Research Topics
Genomes and Genes | G RammesSummaryAffiliation: Max Planck Institute of Psychiatry Country: Germany Publications
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Publications
Expression of early hippocampal CA1 LTP does not lead to changes in AMPA-EPSC kinetics or sensitivity to cyclothiazideG Rammes
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, D 91054 Erlangen, Germany
Pflugers Arch 437:191-6. 1999..Our findings argue against changes in (de-)activation or desensitization of AMPA receptors as the molecular basis for the expression of LTP...
The fraction of activated N-methyl-D-aspartate receptors during synaptic transmission remains constant in the presence of the glutamate release inhibitor riluzoleG Rammes
Clinical Neuropharmacology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804, Munich, Germany
J Neural Transm 115:1119-26. 2008..It is therefore likely that NMDA receptor antagonists would be able to exert additional therapeutic effects in combination therapy with GRIs...
Isoflurane anaesthesia reversibly improves cognitive function and long-term potentiation (LTP) via an up-regulation in NMDA receptor 2B subunit expressionGerhard Rammes
Department of Anaesthesiology, Technische Universitat Munchen, D 81675 Munich, Germany
Neuropharmacology 56:626-36. 2009..The present data suggests that isoflurane anaesthesia induces a hippocampus-specific elevation of NR2B subunit composition, enhances LTP in CA1 neurones, and produces hippocampal-dependent cognitive improvement...- Neramexane (merz pharmaceuticals/forest laboratories)Gerhard Rammes
Clinical Neuropharmacology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
IDrugs 9:128-35. 2006.... - Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptorsGerhard Rammes
Max Planck Institute of Psychiatry, Munich, Germany
PLoS ONE 4:e6715. 2009..8-13.4 nM). Thus, individual differences in the primary sequence of 5-HT(3) receptors may be crucial for the antipsychotic potency and/or the side effect profile of clozapine... - Modulation of ligand-gated ion channels by antidepressants and antipsychoticsGerhard Rammes
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, 80804, Germany
Mol Neurobiol 35:160-74. 2007..In this review, we focus on the direct interaction of antidepressants and antipsychotics with LGICs, which may provide a basis for the development of novel psychopharmacological drugs... - Long-term depression in the basolateral amygdala of the mouse involves the activation of interneuronsG Rammes
Max Planck Institute of Psychiatry, Munich, Germany
Neuroscience 107:85-97. 2001..A synopsis of these findings suggests a pivotal role of GABAergic interneurons and serotonergic afferents in the induction of LTD in the basolateral nucleus of the amygdala... - The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801G Rammes
Clinical Neuropharmacology, Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
Neuropharmacology 40:749-60. 2001.... - Synaptic plasticity in the basolateral amygdala in transgenic mice expressing dominant-negative cAMP response element-binding protein (CREB) in forebrainG Rammes
Max Planck Institute of Psychiatry, Munchen, Germany
Eur J Neurosci 12:2534-46. 2000..These results could suggest that residual CREB activity was still present or that CREB per se is dispensable. Alternatively, other CREB-like proteins were able to compensate for impaired CREB function... - The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive mannerG Rammes
Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, D 80804, Munchen, Germany
Neurosci Lett 306:81-4. 2001.... - Isoflurane slows inactivation kinetics of rat recombinant alpha1beta2gamma2L GABA(A) receptors: enhancement of GABAergic transmission despite an open-channel blockG Hapfelmeier
Department of Anesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
Neurosci Lett 307:97-100. 2001..Under these conditions, ISO increases the GABA-induced charge transfer and, thus, could enhance GABAergic inhibition despite the concomitant open-channel block causing the decrease in the current amplitude... - Antipsychotic drugs antagonize human serotonin type 3 receptor currents in a noncompetitive mannerG Rammes
Max-Planck-Institute of Psychiatry, Munich, Germany
Mol Psychiatry 9:846-58, 818. 2004.... - Isoflurane blocks synaptic plasticity in the mouse hippocampusW Simon
Max-Planck-Institute of Psychiatry, Munich, Germany
Anesthesiology 94:1058-65. 2001..An impairment of these processes may be a cause for the transient loss of recall and cognitive impairment after anesthesia in juvenile and adult brains... - Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptorB Eisensamer
Max-Planck-Institute of Psychiatry, Munich, Germany
Mol Psychiatry 8:994-1007. 2003..In conclusion, structurally different types of antidepressants modulate the function of this ligand-gated ion channel. This may represent a yet unrecognized pharmacological principle of antidepressants... - The endogenous cannabinoid system controls extinction of aversive memoriesGiovanni Marsicano
Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Nature 418:530-4. 2002..We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala... - Altered synaptic plasticity and behavioral abnormalities in CNGA3-deficient miceS Michalakis
Munich Center for Integrated Protein Science, Department of Pharmacy Center for Drug Research, Ludwig Maximilians Universitat Munchen, Butenandstrasse 5 13, Munich, Germany
Genes Brain Behav 10:137-48. 2011..Despite the dissociation between physiological and behavioral parameters, our data describe a so far unrecognized role of CNGA3 in modulation of hippocampal plasticity and amygdala-dependent fear memory... - Activation of CB1 specifically located on GABAergic interneurons inhibits LTD in the lateral amygdalaShahnaz Christina Azad
Max Planck Institute of Psychiatry, Clinical Neuropharmacology, 80804 Munich, Germany
Learn Mem 15:143-52. 2008..These findings suggest that CB1 expressed on either glutamatergic or GABAergic neurons play a differential role in the control of synaptic transmission and plasticity... - Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticityAnja Schierloh
Clinical Neuropharmacology, Max Planck Institute of Psychiatry, Kraepelinstr 2 10, Munich, Germany
Neurosci Lett 416:82-6. 2007.... - GABA(A) and GABA(B) receptors on neocortical neurons are differentially distributedM Eder
Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
Eur J Neurosci 13:1065-9. 2001..Such a specific distribution of GABA(A) and GABA(B) receptors may serve to compensate for differences in electrotonic voltage attenuation between GABA(A) and GABA(B) receptor-mediated inhibitory postsynaptic potentials (IPSPs)... - Nitrous oxide (N2O) pre- and postsynaptically attenuates NMDA receptor-mediated neurotransmission in the amygdalaAndreas Ranft
Klinische Neuropharmakologie, Max Planck Institut fur Psychiatrie, Munchen, Germany
Neuropharmacology 52:716-23. 2007..It is conceivable that these effects not only contribute to anaesthesia and anxiolysis, but also have bearings on learning and memory as well as excitotoxicity in the amygdala... - GABA(A) receptor activation and open-channel block by volatile anaesthetics: a new principle of receptor modulation?Rainer Haseneder
Department of Anaesthesiology, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
Eur J Pharmacol 451:43-50. 2002..Open-channel blocks might also be operative in other ligand-gated ion channels to modulate synaptic strength... - Co-expression of the 5-HT3B serotonin receptor subunit alters the biophysics of the 5-HT3 receptorG Hapfelmeier
Department of Anaesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
Biophys J 84:1720-33. 2003.... - Effects of the monoamine oxidase A inhibitor moclobemide on hippocampal plasticity in GR-impaired transgenic miceT Steckler
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804, Munich, Germany
J Psychiatr Res 35:29-42. 2001.... - Activation of kappa opioid receptors decreases synaptic transmission and inhibits long-term potentiation in the basolateral amygdala of the mouseVolker Huge
Clinical Neuropharmacology Group, Max Planck Institut fur Psychiatrie, Kraepelinstrasse 2 10, 80804 Munich, Germany
Eur J Pain 13:124-9. 2009..The role of kappa opioid receptors in these pain conditions is only partly known. The present study investigates the effect of kappa receptor activation on synaptic transmission and synaptic plasticity in the amygdala... - Activation of mGlu receptors induces LTD without affecting postsynaptic sensitivity of CA1 neurons in rat hippocampal slicesGerhard Rammes
Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
J Physiol 546:455-60. 2003..These data do not support the notion that DHPG-induced LTD requires a modification of AMPA receptors, such as their internalisation, but are compatible with a presynaptic mechanism of expression... - Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient miceRudolph Marsch
Max Planck Institute of Psychiatry, D 80804 Munich, Germany
J Neurosci 27:832-9. 2007..Our data provide first evidence for fear-promoting effects of TRPV1 with respect to both innate and conditioned fear and for a decisive role of this receptor in synaptic plasticity... - Cannabinoid receptor type 1 located on presynaptic terminals of principal neurons in the forebrain controls glutamatergic synaptic transmissionMaria R Domenici
Department of Clinical Neuropharmacology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
J Neurosci 26:5794-9. 2006..The present data strongly indicate that excitatory synaptic transmission in forebrain areas is directly modulated by CB1 expressed on presynaptic axon terminals originating from glutamatergic neurons... - Alpha-thujone reduces 5-HT3 receptor activity by an effect on the agonist-reduced desensitizationT Deiml
Department of Psychiatry, , Munich, Germany
Neuropharmacology 46:192-201. 2004..It remains to be shown if this inhibitory action on serotonergic responses contributes to behavioral effects of alpha-thujone... - [Endogenous cannabinoid system. Effect on neuronal plasticity and pain memory]S C Azad
Abt Klinische Neuropharmakologie, Max Planck Institut für Psychiatrie München
Schmerz 19:521-7. 2005..The aim of this study was to evaluate the role of the endogenous cannabinoid system in controlling neuroplasticity... - Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptorsInge Sillaber
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Science 296:931-3. 2002..Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism... - Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressantsCaroline Nothdurfter
Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
Neuropsychopharmacology 35:1510-9. 2010.... - Isoflurane and sevoflurane dose-dependently impair hippocampal long-term potentiationRainer Haseneder
Department of Anaesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
Eur J Pharmacol 623:47-51. 2009..7-fold (1.7- and 2.2-fold) MAC, LTP was blocked. Our results indicate, that both anaesthetics influence synaptic strength to a similar degree, with only high concentrations blocking hippocampal CA1 stratum radiatum long-term potentiation... - Cloned human and murine serotonin(3A) receptors expressed in human embryonic kidney 293 cells display different single-channel kineticsGerhard Hapfelmeier
Department of Anaesthesiology, Technische Universitat Munchen, Munich, Germany
Neurosci Lett 335:44-8. 2002..1+/-2.9 ms vs. 4.1+/-0.8 ms) indicating species-dependent gating mechanisms of 5-HT(3) receptors... - The xenon-mediated antagonism against the NMDA receptor is non-selective for receptors containing either NR2A or NR2B subunits in the mouse amygdalaRainer Haseneder
Department of Anaesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
Eur J Pharmacol 619:33-7. 2009..These results provide evidence, that the Xe-induced antagonism against NMDA receptors is non-selective against NR2A- or NR2B-containing receptors... - Chronic social stress during adolescence induces cognitive impairment in aged miceVera Sterlemann
Max Planck Institute of Psychiatry, Munich, Germany
Hippocampus 20:540-9. 2010..Taken together, our results identify possible molecular mechanisms underlying cognitive impairment during aging, demonstrating the detrimental impact of stress during adolescence on hippocampus-dependent cognitive function in aged mice... - Xenon attenuates excitatory synaptic transmission in the rodent prefrontal cortex and spinal cord dorsal hornRainer Haseneder
Department of Anesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
Anesthesiology 111:1297-307. 2009..In the current study, the authors examined the effects of xenon on synaptic transmission in the prefrontal cortex and the spinal cord dorsal horn (substantia gelatinosa)... - Activation of the cannabinoid receptor type 1 decreases glutamatergic and GABAergic synaptic transmission in the lateral amygdala of the mouseShahnaz Christina Azad
Max Planck Institute of Psychiatry, Clinical Neuropharmacology, Kraepelinstrasse 2 10, 80804 Munich, Germany
Learn Mem 10:116-28. 2003..Our results indicate that the mechanisms underlying cannabinoid action in the LA partly resemble those observed in the nucleus accumbens and differ from those described for the hippocampus... - Xenon reduces N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated synaptic transmission in the amygdalaRainer Haseneder
Department of Anesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse22, D 81675 Munich, Germany
Anesthesiology 109:998-1006. 2008..In the current study, the authors evaluated for the first time the effect of xenon on synaptic transmission in the basolateral amygdala in an in vitro brain slice preparation of the mouse... - Distribution and properties of functional postsynaptic kainate receptors on neocortical layer V pyramidal neuronsMatthias Eder
Clinical Neuropharmacology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
J Neurosci 23:6660-70. 2003..Furthermore, it is feasible to assume that extrasynaptic KARs could be activated by a "spillover" of synaptically released glutamate, ambient glutamate in the CSF, or glutamate released from adjacent astrocytes... - Isoflurane reduces glutamatergic transmission in neurons in the spinal cord superficial dorsal horn: evidence for a presynaptic site of an analgesic actionRainer Haseneder
Department of Anaesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Kraepelinstrasse 2 10, 80804 Munich, Germany
Anesth Analg 98:1718-23, table of contents. 2004..This effect may contribute to the anesthetic action of volatile anesthetics at the spinal cord level... - The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in miceShahnaz Christina Azad
Max Planck Institute of Psychiatry, Clinical Neuropharmacology, Kraepelinstrasse 2, 80804 München, Germany
Neurosci Lett 370:186-90. 2004..The observed effects on synaptic strength could underly the beneficial effects of flupirtine on different types of chronic pain... - Circuitry for associative plasticity in the amygdala involves endocannabinoid signalingShahnaz C Azad
Clinical Neuropharmacology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
J Neurosci 24:9953-61. 2004..This disinhibition increases the activity of common output neurons and could provide a prerequisite for extinction by formation of new memory... - Early life environment determines the development of adult phobic-like fear responses in BALB/cAnN miceC K Thoeringer
Max Planck Institute of Psychiatry, Technical University Munich, Munich, Germany
Genes Brain Behav 9:947-57. 2010.... - Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant responseK Ganea
Max Planck Institute of Psychiatry, Munich, Germany
Transl Psychiatry 2:e177. 2012..Further, our data suggest this pathway to be a target for more rapid-acting antidepressants in the future... - Translocator protein (18 kDa) as a target for novel anxiolytics with a favourable side-effect profileC Nothdurfter
Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
J Neuroendocrinol 24:82-92. 2012..In this review, we focus on the pathophysiology of anxiety disorders and TSPO ligands as a novel pharmacological approach in the treatment of these disorders... - Pharmacodynamics of memantine: an updateG Rammes
Clinical Neuropharmacology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
Curr Neuropharmacol 6:55-78. 2008..In addition, there has been further confirmation of the MOA of memantine as an uncompetitive NMDA receptor antagonist and essentially no data contradicting our understanding of the benign side effect profile of memantine... - Antidepressants and antipsychotic drugs colocalize with 5-HT3 receptors in raft-like domainsBrigitte Eisensamer
Max-Planck-Institute of Psychiatry, D-80804 Munich, Germany
J Neurosci 25:10198-206. 2005..In conclusion, enrichment of antidepressants and antipsychotics in raft-like domains within the cell membrane appears to be crucial for their antagonistic effects at ligand-gated ion channels such as 5-HT3 receptors...