Matthias Meyer

Summary

Affiliation: Max Planck Institute for Evolutionary Anthropology
Country: Germany

Publications

  1. doi request reprint Parallel tagged sequencing on the 454 platform
    Matthias Meyer
    Max Planck Institute for Evolutionary Anthropology, Department of Evolutionary Genetics, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nat Protoc 3:267-78. 2008
  2. pmc Targeted investigation of the Neandertal genome by array-based sequence capture
    Hernán A Burbano
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:723-5. 2010
  3. doi request reprint A draft sequence of the Neandertal genome
    Richard E Green
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:710-22. 2010
  4. pmc Patterns of coding variation in the complete exomes of three Neandertals
    Sergi Castellano
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 111:6666-71. 2014
  5. pmc The complete genome sequence of a Neanderthal from the Altai Mountains
    Kay Prüfer
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
    Nature 505:43-9. 2014
  6. pmc A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Cell 134:416-26. 2008
  7. pmc Road blocks on paleogenomes--polymerase extension profiling reveals the frequency of blocking lesions in ancient DNA
    Patricia Heyn
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nucleic Acids Res 38:e161. 2010
  8. pmc Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Nucleic Acids Res 38:e87. 2010
  9. doi request reprint A mitochondrial genome sequence of a hominin from Sima de los Huesos
    Matthias Meyer
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Nature 505:403-6. 2014
  10. pmc Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments
    Jesse Dabney
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 110:15758-63. 2013

Detail Information

Publications23

  1. doi request reprint Parallel tagged sequencing on the 454 platform
    Matthias Meyer
    Max Planck Institute for Evolutionary Anthropology, Department of Evolutionary Genetics, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nat Protoc 3:267-78. 2008
    ..Most of the reactions can be performed in a multichannel setup on 96-well reaction plates, allowing for processing up to several hundreds of samples in a few days...
  2. pmc Targeted investigation of the Neandertal genome by array-based sequence capture
    Hernán A Burbano
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:723-5. 2010
    ..By generating the sequence of one Neandertal and 50 present-day humans at these positions, we have identified 88 amino acid substitutions that have become fixed in humans since our divergence from the Neandertals...
  3. doi request reprint A draft sequence of the Neandertal genome
    Richard E Green
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:710-22. 2010
    ....
  4. pmc Patterns of coding variation in the complete exomes of three Neandertals
    Sergi Castellano
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 111:6666-71. 2014
    ....
  5. pmc The complete genome sequence of a Neanderthal from the Altai Mountains
    Kay Prüfer
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
    Nature 505:43-9. 2014
    ..In addition, the high-quality Neanderthal genome allows us to establish a definitive list of substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans. ..
  6. pmc A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Cell 134:416-26. 2008
    ..There is evidence that purifying selection in the Neandertal mtDNA was reduced compared with other primate lineages, suggesting that the effective population size of Neandertals was small...
  7. pmc Road blocks on paleogenomes--polymerase extension profiling reveals the frequency of blocking lesions in ancient DNA
    Patricia Heyn
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nucleic Acids Res 38:e161. 2010
    ....
  8. pmc Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Nucleic Acids Res 38:e87. 2010
    ..In addition, our results demonstrate that Neandertal DNA retains in vivo patterns of CpG methylation, potentially allowing future studies of gene inactivation and imprinting in ancient organisms...
  9. doi request reprint A mitochondrial genome sequence of a hominin from Sima de los Huesos
    Matthias Meyer
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Nature 505:403-6. 2014
    ..Our results pave the way for DNA research on hominins from the Middle Pleistocene. ..
  10. pmc Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments
    Jesse Dabney
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 110:15758-63. 2013
    ..Moreover, the techniques presented enable the retrieval of phylogenetically informative sequences from samples in which virtually all DNA is diminished to fragments shorter than 50 bp. ..
  11. pmc From micrograms to picograms: quantitative PCR reduces the material demands of high-throughput sequencing
    Matthias Meyer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nucleic Acids Res 36:e5. 2008
    ..The method should also apply to Illumina/Solexa and ABI/SOLiD sequencing, and should therefore help to widen the accessibility of all three platforms...
  12. pmc Direct multiplex sequencing (DMPS)--a novel method for targeted high-throughput sequencing of ancient and highly degraded DNA
    Mathias Stiller
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Genome Res 19:1843-8. 2009
    ..Embedded in our approach, we present a new protocol for the construction of barcoded sequencing libraries, which is compatible with all current high-throughput technologies and can be performed entirely in plate setup...
  13. pmc A high-coverage genome sequence from an archaic Denisovan individual
    Matthias Meyer
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 338:222-6. 2012
    ....
  14. ncbi request reprint Illumina sequencing library preparation for highly multiplexed target capture and sequencing
    Matthias Meyer
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Cold Spring Harb Protoc 2010:pdb.prot5448. 2010
    ..Libraries can be prepared from any type of double-stranded DNA, even if present in subnanogram quantity...
  15. doi request reprint Single-stranded DNA library preparation for the sequencing of ancient or damaged DNA
    Marie Theres Gansauge
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Nat Protoc 8:737-48. 2013
    ..We estimate that intact DNA strands are recovered in the library with ∼50% efficiency. Libraries can be generated from up to 12 DNA or oligonucleotide samples in parallel within 2 d...
  16. pmc Targeted high-throughput sequencing of tagged nucleic acid samples
    Matthias Meyer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nucleic Acids Res 35:e97. 2007
    ..PTS dramatically increases the sequencing throughput of samples in parallel and thus fully mobilizes the resources of the 454 technology for targeted sequencing...
  17. pmc Patterns of damage in genomic DNA sequences from a Neandertal
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 104:14616-21. 2007
    ..The results suggest that reliable genome sequences can be obtained from Pleistocene organisms...
  18. pmc A mitogenomic phylogeny of living primates
    Knut Finstermeier
    Research Group Molecular Ecology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS ONE 8:e69504. 2013
    ..Finally, we show that mt genomes are a useful tool for resolving primate phylogenetic relationships on various taxonomic levels. ..
  19. doi request reprint A recent evolutionary change affects a regulatory element in the human FOXP2 gene
    Tomislav Maricic
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 30:844-52. 2013
    ....
  20. pmc Double indexing overcomes inaccuracies in multiplex sequencing on the Illumina platform
    Martin Kircher
    Max Planck Institute for Evolutionary Anthropology, Department of Evolutionary Genetics, 04103 Leipzig, Germany
    Nucleic Acids Res 40:e3. 2012
    ..Double-indexing eliminates these problems and increases both the scope and accuracy of multiplex sequencing on the Illumina platform...
  21. doi request reprint Length and GC-biases during sequencing library amplification: a comparison of various polymerase-buffer systems with ancient and modern DNA sequencing libraries
    Jesse Dabney
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Biotechniques 52:87-94. 2012
    ....
  22. ncbi request reprint Multiplex amplification of ancient DNA
    Holger Römpler
    Molecular Biochemistry, Institute of Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Nat Protoc 1:720-8. 2006
    ..It thus combines optimal template usage with a high specificity and can be performed within a day...
  23. ncbi request reprint A genomic region evolving toward different GC contents in humans and chimpanzees indicates a recent and regionally limited shift in the mutation pattern
    Ingo Ebersberger
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 22:1240-5. 2005
    ..Based on our analysis, we suggest a recent and species-specific shift in the region's mutation pattern as the cause of its differing evolution in humans and chimpanzees...