Elena Olkhova

Summary

Affiliation: Max Planck Institute of Biophysics
Country: Germany

Publications

  1. pmc The influence of protonation states on the dynamics of the NhaA antiporter from Escherichia coli
    Elena Olkhova
    Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, D 60438 Frankfurt am Main, Germany
    Biophys J 92:3784-91. 2007
  2. ncbi request reprint Combined computational and biochemical study reveals the importance of electrostatic interactions between the "pH sensor" and the cation binding site of the sodium/proton antiporter NhaA of Escherichia coli
    Elena Olkhova
    Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany
    Proteins 76:548-59. 2009
  3. pmc Multiconformation continuum electrostatics analysis of the NhaA Na+/H+ antiporter of Escherichia coli with functional implications
    Elena Olkhova
    Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Max von Laue Strasse 3, D 60438 Frankfurt am Main, Germany
    Proc Natl Acad Sci U S A 103:2629-34. 2006
  4. pmc Titration behavior of residues at the entrance of the D-pathway of cytochrome c oxidase from paracoccus denitrificans investigated by continuum electrostatic calculations
    Elena Olkhova
    Max Planck Institute of Biophysics, Department of Molecular Membrane Biology, D 60438 Frankfurt, Germany
    Biophys J 89:2324-31. 2005
  5. doi request reprint High resolution crystal structure of Paracoccus denitrificans cytochrome c oxidase: new insights into the active site and the proton transfer pathways
    Juergen Koepke
    Max Planck Institute of Biophysics, Department of Molecular Membrane Biology, Max von Laue Str 3, D 60438 Frankfurt Main, Germany
    Biochim Biophys Acta 1787:635-45. 2009
  6. doi request reprint A L-lysine transporter of high stereoselectivity of the amino acid-polyamine-organocation (APC) superfamily: production, functional characterization, and structure modeling
    Jagdeep Kaur
    From the Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Frankfurt am Main 60438, Germany
    J Biol Chem 289:1377-87. 2014
  7. doi request reprint Homology model of the Na+/proline transporter PutP of Escherichia coli and its functional implications
    Elena Olkhova
    Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Max von Laue Str 3, D 60438 Frankfurt am Main, Germany
    J Mol Biol 406:59-74. 2011
  8. pmc Dynamic water networks in cytochrome C oxidase from Paracoccus denitrificans investigated by molecular dynamics simulations
    Elena Olkhova
    Max Planck Institute of Biophysics, Department of Molecular Membrane Biology, Frankfurt am Main, Germany
    Biophys J 86:1873-89. 2004

Collaborators

Detail Information

Publications8

  1. pmc The influence of protonation states on the dynamics of the NhaA antiporter from Escherichia coli
    Elena Olkhova
    Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, D 60438 Frankfurt am Main, Germany
    Biophys J 92:3784-91. 2007
    ..In the variant Gly(338)Ser that lost pH control, a hydrogen-bonded chain between Ser(338) and Lys(300) was found to block the pH-induced conformational reorganization of helix X...
  2. ncbi request reprint Combined computational and biochemical study reveals the importance of electrostatic interactions between the "pH sensor" and the cation binding site of the sodium/proton antiporter NhaA of Escherichia coli
    Elena Olkhova
    Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany
    Proteins 76:548-59. 2009
    ..Our results unravel the unique electrostatic network of NhaA that connect the coupled clusters of the "pH sensor" with the binding site, which is crucial for pH activation of NhaA...
  3. pmc Multiconformation continuum electrostatics analysis of the NhaA Na+/H+ antiporter of Escherichia coli with functional implications
    Elena Olkhova
    Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Max von Laue Strasse 3, D 60438 Frankfurt am Main, Germany
    Proc Natl Acad Sci U S A 103:2629-34. 2006
    ..The results of the calculations provide valuable information on the activation of the antiporter and the role of individual amino acid residues, and provide a solid framework for further experiments...
  4. pmc Titration behavior of residues at the entrance of the D-pathway of cytochrome c oxidase from paracoccus denitrificans investigated by continuum electrostatic calculations
    Elena Olkhova
    Max Planck Institute of Biophysics, Department of Molecular Membrane Biology, D 60438 Frankfurt, Germany
    Biophys J 89:2324-31. 2005
    ..We also investigated the effect of the mutations N131D, N131C, and N131V on the residue Glu-I-278 in terms of its pK(a) value and electrostatic interaction energies...
  5. doi request reprint High resolution crystal structure of Paracoccus denitrificans cytochrome c oxidase: new insights into the active site and the proton transfer pathways
    Juergen Koepke
    Max Planck Institute of Biophysics, Department of Molecular Membrane Biology, Max von Laue Str 3, D 60438 Frankfurt Main, Germany
    Biochim Biophys Acta 1787:635-45. 2009
    ..Above the hemes a cluster of 13 water molecules is observed which potentially form multiple exit pathways for pumped protons. The hydrogen bond pattern excludes that the Cu(B) ligand His326 is present in the imidazolate form...
  6. doi request reprint A L-lysine transporter of high stereoselectivity of the amino acid-polyamine-organocation (APC) superfamily: production, functional characterization, and structure modeling
    Jagdeep Kaur
    From the Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Frankfurt am Main 60438, Germany
    J Biol Chem 289:1377-87. 2014
    ..Molecular aspects of the observed ligand specificity are discussed...
  7. doi request reprint Homology model of the Na+/proline transporter PutP of Escherichia coli and its functional implications
    Elena Olkhova
    Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Max von Laue Str 3, D 60438 Frankfurt am Main, Germany
    J Mol Biol 406:59-74. 2011
    ....
  8. pmc Dynamic water networks in cytochrome C oxidase from Paracoccus denitrificans investigated by molecular dynamics simulations
    Elena Olkhova
    Max Planck Institute of Biophysics, Department of Molecular Membrane Biology, Frankfurt am Main, Germany
    Biophys J 86:1873-89. 2004
    ....