A Steiger

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. doi request reprint Pathology of sleep, hormones and depression
    A Steiger
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacopsychiatry 46:S30-5. 2013
  2. pmc The renin-angiotensin-aldosterone system in patients with depression compared to controls--a sleep endocrine study
    Harald Murck
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    BMC Psychiatry 3:15. 2003
  3. ncbi request reprint [Thyroid gland and sleep]
    A Steiger
    Psychiatrischen Klinik des Max Planck Instituts für Psychiatrie, Munchen, Deutschland
    Acta Med Austriaca 26:132-3. 1999
  4. doi request reprint Wake and sleep EEG provide biomarkers in depression
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    J Psychiatr Res 44:242-52. 2010
  5. doi request reprint Ghrelin in mental health, sleep, memory
    Axel Steiger
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Cell Endocrinol 340:88-96. 2011
  6. ncbi request reprint Sleep and the hypothalamo-pituitary-adrenocortical system
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Sleep Med Rev 6:125-38. 2002
  7. ncbi request reprint Neurochemical regulation of sleep
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 41:537-52. 2007
  8. ncbi request reprint Effects of hormones on sleep
    A Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Horm Res 49:125-30. 1998
  9. ncbi request reprint Nocturnal secretion of prolactin and cortisol and the sleep EEG in patients with major endogenous depression during an acute episode and after full remission
    A Steiger
    Department of Psychiatry, University of Mainz, Germany
    Psychiatry Res 72:81-8. 1997
  10. ncbi request reprint Sleep and endocrinology
    A Steiger
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    J Intern Med 254:13-22. 2003

Collaborators

Detail Information

Publications81

  1. doi request reprint Pathology of sleep, hormones and depression
    A Steiger
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacopsychiatry 46:S30-5. 2013
    ..This effect is absent in depressed patients who are at least 30 years old, and is probably related to elevated glucocorticoid levels...
  2. pmc The renin-angiotensin-aldosterone system in patients with depression compared to controls--a sleep endocrine study
    Harald Murck
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    BMC Psychiatry 3:15. 2003
    ..angiotensin II (ATII) releases CRH and vasopressin from the hypothalamus. Furthermore renin and aldosterone secretion are synchronized to the rapid eyed movement (REM)-nonREM cycle...
  3. ncbi request reprint [Thyroid gland and sleep]
    A Steiger
    Psychiatrischen Klinik des Max Planck Instituts für Psychiatrie, Munchen, Deutschland
    Acta Med Austriaca 26:132-3. 1999
    ..Slow wave sleep was reduced in patients with hypothyroidism in comparison to normal controls. The sleep EEG normalised after therapy...
  4. doi request reprint Wake and sleep EEG provide biomarkers in depression
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    J Psychiatr Res 44:242-52. 2010
    ..Some of these predictive sleep-EEG markers of the longterm course of depression appear to be closely related to hypothalamo-pituitary-adrenocortical system activity...
  5. doi request reprint Ghrelin in mental health, sleep, memory
    Axel Steiger
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Cell Endocrinol 340:88-96. 2011
    ..Furthermore ghrelin appears to be related to memory and to be involved in the pathophysiology of CNS disorders, particularly depression...
  6. ncbi request reprint Sleep and the hypothalamo-pituitary-adrenocortical system
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Sleep Med Rev 6:125-38. 2002
    ..Some data suggest a major effect of light on cortisol secretion. Sleeping is widely associated with blunting and awakenings are linked with increases of HPA hormones...
  7. ncbi request reprint Neurochemical regulation of sleep
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 41:537-52. 2007
    ....
  8. ncbi request reprint Effects of hormones on sleep
    A Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Horm Res 49:125-30. 1998
    ..Cortisol stimulates SWS and GH, probably by feedback inhibition of CRH. Neuroactive steroids exert specific effects on the sleep EEG, which can be explained by gamma-aminobutyric acid(A) receptor modulation...
  9. ncbi request reprint Nocturnal secretion of prolactin and cortisol and the sleep EEG in patients with major endogenous depression during an acute episode and after full remission
    A Steiger
    Department of Psychiatry, University of Mainz, Germany
    Psychiatry Res 72:81-8. 1997
    ..The above findings were not altered when age was used as a covariate in statistical analysis. Our data suggest that neither depression nor aging exerts distinct effects on prolactin secretion...
  10. ncbi request reprint Sleep and endocrinology
    A Steiger
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    J Intern Med 254:13-22. 2003
    ..Cortisol appears to enhance REMS. Finally, gonadal hormones participate in sleep regulation. Oestrogen replacement therapy and CRH-1 receptor antagonism in depression are beneficial clinical applications of sleep-endocrine research...
  11. ncbi request reprint Sleep and endocrine regulation
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Front Biosci 8:s358-76. 2003
    ..Finally gonadal hormones participate in sleep regulation. Estrogen replacement therapy and CRH-1 receptor antagonism in depression are beneficial clinical applications of the basic research presented here...
  12. ncbi request reprint Trimipramine and imipramine exert different effects on the sleep EEG and on nocturnal hormone secretion during treatment of major depression
    A Sonntag
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Depression 4:1-13. 1996
    ..We conclude that trimipramine is an antidepressant with sleep-improving qualities that possibly acts through inhibition of hypothalamic-pituitary-adrenocortical system activity by a yet unknown mechanism...
  13. ncbi request reprint Renin-angiotensin-aldosterone system, HPA-axis and sleep-EEG changes in unmedicated patients with depression after total sleep deprivation
    H Murck
    Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacopsychiatry 39:23-9. 2006
    ..Additionally we explored the HPA-system and the sleep-EEG-changes...
  14. ncbi request reprint Growth hormone-releasing hormone and corticotropin-releasing hormone enhance non-rapid-eye-movement sleep after sleep deprivation
    P Schussler
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Am J Physiol Endocrinol Metab 291:E549-56. 2006
    ..No sex differences were found in these changes. Our data suggest that GHRH and CRH augment NREMS promotion after SD. Marked differences appear to exist in peptidergic sleep regulation between spontaneous and recovery sleep...
  15. ncbi request reprint Sexually dimorphic effects of GHRH on sleep-endocrine activity in patients with depression and normal controls - part I: the sleep eeg
    I A Antonijevic
    Max Planc Institute of Psychiatry, Department of Psychiatry, Munich D 80804, Germany
    Sleep Res Online 3:5-13. 2000
    ..These data support the hypothesis that female gender, aging and depression are associated with a shift in the GHRH/CRH ratio towards CRH...
  16. ncbi request reprint Sexually dimorphic effects of GHRH on sleep-endocrine activity in patients with depression and normal controls - part II: hormone secretion
    I A Antonijevic
    Max Planc Institute of Psychiatry, Department of Psychiatry, Munich D 80804, Germany
    Sleep Res Online 3:15-21. 2000
    ..In men, GHRH can restore some of the sleep-endocrine alterations associated with depression and aging...
  17. ncbi request reprint Neuropeptide Y promotes sleep and inhibits ACTH and cortisol release in young men
    I A Antonijevic
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804, Munich, Germany
    Neuropharmacology 39:1474-81. 2000
    ..In summary, NPY promotes sleep and inhibits the hypothalamo-pituitary-adrenocortical (HPA) axis in humans, pointing to a possible role of NPY agonists for the development of novel treatment strategies for affective disorders...
  18. ncbi request reprint Effects of trimipramine on sleep EEG, penile tumescence and nocturnal hormonal secretion. A long-term study in 3 normal controls
    A Steiger
    Department of Psychiatry, University of Mainz, FRG
    Neuropsychobiology 21:71-5. 1989
    ..Our data illustrate that the neurobiological effects of TR are different from those of other antidepressants. We suggest that some of the psychotropic effects of TR are mediated by suppression of cortisol...
  19. ncbi request reprint On the role of menopause for sleep-endocrine alterations associated with major depression
    I A Antonijevic
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    Psychoneuroendocrinology 28:401-18. 2003
    ..Whether the predominant alteration of the distribution of SWS and delta EEG activity in younger patients with a first episode of major depression has a predictive value for the future course of the disease remains to be investigated...
  20. ncbi request reprint Nocturnal ghrelin, ACTH, GH and cortisol secretion after sleep deprivation in humans
    P Schussler
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychoneuroendocrinology 31:915-23. 2006
    ..Whereas the effects of SD on ghrelin levels were relatively weak, our findings are in line with the hypothesis that ghrelin is a sleep-promoting factor in humans. Ghrelin may be involved in sleep promotion after SD...
  21. ncbi request reprint Effect of the GABAA agonist gaboxadol on nocturnal sleep and hormone secretion in healthy elderly subjects
    M Lancel
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Am J Physiol Endocrinol Metab 281:E130-7. 2001
    ....
  22. ncbi request reprint The GABA uptake inhibitor tiagabine promotes slow wave sleep in normal elderly subjects
    S Mathias
    Max Planck Institute of Psychiatry, Munich, Germany
    Neurobiol Aging 22:247-53. 2001
    ....
  23. ncbi request reprint Galanin has REM-sleep deprivation-like effects on the sleep EEG in healthy young men
    H Murck
    Max Planck Institute of Psychiatry, Munich, Germany
    J Psychiatr Res 33:225-32. 1999
    ..Our data are consistent with the assumption of a functional resemblance between the effect of galanin and that of REM sleep deprivation, which is known to have antidepressive efficacy...
  24. ncbi request reprint On the gender differences in sleep-endocrine regulation in young normal humans
    I A Antonijevic
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuroendocrinology 70:280-7. 1999
    ..7, p < 0.05). Our data are compatible with the hypothesis that in women compared to men activity of hypothalamic CRH neurons and central CRH release is greater, but is not reflected by greater HPA activity...
  25. ncbi request reprint Treatment with the CRH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression
    K Held
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804, Munich, Germany
    J Psychiatr Res 38:129-36. 2004
    ....
  26. doi request reprint Progesterone reduces wakefulness in sleep EEG and has no effect on cognition in healthy postmenopausal women
    P Schussler
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Psychoneuroendocrinology 33:1124-31. 2008
    ..Progesterone might be useful in the treatment of sleep disturbances of postmenopausal women...
  27. ncbi request reprint Open clinical trial on the sigma ligand panamesine in patients with schizophrenia
    R M Frieboes
    Max Planck Institute of Psychiatry, Clinical Institute, Department of Psychiatry, Munich, Germany
    Psychopharmacology (Berl) 132:82-8. 1997
    ..In all patients prolactin levels increased during treatment, probably due to an active metabolite with weak dopamine-2-receptor antagonistic effects. No major side effects occurred, and in particular, no EPMS symptoms were seen...
  28. ncbi request reprint Mg2+ reduces ACTH secretion and enhances spindle power without changing delta power during sleep in men -- possible therapeutic implications
    H Murck
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Psychopharmacology (Berl) 137:247-52. 1998
    ..The findings are consistent with the assumption that Mg2+ has GABA(A)-agonistic or NMDA-antagonistic effects on sleep and nocturnal hormonal secretion and hence may be useful in controlling depressive symptoms and seizures...
  29. ncbi request reprint Aging does not affect the sleep endocrine response to total sleep deprivation in humans
    H Murck
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Neurobiol Aging 20:665-8. 1999
    ..Thus, the plasticity of the sleep-endocrine system in response to TSD is sustained during aging. The possible involvement of the GABAergic system, that seems not to be severely impaired with age, is proposed...
  30. ncbi request reprint Elevated nocturnal profiles of serum leptin in patients with depression
    I A Antonijevic
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    J Psychiatr Res 32:403-10. 1998
    ..Elevated serum leptin in depression might in turn further promote CRH release, as shown in animals and, hence, contribute to HPA system hyperactivity seen in depression...
  31. ncbi request reprint Reboxetine induces similar sleep-EEG changes like SSRI's in patients with depression
    H E Kuenzel
    Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacopsychiatry 37:193-5. 2004
    ..Reboxetine is a novel selective noradrenaline reuptake inhibitor. The antidepressive properties of the substance are established...
  32. ncbi request reprint Nocturnal hormone secretion and the sleep EEG in patients several months after traumatic brain injury
    R M Frieboes
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    J Neuropsychiatry Clin Neurosci 11:354-60. 1999
    ..The resulting data show a pattern of sleep-endocrine changes in patients after TBI, which has some similarities to that of patients with remitted depression...
  33. ncbi request reprint Hyporesponsiveness of the pituitary to CRH during slow wave sleep is not mimicked by systemic GHRH
    I A Antonijevic
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Neuroendocrinology 69:88-96. 1999
    ....
  34. ncbi request reprint Effects of thyrotropin-releasing hormone on the sleep EEG and nocturnal hormone secretion in male volunteers
    U Hemmeter
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychobiology 38:25-31. 1998
    ..On the basis of these findings, we surmise that TRH may contribute to the disturbed sleep continuity seen in depressed patients, probably acting as a cofactor of CRH in a synergistic manner...
  35. ncbi request reprint Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers--a potential link to low-melatonin syndrome in depression?
    M Kellner
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Neuroendocrinology 65:284-90. 1997
    ....
  36. ncbi request reprint State markers of depression in sleep EEG: dependency on drug and gender in patients treated with tianeptine or paroxetine
    H Murck
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 28:348-58. 2003
    ..The study further points to the importance of the higher sigma frequency range in the sleep EEG of non-REM sleep and REM density as a marker of treatment response...
  37. ncbi request reprint Enhanced slow wave sleep in patients with prolactinoma
    R M Frieboes
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    J Clin Endocrinol Metab 83:2706-10. 1998
    ..These findings are in accordance with reports of good sleep quality in patients with prolactinoma, which is in contrast to that of patients with other endocrine diseases...
  38. ncbi request reprint The GABA(A) agonist gaboxadol improves the quality of post-nap sleep
    S Mathias
    Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany
    Psychopharmacology (Berl) 157:299-304. 2001
    ....
  39. ncbi request reprint Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans
    Katja Held
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    Pharmacopsychiatry 35:135-43. 2002
    ..The similarities of the effect of Mg(2+) and that of the related electrolyte Li+ furthermore supports the possible efficacy of Mg(2+) as a mood stabilizer...
  40. doi request reprint Sleep timing is more important than sleep length or quality for medical school performance
    L Genzel
    Max Planck Institute of Psychiatry, Munich, Germany
    Chronobiol Int 30:766-71. 2013
    ....
  41. ncbi request reprint Distinct temporal pattern of the effects of the combined serotonin-reuptake inhibitor and 5-HT1A agonist EMD 68843 on the sleep EEG in healthy men
    H Murck
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychopharmacology (Berl) 155:187-92. 2001
    ..CONCLUSION: The sleep EEG effects of EMD fit with its pharmacological profile, which might lead to adaptive changes suggested to characterize an antidepressive substance...
  42. ncbi request reprint Neuropeptides and human sleep
    A Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Sleep 20:1038-52. 1997
    ..This paper reviews recent work investigating the influence of these various neuropeptides on sleep...
  43. ncbi request reprint Temporal EEG dynamics of non-REM sleep episodes in humans
    H Tagaya
    Max Planck Institute of Psychiatry, Clinical Institute, Kraepelinstrasse 10, D 80804, Munich, Germany
    Brain Res 861:233-40. 2000
    ....
  44. ncbi request reprint The somatostatin analogue octreotide impairs sleep and decreases EEG sigma power in young male subjects
    M Ziegenbein
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 29:146-51. 2004
    ..Obviously, the influence of octreotide on sleep is superior to that of short-acting SRIF, which did not affect sleep in young men. We suggest a reciprocal interaction of GHRH and SRIF in sleep regulation...
  45. ncbi request reprint Characterization of the sigma ligand panamesine, a potential antipsychotic, by immune response in patients with schizophrenia and by sleep-EEG changes in normal controls
    R M Frieboes
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychopharmacology (Berl) 141:107-10. 1999
    ..Our results support the hypothesis that the sigma ligand PAN, which has antipsychotic properties, shares biological aspects with haloperidol...
  46. ncbi request reprint Ghrelin promotes slow-wave sleep in humans
    J C Weikel
    Max Planck Institute of Psychiatry, Department of Psychiatry, 80804 Munich, Germany
    Am J Physiol Endocrinol Metab 284:E407-15. 2003
    ..Furthermore, ghrelin appears to be a common stimulus of the somatotropic and hypothalamo-pituitary-adrenocortical systems. It appears that ghrelin is a sleep-promoting factor in humans...
  47. ncbi request reprint Modelling and exploring human sleep with event history analysis
    A Yassouridis
    Department of Statistics, Max Planck Institute of Psychiatry, Munich, Germany
    J Sleep Res 8:25-36. 1999
    ....
  48. ncbi request reprint Clinical outcome after trimipramine in patients with delusional depression - a pilot study
    R M Frieboes
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Pharmacopsychiatry 36:12-7. 2003
    ..We suggest that the clinical use of high-dose trimipramine in delusional depression seems to be a promising treatment strategy...
  49. ncbi request reprint Dehydroepiandrosterone--a neurosteroid
    E Friess
    Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Clin Invest 30:46-50. 2000
    ..Today, despite promising preclinical and human data the present clinical studies provide only weak evidence, if any, in favour of a DHEA replacement therapy...
  50. doi request reprint The interaction between sleep quality and academic performance
    K Ahrberg
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    J Psychiatr Res 46:1618-22. 2012
    ..However, poor sleep quality may negatively impact test performance as well, creating a vicious circle. Furthermore, the rate of sleep disturbances in medical students should be cause for intervention...
  51. doi request reprint Neuroscience-driven discovery and development of sleep therapeutics
    M Dresler
    Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacol Ther 141:300-34. 2014
    ..Here we review the current state of the neuroscience of sleep, sleep disorders and sleep therapeutics and will give some leads to promote the discovery and development of sleep medicines that are better than those we have today. ..
  52. ncbi request reprint Sleep endocrine effects of the 11-beta-hydroxysteroiddehydrogenase inhibitor metyrapone
    Holger Jahn
    Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Germany
    Sleep 26:823-9. 2003
    ....
  53. ncbi request reprint Sleep onset REM periods in obsessive compulsive disorder
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychiatry Res 152:29-35. 2007
    ..05) more severe in these patients (Y-BOCS: 32+/-2.0) compared to those without SOREMPs (Y-BOCS 26+/-4.2). This is, to our knowledge, the first report of sleep onset REM periods in OCD...
  54. ncbi request reprint Pituitary adenylate cyclase-activating peptide affects homeostatic sleep regulation in healthy young men
    Harald Murck
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    Am J Physiol Endocrinol Metab 292:E853-7. 2007
    ..Both effects are the opposite of those seen after sleep deprivation but similar to the changes after napping, i.e., a reduced sleep propensity. This implies that PACAP might be involved in homeostatic sleep regulation...
  55. ncbi request reprint Increased nocturnal secretion of ACTH and cortisol in obsessive compulsive disorder
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 41:928-33. 2007
    ..4; cortisol: 2148.4 +/-271.7) than in controls (ACTH: 460.2 +/- 61.0; cortisol: 1191.2 +/- 124.1). In conclusion, our findings suggest that the activity of the HPA axis in patients with OCD is increased compared to healthy controls...
  56. ncbi request reprint Ghrelin administered in the early morning increases secretion of cortisol and growth hormone without affecting sleep
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 32:287-92. 2007
    ..Sleep variables did not differ in both conditions. In contrast to GHRH, ghrelin's stimulatory effects were apparently not counteracted (GH), and enhanced (cortisol), respectively, by high CRH in the second half of night...
  57. ncbi request reprint Duloxetine increases stage 3 sleep and suppresses rapid eye movement (REM) sleep in patients with major depression
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Eur Neuropsychopharmacol 17:527-31. 2007
    ..005) increased from 58.5+/-31.1 to 193.6+/-72.6 min. REM sleep significantly (P<0.005) decreased from 94.8+/-34.5 to 51.5+/-42.5 min. These results partly differ from those in healthy subjects receiving duloxetine...
  58. ncbi request reprint Persistent generalized anxiety after brief exposure to the dopamine antagonist metoclopramide
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychiatry Clin Neurosci 61:193-5. 2007
    ..The case might provide an initial piece of evidence that dopaminergic neurotransmission can be involved in the pathogenesis of generalized anxiety disorder...
  59. ncbi request reprint Systemic growth hormone-releasing hormone (GHRH) impairs sleep in healthy young women
    Stefan Mathias
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 32:1021-7. 2007
    ..After both dosages GH increased whereas ACTH and cortisol remained unchanged. This study confirms that systemic GHRH impairs sleep in women...
  60. ncbi request reprint Ghrelin enhances the nocturnal secretion of cortisol and growth hormone in young females without influencing sleep
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychoneuroendocrinology 32:1079-85. 2007
    ..In contrast to findings in young men, ghrelin did not affect sleep in young women, indicating a sexual dimorphism. In accordance with the findings in young men, ghrelin stimulated secretion of GH and cortisol...
  61. doi request reprint Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 33:497-506. 2008
    ..CRH had sleep-improving and REM permissive effects when co-administered with ghrelin, being in contrast to the effect of CRH alone in previous studies...
  62. ncbi request reprint Nocturnal secretion of TSH and ACTH in male patients with depression and healthy controls
    Christian Peteranderl
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    J Psychiatr Res 36:189-96. 2002
    ..The ratio TSH/ACTH might be a tool to characterize alterations of both the HPT and HPA axis in depression during the first half of the night...
  63. ncbi request reprint Altered nocturnal growth hormone (GH) secretion in obsessive compulsive disorder
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 31:1098-104. 2006
    ..In conclusion, our results indicate that the nocturnal GH secretion in patients with OCD is altered compared to controls...
  64. ncbi request reprint Ghrelin and sleep-wake regulation
    Axel Steiger
    Am J Physiol Regul Integr Comp Physiol 292:R573-4. 2007
  65. ncbi request reprint Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers
    Ralf Michael Frieboes
    Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    Psychoneuroendocrinology 29:851-60. 2004
    ..We hypothesize that sleep is impaired after hexarelin since the GHRH/corticotropin-releasing hormone (CRH) ratio is changed in favour of CRH. There are no hints for an interaction of hexarelin and the immune system...
  66. ncbi request reprint Intravenous administration of the neuropeptide galanin has fast antidepressant efficacy and affects the sleep EEG
    Harald Murck
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    Psychoneuroendocrinology 29:1205-11. 2004
    ..As this effect could imply an antidepressive potency we studied the effect of intravenous galanin administration on psychopathology and sleep EEG in patients with depression...
  67. ncbi request reprint Night sleep EEG and daytime sleep propensity in adult hypopituitary patients with growth hormone deficiency before and after six months of growth hormone replacement
    Harald Jorn Schneider
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Psychoneuroendocrinology 30:29-37. 2005
    ..No reports exist about objective measures of daytime sleepiness in GH deficient patients before and during GH-therapy...
  68. ncbi request reprint Depression-like changes of the sleep-EEG during high dose corticosteroid treatment in patients with multiple sclerosis
    Irina A Antonijevic
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Psychoneuroendocrinology 28:780-95. 2003
    ..Further prospective studies with longer-term follow-up are needed to examine the clinical relevance of our preliminary data...
  69. ncbi request reprint Eating and sleeping--their relationship to ghrelin and leptin
    Axel Steiger
    Am J Physiol Regul Integr Comp Physiol 287:R1031-2. 2004
  70. ncbi request reprint Effect of repeated gaboxadol administration on night sleep and next-day performance in healthy elderly subjects
    Stefan Mathias
    Section of Sleep Pharmacology, Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 30:833-41. 2005
    ..Gaboxadol persistently improved subjective and objective sleep quality and was devoid of residual effects. Thus, at the employed dose, it seems an effective hypnotic in elderly subjects...
  71. ncbi request reprint Ghrelin stimulates appetite, imagination of food, GH, ACTH, and cortisol, but does not affect leptin in normal controls
    Dagmar A Schmid
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 30:1187-92. 2005
    ..Our data suggest that i.v. ghrelin stimulates appetite and images of food in young women and men. Obviously, leptin is not involved in these effects...
  72. ncbi request reprint Changes in sleep electroencephalogram and nocturnal hormone secretion after administration of the antidyskinetic agent sarizotan in healthy young male volunteers
    Heike E Kuenzel
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804, Munich, Germany
    Psychopharmacology (Berl) 180:327-32. 2005
    ..Data from an open pilot study in patients with Parkinson's disease show clear indication of a treatment effect against L: -dopa-induced dyskinesia...
  73. ncbi request reprint Elevated plasma ghrelin levels in night-eating syndrome
    Marcus C Rosenhagen
    Am J Psychiatry 162:813. 2005
  74. ncbi request reprint Alpha-helical CRH exerts CRH agonistic effects on sleep-endocrine activity in humans
    Katja Held
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Neuropsychobiology 52:62-7. 2005
    ..ACTH (2nd half of the night) and cortisol (total night and 1st half of the night) increased. The results of the present study correspond to a mixture of agonistic and antagonistic effects of alpha-helical CRH...
  75. ncbi request reprint Neuropeptide Y (NPY) shortens sleep latency but does not suppress ACTH and cortisol in depressed patients and normal controls
    Katja Held
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 31:100-7. 2006
    ..The lack of effects on time awake and HPA hormones may be explained by the higher CRH activity due to age and depression in the investigated samples in comparison to our recent study in young subjects...
  76. ncbi request reprint Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin, and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazapine
    Dagmar A Schmid
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 31:832-44. 2006
    ..A weight gain of approximately 3 kg was observed. This unique profile of changes is compatible with the action of mirtazapine at 5-HT-2 receptors, at presynaptic adrenergic alpha 2 receptors, at the HPA system, and on ghrelin and leptin...
  77. ncbi request reprint Nocturnal ghrelin levels--relationship to sleep EEG, the levels of growth hormone, ACTH and cortisol--and gender differences
    Petra Schuessler
    Max Planck Institute of Psychiatry, Munich, Germany
    J Sleep Res 14:329-36. 2005
    ..No peak in plasma ghrelin levels resembling the GH surge was observed. We suggest that under naturalistic conditions plasma ghrelin levels show no distinct interaction with sleep...
  78. ncbi request reprint Clinical and neurobiological effects of tianeptine and paroxetine in major depression
    Thomas Nickel
    Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Psychopharmacol 23:155-68. 2003
    ..The normalization of the HPA system as a common mode of action of different antidepressants seems to be of special interest...
  79. ncbi request reprint Ghrelin suppresses secretion of luteinizing hormone in humans
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Clin Endocrinol Metab 92:3202-5. 2007
    ..Ghrelin affects the hypothalamic-pituitary-gonadal axis in various nonhuman mammalians, predominantly by suppressing secretion of LH. However, for humans, no such evidence exists...
  80. ncbi request reprint Combination therapy of lamotrigine and escitalopram may cause myoclonus
    Marcus C Rosenhagen
    J Clin Psychopharmacol 26:346-7. 2006
  81. ncbi request reprint Increase in amino acids in the pons after sleep deprivation: a pilot study using proton magnetic resonance spectroscopy
    Harald Murck
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychobiology 45:120-3. 2002
    ..These preliminary data support earlier animal data and indirect findings in humans suggesting that GABA and Gln, especially in the pontine structures, may play a key role in the mechanism of TSD...