Markus Ralser

Summary

Affiliation: Max Planck Institute for Molecular Genetics
Country: Germany

Publications

  1. pmc Surviving in the cold: yeast mutants with extended hibernating lifespan are oxidant sensitive
    Lucie Postma
    Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
    Aging (Albany NY) 1:957-60. 2009
  2. pmc A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging
    Bernd Timmermann
    Next Generation Sequencing Group, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
    Aging (Albany NY) 2:475-86. 2010
  3. pmc Interfering with glycolysis causes Sir2-dependent hyper-recombination of Saccharomyces cerevisiae plasmids
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 4:e5376. 2009
  4. pmc A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 105:17807-11. 2008
  5. pmc Reductive stress on life span extension in C. elegans
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    BMC Res Notes 1:19. 2008
  6. pmc Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    BMC Genet 9:38. 2008
  7. pmc Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    J Biol 6:10. 2007
  8. pmc Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells
    Nana Maria Grüning
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Cell Metab 14:415-27. 2011
  9. pmc Triose phosphate isomerase deficiency is caused by altered dimerization--not catalytic inactivity--of the mutant enzymes
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 1:e30. 2006
  10. ncbi request reprint Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Hum Mol Genet 14:2893-909. 2005

Collaborators

Detail Information

Publications25

  1. pmc Surviving in the cold: yeast mutants with extended hibernating lifespan are oxidant sensitive
    Lucie Postma
    Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
    Aging (Albany NY) 1:957-60. 2009
    ..Indeed, maintaining the energy consuming anti-oxidative machinery seems to be disadvantageous under coldroom conditions...
  2. pmc A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging
    Bernd Timmermann
    Next Generation Sequencing Group, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
    Aging (Albany NY) 2:475-86. 2010
    ..In addition, this study shows that the re-sequencing of entire genomes is becoming a promising alternative for the identification of functional alleles in approaches of classic molecular genetics...
  3. pmc Interfering with glycolysis causes Sir2-dependent hyper-recombination of Saccharomyces cerevisiae plasmids
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 4:e5376. 2009
    ..We conclude that GAPDH influences yeast episome stability via Sir2 and propose a model for the interplay of Sir2, GAPDH, and the glycolytic flux...
  4. pmc A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 105:17807-11. 2008
    ..Thus, processes beyond the metabolic block are essential for the biological properties of 2-DG...
  5. pmc Reductive stress on life span extension in C. elegans
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    BMC Res Notes 1:19. 2008
    ..We draw attention to this condition as an explanation for some contradictory observations including the deleterious effects from antioxidants...
  6. pmc Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    BMC Genet 9:38. 2008
    ..However, comprehensive genetic information about the TPI1 locus is still lacking...
  7. pmc Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    J Biol 6:10. 2007
    ..Eukaryotic cells have evolved various response mechanisms to counteract the deleterious consequences of oxidative stress. Among these processes, metabolic alterations seem to play an important role...
  8. pmc Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells
    Nana Maria Grüning
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Cell Metab 14:415-27. 2011
    ..Originating from a single catalytic step, this autonomous reconfiguration of central carbon metabolism prevents oxidative stress upon shifts between fermentation and respiration...
  9. pmc Triose phosphate isomerase deficiency is caused by altered dimerization--not catalytic inactivity--of the mutant enzymes
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 1:e30. 2006
    ..This observed advantage might serve to explain the high allelic frequency of TPI null alleles detected among human populations...
  10. ncbi request reprint Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Hum Mol Genet 14:2893-909. 2005
    ..Thus, our findings suggest an interplay between ataxin-2, endophilin proteins and huntingtin in plastin-associated cellular pathways...
  11. pmc Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules
    Ute Nonhoff
    Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
    Mol Biol Cell 18:1385-96. 2007
    ..Thus, our data imply that the cellular ataxin-2 concentration is important for the assembly of stress granules and P-bodies, which are main compartments for regulating and controlling mRNA degradation, stability, and translation...
  12. ncbi request reprint Generation of a yeast two-hybrid strain suitable for competitive protein binding analysis
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    Biotechniques 39:165-6, 168. 2005
  13. doi request reprint The pentose phosphate pathway is a metabolic redox sensor and regulates transcription during the antioxidant response
    Antje Krüger
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    Antioxid Redox Signal 15:311-24. 2011
    ..A shift in primary carbon metabolism is the fastest response to oxidative stress. Induced within seconds, it precedes transcriptional regulation, and produces reducing equivalents in form of NADPH within the pentose phosphate pathway (PPP)...
  14. pmc No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis
    Katharina Bluemlein
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    Oncotarget 2:393-400. 2011
    ....
  15. doi request reprint The KRAB-containing zinc-finger transcriptional regulator ZBRK1 activates SCA2 gene transcription through direct interaction with its gene product, ataxin-2
    Linda Hallen
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    Hum Mol Genet 20:104-14. 2011
    ..Thus, our results provide first evidence that ataxin-2 acts as a co-regulator of ZBRK1 activating its own transcription, thereby representing the first identified ZBRK1 co-activator...
  16. ncbi request reprint An integrative approach to gain insights into the cellular function of human ataxin-2
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    J Mol Biol 346:203-14. 2005
    ..Immunofluorescence studies revealed that ATX2 and PABP co-localize in mammalian cells, remarkably, even under conditions in which PABP accumulates in distinct cytoplasmic foci representing sites of mRNA triage...
  17. doi request reprint Tpo1-mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response
    Antje Krüger
    1 Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK 2 Max Planck Institute for Molecular Genetics, Ihnestr 73, 14195 Berlin, Germany
    EMBO Rep 14:1113-9. 2013
    ..Moreover, Tpo1 determines a cell cycle delay during adaptation to increased oxidant levels, and affects H2O2 tolerance. Thus, central components of the stress response are timed through Tpo1-controlled polyamine export. ..
  18. doi request reprint Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming
    Alessandro Prigione
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Stem Cells 29:1338-48. 2011
    ..Finally, we speculate that this random rearrangement of mtDNA molecules might prove beneficial for the derivation of mutation-free iPSCs from patients with mtDNA disorders...
  19. doi request reprint HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2
    Alessandro Prigione
    Molecular Embryology and Ageing Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany Department of Neuroproteomics, Max Delbrueck Center for Molecular Medicine MDC, Berlin, Germany
    Stem Cells 32:364-76. 2014
    ..These findings implicate the HIF1α pathway as an enabling regulator of cellular reprogramming...
  20. pmc Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling
    Jakob Vowinckel
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    FEBS Lett 586:3819-24. 2012
    ..Protein αmonoaminylations, thus including histaminylation, serotonylation, dopaminylation and norepinephrinylation, hence emerge as a novel class of regulatory PTMs...
  21. doi request reprint Monitoring protein expression in whole-cell extracts by targeted label- and standard-free LC-MS/MS
    Katharina Bluemlein
    Mass Spectrometry Unit, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Nat Protoc 6:859-69. 2011
    ....
  22. pmc Functional analysis of centrosomal kinase substrates in Drosophila melanogaster reveals a new function of the nuclear envelope component otefin in cell cycle progression
    Karin Habermann
    Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Berlin, Germany
    Mol Cell Biol 32:3554-69. 2012
    ..We propose that phosphorylation of this site plays a dual role in controlling mitotic exit when phosphorylated while dephosphorylation promotes G(2)/M transition in Drosophila SL2 cells...
  23. doi request reprint ATM is a redox sensor linking genome stability and carbon metabolism
    Antje Krüger
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    Sci Signal 4:pe17. 2011
    ..By linking genome stability, the cell cycle, and carbon catabolism, ATM emerges as a central regulator of cellular metabolism with implications for cancer...
  24. ncbi request reprint An efficient and economic enhancer mix for PCR
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    Biochem Biophys Res Commun 347:747-51. 2006
    ..Thus, we propose the routine application of this PCR enhancer mix for low- and high-throughput experiments...
  25. doi request reprint Regulatory crosstalk of the metabolic network
    Nana Maria Grüning
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Trends Biochem Sci 35:220-7. 2010
    ..The metabolic network controls its own balance, chromatin structure and the biosynthesis of molecular cofactors; moreover, metabolic shifts are crucial in the response to oxidative stress and play a regulatory role in cancer...