Christina C Hellbusch
    Department of Pediatrics, Division of Inborn Metabolic Diseases, Section of Neonatology, University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    J Biol Chem 282:10762-72. 2007
    ..The diversity of these phenotypic aspects demonstrates the broad general impact of fucosylation in the mammalian organism...
  70. ncbi request reprint The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity
    Klaus Ebnet
    Institute of Cell Biology, ZMBE, University of Munster, Germany
    J Cell Sci 116:3879-91. 2003
    ..Our findings suggest that JAM-2 affects endothelial cell junctions by its regulated clustering at intercellular contacts, and they support a role for JAM-2, and possibly JAM-3, in tight junction formation of endothelial cells...
  71. pmc Multistep nature of microvascular recruitment of ex vivo-expanded embryonic endothelial progenitor cells during tumor angiogenesis
    Peter Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    J Exp Med 197:1755-65. 2003
    ..This paper provides the first in vivo insights into the mechanisms of endothelial progenitor cell recruitment and, thus, indicates novel ways to interfere with pathological neovascularization...
  72. pmc Pathogenic role of P-selectin in experimental cerebral malaria: importance of the endothelial compartment
    Valery Combes
    Experimental Parasitology Unit, Faculty of Medicine, Institut Federatif de Recherche 48, Universite de la Mediterranee, Marseille Cedex, France
    Am J Pathol 164:781-6. 2004
    ..These results indicate that endothelial P-selectin plays an important role in the pathogenesis of cerebral malaria...