S Paabo

Summary

Affiliation: Max Planck Institute for Evolutionary Anthropology
Country: Germany

Publications

  1. ncbi request reprint Human evolution
    S Paabo
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Trends Cell Biol 9:M13-6. 1999
  2. pmc Toward a neutral evolutionary model of gene expression
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Genetics 170:929-39. 2005
  3. pmc No evidence of Neandertal mtDNA contribution to early modern humans
    David Serre
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E57. 2004
  4. pmc A neutral model of transcriptome evolution
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E132. 2004
  5. pmc Computational challenges in the analysis of ancient DNA
    Kay Prüfer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Genome Biol 11:R47. 2010
  6. pmc Metabolic changes in schizophrenia and human brain evolution
    Philipp Khaitovich
    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Yue Yang Road, Shanghai, 200031, PR China
    Genome Biol 9:R124. 2008
  7. pmc Functional analysis of human and chimpanzee promoters
    Florian Heissig
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Genome Biol 6:R57. 2005
  8. pmc Mitochondrial genomes reveal an explosive radiation of extinct and extant bears near the Miocene-Pliocene boundary
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    BMC Evol Biol 8:220. 2008
  9. pmc FUNC: a package for detecting significant associations between gene sets and ontological annotations
    Kay Prüfer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    BMC Bioinformatics 8:41. 2007
  10. ncbi request reprint The mosaic that is our genome
    Svante Paabo
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nature 421:409-12. 2003

Detail Information

Publications72

  1. ncbi request reprint Human evolution
    S Paabo
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Trends Cell Biol 9:M13-6. 1999
    ..These concern the questions of where and when our species originated, what the genetic background for characters that differ between us and apes is, and how the phenotypic traits that vary among human groups have evolved...
  2. pmc Toward a neutral evolutionary model of gene expression
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Genetics 170:929-39. 2005
    ..We discuss the latter result with respect to a neutral model of transcriptome evolution and show that a small number of genes expressed in brain can account for the observed data...
  3. pmc No evidence of Neandertal mtDNA contribution to early modern humans
    David Serre
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E57. 2004
    ..In combination with current mtDNA data, this excludes any large genetic contribution by Neandertals to early modern humans, but does not rule out the possibility of a smaller contribution...
  4. pmc A neutral model of transcriptome evolution
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E132. 2004
    ..Furthermore, it may be possible to apply a molecular clock based on expression differences to infer the evolutionary history of tissues...
  5. pmc Computational challenges in the analysis of ancient DNA
    Kay Prüfer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Genome Biol 11:R47. 2010
    ..We show that more accurate genome divergence estimates from ancient DNA sequence can be attained using at least two outgroup genomes and appropriate filtering...
  6. pmc Metabolic changes in schizophrenia and human brain evolution
    Philipp Khaitovich
    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Yue Yang Road, Shanghai, 200031, PR China
    Genome Biol 9:R124. 2008
    ....
  7. pmc Functional analysis of human and chimpanzee promoters
    Florian Heissig
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Genome Biol 6:R57. 2005
    ....
  8. pmc Mitochondrial genomes reveal an explosive radiation of extinct and extant bears near the Miocene-Pliocene boundary
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    BMC Evol Biol 8:220. 2008
    ..Widely divergent topologies have been suggested based on various data sets and methods...
  9. pmc FUNC: a package for detecting significant associations between gene sets and ontological annotations
    Kay Prüfer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    BMC Bioinformatics 8:41. 2007
    ..However, it is often difficult to assess the statistical significance of such analyses since many inter-dependent categories are tested simultaneously...
  10. ncbi request reprint The mosaic that is our genome
    Svante Paabo
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nature 421:409-12. 2003
    ....
  11. ncbi request reprint Genetic analyses from ancient DNA
    Svante Paabo
    Max Planck Institute for Evolutionary Anthropology, D 04013 Leipzig, Germany
    Annu Rev Genet 38:645-79. 2004
    ..We also highlight some significant results and areas of promising future research...
  12. pmc Patterns of nucleotide misincorporations during enzymatic amplification and direct large-scale sequencing of ancient DNA
    M Stiller
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 103:13578-84. 2006
    ....
  13. ncbi request reprint Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Science 309:1850-4. 2005
    ....
  14. ncbi request reprint Intra- and interspecific variation in primate gene expression patterns
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Science 296:340-3. 2002
    ..We identified species-specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain...
  15. ncbi request reprint Evidence for a complex demographic history of chimpanzees
    Anne Fischer
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 21:799-808. 2004
    ..This suggests that careful attention should be paid to geographic sampling in studies of chimpanzee genetic variation...
  16. ncbi request reprint Extensive nuclear DNA sequence diversity among chimpanzees
    H Kaessmann
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Science 286:1159-62. 1999
    ..Phylogenetic analyses show the sequences from the different chimpanzee subspecies to be intermixed and the distance between some chimpanzee sequences to be greater than the distance between them and the bonobo sequences...
  17. ncbi request reprint The genetical history of humans and the great apes
    H Kaessmann
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    J Intern Med 251:1-18. 2002
    ..Furthermore, genetic data indicate that humans, but not the great apes, have experienced a period of dramatic growth in their early history...
  18. pmc Targeted investigation of the Neandertal genome by array-based sequence capture
    Hernán A Burbano
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:723-5. 2010
    ..By generating the sequence of one Neandertal and 50 present-day humans at these positions, we have identified 88 amino acid substitutions that have become fixed in humans since our divergence from the Neandertals...
  19. pmc Absence of the TAP2 human recombination hotspot in chimpanzees
    Susan E Ptak
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:e155. 2004
    ....
  20. ncbi request reprint Molecular evolution of FOXP2, a gene involved in speech and language
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nature 418:869-72. 2002
    ..Here we show that human FOXP2 contains changes in amino-acid coding and a pattern of nucleotide polymorphism, which strongly suggest that this gene has been the target of selection during recent human evolution...
  21. pmc Extensive linkage disequilibrium in small human populations in Eurasia
    Henrik Kaessmann
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 70:673-85. 2002
    ..These findings suggest that populations such as the Evenki and the Saami, rather than the Finns, may be particularly suited for the initial coarse mapping of common complex diseases...
  22. pmc The Neandertal genome and ancient DNA authenticity
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    EMBO J 28:2494-502. 2009
    ..For analyses of other fossil hominins, which may become possible in the future, we suggest a similar 'boot-strap' approach in which interim approaches are applied until sufficient data for more definitive direct assays are acquired...
  23. ncbi request reprint Neanderthals in central Asia and Siberia
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nature 449:902-4. 2007
    ..Thus, the geographic range of Neanderthals is likely to have extended at least 2,000 km further to the east than commonly assumed...
  24. ncbi request reprint Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees
    Takashi Kitano
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 20:1281-9. 2003
    ..A possible exception is FMR2, which shows a higher number of nonsynonymous than synonymous substitutions on the human lineage, suggesting the action of positive selection...
  25. pmc A molecular analysis of dietary diversity for three archaic Native Americans
    H N Poinar
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 98:4317-22. 2001
    ..Thus, human paleofecal remains represent a source of ancient DNA that significantly complements and may in some cases be superior to that from skeletal tissue...
  26. ncbi request reprint A molecular analysis of ground sloth diet through the last glaciation
    M Hofreiter
    Max Planck Institute for Evolutionary Anthropology, Inselstr 22, D 04103 Leipzig, Germany
    Mol Ecol 9:1975-84. 2000
    ..The plants in the boluses further indicate that the climate 11 000 years BP was dryer than 20 000 and 28 500 years BP. However, the sloths seem to have visited water sources more frequently at 11 000 BP than at earlier times...
  27. ncbi request reprint The population history of extant and extinct hyenas
    Nadin Rohland
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 22:2435-43. 2005
    ..Both striped and brown hyenas show low amounts of genetic diversity, with the latter ones displaying just a single haplotype...
  28. ncbi request reprint Evolution of primate gene expression
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nat Rev Genet 7:693-702. 2006
    ....
  29. ncbi request reprint Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nature 439:724-7. 2006
    ..However, the divergence of mammoth, African and Asian elephants occurred over a short time, corresponding to only about 7% of the total length of the phylogenetic tree for the three evolutionary lineages...
  30. ncbi request reprint The complex evolutionary history of gorillas: insights from genomic data
    O Thalmann
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 24:146-58. 2007
    ..9-1.6 MYA and subsequent, primarily male-mediated gene flow until approximately 80,000-200,000 years ago. Furthermore, simulations revealed that more gene flow took place from eastern to western gorilla populations than vice versa...
  31. ncbi request reprint DNA sequence variation in a non-coding region of low recombination on the human X chromosome
    H Kaessmann
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Nat Genet 22:78-81. 1999
    ..The time elapsed since the most recent common ancestor (MRCA) is 535,000+/-119,000 years. We expect this type of nuclear locus to provide more answers about the genetic origin and history of humans...
  32. ncbi request reprint Nuclear DNA sequences from late Pleistocene megafauna
    A D Greenwood
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 16:1466-73. 1999
    ..The nuclear sequences retrieved from the mammoths suggest that mammoths were more similar to Asian elephants than to African elephants...
  33. pmc A neutral explanation for the correlation of diversity with recombination rates in humans
    Ines Hellmann
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 72:1527-35. 2003
    ..Consistent with this hypothesis, diversity levels no longer increase significantly with recombination rates after correction for divergence to chimpanzee...
  34. ncbi request reprint The derived FOXP2 variant of modern humans was shared with Neandertals
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Curr Biol 17:1908-12. 2007
    ..Thus, these results illustrate the usefulness of retrieving direct genetic information from ancient remains for understanding recent human evolution...
  35. pmc Genomewide comparison of DNA sequences between humans and chimpanzees
    Ingo Ebersberger
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Am J Hum Genet 70:1490-7. 2002
    ..However, since the extent of divergence differs significantly among autosomes, additional unknown factors must also influence the accumulation of substitutions in the human genome...
  36. ncbi request reprint Unreliable mtDNA data due to nuclear insertions: a cautionary tale from analysis of humans and other great apes
    O Thalmann
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig 04103, Germany
    Mol Ecol 13:321-35. 2004
    ..One implication is that explicit measures need to be taken to authenticate mtDNA sequences in newly studied taxa or when any irregularities arise. Furthermore, some taxa may not be amenable to analysis of mtDNA variation at all...
  37. pmc Patterns of damage in genomic DNA sequences from a Neandertal
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 104:14616-21. 2007
    ..The results suggest that reliable genome sequences can be obtained from Pleistocene organisms...
  38. pmc From micrograms to picograms: quantitative PCR reduces the material demands of high-throughput sequencing
    Matthias Meyer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nucleic Acids Res 36:e5. 2008
    ..The method should also apply to Illumina/Solexa and ABI/SOLiD sequencing, and should therefore help to widen the accessibility of all three platforms...
  39. doi request reprint The complete mitochondrial DNA genome of an unknown hominin from southern Siberia
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nature 464:894-7. 2010
    ..The stratigraphy of the cave where the bone was found suggests that the Denisova hominin lived close in time and space with Neanderthals as well as with modern humans...
  40. doi request reprint Phenotypic differences in behavior, physiology and neurochemistry between rats selected for tameness and for defensive aggression towards humans
    Frank W Albert
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Horm Behav 53:413-21. 2008
    ..Our findings reinforce the notion that tameness is correlated with differences in stress response and will facilitate future efforts to uncover the genetic basis for animal tameness...
  41. pmc Human and chimpanzee gene expression differences replicated in mice fed different diets
    Mehmet Somel
    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 3:e1504. 2008
    ..Our results suggest that the mouse can be used to study at least some aspects of human-specific traits...
  42. ncbi request reprint Optimization of 454 sequencing library preparation from small amounts of DNA permits sequence determination of both DNA strands
    Tomislav Maricic
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Biotechniques 46:51-2, 54-7. 2009
    ..Using this approach, we confirm that C/G base pairs observed as T/A base pairs in Neanderthal DNA sequences are due to a modification of the cytosine rather than guanine residues...
  43. pmc Genetic architecture of tameness in a rat model of animal domestication
    Frank W Albert
    Department of Genetics and Pathology, Uppsala University, 75123 Uppsala, Sweden
    Genetics 182:541-54. 2009
    ..The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general...
  44. doi request reprint A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Cell 137:961-71. 2009
    ..Since mice carrying one nonfunctional Foxp2 allele show opposite effects, this suggests that alterations in cortico-basal ganglia circuits might have been important for the evolution of speech and language in humans...
  45. doi request reprint Targeted retrieval and analysis of five Neandertal mtDNA genomes
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 325:318-21. 2009
    ..Together with analyses of mtDNA protein evolution, these data suggest that the long-term effective population size of Neandertals was smaller than that of modern humans and extant great apes...
  46. pmc Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Nucleic Acids Res 38:e87. 2010
    ..In addition, our results demonstrate that Neandertal DNA retains in vivo patterns of CpG methylation, potentially allowing future studies of gene inactivation and imprinting in ancient organisms...
  47. doi request reprint A complete mtDNA genome of an early modern human from Kostenki, Russia
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Curr Biol 20:231-6. 2010
    ..We use these features to determine a complete mtDNA sequence from a approximately 30,000-year-old EMH from the Kostenki 14 site in Russia...
  48. ncbi request reprint Analysis of one million base pairs of Neanderthal DNA
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nature 444:330-6. 2006
    ..Existing technology and fossil resources are now sufficient to initiate a Neanderthal genome-sequencing effort...
  49. ncbi request reprint Nuclear gene sequences from a late pleistocene sloth coprolite
    Hendrik Poinar
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Curr Biol 13:1150-2. 2003
    ..These results show that ancient single-copy nuclear DNA can be recovered from warm, arid climates. Thus, nuclear DNA preservation is not restricted to cold climates...
  50. ncbi request reprint Evidence for reproductive isolation between cave bear populations
    Michael Hofreiter
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103, Leipzig, Germany
    Curr Biol 14:40-3. 2004
    ..We also find no evidence that the morphology of the bears in the two caves changed to become more similar over time. We suggest that the two cave bear forms may have represented two reproductively isolated subspecies or species...
  51. pmc Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primates
    Yoav Gilad
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E5. 2004
    ..Our findings suggest that the deterioration of the olfactory repertoire occurred concomitant with the acquisition of full trichromatic color vision in primates...
  52. pmc Natural selection on the olfactory receptor gene family in humans and chimpanzees
    Yoav Gilad
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 73:489-501. 2003
    ..These observations are likely due to differences in lifestyle, between humans and great apes, that have led to distinct sensory needs...
  53. pmc Regional patterns of gene expression in human and chimpanzee brains
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 14:1462-73. 2004
    ..Furthermore, genes that show an elevated expression level in humans are statistically significantly enriched in regions that are recently duplicated in humans...
  54. pmc Lack of phylogeography in European mammals before the last glaciation
    Michael Hofreiter
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 101:12963-8. 2004
    ....
  55. pmc Evidence for gradients of human genetic diversity within and among continents
    David Serre
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 14:1679-85. 2004
    ..Therefore, there is no reason to assume that major genetic discontinuities exist between different continents or "races."..
  56. ncbi request reprint Evolution of bitter taste receptors in humans and apes
    Anne Fischer
    Max Plank Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Mol Biol Evol 22:432-6. 2005
    ..However, in contrast to the olfactory receptor gene repertoire, where humans have a higher proportion of pseudogenes than apes, there is no evidence that the rate of loss of bitter taste receptor genes varies among humans and apes...
  57. ncbi request reprint Fine-scale recombination patterns differ between chimpanzees and humans
    Susan E Ptak
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6 04103, Leipzig, Germany
    Nat Genet 37:429-34. 2005
    ..Therefore, the recombination landscape has changed markedly between the two species...
  58. ncbi request reprint Demographic history and genetic differentiation in apes
    Anne Fischer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Curr Biol 16:1133-8. 2006
    ....
  59. pmc Human specific loss of olfactory receptor genes
    Yoav Gilad
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, Leipzig D 04103, Germany
    Proc Natl Acad Sci U S A 100:3324-7. 2003
    ..As a consequence, the fraction of OR pseudogenes in humans is almost twice as high as in the non-human primates, suggesting a human-specific process of OR gene disruption, likely due to a reduced chemosensory dependence relative to apes...
  60. pmc Why do human diversity levels vary at a megabase scale?
    Ines Hellmann
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 15:1222-31. 2005
    ..Because there are indications that recombination rates may have changed rapidly during human evolution, we favor the latter explanation...
  61. ncbi request reprint Ancient DNA analyses reveal high mitochondrial DNA sequence diversity and parallel morphological evolution of late pleistocene cave bears
    Michael Hofreiter
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 19:1244-50. 2002
    ..This suggests that small size may have been an ancestral trait in cave bears and that large size evolved at least twice independently...
  62. ncbi request reprint Neandertals
    Jean Jacques Hublin
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Curr Biol 16:R113-4. 2006
  63. pmc Functionality of intergenic transcription: an evolutionary comparison
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Genet 2:e171. 2006
    ..Further, we find that about half of the expression differences between humans and chimpanzees are due to intergenic transcripts...
  64. pmc A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Cell 134:416-26. 2008
    ..There is evidence that purifying selection in the Neandertal mtDNA was reduced compared with other primate lineages, suggesting that the effective population size of Neandertals was small...
  65. pmc Multiplexed DNA sequence capture of mitochondrial genomes using PCR products
    Tomislav Maricic
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS ONE 5:e14004. 2010
    ..The majority of these require reagents and equipment that are only available from commercial vendors and are not suitable for the targets that are a few kilobases in length...
  66. doi request reprint A draft sequence of the Neandertal genome
    Richard E Green
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:710-22. 2010
    ....
  67. ncbi request reprint Improved cycle sequencing of GC-rich templates by a combination of nucleotide analogs
    M Motz
    MPI for Evolutionary Anthropology, Leipzig, Germany
    Biotechniques 29:268-70. 2000
    ....
  68. ncbi request reprint Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans
    R Erlandsson
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 17:804-12. 2000
    ..The male-to-female mutation rate ratio was estimated to be 2.5...
  69. ncbi request reprint Early allelic selection in maize as revealed by ancient DNA
    Viviane Jaenicke-Despres
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Science 302:1206-8. 2003
    ..The results reveal that the alleles typical of contemporary maize were present in Mexican maize by 4400 years ago. However, as recently as 2000 years ago, allelic selection at one of the genes may not yet have been complete...
  70. pmc Sequential DEXAS: a method for obtaining DNA sequences from genomic DNA and blood in one reaction
    Michael Motz
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nucleic Acids Res 31:e121. 2003
    ..We show that Sequential DEXAS yields high quality sequencing results directly from genomic DNA as well as directly from human blood without any prior isolation or purification of DNA...
  71. pmc Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection
    F W Albert
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Heredity (Edinb) 107:205-14. 2011
    ..Together, these results show that the QTL is probably not caused by a single selected site, but may instead represent the joint effects of several sites that were targets of polygenic selection...
  72. pmc Evidence for import of a lysyl-tRNA into marsupial mitochondria
    M Dorner
    Max Planck Institute for Evolutionary Anthropology, D 04105 Leipzig, Germany
    Mol Biol Cell 12:2688-98. 2001
    ..We conclude that a functional tRNA(Lys) encoded in the nuclear genome is imported into mitochondria in marsupials. Thus, tRNA import is not restricted to plant, yeast, and protozoan mitochondria but also occurs also in mammals...