Molly Przeworski

Summary

Affiliation: Max Planck Institute for Evolutionary Anthropology
Country: Germany

Publications

  1. pmc Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primates
    Yoav Gilad
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E5. 2004
  2. pmc The signature of positive selection at randomly chosen loci
    Molly Przeworski
    Department of Statistics, University of Oxford, Oxford OX1 3TG, United Kingdom
    Genetics 160:1179-89. 2002
  3. pmc Estimating the time since the fixation of a beneficial allele
    Molly Przeworski
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Genetics 164:1667-76. 2003
  4. ncbi request reprint Evidence for a complex demographic history of chimpanzees
    Anne Fischer
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 21:799-808. 2004
  5. ncbi request reprint Fine-scale recombination patterns differ between chimpanzees and humans
    Susan E Ptak
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6 04103, Leipzig, Germany
    Nat Genet 37:429-34. 2005
  6. pmc Absence of the TAP2 human recombination hotspot in chimpanzees
    Susan E Ptak
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:e155. 2004
  7. pmc Insights into recombination from patterns of linkage disequilibrium in humans
    Susan E Ptak
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genetics 167:387-97. 2004
  8. ncbi request reprint The rise and fall of the chemoattractant receptor GPR33
    Holger Römpler
    Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany
    J Biol Chem 280:31068-75. 2005
  9. pmc A neutral explanation for the correlation of diversity with recombination rates in humans
    Ines Hellmann
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 72:1527-35. 2003
  10. ncbi request reprint Molecular evolution of FOXP2, a gene involved in speech and language
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nature 418:869-72. 2002

Detail Information

Publications25

  1. pmc Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primates
    Yoav Gilad
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E5. 2004
    ..Our findings suggest that the deterioration of the olfactory repertoire occurred concomitant with the acquisition of full trichromatic color vision in primates...
  2. pmc The signature of positive selection at randomly chosen loci
    Molly Przeworski
    Department of Statistics, University of Oxford, Oxford OX1 3TG, United Kingdom
    Genetics 160:1179-89. 2002
    ..Alternatively, positive selection may not operate as is commonly modeled. In particular, the rate of fixation of advantageous mutations may have increased in the recent past...
  3. pmc Estimating the time since the fixation of a beneficial allele
    Molly Przeworski
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Genetics 164:1667-76. 2003
    ..The data support the recent fixation of a favored allele, consistent with what is known about the importance of tb1 in the domestication process of maize...
  4. ncbi request reprint Evidence for a complex demographic history of chimpanzees
    Anne Fischer
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 21:799-808. 2004
    ..This suggests that careful attention should be paid to geographic sampling in studies of chimpanzee genetic variation...
  5. ncbi request reprint Fine-scale recombination patterns differ between chimpanzees and humans
    Susan E Ptak
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6 04103, Leipzig, Germany
    Nat Genet 37:429-34. 2005
    ..Therefore, the recombination landscape has changed markedly between the two species...
  6. pmc Absence of the TAP2 human recombination hotspot in chimpanzees
    Susan E Ptak
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:e155. 2004
    ....
  7. pmc Insights into recombination from patterns of linkage disequilibrium in humans
    Susan E Ptak
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genetics 167:387-97. 2004
    ..However, as we demonstrate by simulation, inferences about gene conversion are unreliable, even with extensive data from homogeneous regions of the genome, and are confounded by genotyping error...
  8. ncbi request reprint The rise and fall of the chemoattractant receptor GPR33
    Holger Römpler
    Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany
    J Biol Chem 280:31068-75. 2005
    ..7 million years ago. The coincidental inactivation and its fixation in several species of distantly related mammalian orders suggest a selective pressure on this chemoattractant receptor gene...
  9. pmc A neutral explanation for the correlation of diversity with recombination rates in humans
    Ines Hellmann
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 72:1527-35. 2003
    ..Consistent with this hypothesis, diversity levels no longer increase significantly with recombination rates after correction for divergence to chimpanzee...
  10. ncbi request reprint Molecular evolution of FOXP2, a gene involved in speech and language
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nature 418:869-72. 2002
    ..Here we show that human FOXP2 contains changes in amino-acid coding and a pattern of nucleotide polymorphism, which strongly suggest that this gene has been the target of selection during recent human evolution...
  11. ncbi request reprint Evidence for population growth in humans is confounded by fine-scale population structure
    Susan E Ptak
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, 04103, Leipzig, Germany
    Trends Genet 18:559-63. 2002
    ..They suggest that the geographic sampling strategy should be considered carefully, especially when the aim is to infer the demographic history of humans...
  12. pmc Combining sperm typing and linkage disequilibrium analyses reveals differences in selective pressures or recombination rates across human populations
    Vanessa J Clark
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 175:795-804. 2007
    ....
  13. pmc Genetic structure of chimpanzee populations
    Celine Becquet
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 3:e66. 2007
    ..The data also provide historical insights, demonstrating that the western chimpanzee population diverged first, and that the eastern and central populations are more closely related in time...
  14. pmc A new approach to estimate parameters of speciation models with application to apes
    Celine Becquet
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genome Res 17:1505-19. 2007
    ..Similarly, Eastern and Western gorillas and Sumatran and Bornean orangutans appear to have experienced gene flow since their splits approximately 90 and over 250 Kya, respectively...
  15. pmc No effect of recombination on the efficacy of natural selection in primates
    Kevin Bullaughey
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Genome Res 18:544-54. 2008
    ..An interesting implication is that indirect selection for recombination modifiers has probably been a weak force in primate evolution...
  16. ncbi request reprint High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans
    Graham Coop
    Department of Human Genetics, University of Chicago, 920 East 58th Street, Cummings Life Science Center, Chicago, IL 60637, USA
    Science 319:1395-8. 2008
    ..Notably, however, we found extensive and heritable variation among both males and females in the proportion of crossovers occurring in these hotspots...
  17. ncbi request reprint An evolutionary view of human recombination
    Graham Coop
    Department of Human Genetics, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
    Nat Rev Genet 8:23-34. 2007
    ....
  18. pmc How reliable are empirical genomic scans for selective sweeps?
    Kosuke M Teshima
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genome Res 16:702-12. 2006
    ..g., the dominance coefficient) affect the power to detect targets of selection, genomic scans will yield an unrepresentative subset of loci that contribute to adaptations...
  19. ncbi request reprint The signature of positive selection on standing genetic variation
    Molly Przeworski
    Department of Human Genetics, University of Chicago, Illinois 60637, USA
    Evolution 59:2312-23. 2005
    ..These findings highlight the importance of an accurate characterization of the effects of positive selection, if we are to reliably identify recent adaptations from polymorphism data...
  20. pmc Directional positive selection on an allele of arbitrary dominance
    Kosuke M Teshima
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 172:713-8. 2006
    ..We find that, for a given mean fixation time, a beneficial allele has a much weaker effect on diversity at linked neutral sites when the allele is recessive...
  21. pmc Evidence for positive selection and population structure at the human MAO-A gene
    Yoav Gilad
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 99:862-7. 2002
    ....
  22. ncbi request reprint Genetics. Motivating hotspots
    Molly Przeworski
    Department of Human Genetics, University of Chicago, 920 East 57th Street, 507F CLSC, Chicago, IL 60637, USA
    Science 310:247-8. 2005
    ..More than 25,000 putative hotspots have been identified, as well as the first motifs that appear to influence their intensity...
  23. pmc Testing models of selection and demography in Drosophila simulans
    Jeffrey D Wall
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 162:203-16. 2002
    ..autosome variability levels, they suggest that demography alone may account for patterns of linkage disequilibrium and the frequency spectrum of segregating mutations in this population of D. simulans...
  24. pmc The timing of selection at the human FOXP2 gene
    Graham Coop
    Mol Biol Evol 25:1257-9. 2008
    ..We find that, depending on the assumptions, additional control experiments may be needed to rule out contamination at FOXP2...
  25. pmc Natural selection on genes that underlie human disease susceptibility
    Ran Blekhman
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Curr Biol 18:883-9. 2008
    ..In contrast, the class of genes that influence complex-disease risk shows little signs of evolutionary conservation, possibly because this category includes targets of both purifying and positive selection...