Research Topics
Genomes and Genes | Molly PrzeworskiSummaryAffiliation: Max Planck Institute for Evolutionary Anthropology Country: Germany Publications
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Publications
Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primatesYoav Gilad
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
PLoS Biol 2:E5. 2004..Our findings suggest that the deterioration of the olfactory repertoire occurred concomitant with the acquisition of full trichromatic color vision in primates...- The signature of positive selection at randomly chosen lociMolly Przeworski
Department of Statistics, University of Oxford, Oxford OX1 3TG, United Kingdom
Genetics 160:1179-89. 2002..Alternatively, positive selection may not operate as is commonly modeled. In particular, the rate of fixation of advantageous mutations may have increased in the recent past... - Estimating the time since the fixation of a beneficial alleleMolly Przeworski
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
Genetics 164:1667-76. 2003..The data support the recent fixation of a favored allele, consistent with what is known about the importance of tb1 in the domestication process of maize... 
Fine-scale recombination patterns differ between chimpanzees and humansSusan E Ptak
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6 04103, Leipzig, Germany
Nat Genet 37:429-34. 2005..Therefore, the recombination landscape has changed markedly between the two species...- Evidence for a complex demographic history of chimpanzeesAnne Fischer
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Mol Biol Evol 21:799-808. 2004..This suggests that careful attention should be paid to geographic sampling in studies of chimpanzee genetic variation... - Absence of the TAP2 human recombination hotspot in chimpanzeesSusan E Ptak
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
PLoS Biol 2:e155. 2004.... - Insights into recombination from patterns of linkage disequilibrium in humansSusan E Ptak
Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany
Genetics 167:387-97. 2004..However, as we demonstrate by simulation, inferences about gene conversion are unreliable, even with extensive data from homogeneous regions of the genome, and are confounded by genotyping error... - A neutral explanation for the correlation of diversity with recombination rates in humansInes Hellmann
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Am J Hum Genet 72:1527-35. 2003..Consistent with this hypothesis, diversity levels no longer increase significantly with recombination rates after correction for divergence to chimpanzee... - The rise and fall of the chemoattractant receptor GPR33Holger Römpler
Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany
J Biol Chem 280:31068-75. 2005..7 million years ago. The coincidental inactivation and its fixation in several species of distantly related mammalian orders suggest a selective pressure on this chemoattractant receptor gene... - Molecular evolution of FOXP2, a gene involved in speech and languageWolfgang Enard
Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
Nature 418:869-72. 2002..Here we show that human FOXP2 contains changes in amino-acid coding and a pattern of nucleotide polymorphism, which strongly suggest that this gene has been the target of selection during recent human evolution... - Evidence for population growth in humans is confounded by fine-scale population structureSusan E Ptak
Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, 04103, Leipzig, Germany
Trends Genet 18:559-63. 2002..They suggest that the geographic sampling strategy should be considered carefully, especially when the aim is to infer the demographic history of humans... 
High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humansGraham Coop
Department of Human Genetics, University of Chicago, 920 East 58th Street, Cummings Life Science Center, Chicago, IL 60637, USA
Science 319:1395-8. 2008..Notably, however, we found extensive and heritable variation among both males and females in the proportion of crossovers occurring in these hotspots...- No effect of recombination on the efficacy of natural selection in primatesKevin Bullaughey
Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
Genome Res 18:544-54. 2008..An interesting implication is that indirect selection for recombination modifiers has probably been a weak force in primate evolution... - A new approach to estimate parameters of speciation models with application to apesCeline Becquet
Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
Genome Res 17:1505-19. 2007..Similarly, Eastern and Western gorillas and Sumatran and Bornean orangutans appear to have experienced gene flow since their splits approximately 90 and over 250 Kya, respectively... - Genetic structure of chimpanzee populationsCeline Becquet
Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
PLoS Genet 3:e66. 2007..The data also provide historical insights, demonstrating that the western chimpanzee population diverged first, and that the eastern and central populations are more closely related in time... - Combining sperm typing and linkage disequilibrium analyses reveals differences in selective pressures or recombination rates across human populationsVanessa J Clark
Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
Genetics 175:795-804. 2007.... - An evolutionary view of human recombinationGraham Coop
Department of Human Genetics, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
Nat Rev Genet 8:23-34. 2007.... - How reliable are empirical genomic scans for selective sweeps?Kosuke M Teshima
Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
Genome Res 16:702-12. 2006..g., the dominance coefficient) affect the power to detect targets of selection, genomic scans will yield an unrepresentative subset of loci that contribute to adaptations... - The signature of positive selection on standing genetic variationMolly Przeworski
Department of Human Genetics, University of Chicago, Illinois 60637, USA
Evolution 59:2312-23. 2005..These findings highlight the importance of an accurate characterization of the effects of positive selection, if we are to reliably identify recent adaptations from polymorphism data... - Directional positive selection on an allele of arbitrary dominanceKosuke M Teshima
Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
Genetics 172:713-8. 2006..We find that, for a given mean fixation time, a beneficial allele has a much weaker effect on diversity at linked neutral sites when the allele is recessive... - Evidence for positive selection and population structure at the human MAO-A geneYoav Gilad
Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
Proc Natl Acad Sci U S A 99:862-7. 2002.... - Genetics. Motivating hotspotsMolly Przeworski
Department of Human Genetics, University of Chicago, 920 East 57th Street, 507F CLSC, Chicago, IL 60637, USA
Science 310:247-8. 2005..More than 25,000 putative hotspots have been identified, as well as the first motifs that appear to influence their intensity... - Testing models of selection and demography in Drosophila simulansJeffrey D Wall
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genetics 162:203-16. 2002..autosome variability levels, they suggest that demography alone may account for patterns of linkage disequilibrium and the frequency spectrum of segregating mutations in this population of D. simulans... - The timing of selection at the human FOXP2 geneGraham Coop
Mol Biol Evol 25:1257-9. 2008..We find that, depending on the assumptions, additional control experiments may be needed to rule out contamination at FOXP2... - Natural selection on genes that underlie human disease susceptibilityRan Blekhman
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Curr Biol 18:883-9. 2008..In contrast, the class of genes that influence complex-disease risk shows little signs of evolutionary conservation, possibly because this category includes targets of both purifying and positive selection...