Research Topics
Genomes and Genes
| Markus RalserSummaryAffiliation: Max Planck Institute for Molecular Genetics Country: Germany Publications
| Collaborators
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Detail Information
Publications
Reductive stress on life span extension in C. elegansMarkus Ralser
Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
BMC Res Notes 1:19. 2008..We draw attention to this condition as an explanation for some contradictory observations including the deleterious effects from antioxidants...- Interfering with glycolysis causes Sir2-dependent hyper-recombination of Saccharomyces cerevisiae plasmidsMarkus Ralser
Max Planck Institute for Molecular Genetics, Berlin, Germany
PLoS ONE 4:e5376. 2009..We conclude that GAPDH influences yeast episome stability via Sir2 and propose a model for the interplay of Sir2, GAPDH, and the glycolytic flux... - A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growthMarkus Ralser
Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
Proc Natl Acad Sci U S A 105:17807-11. 2008..Thus, processes beyond the metabolic block are essential for the biological properties of 2-DG... - Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived GermansMarkus Ralser
Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
BMC Genet 9:38. 2008..However, comprehensive genetic information about the TPI1 locus is still lacking... - Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stressMarkus Ralser
Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
J Biol 6:10. 2007..Eukaryotic cells have evolved various response mechanisms to counteract the deleterious consequences of oxidative stress. Among these processes, metabolic alterations seem to play an important role... - Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cellsNana Maria Grüning
Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
Cell Metab 14:415-27. 2011..Originating from a single catalytic step, this autonomous reconfiguration of central carbon metabolism prevents oxidative stress upon shifts between fermentation and respiration... - Triose phosphate isomerase deficiency is caused by altered dimerization--not catalytic inactivity--of the mutant enzymesMarkus Ralser
Max Planck Institute for Molecular Genetics, Berlin, Germany
PLoS ONE 1:e30. 2006..This observed advantage might serve to explain the high allelic frequency of TPI null alleles detected among human populations... 
Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathwaysMarkus Ralser
Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
Hum Mol Genet 14:2893-909. 2005..Thus, our findings suggest an interplay between ataxin-2, endophilin proteins and huntingtin in plastin-associated cellular pathways...- A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature agingBernd Timmermann
Next Generation Sequencing Group, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
Aging (Albany NY) 2:475-86. 2010..In addition, this study shows that the re-sequencing of entire genomes is becoming a promising alternative for the identification of functional alleles in approaches of classic molecular genetics... - Surviving in the cold: yeast mutants with extended hibernating lifespan are oxidant sensitiveLucie Postma
Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
Aging (Albany NY) 1:957-60. 2009..Indeed, maintaining the energy consuming anti-oxidative machinery seems to be disadvantageous under coldroom conditions... - Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granulesUte Nonhoff
Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
Mol Biol Cell 18:1385-96. 2007..Thus, our data imply that the cellular ataxin-2 concentration is important for the assembly of stress granules and P-bodies, which are main compartments for regulating and controlling mRNA degradation, stability, and translation... - Generation of a yeast two-hybrid strain suitable for competitive protein binding analysisMarkus Ralser
Max Planck Institute for Molecular Genetics, Berlin, Germany
Biotechniques 39:165-6, 168. 2005 
The pentose phosphate pathway is a metabolic redox sensor and regulates transcription during the antioxidant responseAntje Krüger
Max Planck Institute for Molecular Genetics, Berlin, Germany
Antioxid Redox Signal 15:311-24. 2011..A shift in primary carbon metabolism is the fastest response to oxidative stress. Induced within seconds, it precedes transcriptional regulation, and produces reducing equivalents in form of NADPH within the pentose phosphate pathway (PPP)...- No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesisKatharina Bluemlein
Max Planck Institute for Molecular Genetics, Berlin, Germany
Oncotarget 2:393-400. 2011.... - The KRAB-containing zinc-finger transcriptional regulator ZBRK1 activates SCA2 gene transcription through direct interaction with its gene product, ataxin-2Linda Hallen
Max Planck Institute for Molecular Genetics, Berlin, Germany
Hum Mol Genet 20:104-14. 2011..Thus, our results provide first evidence that ataxin-2 acts as a co-regulator of ZBRK1 activating its own transcription, thereby representing the first identified ZBRK1 co-activator... - Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogrammingAlessandro Prigione
Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
Stem Cells 29:1338-48. 2011..Finally, we speculate that this random rearrangement of mtDNA molecules might prove beneficial for the derivation of mutation-free iPSCs from patients with mtDNA disorders... - Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signalingJakob Vowinckel
Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany Cambridge Systems Biology Centre and Dept of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK Electronic address
FEBS Lett 586:3819-24. 2012.... - Monitoring protein expression in whole-cell extracts by targeted label- and standard-free LC-MS/MSKatharina Bluemlein
Mass Spectrometry Unit, Max Planck Institute for Molecular Genetics, Berlin, Germany
Nat Protoc 6:859-69. 2011.... - An integrative approach to gain insights into the cellular function of human ataxin-2Markus Ralser
Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
J Mol Biol 346:203-14. 2005..Immunofluorescence studies revealed that ATX2 and PABP co-localize in mammalian cells, remarkably, even under conditions in which PABP accumulates in distinct cytoplasmic foci representing sites of mRNA triage... - Functional analysis of centrosomal kinase substrates in Drosophila melanogaster reveals a new function of the nuclear envelope component otefin in cell cycle progressionKarin Habermann
Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Berlin, Germany
Mol Cell Biol 32:3554-69. 2012..We propose that phosphorylation of this site plays a dual role in controlling mitotic exit when phosphorylated while dephosphorylation promotes G(2)/M transition in Drosophila SL2 cells... - ATM is a redox sensor linking genome stability and carbon metabolismAntje Krüger
Max Planck Institute for Molecular Genetics, Berlin, Germany
Sci Signal 4:pe17. 2011..By linking genome stability, the cell cycle, and carbon catabolism, ATM emerges as a central regulator of cellular metabolism with implications for cancer... - An efficient and economic enhancer mix for PCRMarkus Ralser
Max Planck Institute for Molecular Genetics, Berlin, Germany
Biochem Biophys Res Commun 347:747-51. 2006..Thus, we propose the routine application of this PCR enhancer mix for low- and high-throughput experiments... - Regulatory crosstalk of the metabolic networkNana Maria Grüning
Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
Trends Biochem Sci 35:220-7. 2010..The metabolic network controls its own balance, chromatin structure and the biosynthesis of molecular cofactors; moreover, metabolic shifts are crucial in the response to oxidative stress and play a regulatory role in cancer...