Georg Nagel

Summary

Affiliation: Max Planck Institute of Biophysics
Country: Germany

Publications

  1. ncbi request reprint Channelrhodopsin-1: a light-gated proton channel in green algae
    Georg Nagel
    Max Planck Institut fur Biophysik, Kennedyallee 70, 60596 Frankfurt am Main, Germany
    Science 296:2395-8. 2002
  2. pmc Channelrhodopsin-2, a directly light-gated cation-selective membrane channel
    Georg Nagel
    Max Planck Institut fur Biophysik, Marie Curie Strasse 15, 60439 Frankfurt, Germany
    Proc Natl Acad Sci U S A 100:13940-5. 2003
  3. doi request reprint Structural guidance of the photocycle of channelrhodopsin-2 by an interhelical hydrogen bond
    Christian Bamann
    Max Planck Institut fur Biophysik, Max von Laue Strasse 3, 60438 Frankfurt, Germany
    Biochemistry 49:267-78. 2010
  4. ncbi request reprint Spectral characteristics of the photocycle of channelrhodopsin-2 and its implication for channel function
    Christian Bamann
    Max Planck Institut fur Biophysik, Max von Laue Strasse 3, 60438 Frankfurt, Germany
    J Mol Biol 375:686-94. 2008
  5. ncbi request reprint Fast manipulation of cellular cAMP level by light in vivo
    Saskia Schröder-Lang
    Max Planck Institut fur Biophysik, 60439 Frankfurt, Germany
    Nat Methods 4:39-42. 2007
  6. ncbi request reprint CFTR, investigated with the two-electrode voltage-clamp technique: the importance of knowing the series resistance
    Georg Nagel
    Max Planck Institute of Biophysics, Marie Curie Str 15, D 60439 Frankfurt Main, Germany
    J Cyst Fibros 3:109-11. 2004
  7. doi request reprint Microbial rhodopsins in the spotlight
    Christian Bamann
    Max Planck Institut fur Biophysik, Max von Laue Strasse 3, 60438 Frankfurt, Germany
    Curr Opin Neurobiol 20:610-6. 2010
  8. ncbi request reprint Apparent affinity of CFTR for ATP is increased by continuous kinase activity
    Tanjef Szellas
    Max Planck Institut fur Biophysik, Kennedyallee 70, D 60596 Frankfurt Main, Germany
    FEBS Lett 535:141-6. 2003
  9. ncbi request reprint The Ca/Ca exchange mode of the Na/Ca exchanger investigated by photolytic Ca2+ concentration jumps
    Andreas Haase
    Max Planck Institut fur Biophysik, Kennedyallee 70, D 60596 Frankfurt, Germany
    Ann N Y Acad Sci 976:113-6. 2002
  10. ncbi request reprint Probing the sensory rhodopsin II binding domain of its cognate transducer by calorimetry and electrophysiology
    Silke Hippler-Mreyen
    Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, Otto Hahn Strasse 11, D 44227 Dortmund, Germany
    J Mol Biol 330:1203-13. 2003

Collaborators

  • Christian Bamann
  • Peter Hegemann
  • Sonja Kleinlogel
  • Markus Fuhrmann
  • Timo Strünker
  • J H Caldwell
  • Tzyh Chang Hwang
  • H Koepsell
  • Ernst Bamberg
  • Feng Zhang
  • Suneel Kateriya
  • Saskia Schröder-Lang
  • Karl Deisseroth
  • Christian Schroll
  • Edward S Boyden
  • Bettina Himmel
  • Tanjef Szellas
  • Silke Hippler-Mreyen
  • Christopher Volk
  • Andreas Haase
  • Allan Powe
  • U Benjamin Kaupp
  • Martin Schwarzel
  • Jens Looser
  • Natalie Watzke
  • Kenneth Kay
  • Alexander Gottschalk
  • Phillip G Wood
  • Reinhard Seifert
  • Li Ping Wang
  • Masakatsu Watanabe
  • Jana F Liewald
  • Martin Brauner
  • Erich Buchner
  • Thomas Hendel
  • Bertram Gerber
  • Thomas Riemensperger
  • André Fiala
  • Thomas Völler
  • Daniel Bucher
  • Karen Erbguth
  • Julia Ehmer
  • Christian Herrmann
  • Valentin Gorboulev
  • Ralf Seidel
  • Ansgar A Wegener
  • M Engelhard
  • Johann P Klare
  • Thomas Budiman
  • Georg Schmies
  • Klaus Hartung
  • Philip G Wood
  • Zhen Zhou
  • Michael Kappl

Detail Information

Publications19

  1. ncbi request reprint Channelrhodopsin-1: a light-gated proton channel in green algae
    Georg Nagel
    Max Planck Institut fur Biophysik, Kennedyallee 70, 60596 Frankfurt am Main, Germany
    Science 296:2395-8. 2002
    ..We suggest that Channelrhodopsins are involved in phototaxis of green algae...
  2. pmc Channelrhodopsin-2, a directly light-gated cation-selective membrane channel
    Georg Nagel
    Max Planck Institut fur Biophysik, Marie Curie Strasse 15, 60439 Frankfurt, Germany
    Proc Natl Acad Sci U S A 100:13940-5. 2003
    ..Finally, we demonstrate that ChR2 may be used to depolarize small or large cells, simply by illumination...
  3. doi request reprint Structural guidance of the photocycle of channelrhodopsin-2 by an interhelical hydrogen bond
    Christian Bamann
    Max Planck Institut fur Biophysik, Max von Laue Strasse 3, 60438 Frankfurt, Germany
    Biochemistry 49:267-78. 2010
    ..Furthermore, we show that the D156A mutant is even more suitable for light control of excitable cells than C128A...
  4. ncbi request reprint Spectral characteristics of the photocycle of channelrhodopsin-2 and its implication for channel function
    Christian Bamann
    Max Planck Institut fur Biophysik, Max von Laue Strasse 3, 60438 Frankfurt, Germany
    J Mol Biol 375:686-94. 2008
    ..We conclude that the red-shifted spectral species represents the open channel state, and the thermal relaxation of this intermediate, the transition from P(3) to P(4), is coupled to channel closing...
  5. ncbi request reprint Fast manipulation of cellular cAMP level by light in vivo
    Saskia Schröder-Lang
    Max Planck Institut fur Biophysik, 60439 Frankfurt, Germany
    Nat Methods 4:39-42. 2007
    ..The activity of PACs is strongly and reversibly enhanced by blue light, providing a powerful tool for light-induced manipulation of cAMP in animal cells...
  6. ncbi request reprint CFTR, investigated with the two-electrode voltage-clamp technique: the importance of knowing the series resistance
    Georg Nagel
    Max Planck Institute of Biophysics, Marie Curie Str 15, D 60439 Frankfurt Main, Germany
    J Cyst Fibros 3:109-11. 2004
    ..A short description of the series resistance (RS) and its influence on measurements of channel characteristics is given...
  7. doi request reprint Microbial rhodopsins in the spotlight
    Christian Bamann
    Max Planck Institut fur Biophysik, Max von Laue Strasse 3, 60438 Frankfurt, Germany
    Curr Opin Neurobiol 20:610-6. 2010
    ....
  8. ncbi request reprint Apparent affinity of CFTR for ATP is increased by continuous kinase activity
    Tanjef Szellas
    Max Planck Institut fur Biophysik, Kennedyallee 70, D 60596 Frankfurt Main, Germany
    FEBS Lett 535:141-6. 2003
    ..Both kinases, when continuously active, increase apparent affinity of CFTR to ATP about two-fold emphasizing the role of phosphorylation in modulating the interaction of ATP with the nucleotide binding domains...
  9. ncbi request reprint The Ca/Ca exchange mode of the Na/Ca exchanger investigated by photolytic Ca2+ concentration jumps
    Andreas Haase
    Max Planck Institut fur Biophysik, Kennedyallee 70, D 60596 Frankfurt, Germany
    Ann N Y Acad Sci 976:113-6. 2002
  10. ncbi request reprint Probing the sensory rhodopsin II binding domain of its cognate transducer by calorimetry and electrophysiology
    Silke Hippler-Mreyen
    Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, Otto Hahn Strasse 11, D 44227 Dortmund, Germany
    J Mol Biol 330:1203-13. 2003
    ....
  11. pmc Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of metabotropic glutamate receptor mGluR7
    John H Caldwell
    Department of Neurochemistry, Max Planck Institute for Brain Research, D 60528 Frankfurt am Main, Germany
    J Biol Chem 283:24300-7. 2008
    ....
  12. ncbi request reprint Millisecond-timescale, genetically targeted optical control of neural activity
    Edward S Boyden
    Department of Bioengineering, Stanford University, 318 Campus Drive West, Stanford, California 94305, USA
    Nat Neurosci 8:1263-8. 2005
    ..This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers...
  13. ncbi request reprint Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses
    Georg Nagel
    Max Planck Institute for Biophysics, Max von Laue Str 3, D 60438 Frankfurt, Germany
    Curr Biol 15:2279-84. 2005
    ..Thus, specific neurons or muscles expressing ChR2 can be quickly and reversibly activated by light in live and behaving, as well as dissected, animals...
  14. ncbi request reprint Multimodal fast optical interrogation of neural circuitry
    Feng Zhang
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 446:633-9. 2007
    ..NpHR and ChR2 form a complete system for multimodal, high-speed, genetically targeted, all-optical interrogation of living neural circuits...
  15. pmc Protein kinase-independent activation of CFTR by phosphatidylinositol phosphates
    Bettina Himmel
    Max Planck Institut fur Biophysik, Marie Curie Str 15, D 60439 Frankfurt Main, Germany
    EMBO Rep 5:85-90. 2004
    ..PIP(2) application to phosphorylated CFTR may inhibit the CFTR chloride current. We suggest that regulation of CFTR by PIP(2) is a previously unrecognized, alternative mechanism to control chloride conductance...
  16. ncbi request reprint Light-induced activation of distinct modulatory neurons triggers appetitive or aversive learning in Drosophila larvae
    Christian Schroll
    Lehrstuhl für Genetik und Neurobiologie, Theodor Boveri Institut für Biowissenschaften, Universitat Wurzburg, Biozentrum, Am Hubland, 97074 Wurzburg, Germany
    Curr Biol 16:1741-7. 2006
    ..These findings demonstrate that antagonistic modulatory subsystems are sufficient to substitute for aversive and appetitive reinforcement during classical conditioning...
  17. ncbi request reprint Different affinities of inhibitors to the outwardly and inwardly directed substrate binding site of organic cation transporter 2
    Christopher Volk
    Institut fur Anatomie und Zellbiologie, Koellikerstr 6, 97070 Wurzburg, Germany
    Mol Pharmacol 64:1037-47. 2003
    ..A model is proposed that describes how substrates and inhibitors might interact with rOCT2. The data provide a theoretical basis to understand drug-drug interactions at polyspecific transporters for organic cations...
  18. ncbi request reprint "Vision" in single-celled algae
    Suneel Kateriya
    Institut fur Biochemie, Universitat Regensburg, 93040 Regensburg, Germany
    News Physiol Sci 19:133-7. 2004
    ..They promise to become a useful tool for noninvasive control of membrane potential and intracellular ion concentrations...
  19. ncbi request reprint Quantitative analysis of ATP-dependent gating of CFTR
    Allan Powe
    Department of Physiology, Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA
    Methods Mol Med 70:67-98. 2002