Eike Staub

Summary

Affiliation: Max Planck Institute for Molecular Genetics
Country: Germany

Publications

  1. pmc The SYSTERS Protein Family Database in 2005
    Thomas Meinel
    Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Ihnestrasse 63 73, 14195 Berlin, Germany
    Nucleic Acids Res 33:D226-9. 2005
  2. ncbi request reprint Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire
    Eike Staub
    metaGen Pharmaceuticals GmbH, Berlin, Germany
    Bioessays 26:567-81. 2004
  3. pmc An expression module of WIPF1-coexpressed genes identifies patients with favorable prognosis in three tumor types
    Eike Staub
    Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany
    J Mol Med (Berl) 87:633-44. 2009
  4. pmc Genome-wide expression patterns of invasion front, inner tumor mass and surrounding normal epithelium of colorectal tumors
    Eike Staub
    Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, Berlin, Germany
    Mol Cancer 6:79. 2007
  5. ncbi request reprint A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family
    Eike Staub
    metaGen Pharmaceuticals GmbH, Oudenarder Str 16, D 13347, Berlin, Germany
    FEBS Lett 527:114-8. 2002
  6. pmc A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer
    Eike Staub
    Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, Berlin, Germany
    Mol Cancer 5:37. 2006
  7. pmc An inventory of yeast proteins associated with nucleolar and ribosomal components
    Eike Staub
    Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Genome Biol 7:R98. 2006
  8. ncbi request reprint The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders
    Eike Staub
    metaGen Pharmaceuticals GmbH, Oudenarder Strasse 16, D 13347 Berlin, Germany
    Trends Biochem Sci 27:441-4. 2002
  9. ncbi request reprint ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer
    Marina Himmelfarb
    metaGen Pharmaceuticals GmbH, Oudenarder Str 16, 13347 Berlin, Germany
    Cancer Lett 204:69-77. 2004
  10. ncbi request reprint About the interrelation of evolutionary rate and protein age
    Hannes Luz
    Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Ihnestr 73, 14195 Berlin, Germany
    Genome Inform 17:240-50. 2006

Collaborators

Detail Information

Publications21

  1. pmc The SYSTERS Protein Family Database in 2005
    Thomas Meinel
    Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Ihnestrasse 63 73, 14195 Berlin, Germany
    Nucleic Acids Res 33:D226-9. 2005
    ..A new access point, PhyloMatrix, allows the retrieval of phylogenetic profiles of SYSTERS families across organisms with completely sequenced genomes...
  2. ncbi request reprint Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire
    Eike Staub
    metaGen Pharmaceuticals GmbH, Berlin, Germany
    Bioessays 26:567-81. 2004
    ..Supplementary material for this article can be found on the BioEssays website at http://www.interscience.wiley.com/jpages/0265-9247/suppmat/index.html...
  3. pmc An expression module of WIPF1-coexpressed genes identifies patients with favorable prognosis in three tumor types
    Eike Staub
    Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany
    J Mol Med (Berl) 87:633-44. 2009
    ....
  4. pmc Genome-wide expression patterns of invasion front, inner tumor mass and surrounding normal epithelium of colorectal tumors
    Eike Staub
    Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, Berlin, Germany
    Mol Cancer 6:79. 2007
    ....
  5. ncbi request reprint A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family
    Eike Staub
    metaGen Pharmaceuticals GmbH, Oudenarder Str 16, D 13347, Berlin, Germany
    FEBS Lett 527:114-8. 2002
    ..The phyletic distribution of CSPG repeats suggests that horizontal gene transfer contributed to their evolutionary history...
  6. pmc A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer
    Eike Staub
    Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, Berlin, Germany
    Mol Cancer 5:37. 2006
    ..Cancer development is accompanied by genetic phenomena like deletion and amplification of chromosome parts or alterations of chromatin structure. It is expected that these mechanisms have a strong effect on regional gene expression...
  7. pmc An inventory of yeast proteins associated with nucleolar and ribosomal components
    Eike Staub
    Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Genome Biol 7:R98. 2006
    ..Phylogenetic profiling and gene expression analysis were carried out to shed light on evolutionary and regulatory aspects of nucleoli and ribosome assembly...
  8. ncbi request reprint The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders
    Eike Staub
    metaGen Pharmaceuticals GmbH, Oudenarder Strasse 16, D 13347 Berlin, Germany
    Trends Biochem Sci 27:441-4. 2002
    ..Genes encoding proteins of this family are located in genomic regions associated with epilepsy and other neurological disorders...
  9. ncbi request reprint ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer
    Marina Himmelfarb
    metaGen Pharmaceuticals GmbH, Oudenarder Str 16, 13347 Berlin, Germany
    Cancer Lett 204:69-77. 2004
    ..ITIH5 mRNA was neither detectable in cancerous nor benign breast cell lines. We propose that loss of ITIH5 expression may be involved in breast cancer development...
  10. ncbi request reprint About the interrelation of evolutionary rate and protein age
    Hannes Luz
    Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Ihnestr 73, 14195 Berlin, Germany
    Genome Inform 17:240-50. 2006
    ..We estimate time points of duplication events that gave rise to novel protein functions and show that younger proteins were duplicated more recently than older ones...
  11. ncbi request reprint Horizontal gene transfer in aminoacyl-tRNA synthetases including leucine-specific subtypes
    Juliane C Dohm
    Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, AG Protein Families and Cellular Evolution, Ihnestrasse 63 73, 14195, Berlin, Germany
    J Mol Evol 63:437-47. 2006
    ..We argue that the traditional division of life into Prokaryota (non-chimeric) and Eukaryota (chimeric) is favorable compared to Woese's trichotomy into Archaea/Bacteria/Eukaryota...
  12. ncbi request reprint Systematic identification of immunoreceptor tyrosine-based inhibitory motifs in the human proteome
    Eike Staub
    metaGen Pharmaceuticals GmbH, Oudenarderstr 16, 13347, Berlin, Germany
    Cell Signal 16:435-56. 2004
    ..We hypothesise that ITIM signalling is not restricted to immune cells, but also functions in diverse solid organs of mouse and man...
  13. pmc Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2
    Petra Seemann
    Institut fur Medizinische Genetik, Charite, Universitatsmedizin Berlin, Berlin, Germany
    J Clin Invest 115:2373-81. 2005
    ..The presented experiments have identified some of the main determinants of GDF5 receptor-binding specificity in vivo and open new prospects for generating antagonists and superagonists of GDF5...
  14. pmc The Spin/Ssty repeat: a new motif identified in proteins involved in vertebrate development from gamete to embryo
    Eike Staub
    metaGen Pharmaceuticals GmbH, Oudenarderstrasse 16, D 13347 Berlin, Germany
    Genome Biol 3:RESEARCH0003. 2002
    ..Thus, Spin/Ssty genes might be important in the transition from sperm cells and oocytes to the early embryo, as well as in mitosis...
  15. ncbi request reprint Transcriptional census of 36 microdissected colorectal cancers yields a gene signature to distinguish UICC II and III
    Joern Groene
    Department of General, Vascular and Thoracic Surgery, Campus Benjamin Franklin, Charite Universitaetsmedizin, Berlin, Germany
    Int J Cancer 119:1829-36. 2006
    ....
  16. ncbi request reprint The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome
    Yan Qin
    Max Planck Institut fur Molekulare Genetik, D 14195 Berlin, Germany
    Cell 127:721-33. 2006
    ..We suggest renaming LepA as elongation factor 4 (EF4)...
  17. ncbi request reprint Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy
    José M Morante-Redolat
    Unitat de Genetica Molecular, Institut de Biomedicina de València CSIC, Jaume Roig 11, E 46010 Valencia, Spain
    Hum Mol Genet 11:1119-28. 2002
    ..Moreover, we provide evidence for genetic heterogeneity within this disorder, since several other families with a phenotype consistent with this type of epilepsy lack mutations in the LGI1 gene...
  18. ncbi request reprint The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition
    Edvards Liepinsh
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, S 17177, Stockholm, Sweden
    J Mol Biol 332:1155-63. 2003
    ....
  19. ncbi request reprint Systematic isolation of genes differentially expressed in normal and cancerous tissue of the pancreas
    Robert Grutzmann
    Department of Visceral, Thoracic and Vascular Surgery, University Clinic Carl Gustav Carus, Technical University Dresden, Dresden, Germany
    Pancreatology 3:169-78. 2003
    ..Identification of these genes is essential for understanding the molecular events in the development of PaCa...
  20. ncbi request reprint Different structural organization of the encephalopsin gene in man and mouse
    Grit Kasper
    metaGen Pharmaceuticals, Oudenarderstrasse 16, 13347 Berlin, Germany
    Gene 295:27-32. 2002
    ..e. the number of genes within a certain cluster may differ between man and mouse. OPN3 provides an exception to this rule, since it is positionally uncoupled from other genes of the opsin family...
  21. ncbi request reprint Nonribosomal peptide synthesis in Schizosaccharomyces pombe and the architectures of ferrichrome-type siderophore synthetases in fungi
    Torsten Schwecke
    Institute of Chemistry, Technical University Berlin, Franklinstrasse 29, 10587 Berlin, Germany
    Chembiochem 7:612-22. 2006
    ..A phylogenetic analysis of both NRPSs and associated L-N5-ornithine monooxygenases revealed that ferrichrome-type siderophore biosynthesis has coevolved in fungi with varying in trans interactions of NRPS domains...