Research Topics
| Mehmet SomelSummaryAffiliation: Max Planck Institute for Evolutionary Anthropology Country: Germany Publications
| Collaborators
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Detail Information
Publications
MicroRNA, mRNA, and protein expression link development and aging in human and macaque brainMehmet Somel
Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Genome Res 20:1207-18. 2010..These results suggest a direct link between developmental regulation and expression changes taking place in aging...- Human and chimpanzee gene expression differences replicated in mice fed different dietsMehmet Somel
Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
PLoS ONE 3:e1504. 2008..Our results suggest that the mouse can be used to study at least some aspects of human-specific traits... - Extension of cortical synaptic development distinguishes humans from chimpanzees and macaquesXiling Liu
Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, 200031 Shanghai, China
Genome Res 22:611-22. 2012..Evolutionarily, this change may have taken place after the split of the human and the Neanderthal lineages... - MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primatesMehmet Somel
Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China
PLoS Biol 9:e1001214. 2011.... - Development and application of a modified dynamic time warping algorithm (DTW-S) to analyses of primate brain expression time seriesYuan Yuan
Key Laboratory for Computational Biology, CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
BMC Bioinformatics 12:347. 2011..While many powerful computation tools for time series alignment have been developed, they do not provide significance estimates for time shift measurements... - Mechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional contentKai Weng
Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China
PLoS ONE 7:e43915. 2012..Here, we addressed this question by investigating whether the gene expression response observed in mice fed human and chimpanzee diets involves the same regulatory mechanisms as expression differences between humans and chimpanzees... - Intergenic and repeat transcription in human, chimpanzee and macaque brains measured by RNA-SeqAugix Guohua Xu
Partner Institute for Computational Biology, Shanghai, China
PLoS Comput Biol 6:e1000843. 2010..Some of these transcripts may play roles in transcriptional regulation and contribute to evolution of human-specific phenotypic traits... - Rapid metabolic evolution in human prefrontal cortexXing Fu
Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, 200031 Shanghai, China
Proc Natl Acad Sci U S A 108:6181-6. 2011..These human-specific metabolic changes are paralleled by changes in expression patterns of the corresponding enzymes, and affect pathways involved in synaptic transmission, memory, and learning... - Accelerated aging-related transcriptome changes in the female prefrontal cortexYuan Yuan
Key Laboratory for Computational Biology, CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
Aging Cell 11:894-901. 2012..Accelerated aging-related changes in the female SFG transcriptome may provide a link between a higher stress exposure or sensitivity in women and the higher prevalence of AD... 
Human brain evolution: transcripts, metabolites and their regulatorsMehmet Somel
1 CAS Key Laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai, 200031, China 2 Department of Integrative Biology, University of California Berkeley, Berkeley, California 94820, USA
Nat Rev Neurosci 14:112-27. 2013..In this Review we show how this strategy has yielded some of the first hints about the mechanisms of human cognition...- Widespread splicing changes in human brain development and agingPavel Mazin
Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China
Mol Syst Biol 9:633. 2013..More than 60% of all splicing changes represented a single splicing pattern reflecting preferential inclusion of gene segments potentially targeting transcripts for nonsense-mediated decay in infants and elderly... - Metabolic changes in schizophrenia and human brain evolutionPhilipp Khaitovich
Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Yue Yang Road, Shanghai, 200031, PR China
Genome Biol 9:R124. 2008.... - Transcriptional neoteny in the human brainMehmet Somel
Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
Proc Natl Acad Sci U S A 106:5743-8. 2009..This delay is not uniform across the human transcriptome but affects a specific subset of genes that play a potential role in neural development... 
Identifying genes underlying skin pigmentation differences among human populationsSean Myles
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Hum Genet 120:613-21. 2007..Moreover, our analyses suggest that it is likely that different genes are responsible for the lighter skin pigmentation found in different non-African populations...