Marily Theodoropoulou

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. doi request reprint Decoding the genetic basis of Cushing's disease: USP8 in the spotlight
    Marily Theodoropoulou
    Department of EndocrinologyMax Planck Institute of Psychiatry, Kraepelinstrasse 10, Munich 80804, GermanyMedizinische Klinik und Poliklinik IVLudwig Maximilians Universität München, Munich, GermanyEndocrine and Diabetes UnitDepartment of Medicine I, University Hospital, University of Wurzburg, Wurzburg, GermanyDepartment of Biological SciencesTokyo Institute of Technology, 4259 B16 Nagatsuta, Midori, Yokohama 226 8501, Japan
    Eur J Endocrinol 173:M73-83. 2015
  2. doi request reprint Somatostatin receptors: from signaling to clinical practice
    Marily Theodoropoulou
    Department of Endocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    Front Neuroendocrinol 34:228-52. 2013
  3. ncbi request reprint Differential expression of menin in sporadic pituitary adenomas
    M Theodoropoulou
    Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany
    Endocr Relat Cancer 11:333-44. 2004
  4. doi request reprint ZAC1 target genes and pituitary tumorigenesis
    Marily Theodoropoulou
    Max Planck Institute of Psychiatry, Department of Endocrinology, Kraepelinstrasse 10, 80804 Munich, Germany
    Mol Cell Endocrinol 326:60-5. 2010
  5. doi request reprint Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly
    Marily Theodoropoulou
    Department of Endocrinology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Int J Cancer 125:2122-6. 2009
  6. ncbi request reprint Expression of epidermal growth factor receptor in neoplastic pituitary cells: evidence for a role in corticotropinoma cells
    M Theodoropoulou
    Neuroendocrinology Group, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Endocrinol 183:385-94. 2004
  7. ncbi request reprint Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression
    Marily Theodoropoulou
    Department of Endocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    Cancer Res 66:1576-82. 2006
  8. doi request reprint The somatostatin analogue octreotide confers sensitivity to rapamycin treatment on pituitary tumor cells
    Vesna Cerovac
    Department of Endocrinology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Cancer Res 70:666-74. 2010
  9. ncbi request reprint Expression and function of sonic hedgehog pathway components in pituitary adenomas: evidence for a direct role in hormone secretion and cell proliferation
    Greisa Vila
    Department of Endocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Endocrinol Metab 90:6687-94. 2005
  10. doi request reprint Interferon-gamma inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway
    Marta Labeur
    Department of Neuroendocrinology, Department of Molecular Neurogenetics Department of Inflammatory Disorders of the CNS at the Max Planck Institute of Psychiatry, Munich 80804, Germany
    J Endocrinol 199:177-89. 2008

Collaborators

Detail Information

Publications18

  1. doi request reprint Decoding the genetic basis of Cushing's disease: USP8 in the spotlight
    Marily Theodoropoulou
    Department of EndocrinologyMax Planck Institute of Psychiatry, Kraepelinstrasse 10, Munich 80804, GermanyMedizinische Klinik und Poliklinik IVLudwig Maximilians Universität München, Munich, GermanyEndocrine and Diabetes UnitDepartment of Medicine I, University Hospital, University of Wurzburg, Wurzburg, GermanyDepartment of Biological SciencesTokyo Institute of Technology, 4259 B16 Nagatsuta, Midori, Yokohama 226 8501, Japan
    Eur J Endocrinol 173:M73-83. 2015
    ..This review presents new developments in the study of the genetics of CD and focuses on the USP8-EGFR system as trigger and target of corticotroph tumorigenesis. ..
  2. doi request reprint Somatostatin receptors: from signaling to clinical practice
    Marily Theodoropoulou
    Department of Endocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    Front Neuroendocrinol 34:228-52. 2013
    ..The ability of SSTR to internalize and the development of rabiolabeled somatostatin analogs have improved the diagnosis and treatment of neuroendocrine tumors. ..
  3. ncbi request reprint Differential expression of menin in sporadic pituitary adenomas
    M Theodoropoulou
    Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany
    Endocr Relat Cancer 11:333-44. 2004
    ..Altogether, our data provide the first information regarding the status of menin expression in human normal and neoplastic pituitary as determined by immunohistochemistry (IHC)...
  4. doi request reprint ZAC1 target genes and pituitary tumorigenesis
    Marily Theodoropoulou
    Max Planck Institute of Psychiatry, Department of Endocrinology, Kraepelinstrasse 10, 80804 Munich, Germany
    Mol Cell Endocrinol 326:60-5. 2010
    ..In fact Zac1 is an essential mediator of the antiproliferative effects of this treatment and correlates to successful outcome in acromegalic patients...
  5. doi request reprint Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly
    Marily Theodoropoulou
    Department of Endocrinology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Int J Cancer 125:2122-6. 2009
    ..These in vivo data combined with the antiproliferative properties of ZAC1/Zac1 provide evidence of a mechanistic role for this transcription factor on SSA induced tumor shrinkage and hormone normalization...
  6. ncbi request reprint Expression of epidermal growth factor receptor in neoplastic pituitary cells: evidence for a role in corticotropinoma cells
    M Theodoropoulou
    Neuroendocrinology Group, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Endocrinol 183:385-94. 2004
    ..On the other hand, somatotropinomas expressing EGFr had high p27/Kip1 immunoreactivity. These data suggest a corticotrope-specific phenomenon and indicate that EGFr may have a role in the unbalanced growth of corticotrope tumoral cells...
  7. ncbi request reprint Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression
    Marily Theodoropoulou
    Department of Endocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    Cancer Res 66:1576-82. 2006
    ..Therefore, in pituitary tumor cells, somatostatin analogues produce their antiproliferative action by acting on the PI3K/Akt signaling pathway and increasing Zac1 gene expression...
  8. doi request reprint The somatostatin analogue octreotide confers sensitivity to rapamycin treatment on pituitary tumor cells
    Vesna Cerovac
    Department of Endocrinology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Cancer Res 70:666-74. 2010
    ..These findings show that adjuvant treatment with a somatostatin analogue can sensitize pituitary tumor cells to the antiproliferative effects of rapamycin...
  9. ncbi request reprint Expression and function of sonic hedgehog pathway components in pituitary adenomas: evidence for a direct role in hormone secretion and cell proliferation
    Greisa Vila
    Department of Endocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Endocrinol Metab 90:6687-94. 2005
    ..Because developmental pathways are involved in pituitary tumorigenesis, we hypothesized that Shh may be important in pituitary tumors...
  10. doi request reprint Interferon-gamma inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway
    Marta Labeur
    Department of Neuroendocrinology, Department of Molecular Neurogenetics Department of Inflammatory Disorders of the CNS at the Max Planck Institute of Psychiatry, Munich 80804, Germany
    J Endocrinol 199:177-89. 2008
    ..In conclusion, our data show for the first time that POMC transcription can be negatively regulated by a JAK-STAT1 and NF-kappaB-dependent pathway...
  11. ncbi request reprint Localization of vascular endothelial growth factor (VEGF) receptors in normal and adenomatous pituitaries: detection of a non-endothelial function of VEGF in pituitary tumours
    Chiara Onofri
    Max Planck Institute of Psychiatry, Neuroendocrinology Group, Kraepelinstr 10, D 80804 Munich, Germany
    J Endocrinol 191:249-61. 2006
    ....
  12. doi request reprint Toll-like receptor-4 is expressed in meningiomas and mediates the antiproliferative action of paclitaxel
    Maria A Tichomirowa
    Department of Endocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    Int J Cancer 123:1956-63. 2008
    ..In conclusion, our in vitro results suggest that paclitaxel alone or in combination with other inhibitors of cell growth (statins, MAPK inhibitors) could provide a potential tool for the treatment of TLR4 expressing meningiomas...
  13. doi request reprint NOD2 receptors in adenopituitary folliculostellate cells: expression and function
    Eliane Correa-de-Santana
    Department of Endocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Endocrinol 203:111-22. 2009
    ..In conclusion, the present study demonstrates that NOD molecules play a modulatory role in the pituitary by regulating the function and activation of FS cells in response to bacterial components...
  14. doi request reprint Sirt1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis
    Jose Monteserin-Garcia
    Department of Endocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    FASEB J 27:1561-71. 2013
    ..In summary, this is a novel mechanism through which Sirt1 intercepts the cAMP pathway by suppressing CREB transcriptional activation, resulting in decreased GH synthesis...
  15. ncbi request reprint Sonic hedgehog regulates CRH signal transduction in the adult pituitary
    Greisa Vila
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, Munich 80804, Germany
    FASEB J 19:281-3. 2005
    ..Taken together, our results demonstrate a new role for Shh and Gli1 in corticotroph function and provide a new link between Shh and CRH signaling pathways...
  16. pmc RSUME is implicated in tumorigenesis and metastasis of pancreatic neuroendocrine tumors
    Yonghe Wu
    Department of Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    Oncotarget . 2016
    ..In sum, RSUME differentially regulates key components of PanNET formation suggesting that the observed loss of RSUME in advanced PanNETs is critically involved in PanNET tumorigenesis, particularly in metastasis formation...
  17. pmc The Gene of the Ubiquitin-Specific Protease 8 Is Frequently Mutated in Adenomas Causing Cushing's Disease
    Luís G Pérez-Rivas
    Medizinische Klinik und Poliklinik IV L G P R, C N, C M B, F B, M R, Ludwig Maximilians Universitat Munchen, 80336 Munich, Germany Department of Endocrinology M The, C D, G S, Max Planck Institute of Psychiatry, 80804 Munich, Germany Centre for Endocrinology F F, M Kor, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ London, United Kingdom Department of Biological Sciences K K, A I A, M Kom, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori 226 8501 Yokohama, Japan Section on Endocrinology and Genetics C A S, F R F, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2425 Division of Endocrinology L E W, M R G, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 21941 913 Rio de Janeiro, Brazil Inserm Unité 1016 G A, Japan
    J Clin Endocrinol Metab 100:E997-1004. 2015
    ..We have recently reported somatic mutations in the ubiquitin-specific protease USP8 gene in a small series of adenomas of patients with Cushing's disease...
  18. doi request reprint Mutations in the deubiquitinase gene USP8 cause Cushing's disease
    Martin Reincke
    Medizinische Klinik und Poliklinik IV, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Nat Genet 47:31-8. 2015
    ..USP8 mutants enhanced promoter activity of the gene encoding proopiomelanocortin. In summary, our data show that dominant mutations in USP8 cause Cushing's disease via activation of EGF receptor signaling. ..