Sebastian H Scharf

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. doi request reprint Chronic social stress during adolescence: interplay of paroxetine treatment and ageing
    Sebastian H Scharf
    RG Molecular Stress Physiology, Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Neuropharmacology 72:38-46. 2013
  2. doi request reprint Animal models of stress vulnerability and resilience in translational research
    Sebastian H Scharf
    Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804, Munich, Germany
    Curr Psychiatry Rep 14:159-65. 2012
  3. pmc Expression and regulation of the Fkbp5 gene in the adult mouse brain
    Sebastian H Scharf
    Research Group Molecular Stress Physiology, Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 6:e16883. 2011
  4. doi request reprint Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss
    Xiao Dong Wang
    Max Planck Institute of Psychiatry, Munich, Germany
    Nat Neurosci 16:706-13. 2013
  5. doi request reprint The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress
    Jakob Hartmann
    Max Planck Institute of Psychiatry, RG Neurobiology of Stress, Kraepelinstr 2 10, 80804 Munich, Germany
    Neuropharmacology 62:332-9. 2012
  6. doi request reprint Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice
    Jakob Hartmann
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 37:2009-21. 2012
  7. pmc Differences in FKBP51 regulation following chronic social defeat stress correlate with individual stress sensitivity: influence of paroxetine treatment
    Klaus V Wagner
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 37:2797-808. 2012
  8. pmc Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits
    Xiao Dong Wang
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 31:13625-34. 2011
  9. ncbi request reprint Evidence supporting the match/mismatch hypothesis of psychiatric disorders
    Sara Santarelli
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany Electronic address
    Eur Neuropsychopharmacol 24:907-18. 2014
  10. pmc Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling
    Xiao Dong Wang
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Neurobiol Dis 42:300-10. 2011

Collaborators

Detail Information

Publications14

  1. doi request reprint Chronic social stress during adolescence: interplay of paroxetine treatment and ageing
    Sebastian H Scharf
    RG Molecular Stress Physiology, Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Neuropharmacology 72:38-46. 2013
    ..Our results demonstrate that chronic stress exposure and antidepressant treatment at the end of the developmental period can have a significant and long-lasting impact, highly relevant for healthy ageing...
  2. doi request reprint Animal models of stress vulnerability and resilience in translational research
    Sebastian H Scharf
    Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804, Munich, Germany
    Curr Psychiatry Rep 14:159-65. 2012
    ..Herein we review recent animal models of stress vulnerability and resilience, with special attention devoted to the readout parameters and the potential for translatability of the results...
  3. pmc Expression and regulation of the Fkbp5 gene in the adult mouse brain
    Sebastian H Scharf
    Research Group Molecular Stress Physiology, Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 6:e16883. 2011
    ....
  4. doi request reprint Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss
    Xiao Dong Wang
    Max Planck Institute of Psychiatry, Munich, Germany
    Nat Neurosci 16:706-13. 2013
    ..Our findings suggest that hippocampal nectin-3 is necessary for the effects of stress on memory and structural plasticity and indicate that the CRH-CRHR1 system interacts with the nectin-afadin complex to mediate such effects...
  5. doi request reprint The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress
    Jakob Hartmann
    Max Planck Institute of Psychiatry, RG Neurobiology of Stress, Kraepelinstr 2 10, 80804 Munich, Germany
    Neuropharmacology 62:332-9. 2012
    ..These results suggest an enhanced negative glucocorticoid feedback within the HPA axis of 51KO mice, possibly modulated by an increased sensitivity of the GR. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  6. doi request reprint Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice
    Jakob Hartmann
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 37:2009-21. 2012
    ..These contrasting results are in line with previous reports showing that FKBP52 is not involved in all branches of GR signaling, but rather acts in a gene-specific manner to regulate GR transcriptional activation...
  7. pmc Differences in FKBP51 regulation following chronic social defeat stress correlate with individual stress sensitivity: influence of paroxetine treatment
    Klaus V Wagner
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 37:2797-808. 2012
    ..These findings strongly support the concept of FKBP51 as a marker for glucocorticoid receptor sensitivity and its involvement in the development of psychiatric disorders...
  8. pmc Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits
    Xiao Dong Wang
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 31:13625-34. 2011
    ....
  9. ncbi request reprint Evidence supporting the match/mismatch hypothesis of psychiatric disorders
    Sara Santarelli
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany Electronic address
    Eur Neuropsychopharmacol 24:907-18. 2014
    ..These results further support the match/mismatch hypothesis and illustrate how mild or moderate aversive conditions during development can shape an individual to be optimally adapted to similar conditions later in life. ..
  10. pmc Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling
    Xiao Dong Wang
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Neurobiol Dis 42:300-10. 2011
    ..These findings underscore the important role of forebrain CRH-CRHR1 signaling in modulating chronic stress-induced cognitive, structural and molecular adaptations, with implications for stress-related psychiatric disorders...
  11. ncbi request reprint A polymorphism in the crhr1 gene determines stress vulnerability in male mice
    Christiana Labermaier
    Max Planck Institute of Psychiatry C L, C K, J H, C D, A A, P W, J A, C Q, K V W, S H S, L C, R W A, J B, R L, F H, M U, F H, E B B, M V S, 80804 Munich, Germany Lundbeck Research USA K A J, Paramus, New Jersey 07652 and Johannes Gutenberg University Medical Center M B M, 55131 Mainz, Germany
    Endocrinology 155:2500-10. 2014
    ..Our results suggest that patients with a specific genetic predisposition in the CRHR1 gene together with an exposure to chronic stress may benefit from a treatment selectively antagonizing CRHR1 hyperactivity. ..
  12. doi request reprint Pituitary glucocorticoid receptor deletion reduces vulnerability to chronic stress
    Klaus V Wagner
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychoneuroendocrinology 36:579-87. 2011
    ....
  13. doi request reprint Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus
    Mathias V Schmidt
    Research Group Neurobiology of Stress, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 30:16949-58. 2010
    ..Those individual differences can be predicted by the assessment of short-term memory, thereby opening up the possibility for a specific treatment by enhancing AMPA receptor function...
  14. pmc Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition
    Mathias V Schmidt
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Proc Natl Acad Sci U S A 108:17213-8. 2011
    ..DRR1 emerges as a protein to link stress with actin dynamics, which in addition is able to act on synaptic function and cognition...