G Rammes

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. doi request reprint Neramexane: a moderate-affinity NMDA receptor channel blocker: new prospects and indications
    Gerhard Rammes
    Max Planck Institute of Psychiatry, Clinical Neuropharmacology, Kraepelinstraße 2, 80804 München, Germany and Klinik rechts der Isar, Department of Anaesthesiology, Technische Universitat, 81675 Munich, Germany
    Expert Rev Clin Pharmacol 2:231-8. 2009
  2. ncbi request reprint Expression of early hippocampal CA1 LTP does not lead to changes in AMPA-EPSC kinetics or sensitivity to cyclothiazide
    G Rammes
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, D 91054 Erlangen, Germany
    Pflugers Arch 437:191-6. 1999
  3. ncbi request reprint Modulation of ligand-gated ion channels by antidepressants and antipsychotics
    Gerhard Rammes
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, 80804, Germany
    Mol Neurobiol 35:160-74. 2007
  4. pmc The fraction of activated N-methyl-D-aspartate receptors during synaptic transmission remains constant in the presence of the glutamate release inhibitor riluzole
    G Rammes
    Clinical Neuropharmacology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804, Munich, Germany
    J Neural Transm 115:1119-26. 2008
  5. doi request reprint Isoflurane anaesthesia reversibly improves cognitive function and long-term potentiation (LTP) via an up-regulation in NMDA receptor 2B subunit expression
    Gerhard Rammes
    Department of Anaesthesiology, Technische Universitat Munchen, D 81675 Munich, Germany
    Neuropharmacology 56:626-36. 2009
  6. ncbi request reprint Neramexane (merz pharmaceuticals/forest laboratories)
    Gerhard Rammes
    Clinical Neuropharmacology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    IDrugs 9:128-35. 2006
  7. pmc Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors
    Gerhard Rammes
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e6715. 2009
  8. ncbi request reprint Long-term depression in the basolateral amygdala of the mouse involves the activation of interneurons
    G Rammes
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuroscience 107:85-97. 2001
  9. ncbi request reprint Synaptic plasticity in the basolateral amygdala in transgenic mice expressing dominant-negative cAMP response element-binding protein (CREB) in forebrain
    G Rammes
    Max Planck Institute of Psychiatry, Munchen, Germany
    Eur J Neurosci 12:2534-46. 2000
  10. ncbi request reprint The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner
    G Rammes
    Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, D 80804, Munchen, Germany
    Neurosci Lett 306:81-4. 2001

Collaborators

Detail Information

Publications50

  1. doi request reprint Neramexane: a moderate-affinity NMDA receptor channel blocker: new prospects and indications
    Gerhard Rammes
    Max Planck Institute of Psychiatry, Clinical Neuropharmacology, Kraepelinstraße 2, 80804 München, Germany and Klinik rechts der Isar, Department of Anaesthesiology, Technische Universitat, 81675 Munich, Germany
    Expert Rev Clin Pharmacol 2:231-8. 2009
    ..Another promising application for neramexane as a neuroprotectant might be chronic neurodegeneration, such as Parkinson's disease, Huntington's disease, vascular dementia, frontal lobe dementia, Down's syndrome and AD. ..
  2. ncbi request reprint Expression of early hippocampal CA1 LTP does not lead to changes in AMPA-EPSC kinetics or sensitivity to cyclothiazide
    G Rammes
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, D 91054 Erlangen, Germany
    Pflugers Arch 437:191-6. 1999
    ..Our findings argue against changes in (de-)activation or desensitization of AMPA receptors as the molecular basis for the expression of LTP...
  3. ncbi request reprint Modulation of ligand-gated ion channels by antidepressants and antipsychotics
    Gerhard Rammes
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, 80804, Germany
    Mol Neurobiol 35:160-74. 2007
    ..In this review, we focus on the direct interaction of antidepressants and antipsychotics with LGICs, which may provide a basis for the development of novel psychopharmacological drugs...
  4. pmc The fraction of activated N-methyl-D-aspartate receptors during synaptic transmission remains constant in the presence of the glutamate release inhibitor riluzole
    G Rammes
    Clinical Neuropharmacology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804, Munich, Germany
    J Neural Transm 115:1119-26. 2008
    ..It is therefore likely that NMDA receptor antagonists would be able to exert additional therapeutic effects in combination therapy with GRIs...
  5. doi request reprint Isoflurane anaesthesia reversibly improves cognitive function and long-term potentiation (LTP) via an up-regulation in NMDA receptor 2B subunit expression
    Gerhard Rammes
    Department of Anaesthesiology, Technische Universitat Munchen, D 81675 Munich, Germany
    Neuropharmacology 56:626-36. 2009
    ..The present data suggests that isoflurane anaesthesia induces a hippocampus-specific elevation of NR2B subunit composition, enhances LTP in CA1 neurones, and produces hippocampal-dependent cognitive improvement...
  6. ncbi request reprint Neramexane (merz pharmaceuticals/forest laboratories)
    Gerhard Rammes
    Clinical Neuropharmacology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    IDrugs 9:128-35. 2006
    ....
  7. pmc Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors
    Gerhard Rammes
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e6715. 2009
    ..8-13.4 nM). Thus, individual differences in the primary sequence of 5-HT(3) receptors may be crucial for the antipsychotic potency and/or the side effect profile of clozapine...
  8. ncbi request reprint Long-term depression in the basolateral amygdala of the mouse involves the activation of interneurons
    G Rammes
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuroscience 107:85-97. 2001
    ..A synopsis of these findings suggests a pivotal role of GABAergic interneurons and serotonergic afferents in the induction of LTD in the basolateral nucleus of the amygdala...
  9. ncbi request reprint Synaptic plasticity in the basolateral amygdala in transgenic mice expressing dominant-negative cAMP response element-binding protein (CREB) in forebrain
    G Rammes
    Max Planck Institute of Psychiatry, Munchen, Germany
    Eur J Neurosci 12:2534-46. 2000
    ..These results could suggest that residual CREB activity was still present or that CREB per se is dispensable. Alternatively, other CREB-like proteins were able to compensate for impaired CREB function...
  10. ncbi request reprint The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner
    G Rammes
    Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, D 80804, Munchen, Germany
    Neurosci Lett 306:81-4. 2001
    ....
  11. ncbi request reprint The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801
    G Rammes
    Clinical Neuropharmacology, Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
    Neuropharmacology 40:749-60. 2001
    ....
  12. ncbi request reprint Isoflurane slows inactivation kinetics of rat recombinant alpha1beta2gamma2L GABA(A) receptors: enhancement of GABAergic transmission despite an open-channel block
    G Hapfelmeier
    Department of Anesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Neurosci Lett 307:97-100. 2001
    ..Under these conditions, ISO increases the GABA-induced charge transfer and, thus, could enhance GABAergic inhibition despite the concomitant open-channel block causing the decrease in the current amplitude...
  13. ncbi request reprint Antipsychotic drugs antagonize human serotonin type 3 receptor currents in a noncompetitive manner
    G Rammes
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 9:846-58, 818. 2004
    ....
  14. ncbi request reprint Alpha2-adrenoreceptor activation inhibits LTP and LTD in the basolateral amygdala: involvement of Gi/o-protein-mediated modulation of Ca2+-channels and inwardly rectifying K+-channels in LTD
    F DeBock
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 München, Germany
    Eur J Neurosci 17:1411-24. 2003
    ....
  15. ncbi request reprint Isoflurane blocks synaptic plasticity in the mouse hippocampus
    W Simon
    Max-Planck-Institute of Psychiatry, Munich, Germany
    Anesthesiology 94:1058-65. 2001
    ..An impairment of these processes may be a cause for the transient loss of recall and cognitive impairment after anesthesia in juvenile and adult brains...
  16. ncbi request reprint Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor
    B Eisensamer
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 8:994-1007. 2003
    ..In conclusion, structurally different types of antidepressants modulate the function of this ligand-gated ion channel. This may represent a yet unrecognized pharmacological principle of antidepressants...
  17. ncbi request reprint The endogenous cannabinoid system controls extinction of aversive memories
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Nature 418:530-4. 2002
    ..We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala...
  18. doi request reprint Altered synaptic plasticity and behavioral abnormalities in CNGA3-deficient mice
    S Michalakis
    Munich Center for Integrated Protein Science, Department of Pharmacy Center for Drug Research, Ludwig Maximilians Universitat Munchen, Butenandstrasse 5 13, Munich, Germany
    Genes Brain Behav 10:137-48. 2011
    ..Despite the dissociation between physiological and behavioral parameters, our data describe a so far unrecognized role of CNGA3 in modulation of hippocampal plasticity and amygdala-dependent fear memory...
  19. ncbi request reprint Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity
    Anja Schierloh
    Clinical Neuropharmacology, Max Planck Institute of Psychiatry, Kraepelinstr 2 10, Munich, Germany
    Neurosci Lett 416:82-6. 2007
    ....
  20. pmc Activation of CB1 specifically located on GABAergic interneurons inhibits LTD in the lateral amygdala
    Shahnaz Christina Azad
    Max Planck Institute of Psychiatry, Clinical Neuropharmacology, 80804 Munich, Germany
    Learn Mem 15:143-52. 2008
    ..These findings suggest that CB1 expressed on either glutamatergic or GABAergic neurons play a differential role in the control of synaptic transmission and plasticity...
  21. ncbi request reprint GABA(A) and GABA(B) receptors on neocortical neurons are differentially distributed
    M Eder
    Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    Eur J Neurosci 13:1065-9. 2001
    ..Such a specific distribution of GABA(A) and GABA(B) receptors may serve to compensate for differences in electrotonic voltage attenuation between GABA(A) and GABA(B) receptor-mediated inhibitory postsynaptic potentials (IPSPs)...
  22. ncbi request reprint Nitrous oxide (N2O) pre- and postsynaptically attenuates NMDA receptor-mediated neurotransmission in the amygdala
    Andreas Ranft
    Klinische Neuropharmakologie, Max Planck Institut fur Psychiatrie, Munchen, Germany
    Neuropharmacology 52:716-23. 2007
    ..It is conceivable that these effects not only contribute to anaesthesia and anxiolysis, but also have bearings on learning and memory as well as excitotoxicity in the amygdala...
  23. ncbi request reprint GABA(A) receptor activation and open-channel block by volatile anaesthetics: a new principle of receptor modulation?
    Rainer Haseneder
    Department of Anaesthesiology, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Eur J Pharmacol 451:43-50. 2002
    ..Open-channel blocks might also be operative in other ligand-gated ion channels to modulate synaptic strength...
  24. pmc Co-expression of the 5-HT3B serotonin receptor subunit alters the biophysics of the 5-HT3 receptor
    G Hapfelmeier
    Department of Anaesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Biophys J 84:1720-33. 2003
    ....
  25. doi request reprint Activation of kappa opioid receptors decreases synaptic transmission and inhibits long-term potentiation in the basolateral amygdala of the mouse
    Volker Huge
    Clinical Neuropharmacology Group, Max Planck Institut fur Psychiatrie, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Eur J Pain 13:124-9. 2009
    ..The role of kappa opioid receptors in these pain conditions is only partly known. The present study investigates the effect of kappa receptor activation on synaptic transmission and synaptic plasticity in the amygdala...
  26. pmc Activation of mGlu receptors induces LTD without affecting postsynaptic sensitivity of CA1 neurons in rat hippocampal slices
    Gerhard Rammes
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    J Physiol 546:455-60. 2003
    ..These data do not support the notion that DHPG-induced LTD requires a modification of AMPA receptors, such as their internalisation, but are compatible with a presynaptic mechanism of expression...
  27. ncbi request reprint Alpha-thujone reduces 5-HT3 receptor activity by an effect on the agonist-reduced desensitization
    T Deiml
    Department of Psychiatry, Ludwig Maximilians Universitat, Munich, Germany
    Neuropharmacology 46:192-201. 2004
    ..It remains to be shown if this inhibitory action on serotonergic responses contributes to behavioral effects of alpha-thujone...
  28. ncbi request reprint Effects of the monoamine oxidase A inhibitor moclobemide on hippocampal plasticity in GR-impaired transgenic mice
    T Steckler
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804, Munich, Germany
    J Psychiatr Res 35:29-42. 2001
    ....
  29. ncbi request reprint Cannabinoid receptor type 1 located on presynaptic terminals of principal neurons in the forebrain controls glutamatergic synaptic transmission
    Maria R Domenici
    Department of Clinical Neuropharmacology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 26:5794-9. 2006
    ..The present data strongly indicate that excitatory synaptic transmission in forebrain areas is directly modulated by CB1 expressed on presynaptic axon terminals originating from glutamatergic neurons...
  30. ncbi request reprint Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice
    Rudolph Marsch
    Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    J Neurosci 27:832-9. 2007
    ..Our data provide first evidence for fear-promoting effects of TRPV1 with respect to both innate and conditioned fear and for a decisive role of this receptor in synaptic plasticity...
  31. ncbi request reprint [Endogenous cannabinoid system. Effect on neuronal plasticity and pain memory]
    S C Azad
    Abt Klinische Neuropharmakologie, Max Planck Institut für Psychiatrie München
    Schmerz 19:521-7. 2005
    ..The aim of this study was to evaluate the role of the endogenous cannabinoid system in controlling neuroplasticity...
  32. pmc Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressants
    Caroline Nothdurfter
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
    Neuropsychopharmacology 35:1510-9. 2010
    ....
  33. doi request reprint Xenon attenuates excitatory synaptic transmission in the rodent prefrontal cortex and spinal cord dorsal horn
    Rainer Haseneder
    Department of Anesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Anesthesiology 111:1297-307. 2009
    ..In the current study, the authors examined the effects of xenon on synaptic transmission in the prefrontal cortex and the spinal cord dorsal horn (substantia gelatinosa)...
  34. doi request reprint Isoflurane and sevoflurane dose-dependently impair hippocampal long-term potentiation
    Rainer Haseneder
    Department of Anaesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Eur J Pharmacol 623:47-51. 2009
    ..7-fold (1.7- and 2.2-fold) MAC, LTP was blocked. Our results indicate, that both anaesthetics influence synaptic strength to a similar degree, with only high concentrations blocking hippocampal CA1 stratum radiatum long-term potentiation...
  35. ncbi request reprint Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors
    Inge Sillaber
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Science 296:931-3. 2002
    ..Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism...
  36. doi request reprint The xenon-mediated antagonism against the NMDA receptor is non-selective for receptors containing either NR2A or NR2B subunits in the mouse amygdala
    Rainer Haseneder
    Department of Anaesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Eur J Pharmacol 619:33-7. 2009
    ..These results provide evidence, that the Xe-induced antagonism against NMDA receptors is non-selective against NR2A- or NR2B-containing receptors...
  37. doi request reprint Chronic social stress during adolescence induces cognitive impairment in aged mice
    Vera Sterlemann
    Max Planck Institute of Psychiatry, Munich, Germany
    Hippocampus 20:540-9. 2010
    ..Taken together, our results identify possible molecular mechanisms underlying cognitive impairment during aging, demonstrating the detrimental impact of stress during adolescence on hippocampus-dependent cognitive function in aged mice...
  38. ncbi request reprint Cloned human and murine serotonin(3A) receptors expressed in human embryonic kidney 293 cells display different single-channel kinetics
    Gerhard Hapfelmeier
    Department of Anaesthesiology, Technische Universitat Munchen, Munich, Germany
    Neurosci Lett 335:44-8. 2002
    ..1+/-2.9 ms vs. 4.1+/-0.8 ms) indicating species-dependent gating mechanisms of 5-HT(3) receptors...
  39. pmc Activation of the cannabinoid receptor type 1 decreases glutamatergic and GABAergic synaptic transmission in the lateral amygdala of the mouse
    Shahnaz Christina Azad
    Max Planck Institute of Psychiatry, Clinical Neuropharmacology, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Learn Mem 10:116-28. 2003
    ..Our results indicate that the mechanisms underlying cannabinoid action in the LA partly resemble those observed in the nucleus accumbens and differ from those described for the hippocampus...
  40. doi request reprint Xenon reduces N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated synaptic transmission in the amygdala
    Rainer Haseneder
    Department of Anesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse22, D 81675 Munich, Germany
    Anesthesiology 109:998-1006. 2008
    ..In the current study, the authors evaluated for the first time the effect of xenon on synaptic transmission in the basolateral amygdala in an in vitro brain slice preparation of the mouse...
  41. ncbi request reprint Distribution and properties of functional postsynaptic kainate receptors on neocortical layer V pyramidal neurons
    Matthias Eder
    Clinical Neuropharmacology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 23:6660-70. 2003
    ..Furthermore, it is feasible to assume that extrasynaptic KARs could be activated by a "spillover" of synaptically released glutamate, ambient glutamate in the CSF, or glutamate released from adjacent astrocytes...
  42. ncbi request reprint Isoflurane reduces glutamatergic transmission in neurons in the spinal cord superficial dorsal horn: evidence for a presynaptic site of an analgesic action
    Rainer Haseneder
    Department of Anaesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Anesth Analg 98:1718-23, table of contents. 2004
    ..This effect may contribute to an antinociceptive action of volatile anesthetics at the spinal cord level...
  43. ncbi request reprint The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice
    Shahnaz Christina Azad
    Max Planck Institute of Psychiatry, Clinical Neuropharmacology, Kraepelinstrasse 2, 80804 München, Germany
    Neurosci Lett 370:186-90. 2004
    ..The observed effects on synaptic strength could underly the beneficial effects of flupirtine on different types of chronic pain...
  44. ncbi request reprint Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling
    Shahnaz C Azad
    Clinical Neuropharmacology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 24:9953-61. 2004
    ..This disinhibition increases the activity of common output neurons and could provide a prerequisite for extinction by formation of new memory...
  45. doi request reprint Early life environment determines the development of adult phobic-like fear responses in BALB/cAnN mice
    C K Thoeringer
    Max Planck Institute of Psychiatry, Technical University Munich, Munich, Germany
    Genes Brain Behav 9:947-57. 2010
    ....
  46. doi request reprint Lack of interaction of endocannabinoids and 5-HT(3) neurotransmission in associative fear circuits of the amygdala: evidence from electrophysiological and behavioural experiments
    D Höfelmann
    Department of Anaesthesiology, Technische Universitat, D 81675 Munich, Germany
    Brain Res 1527:47-56. 2013
    ..In summary, these experiments do not support a functional interaction between CB1 and 5-HT3 receptors at the level of GABA neurotransmission in the BLA nor in terms of fear regulation...
  47. pmc Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response
    K Ganea
    Max Planck Institute of Psychiatry, Munich, Germany
    Transl Psychiatry 2:e177. 2012
    ..Further, our data suggest this pathway to be a target for more rapid-acting antidepressants in the future...
  48. doi request reprint Translocator protein (18 kDa) as a target for novel anxiolytics with a favourable side-effect profile
    C Nothdurfter
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
    J Neuroendocrinol 24:82-92. 2012
    ..In this review, we focus on the pathophysiology of anxiety disorders and TSPO ligands as a novel pharmacological approach in the treatment of these disorders...
  49. pmc Pharmacodynamics of memantine: an update
    G Rammes
    Clinical Neuropharmacology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Curr Neuropharmacol 6:55-78. 2008
    ..In addition, there has been further confirmation of the MOA of memantine as an uncompetitive NMDA receptor antagonist and essentially no data contradicting our understanding of the benign side effect profile of memantine...
  50. ncbi request reprint Antidepressants and antipsychotic drugs colocalize with 5-HT3 receptors in raft-like domains
    Brigitte Eisensamer
    Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    J Neurosci 25:10198-206. 2005
    ..In conclusion, enrichment of antidepressants and antipsychotics in raft-like domains within the cell membrane appears to be crucial for their antagonistic effects at ligand-gated ion channels such as 5-HT3 receptors...