J M Reul

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. ncbi request reprint New mode of hypothalamic-pituitary-adrenocortical axis regulation: significance for stress-related disorders
    J M Reul
    Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, Kraepelinstrasse 2, 80804 Munich, Germany
    Z Rheumatol 59:II/22-5. 2000
  2. ncbi request reprint The brain mineralocorticoid receptor: greedy for ligand, mysterious in function
    J M Reul
    Section of Neuropsychopharmacology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804, Munich, Germany
    Eur J Pharmacol 405:235-49. 2000
  3. ncbi request reprint Altered neuroimmunoendocrine communication during a condition of chronically increased brain corticotropin-releasing hormone drive
    J M Reul
    Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany
    Ann N Y Acad Sci 840:444-55. 1998
  4. ncbi request reprint Increased stress-induced adrenocorticotropin response after long-term intracerebroventricular treatment of rats with antisense mineralocorticoid receptor oligodeoxynucleotides
    J M Reul
    Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany
    Neuroendocrinology 65:189-99. 1997
  5. ncbi request reprint Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression
    Johannes M H M Reul
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804, Munich, Germany
    Curr Opin Pharmacol 2:23-33. 2002
  6. ncbi request reprint Psychological stress increases hippocampal mineralocorticoid receptor levels: involvement of corticotropin-releasing hormone
    A Gesing
    Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, 80804 Munich, Germany
    J Neurosci 21:4822-9. 2001
  7. ncbi request reprint Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2
    J Preil
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Endocrinology 142:4946-55. 2001
  8. ncbi request reprint Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice
    A C Linthorst
    Max Planck Institute of Psychiatry, Section Neuropsychopharmacology, Kraepelinstrasse 2, D 80804 Munich, Germany
    Eur J Neurosci 12:283-91. 2000
  9. ncbi request reprint Brain neurotransmission during peripheral inflammation
    A C Linthorst
    Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany
    Ann N Y Acad Sci 840:139-52. 1998
  10. ncbi request reprint Disease progression in chronic relapsing experimental allergic encephalomyelitis is associated with reduced inflammation-driven production of corticosterone
    A Stefferl
    Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, D-80804 Munich, Germany
    Endocrinology 142:3616-24. 2001

Collaborators

Detail Information

Publications34

  1. ncbi request reprint New mode of hypothalamic-pituitary-adrenocortical axis regulation: significance for stress-related disorders
    J M Reul
    Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, Kraepelinstrasse 2, 80804 Munich, Germany
    Z Rheumatol 59:II/22-5. 2000
    ..This novel mechanism may be of significance for increasing our understanding of the etiology of stress-related disorders...
  2. ncbi request reprint The brain mineralocorticoid receptor: greedy for ligand, mysterious in function
    J M Reul
    Section of Neuropsychopharmacology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804, Munich, Germany
    Eur J Pharmacol 405:235-49. 2000
    ....
  3. ncbi request reprint Altered neuroimmunoendocrine communication during a condition of chronically increased brain corticotropin-releasing hormone drive
    J M Reul
    Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany
    Ann N Y Acad Sci 840:444-55. 1998
    ..These observations provide evidence that chronic CRH hypersecretion is an important factor in the etiology of stress-related disorders...
  4. ncbi request reprint Increased stress-induced adrenocorticotropin response after long-term intracerebroventricular treatment of rats with antisense mineralocorticoid receptor oligodeoxynucleotides
    J M Reul
    Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany
    Neuroendocrinology 65:189-99. 1997
    ..In conclusion, down-regulation of the brain MR produces an enhanced responsiveness of ACTH to stressful situations which appears to be accompanied by a reduced sensitivity of the adrenal gland to ACTH...
  5. ncbi request reprint Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression
    Johannes M H M Reul
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804, Munich, Germany
    Curr Opin Pharmacol 2:23-33. 2002
    ..Thus, CRF, the urocortins and their receptors form an intricate network in the brain involved in the acute phase as well as the recovery phase of the stress response...
  6. ncbi request reprint Psychological stress increases hippocampal mineralocorticoid receptor levels: involvement of corticotropin-releasing hormone
    A Gesing
    Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, 80804 Munich, Germany
    J Neurosci 21:4822-9. 2001
    ..We conclude that the interaction between CRH and MR presents a novel mechanism involved in the adaptation of the brain to psychologically stressful events...
  7. ncbi request reprint Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2
    J Preil
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Endocrinology 142:4946-55. 2001
    ..Within the intraadrenal CRH/ACTH system, our data suggest different roles for CRHR1 and CRHR2 in fine-tuning of adrenocortical corticosterone release...
  8. ncbi request reprint Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice
    A C Linthorst
    Max Planck Institute of Psychiatry, Section Neuropsychopharmacology, Kraepelinstrasse 2, D 80804 Munich, Germany
    Eur J Neurosci 12:283-91. 2000
    ..Moreover, long-term impaired functioning of GR evolves in hyper-responsiveness of the raphe-hippocampal serotonergic system...
  9. ncbi request reprint Brain neurotransmission during peripheral inflammation
    A C Linthorst
    Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany
    Ann N Y Acad Sci 840:139-52. 1998
    ....
  10. ncbi request reprint Disease progression in chronic relapsing experimental allergic encephalomyelitis is associated with reduced inflammation-driven production of corticosterone
    A Stefferl
    Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, D-80804 Munich, Germany
    Endocrinology 142:3616-24. 2001
    ....
  11. ncbi request reprint Bidirectional effects of corticosterone on splenic T-cell activation: critical role of cell density and culture time
    G J Wiegers
    Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, Munich, Germany
    Neuroendocrinology 73:139-48. 2001
    ..e. 'high' cell density), a situation likely to be present in vivo, for instance in lymph nodes. Thus, these findings are relevant to our understanding of the glucocorticoid control of immune function...
  12. ncbi request reprint Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS
    T Trapp
    Max Planck Institute of Psychiatry, Department of Neuroendocrinology Munich, Germany
    Neuron 13:1457-62. 1994
    ..Our findings demonstrate that heterodimerization of MR and GR is a hitherto unrecognized principle for the transcriptional regulation of glucocorticoid-responsive genes in tissue coexpressing these receptors...
  13. ncbi request reprint Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
    P Timpl
    Max Planck Institute of Psychiatry, Munich, Germany
    Nat Genet 19:162-6. 1998
    ..Our results demonstrate a key role of the Crhr1 receptor in mediating the stress response and anxiety-related behaviour...
  14. ncbi request reprint Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders
    Martin E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
    Neuropsychopharmacology 26:94-105. 2002
    ....
  15. ncbi request reprint The selective glucocorticoid receptor antagonist ORG 34116 decreases immobility time in the forced swim test and affects cAMP-responsive element-binding protein phosphorylation in rat brain
    Cornelius G Bachmann
    Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, Munich, Germany
    Neuroendocrinology 81:129-36. 2005
    ....
  16. ncbi request reprint Psychological stress increases histone H3 phosphorylation in adult dentate gyrus granule neurons: involvement in a glucocorticoid receptor-dependent behavioural response
    Alicia Bilang-Bleuel
    Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, Munich, Germany
    Eur J Neurosci 22:1691-700. 2005
    ....
  17. ncbi request reprint Novelty stress induces phospho-acetylation of histone H3 in rat dentate gyrus granule neurons through coincident signalling via the N-methyl-D-aspartate receptor and the glucocorticoid receptor: relevance for c-fos induction
    Yalini Chandramohan
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
    J Neurochem 101:815-28. 2007
    ..Thus, novelty stress induces chromatin remodelling and c-fos induction in mature dentate neurons through concurrent signalling via the NMDA receptor and the glucocorticoid receptor...
  18. ncbi request reprint Voluntary exercise impacts on the rat hypothalamic-pituitary-adrenocortical axis mainly at the adrenal level
    Susanne K Droste
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Bristol, UK
    Neuroendocrinology 86:26-37. 2007
    ..Evidence is accumulating that the regular performance of exercise is beneficial for stress coping. However, the hypothalamic-pituitary-adrenocortical (HPA) axis of voluntarily exercising rats has never been comprehensively investigated...
  19. ncbi request reprint Water temperature determines neurochemical and behavioural responses to forced swim stress: an in vivo microdialysis and biotelemetry study in rats
    Astrid C E Linthorst
    Section of Neurochemistry, Max Planck Institute of Psychiatry, Munich, Germany
    Stress 11:88-100. 2008
    ....
  20. doi request reprint Corticosterone levels in the brain show a distinct ultradian rhythm but a delayed response to forced swim stress
    Susanne K Droste
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Clinical Science South Bristol, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, United Kingdom
    Endocrinology 149:3244-53. 2008
    ..These data are the first to demonstrate that the ultradian rhythm of corticosterone is maintained over the blood-brain barrier and that tissue responses cannot be reliably predicted from the measurement of plasma corticosterone levels...
  21. ncbi request reprint The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-D-aspartate/extracellular signal-regulated kinase/mitogen- and stress-a
    Yalini Chandramohan
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
    Eur J Neurosci 27:2701-13. 2008
    ..We conclude that the forced swimming-induced behavioural immobility response requires histone H3 phospho-acetylation and c-Fos induction in distinct dentate granule neurons through recruitment of the NMDA/ERK/MSK 1/2 pathway...
  22. ncbi request reprint Differential monoaminergic, neuroendocrine and behavioural responses after central administration of corticotropin-releasing factor receptor type 1 and type 2 agonists
    Lotte De Groote
    Max Planck Institute of Psychiatry, Section of Neurochemistry, Munich, Germany
    J Neurochem 94:45-56. 2005
    ....
  23. ncbi request reprint Effect of sleep and sleep deprivation on serotonergic neurotransmission in the hippocampus: a combined in vivo microdialysis/EEG study in rats
    Rosana G Peñalva
    Max Planck Institute of Psychiatry, Section of Neurochemistry, Kraepelinstrasse 2, D 80804 Munich, Germany
    Eur J Neurosci 17:1896-906. 2003
    ..We hypothesize that the elevated hippocampal 5-HT levels during SD may participate in the transient mood enhancing properties of forced wakefulness observed in depressed patients...
  24. ncbi request reprint Influence of regular voluntary exercise on spontaneous and social stress-affected sleep in mice
    Marike Lancel
    Section of Sleep Pharmacology, Max Planck Institute of Psychiatry, Kraeplinstrasse 2, D 80804 Munich, Germany
    Eur J Neurosci 17:2171-9. 2003
    ..In conclusion, regular exercise appears to increase sleep quality and reverses the effects of mild social stress on rapid-eye-movement sleep...
  25. ncbi request reprint Long-term in vivo administration of glucocorticoid hormones attenuates their capacity to accelerate in vitro proliferation of rat splenic T cells
    Philipp Sterzer
    Max Planck Institute of Psychiatry, Munich, Germany
    Endocrinology 145:3630-8. 2004
    ..We conclude that the attenuated acceleration of T cell proliferation after long-term exposure to elevated glucocorticoid levels may underlie the well-known impairment of immune function under chronic stress...
  26. ncbi request reprint Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress
    Marianne B Muller
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, Munich 80804, Germany
    Nat Neurosci 6:1100-7. 2003
    ..Furthermore, we provide evidence for a new role of limbic Crhr1 in neuroendocrine adaptation to stress...
  27. ncbi request reprint Altered serotonergic neurotransmission but normal hypothalamic-pituitary-adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775
    Akihiko Oshima
    Max Planck Institute of Psychiatry, Sections of Neurochemistry and Neuropsychopharmacology, Munich, Germany
    Neuropsychopharmacology 28:2148-59. 2003
    ..Owing to the important role of 5-HT in the pathophysiology of mood and anxiety disorders, the latter observation may contribute to the therapeutical efficacy of CRH-R1 antagonists in these illnesses...
  28. ncbi request reprint Effects of long-term voluntary exercise on the mouse hypothalamic-pituitary-adrenocortical axis
    Susanne K Droste
    Section of Neuropsychopharmacology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2, D 80804 Munich, Germany
    Endocrinology 144:3012-23. 2003
    ..These changes seem to underlie the differential responsiveness of the HPA axis to physical vs. emotional challenges...
  29. ncbi request reprint Effect of chronic administration of selective glucocorticoid receptor antagonists on the rat hypothalamic-pituitary-adrenocortical axis
    Cornelius G Bachmann
    Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, Munich, Germany
    Neuropsychopharmacology 28:1056-67. 2003
    ..Thus, the GR antagonists exert distinct effects on the HPA axis, which may be pertinent for the proposed antidepressant activity of these compounds...
  30. ncbi request reprint Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin-releasing hormone receptor-dependent mechanism
    Astrid C E Linthorst
    Max Planck Institute of Psychiatry, Section of Neurochemistry, Kraepelinstrasse 2, D 80804 Munich, Germany
    Eur J Neurosci 16:2441-52. 2002
    ....
  31. ncbi request reprint Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient mice
    Damian Refojo
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Biologia, Facultad de Ciencias Exactas y Naturales FCEN, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon II, C1428EHA, Buenos Aires, Argentina
    J Neuroimmunol 131:126-34. 2002
    ..These results are consistent with a postulated inhibitory role of endogenous beta-endorphin on the immune system at multiple levels...
  32. pmc Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas
    Damian Refojo
    Departamento Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Laboratorio de Fisiologia y Biologia Molecular, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
    Proc Natl Acad Sci U S A 102:6183-8. 2005
    ..These findings underscore the fact that CRH activates p-ERK1/2 through CRHR1 only in selected brain regions, pointing to a specific role of this pathway in mediating behavioral adaptation to stress...
  33. ncbi request reprint Regular voluntary exercise reduces anxiety-related behaviour and impulsiveness in mice
    Elke Binder
    Section of Behavioral Phenotyping, Max Planck Institute of Psychiatry, Munich D 80804, Germany
    Behav Brain Res 155:197-206. 2004
    ..Thus, our observations fit into the concept that regular exercise strengthens endogenous stress coping mechanisms, thereby protecting the organism against the deleterious effects of stress...