C Touma

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. ncbi Morphological, physiological and behavioural evaluation of a 'Mice in Space' housing system
    Dieter Blottner
    Vegetative Anatomy, Center of Space Medicine Berlin, Neuromuscular Group, Charite Universitatsmedizin Berlin, Freie und Humboldt Universität Berlin, Berlin, Germany
    J Comp Physiol B 179:519-33. 2009
  2. ncbi Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression
    Thomas Fenzl
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    BMC Neurosci 12:29. 2011
  3. ncbi Stress and affective disorders: animal models elucidating the molecular basis of neuroendocrine-behavior interactions
    C Touma
    Research Group of Psychoneuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacopsychiatry 44:S15-26. 2011
  4. ncbi Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression
    Chadi Touma
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e4325. 2009
  5. ncbi Mice selected for high versus low stress reactivity: a new animal model for affective disorders
    Chadi Touma
    Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Psychoneuroendocrinology 33:839-62. 2008
  6. ncbi Measuring fecal glucocorticoid metabolites in mammals and birds: the importance of validation
    Chadi Touma
    Max Planck Institute of Psychiatry, Department of Behavioral Neuroendocrinology, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Ann N Y Acad Sci 1046:54-74. 2005
  7. ncbi Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders
    A Knapman
    Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 44:566-75. 2010
  8. ncbi Intrahippocampal corticosterone response in mice selectively bred for extremes in stress reactivity: a microdialysis study
    J M Heinzmann
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neuroendocrinol 22:1187-97. 2010
  9. ncbi Modeling psychotic and cognitive symptoms of affective disorders: Disrupted latent inhibition and reversal learning deficits in highly stress reactive mice
    A Knapman
    Research Group of Psychoneuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neurobiol Learn Mem 94:145-52. 2010
  10. ncbi Effects of sex and time of day on metabolism and excretion of corticosterone in urine and feces of mice
    Chadi Touma
    Department of Behavioral Biology, Institute of Neuro and Behavioral Biology, University of Muenster, Badestrasse 9, D 48149 Muenster, Germany
    Gen Comp Endocrinol 130:267-78. 2003

Collaborators

Detail Information

Publications16

  1. ncbi Morphological, physiological and behavioural evaluation of a 'Mice in Space' housing system
    Dieter Blottner
    Vegetative Anatomy, Center of Space Medicine Berlin, Neuromuscular Group, Charite Universitatsmedizin Berlin, Freie und Humboldt Universität Berlin, Berlin, Germany
    J Comp Physiol B 179:519-33. 2009
    ..Our results may be even more helpful in developing multidisciplinary protocols with adequate scenarios addressing molecular to systems levels using mice of various genetic phenotypes in many laboratories...
  2. ncbi Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression
    Thomas Fenzl
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    BMC Neurosci 12:29. 2011
    ..Eight adult males of each of the three breeding lines were equipped with epidural EEG and intramuscular electromyogram (EMG) electrodes. After recovery, EEG and EMG recordings were performed for two days...
  3. ncbi Stress and affective disorders: animal models elucidating the molecular basis of neuroendocrine-behavior interactions
    C Touma
    Research Group of Psychoneuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacopsychiatry 44:S15-26. 2011
    ..Such in-depth understanding is ultimately essential to realizing our goal of predictive, preventive, and personalized medicine...
  4. ncbi Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression
    Chadi Touma
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e4325. 2009
    ..This so-called 'stress reactivity' (SR) mouse model consists of three separate breeding lines selected for either high (HR), intermediate (IR), or low (LR) corticosterone increase in response to stressors...
  5. ncbi Mice selected for high versus low stress reactivity: a new animal model for affective disorders
    Chadi Touma
    Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Psychoneuroendocrinology 33:839-62. 2008
    ....
  6. ncbi Measuring fecal glucocorticoid metabolites in mammals and birds: the importance of validation
    Chadi Touma
    Max Planck Institute of Psychiatry, Department of Behavioral Neuroendocrinology, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Ann N Y Acad Sci 1046:54-74. 2005
    ....
  7. ncbi Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders
    A Knapman
    Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 44:566-75. 2010
    ....
  8. ncbi Intrahippocampal corticosterone response in mice selectively bred for extremes in stress reactivity: a microdialysis study
    J M Heinzmann
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neuroendocrinol 22:1187-97. 2010
    ....
  9. ncbi Modeling psychotic and cognitive symptoms of affective disorders: Disrupted latent inhibition and reversal learning deficits in highly stress reactive mice
    A Knapman
    Research Group of Psychoneuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neurobiol Learn Mem 94:145-52. 2010
    ....
  10. ncbi Effects of sex and time of day on metabolism and excretion of corticosterone in urine and feces of mice
    Chadi Touma
    Department of Behavioral Biology, Institute of Neuro and Behavioral Biology, University of Muenster, Badestrasse 9, D 48149 Muenster, Germany
    Gen Comp Endocrinol 130:267-78. 2003
    ..Since mice are extensively used in research world-wide, this could open new perspectives in various fields from ecology to behavioral endocrinology...
  11. ncbi Analyzing corticosterone metabolites in fecal samples of mice: a noninvasive technique to monitor stress hormones
    Chadi Touma
    Department of Behavioural Biology, University of Muenster, D 48149 Muenster, Germany
    Horm Behav 45:10-22. 2004
    ....
  12. ncbi Age- and sex-dependent development of adrenocortical hyperactivity in a transgenic mouse model of Alzheimer's disease
    Chadi Touma
    Department of Behavioural Biology, University of Muenster, Badestrasse 9, D 48149 Muenster, Germany
    Neurobiol Aging 25:893-904. 2004
    ..Thus, the development of adrenocortical hyperactivity might be a key-element in the understanding of AD...
  13. ncbi Activity changes and marked stereotypic behavior precede Abeta pathology in TgCRND8 Alzheimer mice
    Oliver Ambrée
    Department of Behavioural Biology, University of Munster, Badestr 9, D 48149 Munster, Germany
    Neurobiol Aging 27:955-64. 2006
    ..Stereotypic behaviors may be caused by the same mechanisms as non-cognitive behavioral symptoms of AD. Thus, it is likely that analogies to BPSD that precede Abeta pathology are found in APP-overexpressing TgCRND8 mice...
  14. ncbi Prominent corticosteroid disturbance in experimental prion disease
    Till Voigtlander
    Institute of Neurology, Medical University of Vienna, AKH, Wahringer Gurtel 18 20, A 1097 Vienna, Austria
    Eur J Neurosci 23:2723-30. 2006
    ..The dysregulation of corticosteroid excretion might act as a further cofactor in the pathogenesis of scrapie, for example by preconditioning nerve cells to disease-immanent neurotoxic stimuli, such as oxidative stress, and to apoptosis...
  15. ncbi Wheel-running in a transgenic mouse model of Alzheimer's disease: protection or symptom?
    Helene Richter
    Department of Behavioural Biology, University of Munster, Badestrasse 13, Munster, Germany
    Behav Brain Res 190:74-84. 2008
    ..Whether or not access to a running wheel has beneficial effects on Alzheimer-like pathology and symptoms may therefore strongly depend on the exact time when the wheel is provided during development of the disease...
  16. ncbi Impaired daily glucocorticoid rhythm in Per1 ( Brd ) mice
    Robert Dallmann
    Institute of Zoology, School of Veterinary Medicine Hannover, Hannover, Germany
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192:769-75. 2006
    ..In conclusion, our study presents first evidence for a link between an altered metabolism in Per1 and Per2 deficient mice, which in the case of the Per1 ( Brd ) animals might be due to an impaired corticosterone rhythm...