Bernd Lepenies

Summary

Affiliation: Max Planck Institute of Colloids and Interfaces
Country: Germany

Publications

  1. doi request reprint Targeting C-type lectin receptors with multivalent carbohydrate ligands
    Bernd Lepenies
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany Department of Biology, Chemistry, and Pharmacy, Freie Universitat Berlin, Germany Electronic address
    Adv Drug Deliv Rev 65:1271-81. 2013
  2. doi request reprint The promise of glycomics, glycan arrays and carbohydrate-based vaccines
    Bernd Lepenies
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Potsdam, Germany
    Immunopharmacol Immunotoxicol 32:196-207. 2010
  3. doi request reprint Hexameric supramolecular scaffold orients carbohydrates to sense bacteria
    Dan Grünstein
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
    J Am Chem Soc 133:13957-66. 2011
  4. ncbi request reprint Biological Evaluation of Multivalent Lewis X-MGL-1 Interactions
    Magdalena Eriksson
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Muhlenberg 1, 14476 Potsdam Germany Institute for Chemistry and Biochemistry, Freie Universitat Berlin, Arnimallee 22, 14195 Berlin Germany
    Chembiochem 15:844-51. 2014
  5. doi request reprint A platform to screen for C-type lectin receptor-binding carbohydrates and their potential for cell-specific targeting and immune modulation
    Maha Maglinao
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Muhlenberg 1, 14476 Potsdam, Germany Freie Universität Berlin, Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Arnimallee 22, 14195 Berlin, Germany
    J Control Release 175:36-42. 2014
  6. doi request reprint Toward animal cell culture-based influenza vaccine design: viral hemagglutinin N-glycosylation markedly impacts immunogenicity
    Julia Hütter
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany
    J Immunol 190:220-30. 2013
  7. doi request reprint Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting
    Gonçalo J L Bernardes
    Max Planck Institute of Colloids and Interfaces, Research Campus Golm, 14476 Potsdam, Germany
    Org Biomol Chem 8:4987-96. 2010
  8. doi request reprint Defined presentation of carbohydrates on a duplex DNA scaffold
    Mark K Schlegel
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Muhlenberg 1, 14476 Potsdam, Germany
    Chembiochem 12:2791-800. 2011
  9. ncbi request reprint Applications of synthetic carbohydrates to chemical biology
    Bernd Lepenies
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Research Campus Potsdam Golm, 14476 Potsdam, Germany
    Curr Opin Chem Biol 14:404-11. 2010
  10. doi request reprint The C-type lectin receptor DCIR is crucial for the development of experimental cerebral malaria
    Maha Maglinao
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany
    J Immunol 191:2551-9. 2013

Collaborators

  • Erdmann Rapp
  • Daniel Kolarich
  • Niels Christian Reichardt
  • Robert Klopfleisch
  • Maha Maglinao
  • Peter H Seeberger
  • Magdalena Eriksson
  • Mark K Schlegel
  • Julia Hütter
  • Dan Grünstein
  • Mayeul Collot
  • Raghavendra Kikkeri
  • Gonçalo J L Bernardes
  • Stephanie Zimmermann
  • Sonia Serna
  • Timo Johannssen
  • Sebastian Götze
  • Dirk Höper
  • Udo Reichl
  • Jana V Rödig
  • Konstantin Barylyuk
  • Faustin Kamena
  • Renato Zenobi
  • Sung You Hong
  • Paola Laurino

Detail Information

Publications12

  1. doi request reprint Targeting C-type lectin receptors with multivalent carbohydrate ligands
    Bernd Lepenies
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany Department of Biology, Chemistry, and Pharmacy, Freie Universitat Berlin, Germany Electronic address
    Adv Drug Deliv Rev 65:1271-81. 2013
    ..Major emphasis is directed towards targeting of CLRs expressed by antigen-presenting cells to modulate immune responses...
  2. doi request reprint The promise of glycomics, glycan arrays and carbohydrate-based vaccines
    Bernd Lepenies
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Potsdam, Germany
    Immunopharmacol Immunotoxicol 32:196-207. 2010
    ..Furthermore, this review focuses on how immunological research can benefit from these novel tools provided by glycochemistry...
  3. doi request reprint Hexameric supramolecular scaffold orients carbohydrates to sense bacteria
    Dan Grünstein
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
    J Am Chem Soc 133:13957-66. 2011
    ..Simple visualization of binding between a fluorescent, multivalent mannose complex and the Escherichia coli strain ORN178 that possesses mannose-specific receptor sites illustrates the potential for these complexes as biosensors...
  4. ncbi request reprint Biological Evaluation of Multivalent Lewis X-MGL-1 Interactions
    Magdalena Eriksson
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Muhlenberg 1, 14476 Potsdam Germany Institute for Chemistry and Biochemistry, Freie Universitat Berlin, Arnimallee 22, 14195 Berlin Germany
    Chembiochem 15:844-51. 2014
    ..This study provides insights into how multivalent carbohydrate-lectin interactions can be exploited to modulate immune responses. ..
  5. doi request reprint A platform to screen for C-type lectin receptor-binding carbohydrates and their potential for cell-specific targeting and immune modulation
    Maha Maglinao
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Muhlenberg 1, 14476 Potsdam, Germany Freie Universität Berlin, Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Arnimallee 22, 14195 Berlin, Germany
    J Control Release 175:36-42. 2014
    ..The platform described here allows for the identification of CLR ligands, as well as the evaluation of each ligand's cell-specific targeting and immune modulatory properties. ..
  6. doi request reprint Toward animal cell culture-based influenza vaccine design: viral hemagglutinin N-glycosylation markedly impacts immunogenicity
    Julia Hütter
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany
    J Immunol 190:220-30. 2013
    ..In conclusion, this study indicates a crucial importance of HA N-glycosylation for immunogenicity. Our findings have implications for cell line-based influenza vaccine design...
  7. doi request reprint Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting
    Gonçalo J L Bernardes
    Max Planck Institute of Colloids and Interfaces, Research Campus Golm, 14476 Potsdam, Germany
    Org Biomol Chem 8:4987-96. 2010
    ..The d-Gal/d-GalNAc-functionalized βCDs and liposomes presented here enable hepatocyte-specific targeting. Gal-functionalized βCDs are efficient molecular carriers to deliver doxorubicin in vitro into hepatocytes and induce apoptosis...
  8. doi request reprint Defined presentation of carbohydrates on a duplex DNA scaffold
    Mark K Schlegel
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Muhlenberg 1, 14476 Potsdam, Germany
    Chembiochem 12:2791-800. 2011
    ..Surface plasmon resonance and cellular uptake studies with bone-marrow-derived dendritic cells were used to assess the capability of these carbohydrate-modified duplexes to bind to mMGL receptors...
  9. ncbi request reprint Applications of synthetic carbohydrates to chemical biology
    Bernd Lepenies
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Research Campus Potsdam Golm, 14476 Potsdam, Germany
    Curr Opin Chem Biol 14:404-11. 2010
    ..This review focuses on how diverse carbohydrate structures can be synthetically derived and highlights the benefit of synthetic carbohydrates for glycobiology...
  10. doi request reprint The C-type lectin receptor DCIR is crucial for the development of experimental cerebral malaria
    Maha Maglinao
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany
    J Immunol 191:2551-9. 2013
    ..This study indicates that DCIR is critically involved in CM induction, thus highlighting the importance of this CLR in innate immunity during malaria infection. ..
  11. doi request reprint Glycomics, glycoproteomics and the immune system
    Daniel Kolarich
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Muhlenberg 1, 14476 Potsdam, Germany
    Curr Opin Chem Biol 16:214-20. 2012
    ..In this review, we focus on different glycomics and glycoproteomics approaches and their application for studying protein glycosylation in the immune system...