Mehmet Somel

Summary

Affiliation: Max Planck Institute for Evolutionary Anthropology
Country: Germany

Publications

  1. pmc MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain
    Mehmet Somel
    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Genome Res 20:1207-18. 2010
  2. pmc Human and chimpanzee gene expression differences replicated in mice fed different diets
    Mehmet Somel
    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 3:e1504. 2008
  3. pmc Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques
    Xiling Liu
    Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, 200031 Shanghai, China
    Genome Res 22:611-22. 2012
  4. pmc MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates
    Mehmet Somel
    Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China
    PLoS Biol 9:e1001214. 2011
  5. pmc Widespread splicing changes in human brain development and aging
    Pavel Mazin
    Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China
    Mol Syst Biol 9:633. 2013
  6. pmc Development and application of a modified dynamic time warping algorithm (DTW-S) to analyses of primate brain expression time series
    Yuan Yuan
    Key Laboratory for Computational Biology, CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    BMC Bioinformatics 12:347. 2011
  7. pmc Mechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional content
    Kai Weng
    Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 7:e43915. 2012
  8. pmc Rapid metabolic evolution in human prefrontal cortex
    Xing Fu
    Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, 200031 Shanghai, China
    Proc Natl Acad Sci U S A 108:6181-6. 2011
  9. pmc Intergenic and repeat transcription in human, chimpanzee and macaque brains measured by RNA-Seq
    Augix Guohua Xu
    Partner Institute for Computational Biology, Shanghai, China
    PLoS Comput Biol 6:e1000843. 2010
  10. pmc Accelerated aging-related transcriptome changes in the female prefrontal cortex
    Yuan Yuan
    Key Laboratory for Computational Biology, CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Aging Cell 11:894-901. 2012

Collaborators

Detail Information

Publications15

  1. pmc MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain
    Mehmet Somel
    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Genome Res 20:1207-18. 2010
    ..These results suggest a direct link between developmental regulation and expression changes taking place in aging...
  2. pmc Human and chimpanzee gene expression differences replicated in mice fed different diets
    Mehmet Somel
    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 3:e1504. 2008
    ..Our results suggest that the mouse can be used to study at least some aspects of human-specific traits...
  3. pmc Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques
    Xiling Liu
    Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, 200031 Shanghai, China
    Genome Res 22:611-22. 2012
    ..Evolutionarily, this change may have taken place after the split of the human and the Neanderthal lineages...
  4. pmc MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates
    Mehmet Somel
    Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China
    PLoS Biol 9:e1001214. 2011
    ....
  5. pmc Widespread splicing changes in human brain development and aging
    Pavel Mazin
    Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China
    Mol Syst Biol 9:633. 2013
    ..More than 60% of all splicing changes represented a single splicing pattern reflecting preferential inclusion of gene segments potentially targeting transcripts for nonsense-mediated decay in infants and elderly...
  6. pmc Development and application of a modified dynamic time warping algorithm (DTW-S) to analyses of primate brain expression time series
    Yuan Yuan
    Key Laboratory for Computational Biology, CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    BMC Bioinformatics 12:347. 2011
    ..While many powerful computation tools for time series alignment have been developed, they do not provide significance estimates for time shift measurements...
  7. pmc Mechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional content
    Kai Weng
    Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 7:e43915. 2012
    ..Here, we addressed this question by investigating whether the gene expression response observed in mice fed human and chimpanzee diets involves the same regulatory mechanisms as expression differences between humans and chimpanzees...
  8. pmc Rapid metabolic evolution in human prefrontal cortex
    Xing Fu
    Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, 200031 Shanghai, China
    Proc Natl Acad Sci U S A 108:6181-6. 2011
    ..These human-specific metabolic changes are paralleled by changes in expression patterns of the corresponding enzymes, and affect pathways involved in synaptic transmission, memory, and learning...
  9. pmc Intergenic and repeat transcription in human, chimpanzee and macaque brains measured by RNA-Seq
    Augix Guohua Xu
    Partner Institute for Computational Biology, Shanghai, China
    PLoS Comput Biol 6:e1000843. 2010
    ..Some of these transcripts may play roles in transcriptional regulation and contribute to evolution of human-specific phenotypic traits...
  10. pmc Accelerated aging-related transcriptome changes in the female prefrontal cortex
    Yuan Yuan
    Key Laboratory for Computational Biology, CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Aging Cell 11:894-901. 2012
    ..Accelerated aging-related changes in the female SFG transcriptome may provide a link between a higher stress exposure or sensitivity in women and the higher prevalence of AD...
  11. doi request reprint Human brain evolution: transcripts, metabolites and their regulators
    Mehmet Somel
    CAS Key Laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai, 200031, China
    Nat Rev Neurosci 14:112-27. 2013
    ..In this Review we show how this strategy has yielded some of the first hints about the mechanisms of human cognition...
  12. pmc Metabolic changes in schizophrenia and human brain evolution
    Philipp Khaitovich
    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Yue Yang Road, Shanghai, 200031, PR China
    Genome Biol 9:R124. 2008
    ....
  13. pmc Transcriptional neoteny in the human brain
    Mehmet Somel
    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Proc Natl Acad Sci U S A 106:5743-8. 2009
    ..This delay is not uniform across the human transcriptome but affects a specific subset of genes that play a potential role in neural development...
  14. pmc Evolution of human longevity uncoupled from caloric restriction mechanisms
    Guodong Zhao
    CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China Graduate School of Chinese Academy of Sciences, Beijing, China
    PLoS ONE 9:e84117. 2014
    ..Consequently, application of CR or CR-mimicking agents may yet offer a promising direction for the extension of healthy human lifespan. ..
  15. ncbi request reprint Identifying genes underlying skin pigmentation differences among human populations
    Sean Myles
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Hum Genet 120:613-21. 2007
    ..Moreover, our analyses suggest that it is likely that different genes are responsible for the lighter skin pigmentation found in different non-African populations...