Klaus Armin Nave

Summary

Affiliation: Max Planck Institute for Experimental Medicine
Country: Germany

Publications

  1. Nave K, Trapp B. Axon-glial signaling and the glial support of axon function. Annu Rev Neurosci. 2008;31:535-61 pubmed publisher
    ..Loss of glial support causes progressive axon degeneration and possibly local inflammation, both of which are likely to contribute to a variety of neuronal diseases in the central and peripheral nervous systems. ..
  2. Fledrich R, Akkermann D, Schütza V, Abdelaal T, Hermes D, Schäffner E, et al. NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies. Nat Commun. 2019;10:1467 pubmed publisher
    ..We suggest that diseased Schwann cells mount a regeneration program that is beneficial in acute nerve injury, but that overstimulation of Schwann cells in chronic neuropathies is detrimental. ..
  3. Fledrich R, Abdelaal T, Rasch L, Bansal V, Schütza V, Brugger B, et al. Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy. Nat Commun. 2018;9:3025 pubmed publisher
    ..We propose that lipid supplementation is an easily translatable potential therapeutic approach in CMT1A and possibly other dysmyelinating neuropathies. ..
  4. Richert S, Kleinecke S, Günther J, Schaumburg F, Edgar J, Nienhaus G, et al. In vivo labeling of peroxisomes by photoconvertible mEos2 in myelinating glia of mice. Biochimie. 2014;98:127-34 pubmed publisher
  5. Trevisiol A, Nave K. Brain Energy Metabolism: Conserved Functions of Glycolytic Glial Cells. Cell Metab. 2015;22:361-3 pubmed publisher
    ..In this issue, Volkenhoff et al. (2015) show that, in Drosophila, the transfer of lactate from the glial to the neuronal compartment is conserved in evolution, independent of body size. ..
  6. Nave K. Myelination and the trophic support of long axons. Nat Rev Neurosci. 2010;11:275-83 pubmed publisher
    ..This glial support of axonal integrity may be relevant for a number of neurological and psychiatric diseases. ..
  7. Nave K, Werner H. Myelination of the nervous system: mechanisms and functions. Annu Rev Cell Dev Biol. 2014;30:503-33 pubmed publisher
    ..Thus, myelinating cells serve a key role in preserving the connectivity and functions of a healthy nervous system. ..
  8. Poggi G, Boretius S, Möbius W, Moschny N, Baudewig J, Ruhwedel T, et al. Cortical network dysfunction caused by a subtle defect of myelination. Glia. 2016;64:2025-40 pubmed publisher
    ..Thus, subtle but primary abnormalities of CNS myelin can be the cause of a persistent cortical network dysfunction including catatonia, features typical of neuropsychiatric conditions. GLIA 2016;64:2025-2040. ..
  9. Sargin D, El Kordi A, Agarwal A, Muller M, Wojcik S, Hassouna I, et al. Expression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in mice. BMC Biol. 2011;9:27 pubmed publisher
    ..This property of EPOR signaling should be exploited for defining novel strategies to therapeutically enhance cognitive performance in disease conditions. ..

More Information

Publications15

  1. Nave K. Myelination and support of axonal integrity by glia. Nature. 2010;468:244-52 pubmed publisher
    ..This function may be independent of myelin itself. Myelin abnormalities cause a number of neurological diseases, and may also contribute to complex neuropsychiatric disorders. ..
  2. Möbius W, Nave K, Werner H. Electron microscopy of myelin: Structure preservation by high-pressure freezing. Brain Res. 2016;1641:92-100 pubmed publisher
    ..This article is part of a Special Issue entitled SI: Myelin Evolution. ..
  3. Saab A, Tzvetavona I, Trevisiol A, Baltan S, Dibaj P, Kusch K, et al. Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism. Neuron. 2016;91:119-32 pubmed publisher
    ..This reveals a novel aspect of neuronal energy metabolism in which activity-dependent glutamate release enhances oligodendroglial glucose uptake and glycolytic support of fast spiking axons. ..
  4. Supplie L, Düking T, Campbell G, Diaz F, Moraes C, Gotz M, et al. Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo. J Neurosci. 2017;37:4231-4242 pubmed publisher
    ..Here, we report that these mice are fully viable in the absence of any signs of glial or neuronal loss, suggesting that astrocytes are naturally glycolytic cells. ..
  5. Saab A, Nave K. Myelin dynamics: protecting and shaping neuronal functions. Curr Opin Neurobiol. 2017;47:104-112 pubmed publisher
  6. Nave K, Tzvetanova I, Schirmeier S. Glial Cell Evolution: The Origins of a Lipid Store. Cell Metab. 2017;26:701-702 pubmed publisher
    ..In this issue, Liu et al. (2017) demonstrate that neuronal lipid synthesis is driven by the glial lactate shuttle. This lipoprotein-dependent deposition of lipids may be at the origin of glial specializations evolving in vertebrates...