Research Topics
| Laurence PelletierSummaryAffiliation: Max Planck Institute of Molecular Cell Biology and Genetics Country: Germany Publications
| Collaborators
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Detail Information
Publications
Golgi and centrosome cycles in Toxoplasma gondiiJan Hartmann
Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520, USA
Mol Biochem Parasitol 145:125-7. 2006- Genome-scale RNAi profiling of cell division in human tissue culture cellsRalf Kittler
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
Nat Cell Biol 9:1401-12. 2007..Our work provides an experimental framework from which the systematic analysis of novel genes necessary for cell division in human cells can begin... - Systems biology of mammalian cell divisionRalf Kittler
Department of Human Genetics and Institute of Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, USA
Cell Cycle 7:2123-8. 2008..While a fully integrated model of mammalian cell division remains a distant goal, a framework of a systems understanding of this medically relevant process is beginning to emerge... - Centriole assembly in Caenorhabditis elegansLaurence Pelletier
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Nature 444:619-23. 2006..These results define a structural pathway for the assembly of a daughter centriole and should have general relevance for future studies on centriole assembly in other organisms... - The Caenorhabditis elegans centrosomal protein SPD-2 is required for both pericentriolar material recruitment and centriole duplicationLaurence Pelletier
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Curr Biol 14:863-73. 2004..To date, however, the molecular mechanisms that govern these two processes still remain poorly understood... 
Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosisKazuhisa Kinoshita
Max Planck Institute of Molecular Cell Biology and Genetics MPI CBG, 01307 Dresden, Germany
J Cell Biol 170:1047-55. 2005..We propose that Aurora A regulation of TACC3 activity defines a centrosome-specific mechanism for regulation of microtubule polymerization in mitosis...- RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cellsRalf Kittler
Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
Proc Natl Acad Sci U S A 102:2396-401. 2005..We show that this technique can be extended to allow the creation of tagged transgenes, expressed at physiological levels, for the further study of gene function... - An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell divisionRalf Kittler
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
Nature 432:1036-40. 2004..Thus, our study uncovers new aspects of cell division and establishes esiRNA as a versatile approach for genomic RNAi screens in mammalian cells... 
The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesisFei Zhu
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Curr Biol 18:136-41. 2008..Both proteins are then required for NEDD-1 recruitment and the subsequent assembly of gamma-TuRCs and other factors into fully functional centrosomes...- Centriole assembly requires both centriolar and pericentriolar material proteinsAlexander Dammermann
Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Dev Cell 7:815-29. 2004..Thus, both centriolar and pericentriolar material proteins contribute to centriole assembly... - Orchestration of the DNA-damage response by the RNF8 ubiquitin ligaseNadine K Kolas
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G1X5, Ontario, Canada
Science 318:1637-40. 2007..These results demonstrate how the DNA-damage response is orchestrated by ATM-dependent phosphorylation of MDC1 and RNF8-mediated ubiquitination... - Centrioles: duplicating precariouslyLaurence Pelletier
Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
Curr Biol 17:R770-3. 2007..Recent work showing that the overexpression of centriolar proteins can lead to the formation of multiple centrioles in the absence of pre-existing centrioles challenges the idea that it is a self-replicating organelle... - Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis IChristian G Riedel
Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Nature 441:53-61. 2006..Our data are consistent with the notion that efficient cleavage of Rec8 requires phosphorylation of cohesin and that this is blocked by PP2A at meiosis I centromeres... - Transferrin receptor recycling in the absence of perinuclear recycling endosomesDavid Sheff
Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520
J Cell Biol 156:797-804. 2002.... - Golgin tethers define subpopulations of COPI vesiclesJorg Malsam
Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8002, USA
Science 307:1095-8. 2005..Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack... - Golgi biogenesis in Toxoplasma gondiiLaurence Pelletier
Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nature 418:548-52. 2002..Our results indicate that new Golgi grow by autonomous duplication and raise the possibility that the Golgi is a paired structure that is analogous to centrioles... - Centrosomes: keeping tumors in checkLaurence Pelletier
Samuel Lunenfeld Research Institute, Toronto, Ontario M5G 1X5, Canada
Curr Biol 18:R702-4. 2008..Recent work in Drosophila suggests that centrosome defects in asymmetrically dividing cells can induce tumors at a higher frequency than other conditions known to cause genomic instability...