Ralf J Sommer

Summary

Affiliation: Max Planck Institute for Biological Cybernetics
Country: Germany

Publications

  1. ncbi request reprint Isolation of mutations with dumpy-like phenotypes and of collagen genes in the nematode Pristionchus pacificus
    Charlotte Kenning
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Evolutionsbiologie, Spermannstrasse 37 39, D 72076 Tubingen, Germany
    Genesis 40:176-83. 2004
  2. pmc Genome-wide analysis of germline signaling genes regulating longevity and innate immunity in the nematode Pristionchus pacificus
    Robbie Rae
    Department of Evolutionary Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Pathog 8:e1002864. 2012
  3. pmc Tandem-repeat patterns and mutation rates in microsatellites of the nematode model organism Pristionchus pacificus
    Ruxandra I Molnar
    Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    G3 (Bethesda) 2:1027-34. 2012
  4. pmc System wide analysis of the evolution of innate immunity in the nematode model species Caenorhabditis elegans and Pristionchus pacificus
    Amit Sinha
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Tubingen, Germany
    PLoS ONE 7:e44255. 2012
  5. pmc Antagonism of LIN-17/Frizzled and LIN-18/Ryk in nematode vulva induction reveals evolutionary alterations in core developmental pathways
    Xiaoyue Wang
    Department for Evolutionary Biology, Max Planck Institut for Developmental Biology, Tubingen, Germany
    PLoS Biol 9:e1001110. 2011
  6. pmc The evolution of novelty in conserved gene families
    Gabriel V Markov
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstraße 37, 72076 Tubingen, Germany
    Int J Evol Biol 2012:490894. 2012
  7. pmc Pristionchus uniformis, should I stay or should I go? Recent host range expansion in a European nematode
    Isabella D'Anna
    Department of Evolutionary Biology, Max Planck Institute for Developmental Biology Spemannstrasse 37, Tubingen D 72076, Germany
    Ecol Evol 1:468-78. 2011
  8. doi request reprint Nematode model systems in evolution and development
    Ralf J Sommer
    Department Evolutionary Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Wiley Interdiscip Rev Dev Biol 1:389-400. 2012
  9. doi request reprint The nematode Pristionchus pacificus as a model system for integrative studies in evolutionary biology
    Ralf J Sommer
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Tubingen, Germany
    Mol Ecol 22:2380-93. 2013
  10. doi request reprint Evolution of regulatory networks: nematode vulva induction as an example of developmental systems drift
    Ralf J Sommer
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Adv Exp Med Biol 751:79-91. 2012

Collaborators

Detail Information

Publications85

  1. ncbi request reprint Isolation of mutations with dumpy-like phenotypes and of collagen genes in the nematode Pristionchus pacificus
    Charlotte Kenning
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Evolutionsbiologie, Spermannstrasse 37 39, D 72076 Tubingen, Germany
    Genesis 40:176-83. 2004
    ..Using an in silico approach, we identified approximately 150 hits of P. pacificus collagen genes in the available EST, BAC-end, and fosmid-end sequences. However, 1:1 orthologs could only be identified for fewer than 20 collagen genes...
  2. pmc Genome-wide analysis of germline signaling genes regulating longevity and innate immunity in the nematode Pristionchus pacificus
    Robbie Rae
    Department of Evolutionary Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Pathog 8:e1002864. 2012
    ..This is the first study to show that the influence of the reproductive system on extending lifespan and innate immunity is conserved in evolution...
  3. pmc Tandem-repeat patterns and mutation rates in microsatellites of the nematode model organism Pristionchus pacificus
    Ruxandra I Molnar
    Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    G3 (Bethesda) 2:1027-34. 2012
    ..The mutation rates obtained for individual microsatellite markers provide guidelines for divergence time estimates that can be applied in P. pacificus next-generation sequencing approaches of wild isolates...
  4. pmc System wide analysis of the evolution of innate immunity in the nematode model species Caenorhabditis elegans and Pristionchus pacificus
    Amit Sinha
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Tubingen, Germany
    PLoS ONE 7:e44255. 2012
    ..We discuss the potential effects of ecology on evolution of downstream effectors and upstream regulators on evolution of nematode innate immunity...
  5. pmc Antagonism of LIN-17/Frizzled and LIN-18/Ryk in nematode vulva induction reveals evolutionary alterations in core developmental pathways
    Xiaoyue Wang
    Department for Evolutionary Biology, Max Planck Institut for Developmental Biology, Tubingen, Germany
    PLoS Biol 9:e1001110. 2011
    ..These results confirm developmental system drift as an important theory for the evolution of organ systems and they highlight the significance of protein modularity in signal transduction and the dynamics of signaling networks...
  6. pmc The evolution of novelty in conserved gene families
    Gabriel V Markov
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstraße 37, 72076 Tubingen, Germany
    Int J Evol Biol 2012:490894. 2012
    ....
  7. pmc Pristionchus uniformis, should I stay or should I go? Recent host range expansion in a European nematode
    Isabella D'Anna
    Department of Evolutionary Biology, Max Planck Institute for Developmental Biology Spemannstrasse 37, Tubingen D 72076, Germany
    Ecol Evol 1:468-78. 2011
    ..Our results provide evidence for host range expansion through host-switching events in Europe where P. uniformis was originally associated with scarab beetles and the nematode's subsequent invasion of North America...
  8. doi request reprint Nematode model systems in evolution and development
    Ralf J Sommer
    Department Evolutionary Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Wiley Interdiscip Rev Dev Biol 1:389-400. 2012
    ..These studies highlight the importance of developmental systems drift and neutrality in evolution...
  9. doi request reprint The nematode Pristionchus pacificus as a model system for integrative studies in evolutionary biology
    Ralf J Sommer
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Tubingen, Germany
    Mol Ecol 22:2380-93. 2013
    ..pacificus has the long-term prospective to provide both proximate (mechanistic) and ultimate (evolutionary and ecological) causation and might therefore help to overcome the long-term divide between major areas in biology...
  10. doi request reprint Evolution of regulatory networks: nematode vulva induction as an example of developmental systems drift
    Ralf J Sommer
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Adv Exp Med Biol 751:79-91. 2012
    ..I discuss redundancy as an evolutionary mechanism to explain developmental systems drift, a theory predicting conserved morphological structures to be generated by diverse molecular regulatory networks...
  11. doi request reprint Comparative genetics and genomics of nematodes: genome structure, development, and lifestyle
    Ralf J Sommer
    Max Planck Institute for Developmental Biology, D 72076 T bingen, Germany
    Annu Rev Genet 45:1-20. 2011
    ..elegans, and we compare the seven available nematode genomes. One of the most striking findings is the unexpectedly high incidence of gene acquisition through horizontal gene transfer (HGT)...
  12. doi request reprint The future of evo-devo: model systems and evolutionary theory
    Ralf J Sommer
    Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    Nat Rev Genet 10:416-22. 2009
    ..Furthermore, a synthesis of evo-devo with population genetics and evolutionary ecology is needed to meet future challenges...
  13. doi request reprint Hormone signaling and phenotypic plasticity in nematode development and evolution
    Ralf J Sommer
    Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    Curr Biol 21:R758-66. 2011
    ..These examples reveal a conserved and co-opted role of an endocrine signaling module involving the steroid hormone dafachronic acid. We will discuss how hormone signaling might facilitate life-history and morphological evolution...
  14. ncbi request reprint Homology and the hierarchy of biological systems
    Ralf J Sommer
    Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    Bioessays 30:653-8. 2008
    ..I argue that continuity and hierarchy are separate but equally important issues of homology...
  15. ncbi request reprint New inroads to development
    Ralf J Sommer
    Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Tubingen, D 72076, Germany
    Development 133:2451-3. 2006
  16. ncbi request reprint Evolution of nematode development
    R J Sommer
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Tubingen, 72076, Germany
    Curr Opin Genet Dev 10:443-8. 2000
    ..Genetic studies in some nematodes also shed light on the underlying mechanisms of evolutionary change...
  17. ncbi request reprint Comparative genetics: a third model nematode species
    R J Sommer
    Max Planck Institute for Developmental Biology, Abteilung für Evolutionsbiologie, Spemannstrasse 37 39, D 72076, Tubingen, Germany
    Curr Biol 10:R879-81. 2000
    ..A group of vulva-defective mutants in Oscheius has been identified, with defects not seen in C. elegans...
  18. ncbi request reprint As good as they get: cells in nematode vulva development and evolution
    R J Sommer
    Max Planck Institute for Developmental Biology, Spemannstrasse 37 39, D 72076 Tubingen, Germany
    Curr Opin Cell Biol 13:715-20. 2001
    ....
  19. pmc Phylogeny of the nematode genus Pristionchus and implications for biodiversity, biogeography and the evolution of hermaphroditism
    Werner E Mayer
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Tubingen, Germany
    BMC Evol Biol 7:104. 2007
    ..Evolutionary interpretations of differences in developmental, behavioral and ecological patterns require a phylogenetic framework of the genus Pristionchus...
  20. pmc Molecular phylogeny of beetle associated diplogastrid nematodes suggests host switching rather than nematode-beetle coevolution
    Werner E Mayer
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, 72076 Tubingen, Germany
    BMC Evol Biol 9:212. 2009
    ..How this beetle-association evolved and whether beetle-nematode coevolution occurred is still elusive. As a prerequisite to answering this question a robust phylogeny of beetle-associated Diplogastridae is needed...
  21. pmc Conservation of the global sex determination gene tra-1 in distantly related nematodes
    Andre Pires-daSilva
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Evolutionsbiologie, Spemannstrasse 37 39, D 72076 Tubingen, Germany
    Genes Dev 18:1198-208. 2004
    ..A Ppa-tra-1 morpholino phenocopies Ppa-tra-1 mutants and establishes the morpholino technology as a reverse genetic approach in P. pacificus...
  22. doi request reprint Isolation of naturally associated bacteria of necromenic Pristionchus nematodes and fitness consequences
    Robbie Rae
    Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    J Exp Biol 211:1927-36. 2008
    ..Bringing the nematode-bacterial interaction into the laboratory allows detailed functional studies, including the genetic manipulation of the interaction in both nematodes and bacteria...
  23. ncbi request reprint HAIRY-like transcription factors and the evolution of the nematode vulva equivalence group
    Benjamin Schlager
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Curr Biol 16:1386-94. 2006
    ..elegans six, and Pristionchus pacificus only three cells that are competent to form vulval tissue. In P. pacificus, programmed cell death of individual vulval precursor cells alters the size of the vulva equivalence group...
  24. doi request reprint Multi locus analysis of Pristionchus pacificus on La Réunion Island reveals an evolutionary history shaped by multiple introductions, constrained dispersal events and rare out-crossing
    Katy Morgan
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Spermannstr 37, Tubingen, Germany
    Mol Ecol 21:250-66. 2012
    ....
  25. pmc Functional diversification of the nematode mbd2/3 gene between Pristionchus pacificus and Caenorhabditis elegans
    Arturo Gutierrez
    Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    BMC Genet 8:57. 2007
    ..RNAi knock-down of mbd-2 in the two Caenorhabditis species results in varying percentages of lethality...
  26. pmc A conserved endocrine mechanism controls the formation of dauer and infective larvae in nematodes
    Akira Ogawa
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    Curr Biol 19:67-71. 2009
    ..Conservation of this small molecule ligand represents a fundamental link between dauer and infective larvae and might provide a general strategy for nematode parasitism...
  27. ncbi request reprint The nematode Pristionchus pacificus (Nematoda: Diplogastridae) is associated with the oriental beetle Exomala orientalis (Coleoptera: Scarabaeidae) in Japan
    Matthias Herrmann
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Tubingen, Germany
    Zoolog Sci 24:883-9. 2007
    ..orientalis. Together, this study identifies P. pacificus as the most common Pristionchus nematode in field studies in Japan, identifies E. orientalis as an important host species, and provides the basis for the ecology of P. pacificus...
  28. ncbi request reprint Functional specificity of the nematode Hox gene mab-5
    Arturo Gutierrez
    Max Planck Institut fur Entwicklungsbiologie, Abt Evolutionsbiologie, Spemannstr 37 39, D 72076 Tubingen, Germany
    Development 130:983-93. 2003
    ..elegans paralogous Hox proteins can rescue Cel-mab-5. Experiments with chimeric, truncated and mutagenized Hox proteins suggest the specificity to be conferred by the N-terminal arm and helix I, but not helix II of the homeodomain...
  29. ncbi request reprint Distinct patterns of genetic variation in Pristionchus pacificus and Caenorhabditis elegans, two partially selfing nematodes with cosmopolitan distribution
    Hans Zauner
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, 72076 Tubingen, Germany
    Mol Ecol 16:1267-80. 2007
    ..Thus, despite similar lifestyle characteristics in the laboratory, the reproductive mode of hermaphroditism with rare facultative males can result in distinct genetic variability patterns in different ecological settings...
  30. pmc Improving the Caenorhabditis elegans genome annotation using machine learning
    Gunnar Rätsch
    Friedrich Miescher Laboratory, Max Planck Society, Tubingen, Germany
    PLoS Comput Biol 3:e20. 2007
    ..We conclude that the genome annotation of C. elegans and other organisms can be greatly enhanced using modern machine learning technology...
  31. doi request reprint The importance of being regular: Caenorhabditis elegans and Pristionchus pacificus defecation mutants are hypersusceptible to bacterial pathogens
    Robbie Rae
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Spemannstrasse 37 39, 72076 Tubingen, Germany
    Int J Parasitol 42:747-53. 2012
    ..elegans. Thus, intestinal peristalsis is critical to nematode health and contributes significantly to survival when fed Gram-positive bacteria...
  32. doi request reprint A subset of naturally isolated Bacillus strains show extreme virulence to the free-living nematodes Caenorhabditis elegans and Pristionchus pacificus
    Robbie Rae
    Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    Environ Microbiol 12:3007-21. 2010
    ..elegans and P. pacificus. Among 20 pathogenic strains with distinct virulence patterns against the two nematodes, we selected three B. cereus-like strains to investigate resistance and susceptibility immune responses in nematodes...
  33. ncbi request reprint Finally, worm polycomb-like genes meet Hox regulation
    Andre Pires-daSilva
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Evolutionsbiologie, Spemannstrasse 37 39, D 72076, Tubingen, Germany
    Dev Cell 4:770-2. 2003
    ..elegans. However, sequence comparison indicates that these genes may not be homologous to the fly Polycomb genes, suggesting that independent gene recruitment occurred during nematode evolution...
  34. ncbi request reprint sem-4/spalt and egl-17/FGF have a conserved role in sex myoblast specification and migration in P. pacificus and C. elegans
    Andreas Photos
    Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Tubingen, Germany
    Dev Biol 293:142-53. 2006
    ..Mutations in Cel-sem-4 and Cel-egl-17 cause similar defects. Thus, the molecular mechanisms of SM cell specification and migration are conserved between P. pacificus and C. elegans...
  35. pmc Evolution of dnmt-2 and mbd-2-like genes in the free-living nematodes Pristionchus pacificus, Caenorhabditis elegans and Caenorhabditis briggsae
    Arturo Gutierrez
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Evolutionsbiologie, Spemannstrasse 37 39, D 72076 Tubingen, Germany
    Nucleic Acids Res 32:6388-96. 2004
    ..We speculate that both genes were part of an ancestral DNA methylation system in nematodes and that gene loss and sequence divergence have abolished DNA methylation in C.elegans...
  36. pmc Natural variation in Pristionchus pacificus insect pheromone attraction involves the protein kinase EGL-4
    Ray L Hong
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 105:7779-84. 2008
    ..That EGL-4 homologs have been independently implicated for behavioral variations in other invertebrate models suggests that EGL-4 may act as a modulator for interspecies behavioral repertoires across large phylogenetic distances...
  37. pmc The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism
    Christoph Dieterich
    Max Planck Institute for Developmental Biology, Spemannstrasse 37, 72076 Tubingen, Germany
    Nat Genet 40:1193-8. 2008
    ..Thus, comparative genomics analysis of three ecologically distinct nematodes offers a unique opportunity to investigate the association between genome structure and lifestyle...
  38. ncbi request reprint The pax-3 gene is involved in vulva formation in Pristionchus pacificus and is a target of the Hox gene lin-39
    Buqing Yi
    Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    Development 134:3111-9. 2007
    ..Thus, we describe the first specific developmental defect of a nematode pax-3 gene and our data reveal different regulatory networks for the specification of the vulva equivalence group...
  39. pmc A Caenorhabditis motif compendium for studying transcriptional gene regulation
    Christoph Dieterich
    Department of Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 35 37, Tubingen, Germany
    BMC Genomics 9:30. 2008
    ..A comprehensive parts list of putative regulatory motifs was yet missing for this model system. In this study, we compile a set of putative regulatory motifs by combining evidence from conservation and expression data...
  40. doi request reprint Species-specific recognition of beetle cues by the nematode Pristionchus maupasi
    Ray L Hong
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Tuebingen, Germany
    Evol Dev 10:273-9. 2008
    ..We conclude that interception of the insect communication system might be a recurring strategy of Pristionchus nematodes but that different nematodes use distinct chemical cues for finding their beetle hosts...
  41. ncbi request reprint The evolution of developmental mechanisms
    David Rudel
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Evolutionsbiologie, Spemannstrasse 37 39, D 72076 Tubingen, Germany
    Dev Biol 264:15-37. 2003
    ....
  42. ncbi request reprint Nematodes of the genus Pristionchus are closely associated with scarab beetles and the Colorado potato beetle in Western Europe
    Matthias Herrmann
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Spemannstrasse 37 39, D 72076 Tubingen, Germany
    Zoology (Jena) 109:96-108. 2006
    ..We describe the initial evidence for the association of Pristionchus nematodes with beetles and provide a phylogeny based on sequence analysis of the small subunit ribosomal RNA gene...
  43. pmc Divergent gene expression in the conserved dauer stage of the nematodes Pristionchus pacificus and Caenorhabditis elegans
    Amit Sinha
    Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Tubingen, Germany
    BMC Genomics 13:254. 2012
    ..Here, we use a transcriptomic approach to compare the dauer stage in the evolutionary model system Pristionchus pacificus with the dauer stage in C. elegans...
  44. pmc New role for DCR-1/dicer in Caenorhabditis elegans innate immunity against the highly virulent bacterium Bacillus thuringiensis DB27
    Igor Iatsenko
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Tubingen, Germany
    Infect Immun 81:3942-57. 2013
    ..Taken together, these results uncover a previously unknown role for DCR-1/Dicer in C. elegans antibacterial immunity that is largely associated with miRNA processing. ..
  45. pmc Phosphoproteome of Pristionchus pacificus provides insights into architecture of signaling networks in nematode models
    Nadine Borchert
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Tuebingen, Germany
    Mol Cell Proteomics 11:1631-9. 2012
    ..elegans. This study presents the first systematic comparison of phosphoproteomes and kinomes of two model nematodes and, as such, will be a useful resource for comparative studies of their signal transduction networks...
  46. doi request reprint Pristionchus pacificus daf-16 is essential for dauer formation but dispensable for mouth form dimorphism
    Akira Ogawa
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Development 138:1281-4. 2011
    ....
  47. ncbi request reprint Quantitative assessment of the nematode fauna present on Geotrupes dung beetles reveals species-rich communities with a heterogeneous distribution
    Andreas M Weller
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    J Parasitol 96:525-31. 2010
    ..stercorosus to none, with Pelodera spp. being the most abundant group isolated. This study presents the first quantitative data on the Pristionchus spp. infection of beetles...
  48. doi request reprint A developmental switch coupled to the evolution of plasticity acts through a sulfatase
    Erik J Ragsdale
    Department of Evolutionary Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Cell 155:922-33. 2013
    ..EUD-1 thus executes a developmental switch for morphological plasticity in the adult stage, showing that regulatory pathways can evolve by terminal addition of new genes...
  49. pmc AppaDB: an AcedB database for the nematode satellite organism Pristionchus pacificus
    Jagan Srinivasan
    Abteilung für Evolutionsbiologie, Max Planck Institut fur Entwicklungsbiologie, Spemannstrasse 35 37, 72076 Tubingen, Germany
    Nucleic Acids Res 32:D421-2. 2004
    ..Additionally, it provides a platform for the Caenorhabditis elegans community to compare nematode genetic data in an evolutionary perspective...
  50. pmc Limited microsynteny between the genomes of Pristionchus pacificus and Caenorhabditis elegans
    Kwang Zin Lee
    Abteilung für Evolutionsbiologie, Max Planck Institut fur Entwicklungsbiologie, Spemannstrasse 37, 72076 Tubingen, Germany
    Nucleic Acids Res 31:2553-60. 2003
    ..Thus, intrachromosomal rearrange ments occur frequently in nematodes, limiting the likelihood of identifying orthologous genes of P.pacificus and C.elegans based on positional information within the two genomes...
  51. doi request reprint Molecular cloning of a dominant roller mutant and establishment of DNA-mediated transformation in the nematode Pristionchus pacificus
    Benjamin Schlager
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Genesis 47:300-4. 2009
    ..We use the mutant locus as a marker to develop transgenic technique by generating complex arrays and present flourescent-protein based transcriptional reporter constructs for P. pacificus...
  52. pmc Pristionchus.org: a genome-centric database of the nematode satellite species Pristionchus pacificus
    Christoph Dieterich
    Department of Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 35 37, 72076 Tubingen, Germany
    Nucleic Acids Res 35:D498-502. 2007
    ..Content will be continuously improved as we annotate the P.pacificus genome, and will be an indispensable resource for P.pacificus genomics...
  53. doi request reprint Expressional and functional variation of horizontally acquired cellulases in the nematode Pristionchus pacificus
    Lisa N Schuster
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Gene 506:274-82. 2012
    ..These results indicate that horizontal gene transfer-acquired genes undergo rapid evolutionary changes that affect all aspects of their molecular biology...
  54. pmc Computational archaeology of the Pristionchus pacificus genome reveals evidence of horizontal gene transfers from insects
    Christian Rödelsperger
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37, 72076 Tubingen, Germany
    BMC Evol Biol 11:239. 2011
    ..The insect-to-nematode horizontal transfer is of special interest given that P. pacificus shows a tight association with insects...
  55. ncbi request reprint Operon structure and trans-splicing in the nematode Pristionchus pacificus
    Kwang Zin Lee
    Max Planck Institut fur Entwicklungsbiologie, Abteilung für Evolutionsbiologie, Tubingen, Germany
    Mol Biol Evol 20:2097-103. 2003
    ..pacificus contains operons and that downstream genes are trans-spliced to SL2. Surprisingly, the one operon analyzed so far in P. pacificus is not conserved in C. elegans, suggesting unexpected genomic plasticity...
  56. doi request reprint Genetic evidence for pax-3 function in myogenesis in the nematode Pristionchus pacificus
    Buqing Yi
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    Evol Dev 11:669-79. 2009
    ..Together, our results provide the first genetic evidence for a conserved function of PAX-3 in myogenesis between vertebrates and nematodes...
  57. pmc Wnt signaling in Pristionchus pacificus gonadal arm extension and the evolution of organ shape
    David Rudel
    Department of Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37, D 72076 Tuebingen, Germany
    Proc Natl Acad Sci U S A 105:10826-31. 2008
    ..elegans hermaphrodite gonad; the arms fail to extend ventrally. Thus, this genetic analysis of gonad migration provides insight into the mechanisms underlying the generation of morphological novelty and organ shape...
  58. doi request reprint Mutation rates and intraspecific divergence of the mitochondrial genome of Pristionchus pacificus
    Ruxandra I Molnar
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Mol Biol Evol 28:2317-26. 2011
    ..The combination of mutation rate analysis with intraspecific divergence provides a powerful tool for the reconstruction of the natural history of P. pacificus, and we discuss the ecological implication of these findings...
  59. pmc Characterization of genetic diversity in the nematode Pristionchus pacificus from population-scale resequencing data
    Christian Rödelsperger
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Genetics 196:1153-65. 2014
    ..pacificus. ..
  60. ncbi request reprint Gonadogenesis in Pristionchus pacificus and organ evolution: development, adult morphology and cell-cell interactions in the hermaphrodite gonad
    David Rudel
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Evolutionsbiologie, D 72076 Tubingen, Germany
    Dev Biol 277:200-21. 2005
    ..Individual ablation experiments in P. pacificus show significant differences in the effects of individual somatic tissues on germ line patterning in comparison to C. elegans...
  61. doi request reprint System-wide rewiring underlies behavioral differences in predatory and bacterial-feeding nematodes
    Daniel J Bumbarger
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37, 72076 Tubingen, Germany
    Cell 152:109-19. 2013
    ..pacificus. We apply focused centrality methods to identify neurons I1 and I2 as candidates for regulating predatory feeding and predict substantial divergence in the function of pharyngeal glands...
  62. pmc Horizontal gene transfer of microbial cellulases into nematode genomes is associated with functional assimilation and gene turnover
    Werner E Mayer
    Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Spemannstrasse 37, 72076 Tubingen, Germany
    BMC Evol Biol 11:13. 2011
    ..However, little is known about the functional activity and evolutionary longevity of genes acquired by horizontal gene transfer and the mechanisms favoring such processes...
  63. ncbi request reprint Co-option of the hormone-signalling module dafachronic acid-DAF-12 in nematode evolution
    Gilberto Bento
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37 D 72076 Tübingen, Germany
    Nature 466:494-7. 2010
    ..This study shows how hormonal signalling acts by coupling environmental change and genetic regulation and identifies dafachronic acid as a key hormone in nematode evolution...
  64. pmc Evolution of robustness in the signaling network of Pristionchus vulva development
    Hans Zauner
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, D 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 104:10086-91. 2007
    ....
  65. doi request reprint How to become a parasite - lessons from the genomes of nematodes
    Christoph Dieterich
    Max Planck Institute for Developmental Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    Trends Genet 25:203-9. 2009
    ..Finally, some parasitic features evolved under free-living conditions. A recent study revealed a conserved endocrine mechanism controlling the formation of dauer and infective larvae in nematodes...
  66. pmc Proteogenomics of Pristionchus pacificus reveals distinct proteome structure of nematode models
    Nadine Borchert
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Genome Res 20:837-46. 2010
    ..Combined, these results provide the first catalog of the expressed genome of P. pacificus, refinement of its genome annotation, and the first comparison of related nematode models at the proteome level...
  67. ncbi request reprint Chemoattraction in Pristionchus nematodes and implications for insect recognition
    Ray L Hong
    Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Spemannstrasse 37 39, 72076 Tuebingen, Germany
    Curr Biol 16:2359-65. 2006
    ..We conclude that Pristionchus olfaction is highly diverse among closely related species and is likely to be involved in shaping nematode-host interactions...
  68. ncbi request reprint Pristionchus pacificus: a well-rounded nematode
    Ray L Hong
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Bioessays 28:651-9. 2006
    ..pacificus to describe more thoroughly the molecular basis for these changes, as well as to better integrate our molecular knowledge with the biodiversity of Pristionchus species...
  69. pmc Natural variation in Pristionchus pacificus dauer formation reveals cross-preference rather than self-preference of nematode dauer pheromones
    Melanie G Mayer
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tubingen, Germany
    Proc Biol Sci 278:2784-90. 2011
    ..We therefore discuss intraspecific competition among genotypes as a previously unconsidered aspect of dauer formation...
  70. ncbi request reprint The nematode even-skipped homolog vab-7 regulates gonad and vulva position in Pristionchus pacificus
    B Jungblut
    , Abt. Evolutionsbiologie, Spemannstrasse 37-39, , Germany
    Development 128:253-61. 2001
    ..Investigation of Cel-vab-7 mutant animals showed a similar but weaker vulva defective phenotype to the one described for Ppa-vab-7...
  71. ncbi request reprint Evolutionary change in the functional specificity of genes
    A Eizinger
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Evolutionsbiologie, Spemannstrasse 35, 72076 Tubingen, Germany
    Trends Genet 15:197-202. 1999
    ..Ultimately, it is the interplay of conservation and change of the specificity of genes and genetic networks that generates developmental novelty over evolutionary time...
  72. ncbi request reprint Microevolutionary analysis of the nematode genus Pristionchus suggests a recent evolution of redundant developmental mechanisms during vulva formation
    J Srinivasan
    , Abteilung Evolutionsbiologie, , Germany
    Evol Dev 3:229-40. 2001
    ....
  73. ncbi request reprint Cultivation of the rhabditid Poikilolaimus oxycercus as a laboratory nematode for genetic analyses
    Ray L Hong
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37 39, 72076 Tuebingen, Germany
    J Exp Zool A Comp Exp Biol 303:742-60. 2005
    ..This could indicate that Poikilolaimus species possess five bivalent chromosomes in their germ lines, in contrast to the hermaphroditic Caenorhabditis elegans or Pristionchus pacificus, which have six chromosomes...
  74. doi request reprint Wnt signaling induces vulva development in the nematode Pristionchus pacificus
    Huiyu Tian
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    Curr Biol 18:142-6. 2008
    ..pacificus. This study provides the first molecular identification of the inductive vulva signal in a nematode other than Caenorhabditis...
  75. pmc Host-finding behaviour in the nematode Pristionchus pacificus
    Federico D Brown
    Department of Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37, Tubingen 72076, Germany
    Proc Biol Sci 278:3260-9. 2011
    ..We show that nictation behaviour in P. pacificus nematodes serves as a host-finding behaviour. Our results suggest that nictation plays a role in the evolution of new life-history strategies, such as the evolution of parasitism...
  76. ncbi request reprint Evolutionary changes of developmental mechanisms in the absence of cell lineage alterations during vulva formation in the Diplogastridae (Nematoda)
    R J Sommer
    Max Planck Instutut für Entwicklungsbiologie, Abteilung Zellbiologie, Tubingen, Germany
    Development 124:243-51. 1997
    ..These results suggest that developmental mechanisms, some of which are redundantly involved in vulval fate specification of the genetic model organism Caenorhabditis elegans, can evolve without concomitant morphological change...
  77. doi request reprint Pristionchus pacificus: A Genetic Model System for the Study of Evolutionary Developmental Biology and the Evolution of Complex Life-History Traits
    Robbie Rae
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, D 72076 Tubingen, Germany
    CSH Protoc 2008:pdb.emo102. 2008
    ..Thus, P. pacificus is not only an established model system for evolutionary developmental biology, but also an emerging model system for the evolution of complex life-history traits...
  78. doi request reprint Isolation of pristionchus nematodes from beetles
    Robbie Rae
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, D 72076 Tubingen, Germany
    CSH Protoc 2008:pdb.prot5063. 2008
    ..The nematodes are then monitored for a few days and identified using simple morphological characteristics. This method is rapid, easy, and biased for Pristionchus species...
  79. doi request reprint Assessment of the olfactory response to chemicals or bacteria in pristionchus nematodes
    Robbie Rae
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, D 72076 Tubingen, Germany
    CSH Protoc 2008:pdb.prot5064. 2008
    ..It can also be used to examine the food choice of these nematodes when they are faced with a number of bacteria...
  80. ncbi request reprint Evolution and development--the nematode vulva as a case study
    R J Sommer
    Max Planck Institut fur Entwicklungsbiologie, Abt Zellbiologie, Tubingen, Germany
    Bioessays 19:225-31. 1997
    ..I then describe a genetic approach in the nematode Pristionchus pacificus that might identify those genetic and molecular processes that cause evolutionary changes of cell fate specification...
  81. ncbi request reprint An integrated physical and genetic map of the nematode Pristionchus pacificus
    J Srinivasan
    Abteilung für Evolutionsbiologie, Max Planck Institut fur Entwicklungsbiologie, Spemannstrasse 37, 72076 Tubingen, Germany
    Mol Genet Genomics 269:715-22. 2003
    ..pacificus genome. The integrated genome map thus provides a framework for positional cloning and the study of genome evolution in nematodes...
  82. pmc A bacterial artificial chromosome-based genetic linkage map of the nematode Pristionchus pacificus
    Jagan Srinivasan
    Abteilung für Evolutionsbiologie, Max Planck Institut fur Entwicklungsbiologie, 72076 Tubingen, Germany
    Genetics 162:129-34. 2002
    ..pacificus. A mapping strategy using two selected markers per chromosome was devised and the efficiency of this approach was illustrated by the mapping of the Ppa-unc-1/Twitchin gene...
  83. ncbi request reprint Conservation and diversification of Wnt signaling function during the evolution of nematode vulva development
    Min Zheng
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Evolutionsbiologie, Spemannstrasse 37 39, D 72076 Tubingen, Germany
    Nat Genet 37:300-4. 2005
    ..Therefore, whereas the molecular mechanisms that generate vulval symmetry are conserved, the genetic control of vulva induction diversified during evolution...
  84. ncbi request reprint The evolution of signalling pathways in animal development
    Andre Pires-daSilva
    Department of Evolutionary Biology, Max Planck nstitut für Entwicklungsbiologie, Spemannstrasse 37 39, D 72076 Tubingen, Germany
    Nat Rev Genet 4:39-49. 2003
    ....