Research Topics
Genomes and Genes
| Daniel Martins-de-SouzaSummaryAffiliation: Max Planck Institute of Psychiatry Country: Germany Publications
| Collaborators
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Detail Information
Publications
Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patientsD Martins-de-Souza
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
Transl Psychiatry 2:e87. 2012..These findings suggest that it may be possible to contribute to the disease understanding by distinguishing different subtypes of MDD based on distinct brain proteomic profiles...
Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophreniaDaniel Martins-de-Souza
Laboratorio de Neurociencias, Instituto de Psiquiatria, Faculdade de Medicina da USP, Rua Dr Ovidio Pires de Campos, SP, Brazil
J Psychiatr Res 43:978-86. 2009..Our data not only reinforces the involvement of proteins previously implicated in schizophrenia, but also suggests new markers, providing further information to foster the comprehension of this important disease...- Proteome analyses of cultured astrocytes treated with MK-801 and clozapine: similarities with schizophreniaDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804, Munich, Germany
Eur Arch Psychiatry Clin Neurosci 261:217-28. 2011..Interestingly, clozapine reversed protein changes induced by MK-801. The treatment of cell cultures with neural transmission agonists and antagonists might provide useful insights about psychiatric disorders... - Different apolipoprotein E, apolipoprotein A1 and prostaglandin-H2 D-isomerase levels in cerebrospinal fluid of schizophrenia patients and healthy controlsDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Munich, Germany
World J Biol Psychiatry 11:719-28. 2010..To identify proteins differentially expressed in schizophrenia patients, we collected 50 microl cerebrospinal fluid from 17 first-episode schizophrenia patients and 10 healthy controls... - Proteome and transcriptome analysis suggests oligodendrocyte dysfunction in schizophreniaDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
J Psychiatr Res 44:149-56. 2010..The presented data contribute to the composition of a scenario that may lead to a better understanding of schizophrenia pathogenesis... - Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulationDaniel Martins-de-Souza
Laboratorio de Neurociencias, Instituto de Psiquiatria, Faculdade de Medicina da USP, Rua Dr, Ovídio Pires de Campos, no 785, Sao Paulo, SP, CEP 05403 010, Brazil
BMC Psychiatry 9:17. 2009..The superior temporal gyrus is implicated in schizophrenia and executes functions such as the processing of speech, language skills and sound processing... - Shotgun mass spectrometry analysis of the human thalamus proteomeDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Munich, Germany
J Sep Sci 32:1231-6. 2009..The thalamus proteome contributes to the knowledge of the human brain proteome and future applications in basic and clinical research... - Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophreniaDaniel Martins-de-Souza
Laboratorio de Neurociencias, Instituto de Psiquiatria, Universidade de Sao Paulo, Rua Dr Ovidio Pires de Campos, no 785, Consolação, Sao Paulo, SP 05403 010, Brazil
Eur Arch Psychiatry Clin Neurosci 259:151-63. 2009..In addition a number of new potential markers were found that may contribute to the understanding of the pathogenesis of this complex disease... - Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysisDaniel Martins-de-Souza
Laboratorio de Neurociencias, Faculdade de Medicina da USP, Instituto de Psiquiatria, Universidade de Sao Paulo, Rua Dr Ovidio Pires de Campos, no 785, s n Consolação, Sao Paulo, SP, CEP 05403 010, Brazil
J Neural Transm 116:275-89. 2009.... - Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophreniaDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
J Psychiatr Res 44:1176-89. 2010.... - Proteome analysis of schizophrenia brain tissueDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Munich, Germany
World J Biol Psychiatry 11:110-20. 2010..Reviewing the results of 13 proteome studies in SCZ brain tissue, we aimed to provide information regarding potential proteins biomarkers as well as information about the pathophysiology of the disease... - Protein phosphorylation patterns in serum from schizophrenia patients and healthy controlsJulian A J Jaros
Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, United Kingdom
J Proteomics 76:43-55. 2012..This article is part of a Special Issue entitled: Integrated omics... - Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degenerationDaniel Martins-de-Souza
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
J Proteome Res 11:2533-43. 2012..Further studies of aFTLD-U and other FTLD subtypes are warranted, although this will require intensive biobanking efforts... - Sex-specific proteome differences in the anterior cingulate cortex of schizophreniaDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Kraepelinstr 2, 80804 Munich, Germany
J Psychiatr Res 44:989-91. 2010..Our findings not only support previous findings but also indicate areas that warrant further study in schizophrenia... - Proteome analysis of human dorsolateral prefrontal cortex using shotgun mass spectrometryDaniel Martins-de-Souza
Laboratorio de Neurociencias, Instituto de Psiquiatria, Facultdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
J Sep Sci 31:3122-6. 2008..It will also aid comparative studies of different brain areas and medical conditions, with future applications in basic and clinical research... - Analysis of the rat hypothalamus proteome by data-independent label-free LC-MS/MSViktoria Stelzhammer
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
Proteomics 12:3386-92. 2012..Important proteins involved in neurological and synaptic function were identified including several members of the Ras-related protein family and proteins involved in glutamate biosynthesis... - To label or not to label: applications of quantitative proteomics in neuroscience researchMichaela D Filiou
Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Munich, Germany
Proteomics 12:736-47. 2012.... - Characterizing the proteome of the human dorsolateral prefrontal cortex by shotgun mass spectrometryDaniel Martins-de-Souza
Institute of Biotechnology, University of Cambridge, Cambridge, UK
Proteomics 11:2347-53. 2011..Combination of this data set with that obtained by our previous characterization of the same brain region results in a total of 755 unique proteins, making this the most comprehensive analysis of this important brain region to date... - Differential expression of HINT1 in schizophrenia brain tissueJeeva Varadarajulu
Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804, Munich, Germany
Eur Arch Psychiatry Clin Neurosci 262:167-72. 2012..Our results combined to previous studies in human samples and preclinical models support the notion that HINT1 must be more explored as a potential target for psychiatric disorders... - Structural and pharmacological characterization of the crotamine isoforms III-4 (MYX4_CROCu) and III-7 (MYX7_CROCu) isolated from the Crotalus durissus cumanensis venomLuis Alberto Ponce-Soto
Department of Biochemistry, Institute of Biology IB, State University of Campinas UNICAMP, P O Box 6109, 13083 970 Campinas, SP, Brazil
Toxicon 55:1443-52. 2010..Edema-forming activity was also analyzed by injection of the crotamine isoforms into the right paw, since both crotamine isoforms exert a strong pro-inflammatory effect... - Phosphoproteomic differences in major depressive disorder postmortem brains indicate effects on synaptic functionDaniel Martins-de-Souza
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, Cambridgeshire, UK
Eur Arch Psychiatry Clin Neurosci 262:657-66. 2012..The majority of these phosphorylated proteins were associated with synaptic transmission and cellular architecture not only pointing out potential biomarker candidates but mainly shedding light to the comprehension of MDD pathobiology... - The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophreniaDaniel Martins-de-Souza
Dept of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QT, UK
BMC Res Notes 5:146. 2012..Selective reaction monitoring (SRM) has already shown promise in preclinical and clinical studies for multiplex measurement of diagnostic, prognostic and treatment-related biomarkers... - Identification of a blood-based biological signature in subjects with psychiatric disorders prior to clinical manifestationEmanuel Schwarz
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
World J Biol Psychiatry 13:627-32. 2012..To determine whether a molecular signature is present in blood of patients with psychiatric disorders before manifestation of symptoms... - Clinical use of phosphorylated proteins in blood serum analysed by immobilised metal ion affinity chromatography and mass spectrometryJulian A J Jaros
Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, United Kingdom
J Proteomics 76:36-42. 2012..This article is part of a Special Issue entitled: Integrated omics... - The role of energy metabolism dysfunction and oxidative stress in schizophrenia revealed by proteomicsDaniel Martins-de-Souza
Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, Cambridgeshire, United Kingdom
Antioxid Redox Signal 15:2067-79. 2011..Here we review the results of these studies with a focus on the biomarker pattern depicting alterations in energy metabolism and oxidative stress in this debilitating illness... - Abnormalities in metabolism and hypothalamic-pituitary-adrenal axis function in schizophreniaPaul C Guest
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom
Int Rev Neurobiol 101:145-68. 2011.... - Proteomic approaches to unravel the complexity of schizophreniaDaniel Martins-de-Souza
Department of Chemical Engineering and Biotechnology, Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, UK
Expert Rev Proteomics 9:97-108. 2012..Here, we discuss the main outcome of these investigations and suggest a practical means of integrating and translating the findings between the brain and peripheral blood to increase our understanding of schizophrenia pathophysiology... - Shotgun mass spectrometry workflow combining IEF and LC-MALDI-TOF/TOFGiuseppina Maccarrone
Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Kraepelinstrasse 2, 80804, Munich, Germany
Protein J 29:99-102. 2010..Such workflow was successfully applied to a comparative proteome analysis of schizophrenia versus healthy control brain tissues and can be an alternative to proteome researches... - Biochemical and pharmacological characterization of PhTX-I a new myotoxic phospholipase A2 isolated from Porthidium hyoprora snake venomSalomón Huancahuire-Vega
Department of Biochemistry, Institute of Biology, State University of Campinas, SP, Brazil
Comp Biochem Physiol C Toxicol Pharmacol 154:108-19. 2011..In vitro, both induced low cytotoxicity in skeletal muscle myoblasts, however PhTX-I PLA(2) was able to lyse myotubes... - Quantitative proteomics for investigating psychiatric disordersMichaela D Filiou
Proteomics and Biomarkers, Max Planck Institute of Psychiatry, Munich, Germany
Proteomics Clin Appl 5:38-49. 2011..Finally, we explore the applicability of implementing proteomic methods as a routine diagnostic tool in the clinical laboratory... - Proteomic technologies for biomarker studies in psychiatry: advances and needsDaniel Martins-de-Souza
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom
Int Rev Neurobiol 101:65-94. 2011..The future development of such technologies may put proteomics closer to clinical applications in psychiatry... - Characterization of the human primary visual cortex and cerebellum proteomes using shotgun mass spectrometry-data-independent analysesDaniel Martins-de-Souza
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
Proteomics 12:500-4. 2012..The complete mapping of these and other brain proteomes may help in the elucidation of neurological processes and identify potential targets for therapeutic strategies... - Functional and structural characterization of a new serine protease with thrombin-like activity TLBan from Bothrops andianus (Andean Lancehead) snake venomJosé Antonio Valeriano-Zapana
Department of Biochemistry, Institute of Biology IB, State University of Campinas UNICAMP, P O Box 6109, Zip Code 13083 970, Campinas, SP, Brazil
Toxicon 59:231-40. 2012..TLBan showed a potential medical-scientific interest to understand the pathophysiological mechanism of the snake venom action and identification of new blood coagulation cascade acting enzymes of natural sources... - Biological and biochemical characterization of two new PLA2 isoforms Cdc-9 and Cdc-10 from Crotalus durissus cumanensis snake venomFrey Francisco Romero-Vargas
Department of Biochemistry, Institute Biology CP 6109, State University of Campinas, Campinas, SP, Brazil
Comp Biochem Physiol C Toxicol Pharmacol 151:66-74. 2010..However, p-BPB strongly diminishes the local and systemic myotoxic effects... - Proteome profiling of peripheral mononuclear cells from human bloodGiuseppina Maccarrone
Max Planck Institute for Psychiatry, Proteomics and Biomarkers, Munich, Germany
Proteomics 13:893-7. 2013..Mapping the MNC proteome provides a valuable resource for studies on disease pathogenesis and the identification of therapeutic targets... - Proteomic changes induced by anaesthesia and muscle relaxant treatment prior to electroconvulsive therapyViktoria Stelzhammer
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
Proteomics Clin Appl 5:644-9. 2011..g. musculoskeletal injury, during the convulsions. However, most molecular studies investigating the mechanism of action of ECT have not explored the potential effects of the pre-treatment with anaesthetic and/ or muscle relaxant... - Characterization of the human serum depletome by label-free shotgun proteomicsTheodoros A Koutroukides
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
J Sep Sci 34:1621-6. 2011..These results suggest that further studies on this commonly ignored serum fraction may provide new insights into clinical proteomics... - Purification and inflammatory edema induced by two PLA2 (Anch TX-I and Anch TX-II) from sea anemone Anthothoe chilensis (Actiniaria: Sagartiidae)Elen Cristina Teizem Landucci
Departamento de Farmacologia, Faculdade de Ciencias Medicas, CEP 13083 970, Campinas, SP, Brazil
Comp Biochem Physiol B Biochem Mol Biol 161:170-7. 2012..We also investigated the in vivo edematogenic activity of Anch TX-I and Anch TX-II in a model of paw and skin edema in rats and observed that both are able to induce dose-dependent edema... - The role of proteomics in depression researchDaniel Martins-de-Souza
Max Planck Institute for Psychiatry, Kraepelinstr 2, 80804, Munich, Germany
Eur Arch Psychiatry Clin Neurosci 260:499-506. 2010..Here, we will show the potential of proteome analyses as a tool to elucidate the pathophysiological mechanisms of depression as well as the discovery of potential diagnostic, therapeutic and disease course biomarkers... - Affinity depletion of plasma and serum for mass spectrometry-based proteome analysisJulian A J Jaros
University of Cambridge, Cambridge, UK
Methods Mol Biol 1002:1-11. 2013..We describe in detail an affinity depletion method that selectively removes 14 of the most abundant proteins in plasma and serum... - Proteome analysis of spinal cord during the clinical course of monophasic experimental autoimmune encephalomyelitisAlessandro S Farias
Neuroimmunology Unit, Department of Genetics Evolution and Bioagents, University of Campinas, SP, Brazil
Proteomics 12:2656-62. 2012.... - Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3Carolina L Bigarella
Hematology and Hemotherapy Center, University of Campinas, Campinas, Sao Paulo, Brazil
FEBS Lett 586:3522-8. 2012..Interestingly, our results suggest that ARHGAP21 SUMOylation may be related to cell proliferation. Therefore, SUMOylation of ARHGAP21 may represent a way of guiding its function... - Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolismAlana Knapman
Research Group of Psychoneuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
Eur J Neurosci 35:412-22. 2012..Thus, our results provide further support for the involvement of a dysregulated HPA axis and mitochondrial dysfunction in the etiology and pathophysiology of affective disorders... - Characterization of the C-terminal half of human juvenile myoclonic epilepsy protein EFHC1: dimer formation blocks Ca2+ and Mg2+ binding to its functional EF-handMarcelo J Murai
Department of Medical Genetics, Faculty of Medical Sciences, Tessalia Vieira de Camargo, 126, CEP 13083 970, University of Campinas, UNICAMP, Campinas, SP, Brazil
Arch Biochem Biophys 477:131-8. 2008..It was also found that under reducing condition Ca(2+) or Mg(2+) ions bind to EFHC1C in a 1/1 molar ratio, while under oxidizing condition this ratio is reduced, showing that EFHC1C dimerization blocks Ca(2+) and Mg(2+) binding... 
The use of ASB-14 in combination with CHAPS is the best for solubilization of human brain proteins for two-dimensional gel electrophoresisDaniel Martins-de-Souza
Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, 13083 970 Campinas, SP, Brazil
Brief Funct Genomic Proteomic 6:70-5. 2007..Our results confirm that the most efficient solubilizing solution for 2-DE analysis of cytosolic and membrane Human Brain Proteins is SB combined with 4% CHAPS and 2% ASB-14...- Xylella fastidiosa disturbs nitrogen metabolism and causes a stress response in sweet orange Citrus sinensis cv. PeraRúbia P Purcino
Departamento de Fisiologia Vegetal, Instituto de Biologia, Universidade Estadual de Campinas, CP 6109, 13083 970, Campinas, SP, Brazil
J Exp Bot 58:2733-44. 2007..These results showed that significant changes take place in the nitrogen metabolism of DP, probably as a response to the alterations in the absorption, assimilation and distribution of N in the plant...