M Uhr

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. pmc Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations
    Florian Then Bergh
    Section of Neurology, Max Planck Institut fur Psychiatrie, Munchen, Germany
    BMC Neurol 6:19. 2006
  2. ncbi request reprint Blood-brain barrier penetration and pharmacokinetics of amitriptyline and its metabolites in p-glycoprotein (abcb1ab) knock-out mice and controls
    Manfred Uhr
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    J Psychiatr Res 41:179-88. 2007
  3. doi request reprint Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression
    Manfred Uhr
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Neuron 57:203-9. 2008
  4. ncbi request reprint abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice
    Manfred Uhr
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804, Munich, Germany
    J Psychiatr Res 37:179-85. 2003
  5. ncbi request reprint Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins
    M Uhr
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neuroendocrinol 14:753-9. 2002
  6. ncbi request reprint The anti-Parkinson drug budipine is exported actively out of the brain by P-glycoprotein in mice
    Manfred Uhr
    Max Planck Institute of Psychiatry, Munich, Germany
    Neurosci Lett 383:73-6. 2005
  7. ncbi request reprint P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into the mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6
    Manfred Uhr
    Max Planck Institute for Psychiatry, 80804 Munich, Germany
    J Psychopharmacol 18:509-15. 2004
  8. doi request reprint HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients
    E B Binder
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D80804 Munich, Germany
    Psychoneuroendocrinology 34:99-109. 2009
  9. ncbi request reprint Renin-angiotensin-aldosterone system, HPA-axis and sleep-EEG changes in unmedicated patients with depression after total sleep deprivation
    H Murck
    Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacopsychiatry 39:23-9. 2006
  10. doi request reprint Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial
    Heike E Kunzel
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    J Psychiatr Res 43:702-10. 2009

Detail Information

Publications106 found, 100 shown here

  1. pmc Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations
    Florian Then Bergh
    Section of Neurology, Max Planck Institut fur Psychiatrie, Munchen, Germany
    BMC Neurol 6:19. 2006
    ..Intermittent IV-MP, alone or with immunomodulators, has been suggested but insufficiently studied as a strategy to prevent relapses...
  2. ncbi request reprint Blood-brain barrier penetration and pharmacokinetics of amitriptyline and its metabolites in p-glycoprotein (abcb1ab) knock-out mice and controls
    Manfred Uhr
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    J Psychiatr Res 41:179-88. 2007
    ..This confirms the validity of the P-gp knock-out model and allows for a continued research of the interactions between P-gp, the blood-brain barrier and CNS substances such as antidepressants, neuroleptics and others...
  3. doi request reprint Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression
    Manfred Uhr
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Neuron 57:203-9. 2008
    ..This finding can be viewed as a further step into personalized antidepressant treatment...
  4. ncbi request reprint abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice
    Manfred Uhr
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804, Munich, Germany
    J Psychiatr Res 37:179-85. 2003
    ..We hypothesize that inter-individual differences in the activity of the ABCB1 gene can account in part for the great variation in clinical response to antidepressants in psychiatric patients, even at comparable plasma levels...
  5. ncbi request reprint Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins
    M Uhr
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neuroendocrinol 14:753-9. 2002
    ....
  6. ncbi request reprint The anti-Parkinson drug budipine is exported actively out of the brain by P-glycoprotein in mice
    Manfred Uhr
    Max Planck Institute of Psychiatry, Munich, Germany
    Neurosci Lett 383:73-6. 2005
    ..Budipine concentrations in the abcb1ab knock-out animals were 3.1 times higher than in control mice. This study confirms the important role P-gp plays at the blood-brain barrier and shows that budipine is a substrate of P-gp...
  7. ncbi request reprint P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into the mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6
    Manfred Uhr
    Max Planck Institute for Psychiatry, 80804 Munich, Germany
    J Psychopharmacol 18:509-15. 2004
    ..There is an overlap in substrate specificity between P-gp and CYP2D6. P-gp is a factor in the uptake of dextromethorphan, but not of melperone...
  8. doi request reprint HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients
    E B Binder
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D80804 Munich, Germany
    Psychoneuroendocrinology 34:99-109. 2009
    ..In male patients, a single measure of HPA-axis dysregulation at admission may serve as a predictor of response to antidepressant treatment in addition to the previously reported repeated measure of the Dex-CRH test...
  9. ncbi request reprint Renin-angiotensin-aldosterone system, HPA-axis and sleep-EEG changes in unmedicated patients with depression after total sleep deprivation
    H Murck
    Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacopsychiatry 39:23-9. 2006
    ..Additionally we explored the HPA-system and the sleep-EEG-changes...
  10. doi request reprint Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial
    Heike E Kunzel
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    J Psychiatr Res 43:702-10. 2009
    ..In delusional depression HPA overactivity is more distinct than in other subtypes of depression. HPA suppression is thought to contribute to the action of trimipramine...
  11. ncbi request reprint Growth hormone-releasing hormone and corticotropin-releasing hormone enhance non-rapid-eye-movement sleep after sleep deprivation
    P Schussler
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Am J Physiol Endocrinol Metab 291:E549-56. 2006
    ..No sex differences were found in these changes. Our data suggest that GHRH and CRH augment NREMS promotion after SD. Marked differences appear to exist in peptidergic sleep regulation between spontaneous and recovery sleep...
  12. ncbi request reprint Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Nat Genet 36:1319-25. 2004
    ..These findings support a central role of genes regulating the HPA axis in the causality of depression and the mechanism of action of antidepressant drugs...
  13. ncbi request reprint Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption
    Manfred Uhr
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    Biol Psychiatry 54:840-6. 2003
    ....
  14. ncbi request reprint Nocturnal ghrelin, ACTH, GH and cortisol secretion after sleep deprivation in humans
    P Schussler
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychoneuroendocrinology 31:915-23. 2006
    ..Whereas the effects of SD on ghrelin levels were relatively weak, our findings are in line with the hypothesis that ghrelin is a sleep-promoting factor in humans. Ghrelin may be involved in sleep promotion after SD...
  15. pmc Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response
    K Ganea
    Max Planck Institute of Psychiatry, Munich, Germany
    Transl Psychiatry 2:e177. 2012
    ..Further, our data suggest this pathway to be a target for more rapid-acting antidepressants in the future...
  16. ncbi request reprint Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin, and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazapine
    Dagmar A Schmid
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 31:832-44. 2006
    ..A weight gain of approximately 3 kg was observed. This unique profile of changes is compatible with the action of mirtazapine at 5-HT-2 receptors, at presynaptic adrenergic alpha 2 receptors, at the HPA system, and on ghrelin and leptin...
  17. doi request reprint Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression
    S Kloiber
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 15:736-47. 2010
    ..Identifying depressed patients at high risk for MetS using genetic variants could have direct clinical impact on individualized disease management and prevention strategies...
  18. ncbi request reprint P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder
    Susanne Lucae
    The Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Hum Mol Genet 15:2438-45. 2006
    ..This polymorphism results in an amino acid exchange in the C-terminal cytosolic domain of the P2RX7 channel protein, suggesting that the observed P2RX7 polymorphism might play a causal role in the development of depression...
  19. ncbi request reprint Acute cortisol administration increases sleep depth and growth hormone release in patients with major depression
    Dagmar A Schmid
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Psychiatr Res 42:991-9. 2008
    ..Our results suggest that non-REM and REM sleep abnormalities during the acute state of the disease are differentially linked to the activity of the HPA axis...
  20. ncbi request reprint Dehydroepiandrosterone response to the adrenocorticotropin test and the combined dexamethasone and corticotropin-releasing hormone test in patients with multiple sclerosis
    T Kümpfel
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuroendocrinology 70:431-8. 1999
    ..45; p = 0.031). As with the hypothalamic-pituitary-adrenal axis system, our results suggest a dysfunction in the DHEA secretion in patients with MS...
  21. ncbi request reprint Persistent neuroendocrine and behavioral effects of a novel, etiologically relevant mouse paradigm for chronic social stress during adolescence
    M V Schmidt
    Max Planck Institute of Psychiatry, RG Molecular Stress Physiology, Kraepelinstr 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 32:417-29. 2007
    ..Moreover, this paradigm allows to investigate the interaction of genetic susceptibility and environmental risk factors...
  22. doi request reprint TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies
    A Erhardt
    Max Planck Institute of Psychiatry, Munchen, Germany
    Mol Psychiatry 16:647-63. 2011
    ..TMEM132D may thus be an important new candidate gene for PD as well as more generally for anxiety-related behavior...
  23. ncbi request reprint On the role of menopause for sleep-endocrine alterations associated with major depression
    I A Antonijevic
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    Psychoneuroendocrinology 28:401-18. 2003
    ..Whether the predominant alteration of the distribution of SWS and delta EEG activity in younger patients with a first episode of major depression has a predictive value for the future course of the disease remains to be investigated...
  24. ncbi request reprint Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. a prospective study
    A W Zobel
    Max Planck Institute of Psychiatry, Kraepelinstr 2-10, 80804 Munich, Germany
    J Psychiatr Res 35:83-94. 2001
    ..Hence, an exaggerated cortisol response in the combined DEX/CRH test predicts the recurrence of depressive psychopathology. The test performance can be further optimized if gender and age are taken into account...
  25. ncbi request reprint Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption
    M Uhr
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 22:380-7. 2000
    ..Moreover, individual differences in mdr1 gene activity may account for variable response patterns at different episodes and development of therapy resistance...
  26. ncbi request reprint ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder
    Marianne B Muller
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neuropsychopharmacology 28:1991-9. 2003
    ....
  27. doi request reprint Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients
    F Weber
    Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacogenomics J 12:238-45. 2012
    ..Testing for these SNPs and the HLA-DR*0401 or *0408 alleles allows to identify patients at risk to develop antibodies to IFN-β and may provide helpful information for individual treatment decisions...
  28. doi request reprint A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich 80804, Germany
    Arch Gen Psychiatry 66:966-75. 2009
    ..Genetic factors and clinical characteristics contribute to the failure of a favorable treatment outcome...
  29. ncbi request reprint Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks
    Christoph K Thoeringer
    Max Planck Institute of Psychiatry, Munich 80804, Germany
    J Psychiatr Res 41:579-84. 2007
    ..43; 95% CI: 0.19-0.95). In conclusion, these results suggest a central role of DBI genetic variants in the susceptibility for the development of anxiety disorders that are characterized by the occurrence of panic attacks...
  30. doi request reprint Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project
    Johannes M Hennings
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    J Psychiatr Res 43:215-29. 2009
    ..We demonstrated that this subgroup can be characterized by a set of demographic, clinical and neuroendocrine variables allowing to predict unfavorable outcome at an early stage of treatment...
  31. ncbi request reprint Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers
    Ralf Michael Frieboes
    Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    Psychoneuroendocrinology 29:851-60. 2004
    ..We hypothesize that sleep is impaired after hexarelin since the GHRH/corticotropin-releasing hormone (CRH) ratio is changed in favour of CRH. There are no hints for an interaction of hexarelin and the immune system...
  32. doi request reprint Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression
    A Menke
    Department of Molecular Genetics of Affective Disorders, Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    Genes Brain Behav 12:289-96. 2013
    ..This finding suggests that endocrine alterations in depressed patients are determined by genetic variants and may allow identification of specific subgroups...
  33. pmc The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders
    C K Thoeringer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Neural Transm 116:649-57. 2009
    ..These data indicate a high load of genetic variance within SLC6A1 on pathological anxiety and highlight GAT-1 as a promising target for treatment of anxiety disorders with panic symptoms...
  34. ncbi request reprint Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism
    T C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Mol Psychiatry 11:1003-15. 2006
    ..We could show that SNP rs4291 influences ACE activity and HPA-axis hyperactivity and might therefore represent a common pathophysiologic link for unipolar depression and cardiovascular disease...
  35. doi request reprint More CLEC16A gene variants associated with multiple sclerosis
    S Nischwitz
    Max Planck Institute of Psychiatry, Munich, Germany
    Acta Neurol Scand 123:400-6. 2011
    ..Recently, associations of several single-nucleotide polymorphisms (SNPs) within the CLEC16A gene with multiple sclerosis (MS), type-I diabetes, and primary adrenal insufficiency were reported...
  36. doi request reprint Intrahippocampal corticosterone response in mice selectively bred for extremes in stress reactivity: a microdialysis study
    J M Heinzmann
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neuroendocrinol 22:1187-97. 2010
    ....
  37. ncbi request reprint Increased growth hormone response to apomorphine in Parkinson disease compared with multiple system atrophy
    E Friess
    Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
    Arch Neurol 58:241-6. 2001
    ..In search of a suitable endocrinologic challenge test, we investigated dopaminergic sensitivity in patients with de novo parkinsonian syndromes...
  38. ncbi request reprint P-glycoprotein reduces the ability of amitriptyline metabolites to cross the blood brain barrier in mice after a 10-day administration of amitriptyline
    Markus T Grauer
    Max Planck Institute of Psychiatry, Munich, Germany
    J Psychopharmacol 18:66-74. 2004
    ..Recent clinical studies showing different side-effects in patients with P-gp polymorphisms confirm the clinical importance of these findings...
  39. ncbi request reprint Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder
    Angelika Erhardt
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 31:2515-22. 2006
    ..However, differences in the suppression effects and psychopathological correlation patterns between depressed and panic patients suggest different biological mechanisms of HPA system dysregulation in both disorders...
  40. doi request reprint Depression, comorbidities and the TNF-alpha system
    H Himmerich
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804, Munich, Germany
    Eur Psychiatry 23:421-9. 2008
    ..These results confirm earlier studies regarding the comorbidities of depression and support the hypothesis that activation of the TNF-alpha system may contribute to the development of a depressive disorder...
  41. ncbi request reprint Decreased corticotropin-releasing hormone (CRH) concentrations in the cerebrospinal fluid of eucortisolemic suicide attempters
    J Brunner
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804, Munich, Germany
    J Psychiatr Res 35:1-9. 2001
    ..non-attempters. Further studies with more homogeneous samples, drug-free patients and with simultaneous assessment of various parameters of the HPA system are warranted...
  42. ncbi request reprint Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking
    A Heck
    Max Planck Institute of Psychiatry, Munich, Germany
    Genes Brain Behav 8:464-72. 2009
    ..Our results show that HTR2A polymorphisms modulate facets of novelty seeking behaviour in healthy adults suggesting that serotonergic neurotransmission is involved in this phenotype...
  43. ncbi request reprint Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:424-9. 2007
    ..These results further underline a possible important role of genetic variations within the system controlling serotonergic neurotransmission for the development and course of disease in PD...
  44. doi request reprint Sleep and active renin levels--interaction with age, gender, growth hormone and cortisol
    Petra Schussler
    Max Planck Institute of Psychiatry, Munich, Germany schuessler mpipsykl mpg de
    Neuropsychobiology 61:113-21. 2010
    ..Furthermore, there are no data on the effects of age and gender on nocturnal renin and the interaction between these variables, sleep, growth hormone (GH) and cortisol...
  45. ncbi request reprint Sleep enhances nocturnal plasma ghrelin levels in healthy subjects
    Andrea Dzaja
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    Am J Physiol Endocrinol Metab 286:E963-7. 2004
    ..During the first hours of sleep, ghrelin might promote sleep-associated hGH secretion and contribute to the promotion of SWS...
  46. ncbi request reprint Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers
    Ulrich Zimmermann
    Max Planck Institute of Psychiatry, Kraepelinstrasse, Munich, Germany
    Neuropsychopharmacology 29:1156-65. 2004
    ....
  47. ncbi request reprint The effect of the ANKK1/DRD2 Taq1A polymorphism on weight changes of dopaminergic treatment in prolactinomas
    A P Athanasoulia
    Department of Internal Medicine, Endocrinology and Clinical Chemistry, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804, Munich, Germany
    Pituitary 17:240-5. 2014
    ..However, there was no association to the A1 allele of Taq1A, observation that needs to be analysed in larger cohorts. ..
  48. doi request reprint IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations
    F Weber
    Max Planck Institute of Psychiatry, Munich, Germany
    Genes Immun 9:259-63. 2008
    ..1 to 1.5. The discovery and validation of new genetic risk factors in independent populations may help toward the understanding of MS pathogenesis by providing valuable information on biological pathways to be investigated...
  49. ncbi request reprint Prevalence of anterior pituitary insufficiency 3 and 12 months after traumatic brain injury
    H J Schneider
    Max Planck Institute of Psychiatry, Clinical Neuroendocrinology Group Kraepelinstr 10, 80804 Munich, Germany
    Eur J Endocrinol 154:259-65. 2006
    ..This study was conducted to assess hypopituitarism 3 and 12 months after TBI...
  50. ncbi request reprint Alcohol administration acutely inhibits ghrelin secretion in an experiment involving psychosocial stress
    Ulrich S Zimmermann
    Max Planck Institute of Psychiatry, Germany
    Addict Biol 12:17-21. 2007
    ..We could not observe a stress effect on ghrelin, which does not support a role for ghrelin in stress-induced anorexia...
  51. ncbi request reprint P-glycoprotein has negligible effects on estradiol and testosterone in mice
    Martin Ebinger
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Neurosci Lett 427:6-9. 2007
    ..The organ/plasma quotients showed no significant group effects. We concluded that P-gp does not influence the penetration of testosterone and estradiol to a biologically significant extent...
  52. ncbi request reprint Endocrine rhythms in patients with restless legs syndrome
    Thomas C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neurol 249:146-51. 2002
    ..9 +/- 17.1) compared with the controls (12.0 +/- 9.2; p < 0.05). It is suggested that a possible dysfunction of the dopaminergic system in RLS does not affect the release of prolactin and hGH from the pituitary gland...
  53. ncbi request reprint Pharmacological and nonpharmacological factors influencing hypothalamic-pituitary-adrenocortical axis reactivity in acutely depressed psychiatric in-patients, measured by the Dex-CRH test
    H E Künzel
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 28:2169-78. 2003
    ..Finally, more severe vegetative symptoms are associated with an enhanced HPA-axis activity...
  54. ncbi request reprint Polymorphisms of the drug transporter gene ABCB1 predict side effects of treatment with cabergoline in patients with PRL adenomas
    A P Athanasoulia
    Department of Internal Medicine, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Eur J Endocrinol 167:327-35. 2012
    ..Central side effects may depend on a substance's ability to pass the blood-brain barrier, which can be actively controlled by transporter molecules such as the P-glycoprotein (P-gp) encoded by the ABCB1 gene...
  55. ncbi request reprint Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers
    U Zimmermann
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    J Psychiatr Res 38:385-93. 2004
    ..This might imply some short-term positive alcohol effect in sons of alcoholics, but also constitute a mechanism by which their risk to develop alcohol use disorders is increased...
  56. ncbi request reprint Differential induction of NF-kappaB activity and neural cell death by antidepressants in vitro
    A Post
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Eur J Neurosci 12:4331-7. 2000
    ..These results indicate that some antidepressant drugs may cause both oxidative stress and changes in cellular antioxidative capacity, resulting in altered NF-kappaB activity and, ultimately, cell death...
  57. ncbi request reprint Ghrelin promotes slow-wave sleep in humans
    J C Weikel
    Max Planck Institute of Psychiatry, Department of Psychiatry, 80804 Munich, Germany
    Am J Physiol Endocrinol Metab 284:E407-15. 2003
    ..Furthermore, ghrelin appears to be a common stimulus of the somatotropic and hypothalamo-pituitary-adrenocortical systems. It appears that ghrelin is a sleep-promoting factor in humans...
  58. ncbi request reprint Reduced leptin levels in human narcolepsy
    A Schuld
    Max Planck Institute of Psychiatry Munich, Germany
    Neuroendocrinology 72:195-8. 2000
    ..The significance of these alterations for the core symptomatology of narcolepsy should be a target of future research...
  59. ncbi request reprint Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome
    Juliane Winkelmann
    Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich, Germany
    Mov Disord 23:350-8. 2008
    ..Potential usage of NO modulating agents as new treatment options for RLS have become a challenging aspect for future research of this disorder...
  60. doi request reprint Ghrelin suppresses secretion of FSH in males
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Clin Endocrinol (Oxf) 70:920-3. 2009
    ..Ghrelin decreases the secretion of LH probably by suppressing the release of hypothalamic GnRH. So far however, there is no evidence that ghrelin affects also the secretion of FSH in humans, the other gonadotrophin regulated by GnRH...
  61. doi request reprint Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 33:497-506. 2008
    ..CRH had sleep-improving and REM permissive effects when co-administered with ghrelin, being in contrast to the effect of CRH alone in previous studies...
  62. doi request reprint Ghrelin plasma levels are not altered in major depression
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychobiology 59:199-204. 2009
    ..In addition, ghrelin levels in depressed patients decrease with psychopathological improvement. Therefore, we hypothesized that ghrelin levels in patients with major depression would be higher than in healthy subjects...
  63. doi request reprint Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients
    Angela Heck
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:104-14. 2009
    ..These results suggest that the ACE gene is involved in the development of coping strategies...
  64. pmc Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Neuropsychopharmacology 35:1583-92. 2010
    ..The reported associations in independent samples of AD and MDD support an estrogen-dependent function of GAL in pathophysiology of anxiety and depression, affecting response to antidepressant treatment...
  65. pmc Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients
    Martin A Kohli
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Arch Gen Psychiatry 67:348-59. 2010
    ..Especially in suicide victims, lower postmortem brain messenger RNA and protein levels of neurotrophins and their receptors have been reported...
  66. doi request reprint Ghrelin increases slow wave sleep and stage 2 sleep and decreases stage 1 sleep and REM sleep in elderly men but does not affect sleep in elderly women
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 35:297-304. 2010
    ..In both sexes, ghrelin caused comparable increases and secretion patterns of GH and cortisol. In conclusion, ghrelin affects sleep in elderly men but not women resembling findings in young subjects...
  67. ncbi request reprint Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Eur J Neurosci 28:389-98. 2008
    ..This reaction pattern suggests that subjects carrying these variants are at risk of displaying chronically elevated cortisol levels after repeated stress constituting a risk factor for stress-related diseases...
  68. doi request reprint Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action
    Sonja Horstmann
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 34:238-48. 2009
    ..Our results confirm that dex/CRH tests can be used as predictors of clinical course also under mirtazapine treatment...
  69. ncbi request reprint Ghrelin enhances the nocturnal secretion of cortisol and growth hormone in young females without influencing sleep
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychoneuroendocrinology 32:1079-85. 2007
    ..In contrast to findings in young men, ghrelin did not affect sleep in young women, indicating a sexual dimorphism. In accordance with the findings in young men, ghrelin stimulated secretion of GH and cortisol...
  70. ncbi request reprint Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects
    Heike E Kunzel
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
    J Psychiatr Res 37:525-33. 2003
    ..No effects of R121919 on clinical laboratory parameters including liver enzymes, EEG and ECG were observed. These results encourage the development of other CRH-1-R antagonists as a novel class of antidepressive drugs...
  71. ncbi request reprint Vasopressin in CSF and plasma in depressed suicide attempters: preliminary results
    Jurgen Brunner
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
    Eur Neuropsychopharmacol 12:489-94. 2002
    ..Suicide attempters did not differ from nonattempters. In depressed patients, plasma AVP correlated positively with cortisol. There was no relationship between CSF AVP and monoamine metabolites in CSF...
  72. ncbi request reprint ABC drug transporter at the blood-brain barrier: effects on drug metabolism and drug response
    Martin Ebinger
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 256:294-8. 2006
    ..Finally, we discuss genetic polymorphisms of the genes encoding for P-gp and their effects on drug response...
  73. ncbi request reprint Hypothalamic-pituitary-adrenocortical system and mood disorders: highlights from mutant mice
    Marianne B Muller
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuroendocrinology 79:1-12. 2004
    ..The identification and detailed characterization of these molecular pathways will ultimately lead to the development of novel neuropharmacological intervention strategies...
  74. ncbi request reprint Successful antidepressant therapy restores the disturbed interplay between TNF-alpha system and HPA axis
    Hubertus Himmerich
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 60:882-8. 2006
    ....
  75. ncbi request reprint Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:47-54. 2007
    ..In the present study, we examined whether change in HPA system function during the first weeks of hospitalization predicts response to antidepressant treatment in major depression and thus constitutes a potential biomarker...
  76. ncbi request reprint Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders
    Angelika Erhardt
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 München, Germany
    J Affect Disord 101:159-68. 2007
    ..This region contains two candidate genes for purinergic ligand-gated ion channels, P2RX7 and P2RX4, and one gene coding for calmodulin-dependent protein kinase kinase b (CaMKKb)...
  77. ncbi request reprint High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neuropsychopharmacology 32:1941-9. 2007
    ..NBI-34041 demonstrates that inhibition of the CRF system is a promising target for drug development against depression and anxiety disorders...
  78. ncbi request reprint Ghrelin suppresses secretion of luteinizing hormone in humans
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Clin Endocrinol Metab 92:3202-5. 2007
    ..Ghrelin affects the hypothalamic-pituitary-gonadal axis in various nonhuman mammalians, predominantly by suppressing secretion of LH. However, for humans, no such evidence exists...
  79. ncbi request reprint Mechanisms underlying the protective potential of alpha-tocopherol (vitamin E) against haloperidol-associated neurotoxicity
    Anke Post
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neuropsychopharmacology 26:397-407. 2002
    ..Collectively, the data indicate the usefulness of vitamin E as an adjunct to haloperidol treatment and provide initial clues about the underlying molecular mechanisms involved in these effects...
  80. ncbi request reprint Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 28:235-43. 2003
    ..This novel mechanism of action of paroxetine on vasopressin gene regulation renders vasopressinergic neuronal circuits a promising target for the development of more causal antidepressant treatment strategies...
  81. ncbi request reprint Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 München, Germany
    J Affect Disord 105:177-84. 2008
    ..Furthermore, GAL is involved in hypothalamic-hypophysiotropic signalling and cosecreted with luteinizing hormone-releasing hormone (LHRH), possibly acting as a mediator of estrogen action...
  82. ncbi request reprint Nocturnal ghrelin levels--relationship to sleep EEG, the levels of growth hormone, ACTH and cortisol--and gender differences
    Petra Schuessler
    Max Planck Institute of Psychiatry, Munich, Germany
    J Sleep Res 14:329-36. 2005
    ..No peak in plasma ghrelin levels resembling the GH surge was observed. We suggest that under naturalistic conditions plasma ghrelin levels show no distinct interaction with sleep...
  83. ncbi request reprint Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans
    Katja Held
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    Pharmacopsychiatry 35:135-43. 2002
    ..The similarities of the effect of Mg(2+) and that of the related electrolyte Li+ furthermore supports the possible efficacy of Mg(2+) as a mood stabilizer...
  84. ncbi request reprint Time of interferon-beta 1a injection and duration of treatment affect clinical side effects and acute changes of plasma hormone and cytokine levels in multiple sclerosis patients
    T Kümpfel
    Institute of Clinical Neuroimmunology, Klinikum Grosshadern, Ludwig Maximilians Universitat, Munich, Germany
    Mult Scler 13:1138-45. 2007
    ..This may have implications on the tolerability and effectiveness of IFN-beta therapy...
  85. ncbi request reprint Fatigue and regulation of the hypothalamo-pituitary-adrenal axis in multiple sclerosis
    Michaela Gottschalk
    Max Planck Institute of Psychiatry, Munich, Germany
    Arch Neurol 62:277-80. 2005
    ..Fatigue is a common and disabling symptom in patients with multiple sclerosis (MS). Underlying mechanisms postulated so far have involved localization of brain lesions and abnormalities of the neuroendocrine system and cytokine regulation...
  86. ncbi request reprint Ghrelin stimulates appetite, imagination of food, GH, ACTH, and cortisol, but does not affect leptin in normal controls
    Dagmar A Schmid
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 30:1187-92. 2005
    ..Our data suggest that i.v. ghrelin stimulates appetite and images of food in young women and men. Obviously, leptin is not involved in these effects...
  87. doi request reprint Ghrelin affects the hypothalamus-pituitary-thyroid axis in humans by increasing free thyroxine and decreasing TSH in plasma
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, Germany
    Eur J Endocrinol 162:1059-65. 2010
    ..g. by increasing energy expenditure. We therefore hypothesized that ghrelin suppresses the HPT axis in humans, counteracting its energy-saving effect...
  88. doi request reprint Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis
    Sandra Nischwitz
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neuroimmunol 227:162-6. 2010
    ..No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433...
  89. ncbi request reprint Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression
    Heike E Kunzel
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 Munich, Germany
    J Psychiatr Res 39:173-7. 2005
    ..Together with previous findings indicating safety, tolerability, and clinical efficacy CRH1R antagonists are highly promising as a new treatment option in depression...
  90. ncbi request reprint Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters
    Jurgen Brunner
    Facharzt für Psychiatrie und Psychotherapie, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 255:438-40. 2005
    ..2. Proteomic analysis of the CSF is a promising non hypothesis-driven screening method for the detection of new candidate genes in neurobiological suicide research...
  91. ncbi request reprint Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients
    M A Dalal
    Max Planck Institute of Psychiatry, Munich, Germany
    Neurology 56:1749-51. 2001
    ..However, plasma orexin A levels did not differ from those observed in controls. These results suggest that orexin deficiency in patients with narcolepsy is a phenomena restricted to the CNS...
  92. doi request reprint Ethanol administration dampens the prolactin response to psychosocial stress exposure in sons of alcohol-dependent fathers
    Ulrich S Zimmermann
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    Psychoneuroendocrinology 34:996-1003. 2009
    ....
  93. pmc Valproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes
    Tatjana Perisic
    Chaperone Research Group, Max Planck Institute of Psychiatry, Munich, Bavaria, Germany
    Neuropsychopharmacology 35:792-805. 2010
    ..In conclusion, VPA and AMI globally exerted chromatin-modulating activities using different mechanisms that divergently precipitated at an astroglial gene locus...
  94. ncbi request reprint Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment
    Hubertus Himmerich
    Max Planck Institut fur Psychiatrie, Munchen, Deutschland
    Neuropsychobiology 55:28-35. 2007
    ..Glucocorticoids themselves are reported to increase leptin synthesis and secretion in humans...
  95. ncbi request reprint Lithium augmentation increases post-dexamethasone cortisol in the dexamethasone suppression test in unipolar major depression
    Tom Bschor
    Department of Psychiatry, Technische Universitat Dresden, Germany
    Depress Anxiety 17:43-8. 2003
    ..This is in contrast to the established decline of HPA system activity during treatment with tricyclic antidepressants...
  96. ncbi request reprint Elevated plasma ghrelin levels in night-eating syndrome
    Marcus C Rosenhagen
    Am J Psychiatry 162:813. 2005
  97. ncbi request reprint Lithium augmentation increases the ACTH and cortisol response in the combined DEX/CRH test in unipolar major depression
    Tom Bschor
    Department of Psychiatry, Technische Universitat Dresden, Dresden, Germany
    Neuropsychopharmacology 27:470-8. 2002
    ..This effect might be explained by the serotonergic effects of lithium...
  98. ncbi request reprint Effects of Hypericum extract (LI160) on the change of auditory evoked potentials by cortisol administration
    Harald Murck
    Lichtwer Pharma AG, Berlin, Germany
    Neuropsychobiology 50:128-33. 2004
    ....
  99. ncbi request reprint Steroid synthesis inhibition with ketoconazole and its effect upon the regulation of the hypothalamus-pituitary-adrenal system in healthy humans
    Michael Deuschle
    Central Institute of Mental Health, Mannheim, Germany
    Neuropsychopharmacology 28:379-83. 2003
    ..7+/-4.6 nmol/l), but not in the young subgroup (pre: 15.6+/-11.3; post: 27.7+/-9.4 nmol/l). We thus conclude that the treatment of healthy controls with steroid-synthesis inhibitors does not lead to a major increase in CRH secretion...
  100. ncbi request reprint Association between response to lithium augmentation and the combined DEX/CRH test in major depressive disorder
    Tom Bschor
    Department of Psychiatry, Technische Universitat Dresden, Fetscherstrasse 74, D 01307, Dresden, Germany
    J Psychiatr Res 37:135-43. 2003
    ..Results of this study should be confirmed in a larger study group...
  101. ncbi request reprint Ethyl-eicosapentaenoate and dexamethasone resistance in therapy-refractory depression
    Harald Murck
    Laxdale Ltd, Stirling, Scotland, UK, FK7 9JQ
    Int J Neuropsychopharmacol 7:341-9. 2004
    ..EPA may, furthermore, enhance the action of antidepressants, like many SSRIs that are p-gp substrates, which are actively transported out of the intracerebral space at the level of the blood-brain barrier...