Klaus Armin Nave

Summary

Affiliation: Max Planck Institute for Experimental Medicine
Country: Germany

Publications

  1. doi request reprint Axon-glial signaling and the glial support of axon function
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Annu Rev Neurosci 31:535-61. 2008
  2. doi request reprint Oligodendrocytes and the "micro brake" of progenitor cell proliferation
    Klaus Armin Nave
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, D 37075 Goettingen, Germany
    Neuron 65:577-9. 2010
  3. ncbi request reprint Mechanisms of disease: inherited demyelinating neuropathies--from basic to clinical research
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Nat Clin Pract Neurol 3:453-64. 2007
  4. doi request reprint Myelination and support of axonal integrity by glia
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Nature 468:244-52. 2010
  5. ncbi request reprint Axonal regulation of myelination by neuregulin 1
    Klaus Armin Nave
    Max Planck Institute of Experimental Medicine, D 37075 Goettingen, Germany
    Curr Opin Neurobiol 16:492-500. 2006
  6. doi request reprint Myelination and the trophic support of long axons
    Klaus Armin Nave
    Klaus Armin Nave is at the Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Herrmann Rein Strasse 3, D 37075 Goettingen, Germany
    Nat Rev Neurosci 11:275-83. 2010
  7. ncbi request reprint High cholesterol level is essential for myelin membrane growth
    Gesine Saher
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Goettingen, Germany
    Nat Neurosci 8:468-75. 2005
  8. doi request reprint The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia
    Anke Schardt
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    J Neurosci Res 87:3465-79. 2009
  9. doi request reprint Critical time window of neuronal cholesterol synthesis during neurite outgrowth
    Ursula Funfschilling
    Department of Neurogenetics, Max Planck Institute for Experimental Medicine, 37075 Gottingen, Germany
    J Neurosci 32:7632-45. 2012
  10. ncbi request reprint Axonal neuregulin-1 regulates myelin sheath thickness
    Galin V Michailov
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Science 304:700-3. 2004

Detail Information

Publications99

  1. doi request reprint Axon-glial signaling and the glial support of axon function
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Annu Rev Neurosci 31:535-61. 2008
    ..Loss of glial support causes progressive axon degeneration and possibly local inflammation, both of which are likely to contribute to a variety of neuronal diseases in the central and peripheral nervous systems...
  2. doi request reprint Oligodendrocytes and the "micro brake" of progenitor cell proliferation
    Klaus Armin Nave
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, D 37075 Goettingen, Germany
    Neuron 65:577-9. 2010
    ..But putting the miRNA brake on oligodendrocyte gene expression is required throughout life...
  3. ncbi request reprint Mechanisms of disease: inherited demyelinating neuropathies--from basic to clinical research
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Nat Clin Pract Neurol 3:453-64. 2007
    ..Transgenic animal models have become essential for dissecting CMT disease mechanisms and exploring novel therapies...
  4. doi request reprint Myelination and support of axonal integrity by glia
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Nature 468:244-52. 2010
    ..This function may be independent of myelin itself. Myelin abnormalities cause a number of neurological diseases, and may also contribute to complex neuropsychiatric disorders...
  5. ncbi request reprint Axonal regulation of myelination by neuregulin 1
    Klaus Armin Nave
    Max Planck Institute of Experimental Medicine, D 37075 Goettingen, Germany
    Curr Opin Neurobiol 16:492-500. 2006
    ..Whether this signaling system operates in central nervous system myelination remains an open question of major importance for human demyelinating diseases...
  6. doi request reprint Myelination and the trophic support of long axons
    Klaus Armin Nave
    Klaus Armin Nave is at the Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Herrmann Rein Strasse 3, D 37075 Goettingen, Germany
    Nat Rev Neurosci 11:275-83. 2010
    ..This glial support of axonal integrity may be relevant for a number of neurological and psychiatric diseases...
  7. ncbi request reprint High cholesterol level is essential for myelin membrane growth
    Gesine Saher
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Goettingen, Germany
    Nat Neurosci 8:468-75. 2005
    ..This shows that cholesterol is an indispensable component of myelin membranes and that cholesterol availability in oligodendrocytes is a rate-limiting factor for brain maturation...
  8. doi request reprint The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia
    Anke Schardt
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    J Neurosci Res 87:3465-79. 2009
    ..We suggest that Rab3A may regulate SNAP-29-mediated membrane fusion during myelination...
  9. doi request reprint Critical time window of neuronal cholesterol synthesis during neurite outgrowth
    Ursula Funfschilling
    Department of Neurogenetics, Max Planck Institute for Experimental Medicine, 37075 Gottingen, Germany
    J Neurosci 32:7632-45. 2012
    ..This study highlights both the flexibility and the limits of horizontal cholesterol transfer in vivo and may have implications for the understanding of neurodegenerative diseases...
  10. ncbi request reprint Axonal neuregulin-1 regulates myelin sheath thickness
    Galin V Michailov
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Science 304:700-3. 2004
    ..We suggest a model by which myelin-forming Schwann cells integrate axonal Nrg1 signals as a biochemical measure of axon size...
  11. pmc Common variants of the genes encoding erythropoietin and its receptor modulate cognitive performance in schizophrenia
    Anne Kastner
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Mol Med 18:1029-40. 2012
    ..Together, these findings reveal a role of endogenous EPO/EPOR for cognition, at least in schizophrenic patients...
  12. doi request reprint A role for Schwann cell-derived neuregulin-1 in remyelination
    Ruth M Stassart
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, Gottingen, Germany
    Nat Neurosci 16:48-54. 2013
    ..We suggest a model in which loss of axonal contact triggers denervated Schwann cells to transiently express NRG1 as an autocrine/paracrine signal that promotes Schwann cell differentiation and remyelination...
  13. doi request reprint Neuroinflammation in white matter tracts of Cnp1 mutant mice amplified by a minor brain injury
    Georg L Wieser
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075, Gottingen, Germany
    Glia 61:869-80. 2013
    ..This interaction of genetic and environmental factors may be relevant for neuropsychiatric diseases associated with secondary neuroinflammation...
  14. doi request reprint Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions
    Ingo Bormuth
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, D 37075 Gottingen, Germany
    J Neurosci 33:641-51. 2013
    ..Our findings define a new stage in corpus callosum development and demonstrate that neocortical projection neurons require transcriptional specification by neuronal bHLH proteins to execute an intrinsic program of remote connectivity...
  15. pmc Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
    Ursula Funfschilling
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Nature 485:517-21. 2012
    ..Because myelinated axons can use lactate when energy-deprived, our findings suggest a model in which axon-glia metabolic coupling serves a physiological function...
  16. doi request reprint Modification of cognitive performance in schizophrenia by complexin 2 gene polymorphisms
    Martin Begemann
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Arch Gen Psychiatry 67:879-88. 2010
    ..In particular, the specific contribution of risk or candidate gene variants to the complex schizophrenic phenotype is largely unknown...
  17. doi request reprint Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet
    Gesine Saher
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Nat Med 18:1130-5. 2012
    ..Dietary cholesterol did not reduce Plp1 overexpression but facilitated incorporation of PLP into myelin membranes. These findings may have implications for therapeutic interventions in patients with PMD...
  18. pmc Expression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in mice
    Derya Sargin
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Biol 9:27. 2011
    ..However, the critical EPO targets in brain are unknown, and separation of direct and indirect effects has remained difficult, given the role of EPO in hematopoiesis and brain oxygen supply...
  19. doi request reprint Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination
    Sandra Goebbels
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany or
    J Neurosci 30:8953-64. 2010
    ..That myelin synthesis is not restricted to early development but can occur later in life is relevant to developmental disorders and myelin disease...
  20. doi request reprint A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system
    Hauke B Werner
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Glia 61:567-86. 2013
    ..However, M6B is not efficiently sorted into mature myelin, in which it is 200-fold less abundant than PLP. Thus, only PLP contributes to the high cholesterol content of myelin by association and co-transport...
  21. ncbi request reprint Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
    Corinna Lappe-Siefke
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Goettingen, Germany
    Nat Genet 33:366-74. 2003
    ..Oligodendrocyte dysfunction, such as that in multiple sclerosis lesions, may suffice to cause secondary axonal loss...
  22. ncbi request reprint Cre/loxP-mediated inactivation of the bHLH transcription factor gene NeuroD/BETA2
    Sandra Goebbels
    Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Genesis 42:247-52. 2005
    ..The NeuroD(loxP) mouse mutant will be a valuable tool to study the developmental and adult function of NeuroD in nervous system and pancreas...
  23. doi request reprint In vivo imaging and noninvasive ablation of pyramidal neurons in adult NEX-CreERT2 mice
    Amit Agarwal
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Goettingen, Germany
    Cereb Cortex 22:1473-86. 2012
    ..This marks a striking difference from similar studies, in which dying oligodendrocytes failed to recruit cells of the adaptive immune system...
  24. doi request reprint A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity
    Celia M Kassmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    FEBS Lett 585:2205-11. 2011
    ..This novel model of a demyelinating neuropathy demonstrates that peroxisomes serve an important function in the peripheral myelin compartment, required for long-term axonal integrity...
  25. ncbi request reprint Global transcriptome analysis of genetically identified neurons in the adult cortex
    Moritz J Rossner
    Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    J Neurosci 26:9956-66. 2006
    ..The combined use of a genetic label with laser-microdissection offers an unbiased approach to map patterns of gene expression onto practically any cell type of the brain...
  26. pmc Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy
    Sandra Goebbels
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    EMBO Mol Med 4:486-99. 2012
    ..We suggest that regions of non-compact myelin are under lifelong protection by PTEN against abnormal membrane outgrowth, and that dysregulated phosphoinositide levels play a critical role in the pathology of tomaculous neuropathies...
  27. pmc Proteolipid protein is required for transport of sirtuin 2 into CNS myelin
    Hauke B Werner
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Goettingen, Germany
    J Neurosci 27:7717-30. 2007
    ..Because normal SIRT2 activity is controlled by the NAD+/NADH ratio, its function may be coupled to the axo-glial metabolism and the long-term support of axons by oligodendrocytes...
  28. pmc Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development
    Hiroshi Kawabe
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Neuron 65:358-72. 2010
    ..We conclude that a Nedd4-1/Rap2A/TNIK signaling pathway regulates neurite growth and arborization in mammalian neurons...
  29. pmc A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia
    Sabrina Grube
    Divison of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    EMBO Mol Med 3:309-19. 2011
    ..Reduction of SK3 function may constitute a pharmacological target to improve cognition in schizophrenia and other conditions with cognitive impairment...
  30. ncbi request reprint Myelin disorders: Causes and perspectives of Charcot-Marie-Tooth neuropathy
    Gerd Meyer zu Horste
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    J Mol Neurosci 28:77-88. 2006
    ..Furthermore, ascorbic acid treatment reduced premature death and demyelination in a CMT1A mouse model. Thus, basic research has opened up new vistas for the understanding and treatment of hereditary neuropathies...
  31. ncbi request reprint Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A)
    Michael W Sereda
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, Hermann Rein Str 3, D 37075 Gottingen, Germany
    Nat Med 9:1533-7. 2003
    ..Taken together, these data provide proof of principle that the progesterone receptor of myelin-forming Schwann cells is a promising pharmacological target for therapy of CMT-1A...
  32. ncbi request reprint Antiprogesterone therapy uncouples axonal loss from demyelination in a transgenic rat model of CMT1A neuropathy
    Gerd Meyer zu Horste
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, University of Gottingen, Gottingen, Germany
    Ann Neurol 61:61-72. 2007
    ....
  33. doi request reprint Misalignment of PLP/DM20 transmembrane domains determines protein misfolding in Pelizaeus-Merzbacher disease
    Ajit Singh Dhaunchak
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    J Neurosci 31:14961-71. 2011
    ..We conclude that an important determinant in the quality control of polytopic membrane proteins is the free alignment of their TM domains...
  34. doi request reprint Neuron-glia signaling and the protection of axon function by Schwann cells
    Susanne Quintes
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    J Peripher Nerv Syst 15:10-6. 2010
    ..Understanding the cross talk between neurons and Schwann cells will help to further define the role of glia in preserving axonal integrity and to develop therapeutic strategies for peripheral neuropathies such as CMT1A...
  35. doi request reprint Quantitative and integrative proteome analysis of peripheral nerve myelin identifies novel myelin proteins and candidate neuropathy loci
    Julia Patzig
    Department of Neurogenetics, and Proteomics Group, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    J Neurosci 31:16369-86. 2011
    ..These results illustrate how the integration of unbiased proteome, transcriptome, and genome data can contribute to a molecular dissection of the biogenesis, cell biology, metabolism, and pathology of myelin...
  36. doi request reprint A phenotype-based genetic association study reveals the contribution of neuregulin1 gene variants to age of onset and positive symptom severity in schizophrenia
    Sergi Papiol
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Am J Med Genet B Neuropsychiatr Genet 156:340-5. 2011
    ..The GRAS Data Collection as a prerequisite for PGAS has enabled us to associate protective NRG1 genotypes with later onset and milder course of schizophrenia...
  37. ncbi request reprint Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes
    Celia M Kassmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Nat Genet 39:969-76. 2007
    ..We conclude that peroxisomes provide oligodendrocytes with an essential neuroprotective function against axon degeneration and neuroinflammation, which is relevant for human demyelinating diseases...
  38. pmc Survival of adult neurons lacking cholesterol synthesis in vivo
    Ursula Funfschilling
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    BMC Neurosci 8:1. 2007
    ..However, the contribution of neurons and glial cells to total brain cholesterol metabolism is unknown...
  39. pmc Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system
    Mostafa Bakhti
    Cellular Neuroscience, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Proc Natl Acad Sci U S A 110:3143-8. 2013
    ..We suggest that loss of electrostatic cell-surface repulsion uncovers weak and unspecific attractive forces in the bilayer that bring the extracellular surfaces of a membrane into close contact over long distances...
  40. pmc Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination
    Viktorija Velanac
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Glia 60:203-17. 2012
    ..Thus, BACE1 is not essential for the activation of NRG1 type III to promote myelination. Taken together, these findings suggest that multiple neuronal proteases collectively regulate NRG1 processing...
  41. doi request reprint Cholesterol: a novel regulatory role in myelin formation
    Gesine Saher
    Max Planck Institute of Experimental Medicine, Neurogenetics, Gottingen, Germany
    Neuroscientist 17:79-93. 2011
    ..In Schwann cells of the PNS, protein trafficking and myelin compaction depend on cholesterol. In this review, the authors summarize the role of cholesterol in myelin biogenesis and myelin disease...
  42. pmc A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain
    Hannelore Ehrenreich
    Max Planck Institute of Experimental Medicine, Georg August University, 37075 Goettingen, Germany
    Proc Natl Acad Sci U S A 102:862-7. 2005
    ..This effect is not only inhibited by EPO but also by neurotrophins. We suggest that the proapoptotic function of TPO helps to select for neurons that have acquired target-derived neurotrophic support...
  43. ncbi request reprint Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory
    Thomas Kleppisch
    Institut fur Pharmakologie und Toxikologie, 80802 Munchen, Germany, Max Planck Institut fur Psychiatrie, 80804 München, Germany
    J Neurosci 23:6005-12. 2003
    ..These results suggest that hippocampal cGKI supports an age- and protein synthesis-dependent form of hippocampal LTP, whereas it is dispensable for hippocampus-dependent spatial reference and contextual memory...
  44. doi request reprint Oligodendroglial impact on axonal function and survival - a hypothesis
    Celia Michèle Kassmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Curr Opin Neurol 21:235-41. 2008
    ..This short review focuses on the possible primary role of oligodendrocytes in axon loss and inflammatory demyelination...
  45. ncbi request reprint Animal models of inherited neuropathies
    Gerd Meyer zu Horste
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Curr Opin Neurol 19:464-73. 2006
    ..This review highlights how animal models of demyelinating CMT have improved our understanding of disease mechanisms. Transgenic CMT models also allow therapies to be developed in a preclinical setting...
  46. pmc A myelin gene causative of a catatonia-depression syndrome upon aging
    Nora Hagemeyer
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    EMBO Mol Med 4:528-39. 2012
    ..Analogously, in man, diffusion tensor imaging points to axonal loss in the frontal corpus callosum. To conclude, subtle white matter abnormalities inducing neurodegenerative changes can cause/amplify psychiatric diseases...
  47. ncbi request reprint Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice
    Sandra Goebbels
    Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Genesis 44:611-21. 2006
    ..The NEX-Cre mouse will be a valuable tool for behavioral research and the conditional inactivation of target genes in pyramidal neurons of the dorsal telencephalon...
  48. pmc Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system
    Bastian G Brinkmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen 37075, Germany
    Neuron 59:581-95. 2008
    ..Thus, NRG1/ErbB signaling is markedly different between Schwann cells and oligodendrocytes that have evolved an NRG/ErbB-independent mechanism of myelination control...
  49. doi request reprint Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction
    Gesine Saher
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Goettingen, Germany
    J Neurosci 29:6094-104. 2009
    ..This demonstrates that high-level cholesterol coordinates P0 export with myelin membrane synthesis, which is required for the correct stoichiometry of myelin components and for myelin compaction...
  50. doi request reprint Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection
    Wiebke Mobius
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Neuron Glia Biol 4:111-27. 2008
    ..We suggest that the molecular shift from P0 to PLP also correlates with the concentration of adhesive forces at the radial component, and that the new balance between membrane adhesion and dynamics was favorable for CNS myelination...
  51. ncbi request reprint Monitoring regulated protein-protein interactions using split TEV
    Michael C Wehr
    Max Planck Institute of Experimental Medicine, Hermann Rein Str 3, D 37075 Gottingen, Germany
    Nat Methods 3:985-93. 2006
    ..In a first biological application, we monitored neuregulin-induced ErbB2/ErbB4 receptor tyrosine kinase heterodimerization...
  52. pmc A common mechanism of PLP/DM20 misfolding causes cysteine-mediated endoplasmic reticulum retention in oligodendrocytes and Pelizaeus-Merzbacher disease
    Ajit Singh Dhaunchak
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Proc Natl Acad Sci U S A 104:17813-8. 2007
    ..Thus, covalent protein cross-links emerge as a cause, rather than as a consequence, of endoplasmic reticulum retention...
  53. doi request reprint Arrest of myelination and reduced axon growth when Schwann cells lack mTOR
    Diane L Sherman
    Centre for Neuroregeneration, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    J Neurosci 32:1817-25. 2012
    ..These data establish a critical role for mTOR signaling in both the longitudinal and radial growth of the myelinating Schwann cell...
  54. doi request reprint Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue
    Nicolas Snaidero
    Max Planck Institute of Experimental Medicine, Cellular Neuroscience, Hermann Rein Strasse, 3, 37075 Gottingen, Germany Department of Neurology, University of Gottingen, Robert Koch Strasse, 40, 37075 Gottingen, Germany
    Cell 156:277-90. 2014
    ..Our model can explain assembly of myelin as a multilayered structure, abnormal myelin outfoldings in neurological disease, and plasticity of myelin biogenesis observed in adult life. PAPERFLICK: ..
  55. ncbi request reprint Reduced oxidative damage in ALS by high-dose enteral melatonin treatment
    Jochen H Weishaupt
    Department of Neurology, Georg August University, Gottingen, Germany
    J Pineal Res 41:313-23. 2006
    ..This combination of preclinical effectiveness and proven safety in humans suggests that high-dose melatonin is suitable for clinical trials aimed at neuroprotection through antioxidation in ALS...
  56. pmc Episode-specific differential gene expression of peripheral blood mononuclear cells in rapid cycling supports novel treatment approaches
    Martin Begemann
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Mol Med 14:546-52. 2008
    ..This case suggests that rapid cycling is a systemic disease, resembling hibernation, with prostaglandins playing a mediator role...
  57. ncbi request reprint Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Georg August University, Gottingen, Germany
    Brain 130:2577-88. 2007
    ..There were no adverse events, no safety concerns and a surprisingly low need of blood-lettings. This first pilot study demonstrates the necessity and feasibility of controlled trials using high-dose rhEPO in chronic progressive MS...
  58. pmc The cross-sectional GRAS sample: a comprehensive phenotypical data collection of schizophrenic patients
    Katja Ribbe
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Psychiatry 10:91. 2010
    ..This approach is different from and complementary to the genome-wide association studies (GWAS) on schizophrenia...
  59. doi request reprint Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium
    Schanila Nawaz
    Max Planck Institute of Experimental Medicine, University of Gottingen, D 37075 Gottingen, Germany
    J Neurosci 29:4794-807. 2009
    ..Together, these results establish that PIP2 is an essential determinant for stable membrane binding of MBP and provide a novel link between glial phosphoinositol metabolism and MBP function in development and disease...
  60. doi request reprint The role of myelin and oligodendrocytes in axonal energy metabolism
    Aiman S Saab
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, Gottingen, Germany
    Curr Opin Neurobiol 23:1065-72. 2013
    ..These include neurological disorders as diverse as multiple sclerosis, leukodystrophies, and amyotrophic lateral sclerosis. ..
  61. doi request reprint Structure and composition of myelinated axons: a multimodal synchrotron spectro-microscopy study
    Tanja Ducić
    Institute for X ray Physics, Georg August University, Gottingen, Germany
    J Struct Biol 173:202-12. 2011
    ..Finally single fiber diffraction in highly focused hard X-ray beams, and soft X-ray microscopy and tomography in absorption contrast are demonstrated as novel techniques for the study of single nerve fibers...
  62. pmc Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice
    Moritz J Rossner
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS ONE 3:e2762. 2008
    ..However, the molecular mechanisms leading to the disintegration of tissue-specific clocks are complex and not well understood...
  63. ncbi request reprint CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS
    Matthew N Rasband
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    Glia 50:86-90. 2005
    ..We suggest that CNP is a glial protein required for maintaining the integrity of paranodes and that disrupted axoglial signaling at this site underlies progressive axonal degeneration, observed later in the CNS of Cnp1-null mice...
  64. ncbi request reprint Early abnormalities in sciatic nerve function and structure in a rat model of Charcot-Marie-Tooth type 1A disease
    Marina Grandis
    Department of Neuroscience, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
    Exp Neurol 190:213-23. 2004
    ..However, the presence of a molecular and functional damage of the axons suggests that this may be the correct moment to start neuroprotective therapies...
  65. ncbi request reprint Experimental Charcot-Marie-Tooth type 1A: a cDNA microarrays analysis
    Tiziana Vigo
    Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Italy, Via De Toni 5, 16132 Genova, Italy
    Mol Cell Neurosci 28:703-14. 2005
    ....
  66. ncbi request reprint Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory
    Sven Moosmang
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, 80802 Munich, Germany
    J Neurosci 25:9883-92. 2005
    ..2 channel-mediated Ca2+ influx to either process...
  67. ncbi request reprint Palmitoylation is a sorting determinant for transport to the myelin membrane
    Anja Schneider
    Department of Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strausse 3, 72076 Tubingen, Germany
    J Cell Sci 118:2415-23. 2005
    ..Thus, we conclude that palmitoylation is a sorting determinant for transport to the myelin membrane...
  68. ncbi request reprint Developmental pluripotency of the nuclei of neurons in the cerebral cortex of juvenile mice
    Tomoharu Osada
    Core Research for Evolutional Science and Technology Research Agency, Japan Science and Technology Agency, Kawaguchi, Saitama 332 0012, Japan
    J Neurosci 25:8368-74. 2005
    ..0%) developed into adults. These findings demonstrate that some of the nuclei of differentiated neurons in the cerebral cortex of juvenile mice maintain developmental pluripotency...
  69. pmc Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone
    Sheng Xi Wu
    Department of Morphological Brain Science and Laboratory of Immunological Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 102:17172-7. 2005
    ..Our data suggest that NEX-positive progenitors within the SVZ are committed to a glutamatergic neuronal fate and have evolved to expand the number of cortical output neurons that is characteristic for the mammalian forebrain...
  70. ncbi request reprint Sox10-rtTA mouse line for tetracycline-inducible expression of transgenes in neural crest cells and oligodendrocytes
    Andreas Ludwig
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    Genesis 40:171-5. 2004
    ..Shut-off, in contrast, exhibited delayed kinetics, which probably correlated with doxycycline clearance rates. This mouse provides a useful tool for generating tetracycline-controlled gene expression in neural crest and oligodendrocytes...
  71. pmc Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination
    Damian Brockschnieder
    Zentrum für Molekulare Neurobiologie, Falkenried 94, 20251 Hamburg, Germany
    Mol Cell Biol 24:7636-42. 2004
    ....
  72. ncbi request reprint Normal metabolism but different physical properties of myelin from mice deficient in proteolipid protein
    Helga Jurevics
    Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Neurosci Res 71:826-34. 2003
    ..Metabolic tracer experiments showed this was not the case. We conclude that PLP(null) myelin is physically less stable and/or less dense than wt myelin...
  73. ncbi request reprint The C264Y missense mutation in the extracellular domain of L1 impairs protein trafficking in vitro and in vivo
    Annette E Rünker
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    J Neurosci 23:277-86. 2003
    ..These observations corroborate the view that impaired cell surface expression of mutated variants of L1 is a potential explanation for the high number of severe pathogenic mutations identified within the human L1 gene...
  74. ncbi request reprint The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling
    Judith Stegmuller
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, Germany
    J Biol Chem 278:3590-8. 2003
    ..AMPA receptor complex in glial-neuronal recognition and signaling...
  75. pmc Notch1 control of oligodendrocyte differentiation in the spinal cord
    Stephane Genoud
    Department of Biology, Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Cell Biol 158:709-18. 2002
    ..These findings establish a widespread function of Notch1 in the late steps of mammalian OPC development in vivo...
  76. ncbi request reprint Identification of the regulatory region of the peripheral myelin protein 22 (PMP22) gene that directs temporal and spatial expression in development and regeneration of peripheral nerves
    Marcel Maier
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Mol Cell Neurosci 20:93-109. 2002
    ....
  77. pmc Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease
    Mikael Simons
    Department of Neurology, University of Tubingen, 72076 Tubingen, Germany
    J Cell Biol 157:327-36. 2002
    ..We propose that these accumulations perturb the process of myelination and impair the viability of oligodendrocytes...
  78. ncbi request reprint Proliferation of Schwann cells and regulation of cyclin D1 expression in an animal model of Charcot-Marie-Tooth disease type 1A
    Suzana Atanasoski
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Neurosci Res 67:443-9. 2002
    ..Thus, cyclin D1 expression and its subcellular localization correlate directly with distinct physiological states of Schwann cells in this animal model of CMT1A...
  79. ncbi request reprint Evolution of myelin proteolipid proteins: gene duplication in teleosts and expression pattern divergence
    Jörn Schweitzer
    Zentrum fuer Molekulare Neurobiologie, University of Hamburg, D 20251 Hamburg, Germany
    Mol Cell Neurosci 31:161-77. 2006
    ..Comparing protein sequences and gene structures from birds, teleosts, one urochordate species, and four invertebrates, we have reconstructed major steps in the evolution of proteolipids...
  80. pmc Evolution of a neuroprotective function of central nervous system myelin
    Xinghua Yin
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cell Biol 172:469-78. 2006
    ..These data support the hypothesis that the P0-PLP shift during vertebrate evolution provided a vital neuroprotective function to myelin-forming CNS glia...
  81. doi request reprint Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells
    Nivedita Chatterjee
    Molecular Cell Biology, Department of Biology, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Biol Chem 283:8310-7. 2008
    ..Thus syntenin plays a role in the migration of oligodendroglial precursors, and we suggest that NG2-syntenin-1 interactions contribute to this...
  82. doi request reprint Early neuronal and glial fate restriction of embryonic neural stem cells
    Delphine Delaunay
    INSERM, Unité 711, 75013 Paris, France
    J Neurosci 28:2551-62. 2008
    ..In addition, we show that glial cells forming at E13.5 arise from a new pool of neuroepithelial progenitors distinct from neuronal progenitors cells, which lends support to the segregating model...
  83. doi request reprint Multiple sclerosis: an immune or neurodegenerative disorder?
    Bruce D Trapp
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Annu Rev Neurosci 31:247-69. 2008
    ....
  84. pmc Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development
    Yves Benninger
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 177:1051-61. 2007
    ..Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles...
  85. pmc FAK is required for axonal sorting by Schwann cells
    Matthew Grove
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH9 1QH, Scotland, UK
    J Cell Biol 176:277-82. 2007
    ..These findings demonstrate the vital relationship between axon defasciculation and Schwann cell number and show the importance of FAK in regulating cell proliferation in the developing nervous system...
  86. pmc Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination
    Martha Zeger
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, USA
    Glia 55:400-11. 2007
    ..These data also provide a fundamental basis for developing strategies with the potential to target IGF-IGF1R signaling pathways in oligodendrocyte lineage cells for the treatment of demyelinating disorders...
  87. ncbi request reprint Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia
    Eva Maria Krämer-Albers
    Department of Biology, Unit of Molecular Cell Biology, University of Mainz, 55099 Mainz, Germany
    J Neurosci 26:11743-52. 2006
    ..Whereas UPR-induced cell death governs the PMD phenotype of the msd mutation, we propose that impaired cholesterol and lipid raft interaction of the rsh protein may contribute to the dysmyelination observed in SPG-2...
  88. ncbi request reprint Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice
    Chi Wang Ip
    Department of Neurology, Section of Developmental Neurobiology, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    Neurobiol Dis 25:105-11. 2007
    ..These findings may have substantial impact on treatment strategies for leukodystrophic disorders and some forms of multiple sclerosis...
  89. ncbi request reprint Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS
    Tina Thurnherr
    Institute for Cell Biology, Department of Biology, Federal Institute of Technology ETH Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 26:10110-9. 2006
    ....
  90. pmc The endocannabinoid system controls key epileptogenic circuits in the hippocampus
    Krisztina Monory
    Department of Physiological Chemistry, Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
    Neuron 51:455-66. 2006
    ..The direct endocannabinoid-mediated control of hippocampal glutamatergic neurotransmission may constitute a promising therapeutic target for the treatment of disorders associated with excessive excitatory neuronal activity...
  91. pmc Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites
    Katarina Trajkovic
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, 37073 Gottingen, Germany
    J Cell Biol 172:937-48. 2006
    ..The release of myelin membrane from LEs/Ls by neuronal signals may represent a mechanism to control myelin membrane growth...
  92. ncbi request reprint Axonal damage and demyelination in long-term dorsal root ganglia cultures from a rat model of Charcot-Marie-Tooth type 1A disease
    Lucilla Nobbio
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy, Via De Toni, 5, 16132, Genoa, Italy
    Eur J Neurosci 23:1445-52. 2006
    ..As axonal damage may occur after just 3 months and tissue cultures represent a strictly controlled environment, this model may be ideal for testing neuroprotective therapies...
  93. ncbi request reprint Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex
    Richard Belvindrah
    Department of Cell Biology, Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 27:13854-65. 2007
    ..We conclude that beta1 integrins in radial glia are required for the proper development of the cerebral cortex, whereas beta1 integrins in migrating neurons are not essential for glial-guided migration and reelin signaling...
  94. ncbi request reprint Subtle myelin defects in PLP-null mice
    Jack Rosenbluth
    Department of Physiology and Neuroscience, New York University School of Medicine, New York 10016, USA
    Glia 54:172-82. 2006
    ....
  95. ncbi request reprint Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination
    Yves Benninger
    Institute for Cell Biology, Department of Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    J Neurosci 26:7665-73. 2006
    ..We conclude that, although beta1-integrin may still contribute to other aspects of oligodendrocyte biology, it is not essential for myelination and remyelination in the CNS...
  96. ncbi request reprint Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes
    Chi Wang Ip
    Department of Neurology, University of Wuerzburg, D 97080 Wuerzburg, Germany
    J Neurosci 26:8206-16. 2006
    ..These findings provide strong evidence that a primary glial damage can cause secondary immune reactions of pathological significance as it has been suggested for some forms of multiple sclerosis and other leukodystrophies...
  97. ncbi request reprint Glial cells under remote control
    Klaus Armin Nave
    Nat Neurosci 8:1420-2. 2005
  98. ncbi request reprint Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections
    Amir H Kashani
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 26:8398-408. 2006
    ..These observations identify LMO4 as a calcium-dependent transactivator that plays a key role in patterning thalamocortical connections during development...
  99. doi request reprint Neuroscience: An ageing view of myelin repair
    Klaus Armin Nave
    Nature 455:478-9. 2008