Christoph Thiele

Summary

Affiliation: Max Planck Institute of Molecular Cell Biology and Genetics
Country: Germany

Publications

  1. doi request reprint Cell biology of lipid droplets
    Christoph Thiele
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, D 01307 Dresden, Germany
    Curr Opin Cell Biol 20:378-85. 2008
  2. pmc Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine
    Christine Moessinger
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    J Biol Chem 286:21330-9. 2011
  3. doi request reprint Live cell multicolor imaging of lipid droplets with a new dye, LD540
    Johanna Spandl
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Traffic 10:1579-84. 2009
  4. ncbi request reprint Lipoprotein particles are required for Hedgehog and Wingless signalling
    Daniela Panàkovà
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Nature 435:58-65. 2005
  5. ncbi request reprint Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets
    Lars Kuerschner
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, D 01307 Dresden, Germany
    Traffic 9:338-52. 2008
  6. pmc Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis
    Kanako Saito
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Proc Natl Acad Sci U S A 106:8350-5. 2009
  7. pmc Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16
    Vitali Matyash
    Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
    PLoS Biol 2:e280. 2004
  8. ncbi request reprint Polyene-lipids: a new tool to image lipids
    Lars Kuerschner
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Nat Methods 2:39-45. 2005
  9. ncbi request reprint StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein
    Monilola A Olayioye
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Victoria 3050, Australia
    J Biol Chem 280:27436-42. 2005

Collaborators

  • Suzanne Eaton
  • Thomas Pomorski
  • Lars Kuerschner
  • Christine Moessinger
  • Johanna Spandl
  • Andrej Shevchenko
  • Kanako Saito
  • Michaela Wilsch-Bräuninger
  • Monilola A Olayioye
  • Daniela Panàkovà
  • Vitali Matyash
  • Veronique Dubreuil
  • Klaus Armin Nave
  • Gesine Saher
  • Yoko Arai
  • Jan Peychl
  • Georg Breier
  • Wieland B Huttner
  • Takaki Miyata
  • Daniel J White
  • Dominik Schwudke
  • Geoffrey J Lindeman
  • Stefanie Vehring
  • Christer S Ejsing
  • Andreas Herrmann
  • Jane E Visvader
  • Kurt I Anderson
  • Eric Marois
  • Peter Muller
  • Kim Ekroos
  • Jurgen Schiller
  • Hein Sprong
  • Arndt W Schmidt
  • Hans Joachim Knölker
  • Fanny Mende
  • Eugeni V Entchev
  • Teymuras V Kurzchalia
  • Samuel Ward

Detail Information

Publications9

  1. doi request reprint Cell biology of lipid droplets
    Christoph Thiele
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, D 01307 Dresden, Germany
    Curr Opin Cell Biol 20:378-85. 2008
    ....
  2. pmc Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine
    Christine Moessinger
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    J Biol Chem 286:21330-9. 2011
    ..This suggests that LPCAT1 and -2 have, in addition to their known function in specialized cells, a ubiquitous role in LD-associated lipid metabolism...
  3. doi request reprint Live cell multicolor imaging of lipid droplets with a new dye, LD540
    Johanna Spandl
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Traffic 10:1579-84. 2009
    ..Its improved specificity, brightness and photostability support live cell imaging, which was used to demonstrate by two-color imaging lipid droplet motility along microtubules...
  4. ncbi request reprint Lipoprotein particles are required for Hedgehog and Wingless signalling
    Daniela Panàkovà
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Nature 435:58-65. 2005
    ..Similarly, the range of Wingless signalling is narrowed. We propose a novel function for lipoprotein particles, in which they act as vehicles for the movement of lipid-linked morphogens and glycophosphatidylinositol-linked proteins...
  5. ncbi request reprint Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets
    Lars Kuerschner
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, D 01307 Dresden, Germany
    Traffic 9:338-52. 2008
    ..In vitro assays on purified lipid droplets show that this fraction of the biosynthetic TG is directly inserted into the growing droplet...
  6. pmc Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis
    Kanako Saito
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Proc Natl Acad Sci U S A 106:8350-5. 2009
    ..Moreover, our data reveal a hitherto unknown compensatory process by which the neural stem and progenitor cells of the developing mammalian brain evade the detrimental consequences of impaired endogenous cholesterol biosynthesis...
  7. pmc Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16
    Vitali Matyash
    Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
    PLoS Biol 2:e280. 2004
    ..This hormonal control of DAF-16 activation is, however, independent of insulin signalling and has no influence on life span...
  8. ncbi request reprint Polyene-lipids: a new tool to image lipids
    Lars Kuerschner
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Nat Methods 2:39-45. 2005
    ..Applying two-photon excitation microscopy, we imaged the distribution of polyene-lipids in living mammalian cells. For the first time, ether lipids, important for the function of the brain, were successfully visualized...
  9. ncbi request reprint StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein
    Monilola A Olayioye
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Victoria 3050, Australia
    J Biol Chem 280:27436-42. 2005
    ..Interestingly, these lipid binding and transfer specificities distinguish StarD10 from the related START domain proteins Pctp and CERT, suggesting a distinct biological function...