Mark Stitt

Summary

Affiliation: Max Planck Institute of Molecular Plant Physiology
Country: Germany

Publications

  1. pmc Variation of enzyme activities and metabolite levels in 24 Arabidopsis accessions growing in carbon-limited conditions
    Joanna M Cross
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Plant Physiol 142:1574-88. 2006
  2. ncbi request reprint Why measure enzyme activities in the era of systems biology?
    Mark Stitt
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam Golm, Germany Electronic address
    Trends Plant Sci 19:256-65. 2014
  3. pmc Ribosome and transcript copy numbers, polysome occupancy and enzyme dynamics in Arabidopsis
    Maria Piques
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, Potsdam Golm, Germany
    Mol Syst Biol 5:314. 2009
  4. pmc A fluorometric assay for trehalose in the picomole range
    Petronia Carillo
    Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, I 81100, Caserta, Italy
    Plant Methods 9:21. 2013
  5. doi request reprint Systems-integration of plant metabolism: means, motive and opportunity
    Mark Stitt
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam Golm, Germany
    Curr Opin Plant Biol 16:381-8. 2013
  6. doi request reprint Progress in understanding and engineering primary plant metabolism
    Mark Stitt
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14474 Potsdam Golm, Germany
    Curr Opin Biotechnol 24:229-38. 2013
  7. doi request reprint Starch turnover: pathways, regulation and role in growth
    Mark Stitt
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, Potsdam Golm, Germany
    Curr Opin Plant Biol 15:282-92. 2012
  8. pmc Integrative analyses of genetic variation in enzyme activities of primary carbohydrate metabolism reveal distinct modes of regulation in Arabidopsis thaliana
    Joost J B Keurentjes
    Laboratory of Genetics, Wageningen University, Arboretumlaan, NL 6703 BD Wageningen, The Netherlands
    Genome Biol 9:R129. 2008
  9. pmc Determining novel functions of Arabidopsis 14-3-3 proteins in central metabolic processes
    Céline Diaz
    RIKEN Plant Science Center, Yokohama, Kanagawa 230 0045, Japan
    BMC Syst Biol 5:192. 2011
  10. pmc Gene expression profiling in susceptible interaction of grapevine with its fungal pathogen Eutypa lata: extending MapMan ontology for grapevine
    Ana Rotter
    National Institute of Biology, Department of Biotechnology and Systems Biology, Vecna pot 111, 1000 Ljubljana, Slovenia
    BMC Plant Biol 9:104. 2009

Detail Information

Publications86

  1. pmc Variation of enzyme activities and metabolite levels in 24 Arabidopsis accessions growing in carbon-limited conditions
    Joanna M Cross
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Plant Physiol 142:1574-88. 2006
    ..We propose that growth is not related to the absolute levels of starch, sugars, and amino acids; instead, it is related to flux, which is indicated by the enzymatic capacity to use these central resources...
  2. ncbi request reprint Why measure enzyme activities in the era of systems biology?
    Mark Stitt
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam Golm, Germany Electronic address
    Trends Plant Sci 19:256-65. 2014
    ..We also discuss how robotized assays could enable the genetic networks that control enzyme abundance to be analyzed. ..
  3. pmc Ribosome and transcript copy numbers, polysome occupancy and enzyme dynamics in Arabidopsis
    Maria Piques
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, Potsdam Golm, Germany
    Mol Syst Biol 5:314. 2009
    ..Global translation rates are used to estimate the energy costs of protein synthesis and relate them to the plant carbon budget, in particular the rates of starch degradation and respiration at night...
  4. pmc A fluorometric assay for trehalose in the picomole range
    Petronia Carillo
    Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, I 81100, Caserta, Italy
    Plant Methods 9:21. 2013
    ....
  5. doi request reprint Systems-integration of plant metabolism: means, motive and opportunity
    Mark Stitt
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam Golm, Germany
    Curr Opin Plant Biol 16:381-8. 2013
    ....
  6. doi request reprint Progress in understanding and engineering primary plant metabolism
    Mark Stitt
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14474 Potsdam Golm, Germany
    Curr Opin Biotechnol 24:229-38. 2013
    ....
  7. doi request reprint Starch turnover: pathways, regulation and role in growth
    Mark Stitt
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, Potsdam Golm, Germany
    Curr Opin Plant Biol 15:282-92. 2012
    ..This review considers to what extent information gained in this weed species maybe applicable to annual crops and perennial species...
  8. pmc Integrative analyses of genetic variation in enzyme activities of primary carbohydrate metabolism reveal distinct modes of regulation in Arabidopsis thaliana
    Joost J B Keurentjes
    Laboratory of Genetics, Wageningen University, Arboretumlaan, NL 6703 BD Wageningen, The Netherlands
    Genome Biol 9:R129. 2008
    ..Quantitative analyses of each trait were performed in the Arabidopsis thaliana Ler x Cvi recombinant inbred line (RIL) population and subjected to correlation and quantitative trait locus (QTL) analysis...
  9. pmc Determining novel functions of Arabidopsis 14-3-3 proteins in central metabolic processes
    Céline Diaz
    RIKEN Plant Science Center, Yokohama, Kanagawa 230 0045, Japan
    BMC Syst Biol 5:192. 2011
    ..In plants, 14-3-3 proteins have major roles as regulators of nitrogen and carbon metabolism, conclusions based on the studies of a few specific 14-3-3 targets...
  10. pmc Gene expression profiling in susceptible interaction of grapevine with its fungal pathogen Eutypa lata: extending MapMan ontology for grapevine
    Ana Rotter
    National Institute of Biology, Department of Biotechnology and Systems Biology, Vecna pot 111, 1000 Ljubljana, Slovenia
    BMC Plant Biol 9:104. 2009
    ..Two microarray platforms were designed based on the TIGR Gene Index database and used in several physiological studies...
  11. ncbi request reprint Steps towards an integrated view of nitrogen metabolism
    Mark Stitt
    Max Planck Institute for Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    J Exp Bot 53:959-70. 2002
    ..Consequently, wild-type plants growing in unfavourable light regimes and antisense RBCS transformants are simultaneously carbon- and nitrogen-limited...
  12. pmc Imaging of metabolites by using a fusion protein between a periplasmic binding protein and GFP derivatives: from a chimera to a view of reality
    Mark Stitt
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Proc Natl Acad Sci U S A 99:9614-6. 2002
  13. ncbi request reprint A plant for all seasons: alterations in photosynthetic carbon metabolism during cold acclimation in Arabidopsis
    Mark Stitt
    Max Planck Institute for Molecular Plant Physiology, 1, 14476 Golm, Am Muhlenberg, Germany
    Curr Opin Plant Biol 5:199-206. 2002
    ..Recent progress has been made in understanding both the signals that trigger these processes and how the regulation of photosynthetic carbon metabolism interacts with other processes during cold acclimation...
  14. ncbi request reprint Temporal responses of transcripts, enzyme activities and metabolites after adding sucrose to carbon-deprived Arabidopsis seedlings
    Daniel Osuna
    Max Planck Institute for Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Plant J 49:463-91. 2007
    ..After 3-8 h, there is a decrease of amino acids, followed by a gradual increase of protein...
  15. ncbi request reprint Multilevel genomic analysis of the response of transcripts, enzyme activities and metabolites in Arabidopsis rosettes to a progressive decrease of temperature in the non-freezing range
    Bjorn Usadel
    Max Planck Institute for Molecular Plant Physiology, Am Muhlenberg 1, 14476, Golm, Germany
    Plant Cell Environ 31:518-47. 2008
    ..The general increase of enzyme activities and metabolites emphasized the positive and compensatory nature of this response...
  16. doi request reprint Mutagenesis of cysteine 81 prevents dimerization of the APS1 subunit of ADP-glucose pyrophosphorylase and alters diurnal starch turnover in Arabidopsis thaliana leaves
    Nadja Hädrich
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Plant J 70:231-42. 2012
    ....
  17. pmc Mild reductions in cytosolic NADP-dependent isocitrate dehydrogenase activity result in lower amino acid contents and pigmentation without impacting growth
    Ronan Sulpice
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Potsdam Golm, Germany
    Amino Acids 39:1055-66. 2010
    ..These data are discussed within the context of current models for the role of the various isoforms of isocitrate dehydrogenase within plant amino acid metabolism...
  18. pmc Feedback inhibition of starch degradation in Arabidopsis leaves mediated by trehalose 6-phosphate
    Marina Camara Mattos Martins
    Max Planck Institute of Molecular Plant Physiology, Wissenschaftspark Golm, 14476 Potsdam Golm, Germany
    Plant Physiol 163:1142-63. 2013
    ..It is proposed that Tre6P is a component in a signaling pathway that mediates the feedback regulation of starch breakdown by sucrose, potentially linking starch turnover to demand for sucrose by growing sink organs at night. ..
  19. pmc Metabolism and growth in Arabidopsis depend on the daytime temperature but are temperature-compensated against cool nights
    Eva Theresa Pyl
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Plant Cell 24:2443-69. 2012
    ..As examples, the rate of starch degradation is completely temperature compensated against even sudden changes in temperature, and polysome loading increases when the night temperature is decreased...
  20. pmc Genome-wide reprogramming of primary and secondary metabolism, protein synthesis, cellular growth processes, and the regulatory infrastructure of Arabidopsis in response to nitrogen
    Wolf Rüdiger Scheible
    Max Planck Institute for Molecular Plant Physiology, 14476 Golm, Germany
    Plant Physiol 136:2483-99. 2004
    ....
  21. pmc Impact of the carbon and nitrogen supply on relationships and connectivity between metabolism and biomass in a broad panel of Arabidopsis accessions
    Ronan Sulpice
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam, Germany
    Plant Physiol 162:347-63. 2013
    ..Thus, robust prediction of biomass across a range of conditions requires condition-specific measurement of metabolic traits to take account of environment-dependent changes of the underlying networks...
  22. pmc Genome-wide identification and testing of superior reference genes for transcript normalization in Arabidopsis
    Tomasz Czechowski
    Max Planck Institute of Molecular Plant Physiology, Potsdam, Germany
    Plant Physiol 139:5-17. 2005
    ..The developed PCR primers or hybridization probes for the novel reference genes will enable better normalization and quantification of transcript levels in Arabidopsis in the future...
  23. pmc A Robot-based platform to measure multiple enzyme activities in Arabidopsis using a set of cycling assays: comparison of changes of enzyme activities and transcript levels during diurnal cycles and in prolonged darkness
    Yves Gibon
    Max Planck Institute of Molecular Plant Physiology, Science Park Golm, 14476 Golm Potsdam, Germany
    Plant Cell 16:3304-25. 2004
    ....
  24. ncbi request reprint Arabidopsis coordinates the diurnal regulation of carbon allocation and growth across a wide range of photoperiods
    Ronan Sulpice
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam Golm, Germany
    Mol Plant 7:137-55. 2014
    ....
  25. pmc Diurnal changes of polysome loading track sucrose content in the rosette of wild-type arabidopsis and the starchless pgm mutant
    Sunil Kumar Pal
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Plant Physiol 162:1246-65. 2013
    ..Costs are also reduced by using amino acids that accumulated in the previous light period. These results uncover a tight coordination of protein synthesis with the momentary supply of carbon. ..
  26. doi request reprint Regulation of flowering by trehalose-6-phosphate signaling in Arabidopsis thaliana
    Vanessa Wahl
    Department of Metabolic Networks, Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam, Germany
    Science 339:704-7. 2013
    ..We show that the T6P pathway affects flowering both in the leaves and at the shoot meristem, and integrate TPS1 into the existing genetic framework of flowering-time control...
  27. pmc Sugars and circadian regulation make major contributions to the global regulation of diurnal gene expression in Arabidopsis
    Oliver E Bläsing
    Max Planck Institute of Molecular Plant Physiology, Potsdam Golm, Germany
    Plant Cell 17:3257-81. 2005
    ..We identified a set of candidate regulatory genes that show robust responses to alterations in sugar levels and change markedly during the diurnal cycle...
  28. ncbi request reprint Large-scale phenotyping of transgenic tobacco plants (Nicotiana tabacum) to identify essential leaf functions
    Wolfgang Lein
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Biotechnol J 6:246-63. 2008
    ....
  29. ncbi request reprint Conversion of MapMan to allow the analysis of transcript data from Solanaceous species: effects of genetic and environmental alterations in energy metabolism in the leaf
    Ewa Urbanczyk-Wochniak
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, Golm, 14476, Germany
    Plant Mol Biol 60:773-92. 2006
    ..Since the Solanaceous MapMan is intended to be a community resource it will be regularly updated on improvements in tomato gene annotation and transcript profiling resources...
  30. pmc Starch as a major integrator in the regulation of plant growth
    Ronan Sulpice
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam Golm, Germany
    Proc Natl Acad Sci U S A 106:10348-53. 2009
    ..The impact of allelic variation at these 2 loci was shown by association mapping, identifying them as candidate lead genes with the potential to increase biomass production...
  31. pmc Integration of metabolite with transcript and enzyme activity profiling during diurnal cycles in Arabidopsis rosettes
    Yves Gibon
    Max Planck Institute of Molecular Plant Physiology, Science Park Golm, Am Muehlenberg, D 14476 Potsdam Golm, Germany
    Genome Biol 7:R76. 2006
    ..This indicates that enzyme activities change slowly, integrating the changes in transcript levels over several diurnal cycles...
  32. ncbi request reprint Regulation of secondary metabolism by the carbon-nitrogen status in tobacco: nitrate inhibits large sectors of phenylpropanoid metabolism
    Christina Fritz
    Department 2, Max Planck Institute for Molecular Plant Physiology, Am Muehlenberg 1, D 14476 Golm, Germany
    Plant J 46:533-48. 2006
    ....
  33. doi request reprint Circadian control of root elongation and C partitioning in Arabidopsis thaliana
    Nima Yazdanbakhsh
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Am Muhlenberg 1, Germany
    Plant Cell Environ 34:877-94. 2011
    ..Thus, while the overall growth rate depends on the carbon supply, the clock orchestrates diurnal carbon allocation and growth...
  34. doi request reprint Adjustment of growth and central metabolism to a mild but sustained nitrogen-limitation in Arabidopsis
    Hendrik Tschoep
    Max Planck Institute of Molecular Plant Physiology, Potsdam Golm, Germany
    Plant Cell Environ 32:300-18. 2009
    ..This metabolic phenotype reveals that Arabidopsis responds adaptively to low N by decreasing the rate of growth, while maintaining the overall protein content, and maintaining or even increasing the levels of many amino acids...
  35. pmc Network analysis of enzyme activities and metabolite levels and their relationship to biomass in a large panel of Arabidopsis accessions
    Ronan Sulpice
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Plant Cell 22:2872-93. 2010
    ..The correlation is additive to that obtained between starch and biomass. Thus, biomass is predicted by two independent integrative metabolic biomarkers: preferential investment in photosynthetic machinery and optimization of carbon use...
  36. ncbi request reprint Adjustment of diurnal starch turnover to short days: depletion of sugar during the night leads to a temporary inhibition of carbohydrate utilization, accumulation of sugars and post-translational activation of ADP-glucose pyrophosphorylase in the followin
    Yves Gibon
    Max Planck Institute of Molecular Plant Physiology, Science Park Golm, Am Muehlenberg 1, 14476 Potsdam Golm, Germany
    Plant J 39:847-62. 2004
    ....
  37. pmc Metabolic fluxes in an illuminated Arabidopsis rosette
    Marek Szecowka
    Central Metabolism Research Group, Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Plant Cell 25:694-714. 2013
    ....
  38. pmc Robin: an intuitive wizard application for R-based expression microarray quality assessment and analysis
    Marc Lohse
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Plant Physiol 153:642-51. 2010
    ....
  39. doi request reprint Use of TILLING and robotised enzyme assays to generate an allelic series of Arabidopsis thaliana mutants with altered ADP-glucose pyrophosphorylase activity
    Nadja Hädrich
    Max Planck Institute of Molecular Plant Physiology, Wissenschaftspark Golm, Am Muhlenberg 1, Potsdam Golm, Germany
    J Plant Physiol 168:1395-405. 2011
    ..These mutants offer some advantages over the available loss-of-function mutants, e.g. adg1, for investigating the effects of subtle changes in the enzyme's activity on the rate of starch synthesis...
  40. pmc ADP-glucose pyrophosphorylase is activated by posttranslational redox-modification in response to light and to sugars in leaves of Arabidopsis and other plant species
    Janneke H M Hendriks
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Physiol 133:838-49. 2003
    ..It complements the well-characterized regulation network that coordinates fluxes of metabolites with the recycling of phosphate during photosynthetic carbon fixation and sucrose synthesis...
  41. ncbi request reprint Description and applications of a rapid and sensitive non-radioactive microplate-based assay for maximum and initial activity of D-ribulose-1,5-bisphosphate carboxylase/oxygenase
    Ronan Sulpice
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, D 14476 Golm, Germany
    Plant Cell Environ 30:1163-75. 2007
    ..Inspection of the genomic regions that span these markers revealed these QTL involved genes not previously implicated in the regulation of Rubisco expression or activity...
  42. ncbi request reprint Adjustment of growth, starch turnover, protein content and central metabolism to a decrease of the carbon supply when Arabidopsis is grown in very short photoperiods
    Yves Gibon
    Max Planck Institute of Molecular Plant Physiology, Golm, Germany
    Plant Cell Environ 32:859-74. 2009
    ..It is discussed how a close coordination of starch turnover, the protein content and growth allows Arabidopsis to avoid carbon starvation, even in very short photoperiods...
  43. pmc Sugar-induced increases in trehalose 6-phosphate are correlated with redox activation of ADPglucose pyrophosphorylase and higher rates of starch synthesis in Arabidopsis thaliana
    John E Lunn
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14424 Potsdam, Germany
    Biochem J 397:139-48. 2006
    ..These results indicate that Tre6P acts as a signalling metabolite of sugar status in plants, and support the proposal that Tre6P mediates sucrose-induced changes in the rate of starch synthesis...
  44. pmc Tomato fruit photosynthesis is seemingly unimportant in primary metabolism and ripening but plays a considerable role in seed development
    Anna Lytovchenko
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Plant Physiol 157:1650-63. 2011
    ....
  45. ncbi request reprint Genome-wide reprogramming of metabolism and regulatory networks of Arabidopsis in response to phosphorus
    Rosa Morcuende
    Max Planck Institute for Molecular Plant Physiology, Science Park Golm, 14476 Potsdam, Germany
    Plant Cell Environ 30:85-112. 2007
    ..The specific responses to Pi differ markedly from those found for nitrate, whereas the long-term responses during P and N deprivation share common and non-specific features...
  46. pmc PageMan: an interactive ontology tool to generate, display, and annotate overview graphs for profiling experiments
    Bjorn Usadel
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam, Germany
    BMC Bioinformatics 7:535. 2006
    ..Currently, most tools focus on a few limited biological aspects, rather than offering a holistic, integrated analysis...
  47. doi request reprint A guide to using MapMan to visualize and compare Omics data in plants: a case study in the crop species, Maize
    Bjorn Usadel
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, Potsdam Golm 14476, Germany
    Plant Cell Environ 32:1211-29. 2009
    ....
  48. pmc Malate plays a crucial role in starch metabolism, ripening, and soluble solid content of tomato fruit and affects postharvest softening
    Danilo C Centeno
    Max Planck Institut fur Molekulare Pflanzenphysiologie, 14476 Potsdam Golm, Germany
    Plant Cell 23:162-84. 2011
    ..The combined data reveal the importance of malate metabolism in tomato fruit metabolism and development and confirm the importance of transitory starch in the determination of agronomic yield in this species...
  49. pmc Identification of enzyme activity quantitative trait loci in a Solanum lycopersicum x Solanum pennellii introgression line population
    Marie Caroline Steinhauser
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Plant Physiol 157:998-1014. 2011
    ..These results point to the genetic control of individual enzyme activities being under the control of a complex program that is dominated by a network of trans-acting genes...
  50. doi request reprint Arabidopsis and primary photosynthetic metabolism - more than the icing on the cake
    Mark Stitt
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, Potsdam Golm, Germany
    Plant J 61:1067-91. 2010
    ....
  51. pmc Extension of the visualization tool MapMan to allow statistical analysis of arrays, display of corresponding genes, and comparison with known responses
    Bjorn Usadel
    Max Planck Institute of Molecular Plant Physiology, 14476 Golm, Germany
    Plant Physiol 138:1195-204. 2005
    ....
  52. doi request reprint Xeml Lab: a tool that supports the design of experiments at a graphical interface and generates computer-readable metadata files, which capture information about genotypes, growth conditions, environmental perturbations and sampling strategy
    Jan Hannemann
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, Golm D 14476, Germany
    Plant Cell Environ 32:1185-200. 2009
    ....
  53. ncbi request reprint MAPMAN: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes
    Oliver Thimm
    Max Planck Institute for Molecular Plant Physiology, Golm, Germany
    Plant J 37:914-39. 2004
    ....
  54. pmc Combined transcript and metabolite profiling of Arabidopsis leaves reveals fundamental effects of the thiol-disulfide status on plant metabolism
    Anna Kolbe
    Max Planck Institute of Molecular Plant Physiology, 14476 Golm Potsdam, Germany
    Plant Physiol 141:412-22. 2006
    ..These results provide a global picture of the effect of redox and reveal the utility of transcript and metabolite profiling as systemic strategies to uncover the occurrence of redox modulation in vivo...
  55. pmc RobiNA: a user-friendly, integrated software solution for RNA-Seq-based transcriptomics
    Marc Lohse
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Nucleic Acids Res 40:W622-7. 2012
    ..In-line help and a step-by-step manual guide users through the analysis. Installer packages for Mac OS X, Windows and Linux are available under the LGPL licence from http://mapman.gabipd.org/web/guest/robin...
  56. pmc Single feature polymorphism (SFP)-based selective sweep identification and association mapping of growth-related metabolic traits in Arabidopsis thaliana
    Liam H Childs
    Max Planck Institute for Molecular Plant Physiology, Am Muhlenberg 1, Potsdam Golm, Germany
    BMC Genomics 11:188. 2010
    ..0 Arrays for the detection of selective sweeps, and identification of associations between sweep regions and growth-related metabolic traits...
  57. ncbi request reprint Impact of the C-N status on the amino acid profile in tobacco source leaves
    Christina Fritz
    Max Planck Institute for Molecular Plant Physiology, Am Muehlenberg 1, 14474 Golm, Germany
    Plant Cell Environ 29:2055-76. 2006
    ..Feeding glutamate, and other downstream amino acids, led to an increase of glutamine, indicating glutamate exerts feedback regulation on ammonium metabolism...
  58. pmc PHO2, microRNA399, and PHR1 define a phosphate-signaling pathway in plants
    Rajendra Bari
    Max Planck Institute for Molecular Plant Physiology, Science Park Golm, 14476 Potsdam, Germany
    Plant Physiol 141:988-99. 2006
    ....
  59. doi request reprint Use of reverse-phase liquid chromatography, linked to tandem mass spectrometry, to profile the Calvin cycle and other metabolic intermediates in Arabidopsis rosettes at different carbon dioxide concentrations
    Stéphanie Arrivault
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg, Germany
    Plant J 59:826-39. 2009
    ..The inhibition of end-product synthesis allows high levels of metabolites to be retained in the Calvin cycle to support a rapid cycle with photorespiration...
  60. doi request reprint Metabolic and signaling aspects underpinning the regulation of plant carbon nitrogen interactions
    Adriano Nunes-Nesi
    Max Planck Institute for Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Mol Plant 3:973-96. 2010
    ....
  61. pmc Starch synthesis in potato tubers is regulated by post-translational redox modification of ADP-glucose pyrophosphorylase: a novel regulatory mechanism linking starch synthesis to the sucrose supply
    Axel Tiessen
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Cell 14:2191-213. 2002
    ..Furthermore, activation of AGPase resulted in a stimulation of starch synthesis and decreased levels of glycolytic intermediates...
  62. pmc Nitrate regulates floral induction in Arabidopsis, acting independently of light, gibberellin and autonomous pathways
    Inmaculada Castro Marín
    Max Planck Institute for Molecular Plant Physiology, Am Muhlenberg 1, 14476, Golm, Germany
    Planta 233:539-52. 2011
    ..We conclude that low nitrate induces flowering via a novel signalling pathway that acts downstream of, but interacts with, the known floral induction pathways...
  63. pmc Enzyme activity profiles during fruit development in tomato cultivars and Solanum pennellii
    Marie Caroline Steinhauser
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Plant Physiol 153:80-98. 2010
    ..We discuss the concept that the metabolite profile is an emergent property that is generated by complex network interactions...
  64. ncbi request reprint Mercator: a fast and simple web server for genome scale functional annotation of plant sequence data
    Marc Lohse
    Max Planck Institute of Molecular Plant Physiology, 14476, Potsdam, Germany
    Plant Cell Environ 37:1250-8. 2014
    ..Mercator is available free of charge via http://mapman.gabipd.org/web/guest/app/Mercator. ..
  65. pmc The sucrose-trehalose 6-phosphate (Tre6P) nexus: specificity and mechanisms of sucrose signalling by Tre6P
    Umesh Prasad Yadav
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    J Exp Bot 65:1051-68. 2014
    ....
  66. doi request reprint Metabolic efficiency underpins performance trade-offs in growth of Arabidopsis thaliana
    Sabrina Kleessen
    Systems Biology and Mathematical Modeling Group, Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, Potsdam Golm D 14476, Germany
    Nat Commun 5:3537. 2014
    ..We illustrate how public domain data can be used to search for additional contending tasks, which may underlie the sub-optimality in some accessions. ..
  67. ncbi request reprint Flux an important, but neglected, component of functional genomics
    Alisdair R Fernie
    Department of Metabolic Networks, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Curr Opin Plant Biol 8:174-82. 2005
    ..We argue the need for, and discuss theoretical and practical aspects of, the determination of metabolic flux as a component of functional genomics...
  68. ncbi request reprint GMD@CSB.DB: the Golm Metabolome Database
    Joachim Kopka
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Bioinformatics 21:1635-8. 2005
    ..AVAILABILITY: http://csbdb.mpimp-golm.mpg.de/gmd.html CONTACT: Steinhauser@mpimp-golm.mpg.de SUPPLEMENTARY INFORMATION: http://csbdb.mpimp-golm.mpg.de/..
  69. doi request reprint Structured patterns in geographic variability of metabolic phenotypes in Arabidopsis thaliana
    Sabrina Kleessen
    Systems Biology and Mathematical Modeling Group, Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Nat Commun 3:1319. 2012
    ..Our approach opens new avenues to investigate relations between geographic origin and heterogeneous molecular phenotypes, like metabolite profiles, which can easily be obtained in species where genome data is not yet available...
  70. ncbi request reprint From measurements of metabolites to metabolomics: an 'on the fly' perspective illustrated by recent studies of carbon-nitrogen interactions
    Mark Stitt
    Departments of Metabolic Networks and Molecular Physiology, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476, Golm, Germany
    Curr Opin Biotechnol 14:136-44. 2003
    ..A major future challenge concerns the integration of the information gained from metabolite profiling into an accessible body of knowledge...
  71. ncbi request reprint Sensitive and high throughput metabolite assays for inorganic pyrophosphate, ADPGlc, nucleotide phosphates, and glycolytic intermediates based on a novel enzymic cycling system
    Yves Gibon
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, D 14476 Golm, Germany
    Plant J 30:221-35. 2002
    ..These techniques are used to investigate changes in overall seed metabolite levels during development and maturation, and in response to a stepwise decrease of the external oxygen concentration...
  72. ncbi request reprint Real-time RT-PCR profiling of over 1400 Arabidopsis transcription factors: unprecedented sensitivity reveals novel root- and shoot-specific genes
    Tomasz Czechowski
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Plant J 38:366-79. 2004
    ..Finally, many of the TF transcripts detected by RT-PCR are not represented in Arabidopsis EST (expressed sequence tag) or Massively Parallel Signature Sequencing (MPSS) databases. These genes can now be annotated as expressed...
  73. pmc Global transcript levels respond to small changes of the carbon status during progressive exhaustion of carbohydrates in Arabidopsis rosettes
    Bjorn Usadel
    Metanomics GmbH, Tegler Weg 33, 10589 Berlin, Germany
    Plant Physiol 146:1834-61. 2008
    ..This is illustrated for AKIN10 and four bZIP transcription factors, and sets of genes involved in trehalose signaling, protein turnover, and starch breakdown...
  74. pmc Metabolite profiling in plant biology: platforms and destinations
    Joachim Kopka
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Genome Biol 5:109. 2004
    ..These techniques will be useful for answering important biological questions in the future...
  75. ncbi request reprint Target-based discovery of novel herbicides
    Wolfgang Lein
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muehlenberg 1, 14476 Golm, Germany
    Curr Opin Plant Biol 7:219-25. 2004
    ..Developments in functional genomics and in pharmaceutical research could aid the development of assay systems for the evaluation of chemicals for their suitability as lead structures in herbicide discovery...
  76. pmc A community resource for high-throughput quantitative RT-PCR analysis of transcription factor gene expression in Medicago truncatula
    Klementina Kakar
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Plant Methods 4:18. 2008
    ..Thus, qRT-PCR is an ideal method to tackle the problem of TF transcript quantification in Medicago and other plants...
  77. ncbi request reprint Pyrimidine and purine biosynthesis and degradation in plants
    Rita Zrenner
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam OT Golm, Germany
    Annu Rev Plant Biol 57:805-36. 2006
    ..Here we review progress in molecular aspects and recent studies on the regulation and manipulation of nucleotide metabolism in plants...
  78. ncbi request reprint The role of raffinose in the cold acclimation response of Arabidopsis thaliana
    Ellen Zuther
    Max Planck Institut fur Molekulare Pflanzenphysiologie, 14424 Potsdam, Germany
    FEBS Lett 576:169-73. 2004
    ..We conclude that raffinose is not essential for basic freezing tolerance or for cold acclimation of A. thaliana...
  79. ncbi request reprint Does elevated atmospheric [CO2] alter diurnal C uptake and the balance of C and N metabolites in growing and fully expanded soybean leaves?
    Elizabeth A Ainsworth
    USDA ARS Photosynthesis Research Unit and Department of Plant Biology, University of Illinois, Urbana, IL 61801, USA
    J Exp Bot 58:579-91. 2007
    ..This work shows that elevated [CO2] alters the balance of carbon and nitrogen pools in both mature and growing soybean leaves, which could have down-stream impacts on growth and productivity...
  80. pmc Barley grain maturation and germination: metabolic pathway and regulatory network commonalities and differences highlighted by new MapMan/PageMan profiling tools
    Nese Sreenivasulu
    Leibniz Institut für Pflanzengenetik und Kulturpflanzenforschung, D 06466 Gatersleben, Germany
    Plant Physiol 146:1738-58. 2008
    ..In summary, new bioinformatics PageMan and MapMan tools developed in barley have been successfully used to investigate in detail the transcriptome relationships between seed maturation and germination in an important crop plant...
  81. ncbi request reprint Decreased Rubisco activity leads to dramatic changes of nitrate metabolism, amino acid metabolism and the levels of phenylpropanoids and nicotine in tobacco antisense RBCS transformants
    Petra Matt
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Golm, Germany
    Plant J 30:663-77. 2002
    ..First, decreased levels of primary metabolites lead to a dramatic decrease in the levels of secondary metabolites. Second, changes of the amino acid : sugar ratio are accompanied by changes of the nicotine:chlorogenic acid ratio...
  82. doi request reprint Reprogramming a maize plant: transcriptional and metabolic changes induced by the fungal biotroph Ustilago maydis
    Gunther Doehlemann
    Max Planck Institute for Terrestrial Microbiology, D 35043 Marburg, Germany
    Plant J 56:181-95. 2008
    ..Our data provide novel insights into the complexity of a biotrophic interaction...
  83. doi request reprint Next generation of elevated [CO2] experiments with crops: a critical investment for feeding the future world
    Elizabeth A Ainsworth
    US Department of Agriculture, Agricultural Research Service and Photosynthesis Research Unit, Urbana, IL, USA
    Plant Cell Environ 31:1317-24. 2008
    ..This is necessary if we are to realize the potential for yield gains in the future...
  84. ncbi request reprint Coordination of carbon supply and plant growth
    Alison M Smith
    Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    Plant Cell Environ 30:1126-49. 2007
    ..Finally, we consider how carbon balance may be linked to growth, and the importance of these linkages for sustained plant growth in a changing environment...
  85. ncbi request reprint Increased C availability at elevated carbon dioxide concentration improves N assimilation in a legume
    Alistair Rogers
    Department of Environmental Sciences, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Plant Cell Environ 29:1651-8. 2006
    ..One possible explanation for these findings is that N fixation had increased, and that these plants had acclimated to the increased N demand at elevated [CO2]...
  86. pmc The lipopolysaccharide of Sinorhizobium meliloti suppresses defense-associated gene expression in cell cultures of the host plant Medicago truncatula
    Verena Tellström
    Proteom und Metabolomforschung, Fakultat fur Biologie, Universitat Bielefeld, D 33501 Bielefeld, Germany
    Plant Physiol 143:825-37. 2007
    ..These data indicate a role for LPS during infection of the plant by its symbiotic partner...