Affiliation: Max Planck Institute of Psychiatry
- Morphological, physiological and behavioural evaluation of a 'Mice in Space' housing systemDieter Blottner
Vegetative Anatomy, Center of Space Medicine Berlin, Neuromuscular Group, Charite Universitatsmedizin Berlin, Freie und Humboldt Universität Berlin, Berlin, Germany
J Comp Physiol B 179:519-33. 2009..Our results may be even more helpful in developing multidisciplinary protocols with adequate scenarios addressing molecular to systems levels using mice of various genetic phenotypes in many laboratories...
- Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depressionThomas Fenzl
Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
BMC Neurosci 12:29. 2011..Eight adult males of each of the three breeding lines were equipped with epidural EEG and intramuscular electromyogram (EMG) electrodes. After recovery, EEG and EMG recordings were performed for two days...
- Stress and affective disorders: animal models elucidating the molecular basis of neuroendocrine-behavior interactionsC Touma
Research Group of Psychoneuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
Pharmacopsychiatry 44:S15-26. 2011..Such in-depth understanding is ultimately essential to realizing our goal of predictive, preventive, and personalized medicine...
- Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depressionChadi Touma
Max Planck Institute of Psychiatry, Munich, Germany
PLoS ONE 4:e4325. 2009..This so-called 'stress reactivity' (SR) mouse model consists of three separate breeding lines selected for either high (HR), intermediate (IR), or low (LR) corticosterone increase in response to stressors...
- Mice selected for high versus low stress reactivity: a new animal model for affective disordersChadi Touma
Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
Psychoneuroendocrinology 33:839-62. 2008....
- Measuring fecal glucocorticoid metabolites in mammals and birds: the importance of validationChadi Touma
Max Planck Institute of Psychiatry, Department of Behavioral Neuroendocrinology, Kraepelinstrasse 2 10, D 80804 Munich, Germany
Ann N Y Acad Sci 1046:54-74. 2005....
- Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disordersA Knapman
Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
J Psychiatr Res 44:566-75. 2010....
- Intrahippocampal corticosterone response in mice selectively bred for extremes in stress reactivity: a microdialysis studyJ M Heinzmann
Max Planck Institute of Psychiatry, Munich, Germany
J Neuroendocrinol 22:1187-97. 2010....
- Modeling psychotic and cognitive symptoms of affective disorders: Disrupted latent inhibition and reversal learning deficits in highly stress reactive miceA Knapman
Research Group of Psychoneuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Neurobiol Learn Mem 94:145-52. 2010....
- Effects of sex and time of day on metabolism and excretion of corticosterone in urine and feces of miceChadi Touma
Department of Behavioral Biology, Institute of Neuro and Behavioral Biology, University of Muenster, Badestrasse 9, D 48149 Muenster, Germany
Gen Comp Endocrinol 130:267-78. 2003..Since mice are extensively used in research world-wide, this could open new perspectives in various fields from ecology to behavioral endocrinology...
- Analyzing corticosterone metabolites in fecal samples of mice: a noninvasive technique to monitor stress hormonesChadi Touma
Department of Behavioural Biology, University of Muenster, D 48149 Muenster, Germany
Horm Behav 45:10-22. 2004....
- Age- and sex-dependent development of adrenocortical hyperactivity in a transgenic mouse model of Alzheimer's diseaseChadi Touma
Department of Behavioural Biology, University of Muenster, Badestrasse 9, D 48149 Muenster, Germany
Neurobiol Aging 25:893-904. 2004..Thus, the development of adrenocortical hyperactivity might be a key-element in the understanding of AD...
- Activity changes and marked stereotypic behavior precede Abeta pathology in TgCRND8 Alzheimer miceOliver Ambrée
Department of Behavioural Biology, University of Munster, Badestr 9, D 48149 Munster, Germany
Neurobiol Aging 27:955-64. 2006..Stereotypic behaviors may be caused by the same mechanisms as non-cognitive behavioral symptoms of AD. Thus, it is likely that analogies to BPSD that precede Abeta pathology are found in APP-overexpressing TgCRND8 mice...
- Prominent corticosteroid disturbance in experimental prion diseaseTill Voigtlander
Institute of Neurology, Medical University of Vienna, AKH, Wahringer Gurtel 18 20, A 1097 Vienna, Austria
Eur J Neurosci 23:2723-30. 2006..The dysregulation of corticosteroid excretion might act as a further cofactor in the pathogenesis of scrapie, for example by preconditioning nerve cells to disease-immanent neurotoxic stimuli, such as oxidative stress, and to apoptosis...
- Wheel-running in a transgenic mouse model of Alzheimer's disease: protection or symptom?Helene Richter
Department of Behavioural Biology, University of Munster, Badestrasse 13, Munster, Germany
Behav Brain Res 190:74-84. 2008..Whether or not access to a running wheel has beneficial effects on Alzheimer-like pathology and symptoms may therefore strongly depend on the exact time when the wheel is provided during development of the disease...
- Impaired daily glucocorticoid rhythm in Per1 ( Brd ) miceRobert Dallmann
Institute of Zoology, School of Veterinary Medicine Hannover, Hannover, Germany
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192:769-75. 2006..In conclusion, our study presents first evidence for a link between an altered metabolism in Per1 and Per2 deficient mice, which in the case of the Per1 ( Brd ) animals might be due to an impaired corticosterone rhythm...