Elly M Tanaka

Summary

Affiliation: Max Planck Institute of Molecular Cell Biology and Genetics
Country: Germany

Publications

  1. ncbi request reprint Mechanisms of muscle dedifferentiation during regeneration
    Karen Echeverri
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, D 01307, Dresden, Germany
    Semin Cell Dev Biol 13:353-60. 2002
  2. ncbi request reprint A germline GFP transgenic axolotl and its use to track cell fate: dual origin of the fin mesenchyme during development and the fate of blood cells during regeneration
    Lidia Sobkow
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Dev Biol 290:386-97. 2006
  3. pmc From biomedicine to natural history research: EST resources for ambystomatid salamanders
    Srikrishna Putta
    Department of Biology, University of Kentucky, Lexington, KY 40506, USA
    BMC Genomics 5:54. 2004
  4. doi request reprint Triggering the regeneration and tissue repair programs
    Elly Tanaka
    Center for Regenerative Therapies in Dresden, Dresden, Germany
    Development 136:349-53. 2009
  5. ncbi request reprint Regeneration: if they can do it, why can't we?
    Elly M Tanaka
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Cell 113:559-62. 2003
  6. ncbi request reprint Cell differentiation and cell fate during urodele tail and limb regeneration
    Elly M Tanaka
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden 01307, Germany
    Curr Opin Genet Dev 13:497-501. 2003
  7. doi request reprint Connective tissue cells, but not muscle cells, are involved in establishing the proximo-distal outcome of limb regeneration in the axolotl
    Eugen Nacu
    Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany
    Development 140:513-8. 2013
  8. ncbi request reprint A clonal analysis of neural progenitors during axolotl spinal cord regeneration reveals evidence for both spatially restricted and multipotent progenitors
    Levan Mchedlishvili
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Development 134:2083-93. 2007
  9. doi request reprint Cells keep a memory of their tissue origin during axolotl limb regeneration
    Martin Kragl
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108
    Nature 460:60-5. 2009
  10. doi request reprint Muscle and connective tissue progenitor populations show distinct Twist1 and Twist3 expression profiles during axolotl limb regeneration
    Martin Kragl
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Dev Biol 373:196-204. 2013

Collaborators

  • Nadia Mercader
  • Karen Echeverri
  • Eugen Nacu
  • Bianca Habermann
  • Michael Brand
  • Denis Corbeil
  • Thomas Kurth
  • Malcolm Maden
  • Richard H W Funk
  • Peter W Reddien
  • Kiyokazu Agata
  • Tetsutaro Hayashi
  • Brigitte Galliot
  • Lidia Sobkow
  • P Ferretti
  • J P Brockes
  • Shahryar Khattak
  • Dunja Knapp
  • Levan Mchedlishvili
  • Martin Kragl
  • Stephanie Protze
  • József Jászai
  • Werner L Straube
  • Akira Tazaki
  • Hans Henning Epperlein
  • Esther Schnapp
  • Yu Zhu
  • Dirk Lindemann
  • Kathleen Roensch
  • Vladimir Mazurov
  • Sylvi Graupner
  • Prayag Murawala
  • Wieland B Huttner
  • Sara Lööf
  • Srikrishna Putta
  • Tina Jacob
  • Madalena Carido
  • Ina Nüsslein
  • Mike O Karl
  • Sergey Novozhilov
  • Yuka Taniguchi
  • Andrea Meinhardt
  • Cynthia Alexander Rascon
  • Marius Ader
  • Tatiana Sandoval-Guzmán
  • Herbert Schulz
  • Juliane Scholz
  • Michael Volkmer
  • Nicole Stanke
  • Mu Le
  • Norbert Hubner
  • Hiroshi Tarui
  • Claire Poulet
  • Kathrin S Grassme
  • Bernhard Robl
  • Joshua D Currie
  • Ursula Ravens
  • Annett Duemmler
  • Yegor B Malashichev
  • Kerstin Goehler
  • Christine A Fargeas
  • Tobias Richter
  • David Drechsel
  • Anja Telzerow
  • Andras Simon
  • Hans H Epperlein
  • Elly M Tamaka
  • Lee Rubin
  • David M Gardiner
  • James Monaghan
  • Amy K Samuels
  • David W Weisrock
  • S Randal Voss
  • Jeramiah J Smith
  • Kevin Kump
  • Susan V Bryant
  • John A Walker
  • Mathieu Rondet
  • David M Parichy
  • David N Drechsel
  • David C King
  • Nicholas J Maness

Detail Information

Publications37

  1. ncbi request reprint Mechanisms of muscle dedifferentiation during regeneration
    Karen Echeverri
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, D 01307, Dresden, Germany
    Semin Cell Dev Biol 13:353-60. 2002
    ..As more and more is known about regeneration and dedifferentiation we can begin to address the question: if given the right signals could mammals also regenerate body structures?..
  2. ncbi request reprint A germline GFP transgenic axolotl and its use to track cell fate: dual origin of the fin mesenchyme during development and the fate of blood cells during regeneration
    Lidia Sobkow
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Dev Biol 290:386-97. 2006
    ..During tail regeneration, we do not observe GFP+ cells contributing to muscle or nerve, suggesting that during tail regeneration blood stem cells do not undergo significant plasticity...
  3. pmc From biomedicine to natural history research: EST resources for ambystomatid salamanders
    Srikrishna Putta
    Department of Biology, University of Kentucky, Lexington, KY 40506, USA
    BMC Genomics 5:54. 2004
    ..We developed ESTs for Mexican axolotl (Ambystoma mexicanum) and Eastern tiger salamander (A. tigrinum tigrinum), species with deep and diverse research histories...
  4. doi request reprint Triggering the regeneration and tissue repair programs
    Elly Tanaka
    Center for Regenerative Therapies in Dresden, Dresden, Germany
    Development 136:349-53. 2009
    ..The meeting also highlighted the progress made in identifying the molecular networks that underlie regeneration in a variety of model systems...
  5. ncbi request reprint Regeneration: if they can do it, why can't we?
    Elly M Tanaka
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Cell 113:559-62. 2003
    ..This longstanding problem is undergoing a renaissance spurred by the availability of new techniques that finally allow analysis on the cellular and molecular level...
  6. ncbi request reprint Cell differentiation and cell fate during urodele tail and limb regeneration
    Elly M Tanaka
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden 01307, Germany
    Curr Opin Genet Dev 13:497-501. 2003
    ....
  7. doi request reprint Connective tissue cells, but not muscle cells, are involved in establishing the proximo-distal outcome of limb regeneration in the axolotl
    Eugen Nacu
    Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany
    Development 140:513-8. 2013
    ..Moreover, we show that, similarly to limb development, muscle patterning in regeneration is influenced by β-catenin signalling...
  8. ncbi request reprint A clonal analysis of neural progenitors during axolotl spinal cord regeneration reveals evidence for both spatially restricted and multipotent progenitors
    Levan Mchedlishvili
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Development 134:2083-93. 2007
    ..These results suggest that neural progenitor identity is destabilized or altered in the terminal vesicle region, from which clear migration of cells into the surrounding blastema is also observed...
  9. doi request reprint Cells keep a memory of their tissue origin during axolotl limb regeneration
    Martin Kragl
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108
    Nature 460:60-5. 2009
    ..Our results show that the complex phenomenon of limb regeneration can be achieved without complete dedifferentiation to a pluripotent state, a conclusion with important implications for regenerative medicine...
  10. doi request reprint Muscle and connective tissue progenitor populations show distinct Twist1 and Twist3 expression profiles during axolotl limb regeneration
    Martin Kragl
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Dev Biol 373:196-204. 2013
    ..Finally, we show by single cell PCR that the mature axolotl limb harbors a small but significant population of Twist1(+) cells...
  11. pmc Reconstitution of the central and peripheral nervous system during salamander tail regeneration
    Levan Mchedlishvili
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 109:E2258-66. 2012
    ....
  12. ncbi request reprint Hedgehog signaling controls dorsoventral patterning, blastema cell proliferation and cartilage induction during axolotl tail regeneration
    Esther Schnapp
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 132:3243-53. 2005
    ....
  13. doi request reprint Regeneration: the ultimate example of wound healing
    Prayag Murawala
    Technische Universitat Dresden, DFG Center for Regenerative Therapies, Fetscherstrasse 105, Dresden 01307, Germany
    Semin Cell Dev Biol 23:954-62. 2012
    ..By examining our current knowledge of regeneration, we can draw parallels with mammalian wound healing to identify the molecular determinants that produce such differing outcomes...
  14. doi request reprint Regeneration and reprogramming
    Dunja Knapp
    Technical University Dresden, DFG Research Center for Regenerative Therapies, Dresden 01307, Germany
    Curr Opin Genet Dev 22:485-93. 2012
    ..In regenerative vertebrates, heart regeneration, lens regeneration, and retinal regeneration provide good examples of dedifferentiation and transdifferentiation. The molecular factors associated with these phenomena are discussed...
  15. doi request reprint Reconstitution of the central nervous system during salamander tail regeneration from the implanted neurospheres
    Levan Mchedlishvili
    DFG Center for Regenerative Therapies Dresden, Cluster of Excellence, University of Technology Dresden, Dresden, Germany
    Methods Mol Biol 916:197-202. 2012
    ..Here we demonstrate the unique method of the axolotl tail spinal cord regeneration from the implanted neurosphere...
  16. ncbi request reprint Ectoderm to mesoderm lineage switching during axolotl tail regeneration
    Karen Echeverri
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Science 298:1993-6. 2002
    ..Spinal cord cells frequently migrate into surrounding tissue to form regenerating muscle and cartilage. Thus, in axolotls, cells switch lineage during a real example of regeneration...
  17. ncbi request reprint Quantitative evaluation of morpholino-mediated protein knockdown of GFP, MSX1, and PAX7 during tail regeneration in Ambystoma mexicanum
    Esther Schnapp
    Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
    Dev Dyn 232:162-70. 2005
    ..Our studies in in vivo muscle fibers so far have shown no influence of overexpressing or down-regulating MSX1 on the dedifferentiation process...
  18. pmc Neural crest does not contribute to the neck and shoulder in the axolotl (Ambystoma mexicanum)
    Hans Henning Epperlein
    Department of Anatomy, University of Technology Dresden, Dresden, Germany
    PLoS ONE 7:e52244. 2012
    ....
  19. pmc Spatial distribution of prominin-1 (CD133)-positive cells within germinative zones of the vertebrate brain
    József Jászai
    Tissue Engineering Laboratories BIOTEC, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 8:e63457. 2013
    ....
  20. ncbi request reprint Plasticity and reprogramming of differentiated cells in amphibian regeneration: partial purification of a serum factor that triggers cell cycle re-entry in differentiated muscle cells
    Werner L Straube
    Max Planck Institute of Molecular Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Cloning Stem Cells 6:333-44. 2004
    ..The purification and molecular identification of the serum factor represents an important avenue in understanding regenerative ability and dedifferentiation capacity on a molecular basis...
  21. ncbi request reprint Reversibility of the differentiated state: regeneration in amphibians
    Werner L Straube
    Max Planck Institute of Molecular Biology and Genetics, Dresden, Germany
    Artif Organs 30:743-55. 2006
    ..In the case of multinucleated skeletal muscle fibers, cell cycle reentry into S-phase as well as fragmentation into mononucleated progenitors is observed both in vitro and in vivo...
  22. pmc Distinct and conserved prominin-1/CD133-positive retinal cell populations identified across species
    József Jászai
    Tissue Engineering Laboratories BIOTEC, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 6:e17590. 2011
    ....
  23. pmc Comparative transcriptional profiling of the axolotl limb identifies a tripartite regeneration-specific gene program
    Dunja Knapp
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    PLoS ONE 8:e61352. 2013
    ..In summary, we identified a set of genes that are expressed specifically during regeneration and are therefore, likely candidates for the regulation of blastema formation...
  24. doi request reprint Considering the evolution of regeneration in the central nervous system
    Elly M Tanaka
    Center for Regeneration Therapies, University of Technology, Dresden, c o Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Nat Rev Neurosci 10:713-23. 2009
    ..Here we compare CNS regeneration among vertebrates and speculate on how this ability may have emerged or been restricted...
  25. ncbi request reprint Proximodistal patterning during limb regeneration
    Karen Echeverri
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstra, 108 01307 Dresden, Germany
    Dev Biol 279:391-401. 2005
    ....
  26. pmc Foamy virus for efficient gene transfer in regeneration studies
    Shahryar Khattak
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    BMC Dev Biol 13:17. 2013
    ..We therefore sought an efficient integrating virus system that could be used to study limb and tail regeneration in salamanders...
  27. doi request reprint A new approach to transcription factor screening for reprogramming of fibroblasts to cardiomyocyte-like cells
    Stephanie Protze
    Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, 01307 Dresden, Germany
    J Mol Cell Cardiol 53:323-32. 2012
    ..Furthermore, our results point to the importance of verifying multiple lineage specific genes when assessing reprogramming...
  28. pmc An Ambystoma mexicanum EST sequencing project: analysis of 17,352 expressed sequence tags from embryonic and regenerating blastema cDNA libraries
    Bianca Habermann
    Scionics Computer Innovation GmbH, Pfotenhauerstrasse 110, Dresden 01307, Germany
    Genome Biol 5:R67. 2004
    ..This is a major limitation for molecular studies on caudate development, regeneration and evolution. To address this lack of sequence information we have generated an expressed sequence tag (EST) database for A. mexicanum...
  29. ncbi request reprint Axolotl (Ambystoma mexicanum) Embryonic Transplantation Methods
    Eugen Nacu
    Center for Regenerative Therapies, Dresden University of Technology, 01307 Dresden, Germany
    CSH Protoc 2009:pdb.prot5265. 2009
    ....
  30. pmc Three-dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium
    Yu Zhu
    Center for Regenerative Therapies, Technical University Dresden, Dresden, Germany
    PLoS ONE 8:e54552. 2013
    ....
  31. pmc Micromanaging regeneration
    Elly M Tanaka
    Center for Regenerative Therapies, 01307 Dresden, Germany
    Genes Dev 22:700-5. 2008
  32. pmc The cellular basis for animal regeneration
    Elly M Tanaka
    Technical University of Dresden, DFG Center for Regenerative Therapies Dresden, c o Max Planck Institute of Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden, Germany
    Dev Cell 21:172-85. 2011
    ..Together, an array of cellular strategies-from pluripotent stem cells to tissue-specific stem cells and dedifferentiation-are utilized for regeneration...
  33. ncbi request reprint Generation of Transgenic Axolotls (Ambystoma mexicanum)
    Shahryar Khattak
    Center for Regenerative Therapies, Dresden University of Technology, 01307 Dresden, Germany
    CSH Protoc 2009:pdb.prot5264. 2009
    ..The integration efficiency is significantly increased if the plasmid DNA contains SceI meganuclease sites and is coinjected with SceI meganuclease, as described in this protocol...
  34. ncbi request reprint Axolotl (Ambystoma mexicanum) In Vitro Fertilization
    Shahryar Khattak
    Center for Regenerative Therapies, Dresden University of Technology, 01307 Dresden, Germany
    CSH Protoc 2009:pdb.prot5263. 2009
    ..This protocol describes preparation of a sperm suspension and in vitro fertilization of axolotl eggs after injection of females with follicle stimulating hormone (FSH)...
  35. ncbi request reprint Proximodistal identity during vertebrate limb regeneration is regulated by Meis homeodomain proteins
    Nadia Mercader
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Campus de Cantoblanco, E 28049 Madrid, Spain
    Development 132:4131-42. 2005
    ..Meis genes are thus crucial targets of RA proximalizing activity on blastema cells...
  36. ncbi request reprint Plasticity of mammalian myotubes upon stimulation with a thrombin-activated serum factor
    Sara Lööf
    Karolinska Institute, Department of Cell and Molecular Biology, Stockholm, Sweden
    Cell Cycle 6:1096-101. 2007
    ..Our results indicate that mammalian myotubes have retained responsiveness to the thrombin-activated serum factor, but full reentry into S-phase is prevented by factors downstream of the immediate early genes...
  37. ncbi request reprint Heads or tails: can Wnt tell which one is up?
    Elly M Tanaka
    Nat Cell Biol 10:122-4. 2008