Affiliation: Max Planck Institute for Experimental Medicine
Prukop T, Epplen D, Nientiedt T, Wichert S, Fledrich R, Stassart R, et al. Progesterone antagonist therapy in a Pelizaeus-Merzbacher mouse model. Am J Hum Genet. 2014;94:533-46 pubmed publisher
..Microarray analysis revealed the upregulation of proapoptotic genes in PMD mice that could be partially rescued by Lonaprisan treatment, which also reduced microgliosis, astrogliosis, and lymphocyte infiltration. ..
Fledrich R, Abdelaal T, Rasch L, Bansal V, Schütza V, Brugger B, et al. Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy. Nat Commun. 2018;9:3025 pubmed publisher
..We propose that lipid supplementation is an easily translatable potential therapeutic approach in CMT1A and possibly other dysmyelinating neuropathies. ..