Rainer Landgraf

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. ncbi request reprint Born to be anxious: neuroendocrine and genetic correlates of trait anxiety in HAB rats
    R Landgraf
    Max Planck Institute of Psychiatry, Munich, Germany
    Stress 6:111-9. 2003
  2. ncbi request reprint Release of vasopressin within the brain contributes to neuroendocrine and behavioral regulation
    R Landgraf
    Max Planck Institute of Psychiatry, Munchen, Germany
    Prog Brain Res 119:201-20. 1998
  3. ncbi request reprint High vs low anxiety-related behavior rats: an animal model of extremes in trait anxiety
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Munich, Germany
    Behav Genet 32:301-14. 2002
  4. ncbi request reprint Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: focus on vasopressin and glyoxalase-I
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Munich, Germany
    Neurosci Biobehav Rev 31:89-102. 2007
  5. ncbi request reprint Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
    Front Neuroendocrinol 25:150-76. 2004
  6. ncbi request reprint The involvement of the vasopressin system in stress-related disorders
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Munich, Germany
    CNS Neurol Disord Drug Targets 5:167-79. 2006
  7. ncbi request reprint Viral vector-mediated gene transfer of the vole V1a vasopressin receptor in the rat septum: improved social discrimination and active social behaviour
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    Eur J Neurosci 18:403-11. 2003
  8. ncbi request reprint Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin
    Alexandra Wigger
    Max Planck Institute of Psychiatry, Behavioural Neuroendocrinology, Munich, Germany
    Neuropsychopharmacology 29:1-14. 2004
  9. ncbi request reprint Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety
    Chris Murgatroyd
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 24:7762-70. 2004
  10. ncbi request reprint Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neurochem 92:1170-9. 2005

Detail Information

Publications99

  1. ncbi request reprint Born to be anxious: neuroendocrine and genetic correlates of trait anxiety in HAB rats
    R Landgraf
    Max Planck Institute of Psychiatry, Munich, Germany
    Stress 6:111-9. 2003
    ..This may have implications for understanding the molecular basis for individual variations in trait anxiety and for psychopathology...
  2. ncbi request reprint Release of vasopressin within the brain contributes to neuroendocrine and behavioral regulation
    R Landgraf
    Max Planck Institute of Psychiatry, Munchen, Germany
    Prog Brain Res 119:201-20. 1998
    ....
  3. ncbi request reprint High vs low anxiety-related behavior rats: an animal model of extremes in trait anxiety
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Munich, Germany
    Behav Genet 32:301-14. 2002
    ..HAB/LAB rats are thus proving to be a unique animal model to identify and characterize neurobiological, neuroendocrine, and genetic correlates of trait anxiety, and perhaps depression, in humans...
  4. ncbi request reprint Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: focus on vasopressin and glyoxalase-I
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Munich, Germany
    Neurosci Biobehav Rev 31:89-102. 2007
    ....
  5. ncbi request reprint Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
    Front Neuroendocrinol 25:150-76. 2004
    ....
  6. ncbi request reprint The involvement of the vasopressin system in stress-related disorders
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Munich, Germany
    CNS Neurol Disord Drug Targets 5:167-79. 2006
    ....
  7. ncbi request reprint Viral vector-mediated gene transfer of the vole V1a vasopressin receptor in the rat septum: improved social discrimination and active social behaviour
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    Eur J Neurosci 18:403-11. 2003
    ..Viral vector-mediated gene transfer provides a valuable tool for studies on the role of localized gene expression on behavioural parameters...
  8. ncbi request reprint Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin
    Alexandra Wigger
    Max Planck Institute of Psychiatry, Behavioural Neuroendocrinology, Munich, Germany
    Neuropsychopharmacology 29:1-14. 2004
    ....
  9. ncbi request reprint Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety
    Chris Murgatroyd
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 24:7762-70. 2004
    ..Taken together, our results demonstrate a role for an AVP gene polymorphism and CBF-A in elevated AVP expression in the PVN of HAB rats likely to contribute to their behavioral and neuroendocrine phenotype...
  10. ncbi request reprint Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neurochem 92:1170-9. 2005
    ..Chronic paroxetine enhanced the presynaptic responsivity in HAB rats, but not LAB rats, pointing to a preferential efficacy of paroxetine in rats with enhanced anxiety/depression-related behaviour...
  11. ncbi request reprint Genetic predisposition to anxiety-related behavior determines coping style, neuroendocrine responses, and neuronal activation during social defeat
    Elisabeth Frank
    Max Planck Institute of Psychiatry, Munich, Germany
    Behav Neurosci 120:60-71. 2006
    ..In the latter, Fos expression upon SD was enhanced in the amygdala and hypothalamic areas compared with LABs, whereas it was diminished in prefrontal and brainstem areas...
  12. ncbi request reprint Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice
    Melanie S Kessler
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Eur J Neurosci 26:2857-64. 2007
    ..Thus, the SNP-associated deficit in plasma and central AVP contributes to signs of cDI and, at least partially, to low trait anxiety, both features being typical of LAB animals...
  13. doi request reprint Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2
    Jan M Deussing
    Max Planck Institut fur Psychiatrie, Munich, Germany
    J Neurosci 30:9103-16. 2010
    ..In conclusion, our results suggest a novel role for UCN3 and CRH-R2 related to the processing of social cues and to the establishment of social memories...
  14. pmc Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways
    Yaoyang Zhang
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Cell Proteomics 10:M111.008110. 2011
    ..Our data demonstrate that the high anxiety-related behavior and low anxiety-related behavior mouse model is a valuable tool for anxiety disorder drug discovery efforts...
  15. ncbi request reprint Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety
    Simone A Krömer
    Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    J Neurosci 25:4375-84. 2005
    ..Additional studies will examine whether glyoxalase-I has an impact beyond that of a biomarker to predict the genetic predisposition to anxiety- and depression-like behavior...
  16. ncbi request reprint Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress
    Tobias Welt
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 31:2573-9. 2006
    ..An increasingly released AVP of magnocellular origin seems to provide a negative tonus on ACTH secretion most probably via inhibiting the release of ACTH secretagogues from the median eminence into hypophyseal portal blood...
  17. pmc A hypomorphic vasopressin allele prevents anxiety-related behavior
    Mirjam Bunck
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e5129. 2009
    ....
  18. doi request reprint The (15)N isotope effect as a means for correlating phenotypic alterations and affected pathways in a trait anxiety mouse model
    Michaela D Filiou
    Department of Proteomics and Biomarkers, Max Planck Institute of Psychiatry, Munich, Germany
    Proteomics 12:2421-7. 2012
    ..Here, we discuss the affected pathways with regard to their relevance for the behavioral phenotype and critically assess the utility of exploiting the (15)N isotope effect for correlating phenotypic and molecular alterations...
  19. doi request reprint Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways
    Michaela D Filiou
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2, Munich, Germany
    Biol Psychiatry 70:1074-82. 2011
    ....
  20. ncbi request reprint Protein biomarkers in a mouse model of extremes in trait anxiety
    Claudia Ditzen
    Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    Mol Cell Proteomics 5:1914-20. 2006
    ..The presence of both protein markers in red or white blood cells, respectively, creates the opportunity to screen for their expression in clinical blood specimens from patients suffering from anxiety...
  21. doi request reprint Mice selected for high versus low stress reactivity: a new animal model for affective disorders
    Chadi Touma
    Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Psychoneuroendocrinology 33:839-62. 2008
    ....
  22. pmc Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression
    Chadi Touma
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e4325. 2009
    ..This so-called 'stress reactivity' (SR) mouse model consists of three separate breeding lines selected for either high (HR), intermediate (IR), or low (LR) corticosterone increase in response to stressors...
  23. ncbi request reprint Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 28:235-43. 2003
    ..This novel mechanism of action of paroxetine on vasopressin gene regulation renders vasopressinergic neuronal circuits a promising target for the development of more causal antidepressant treatment strategies...
  24. pmc The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety
    Mariya Gonik
    Max Planck Institute of Psychiatry, Munich, Germany
    BMC Genomics 13:579. 2012
    ..Its dysfunction is related to several mental disorders, including anxiety and depression. The aim of this study was to identify genetic loci underlying the endocrine regulation of the HPA axis...
  25. doi request reprint Increased levels of conditioned fear and avoidance behavior coincide with changes in phosphorylation of the protein kinase B (AKT) within the amygdala in a mouse model of extremes in trait anxiety
    Yi Chun Yen
    Max Planck Institute of Psychiatry, Kraepelinstr 2, D 80804 Munich, Germany
    Neurobiol Learn Mem 98:56-65. 2012
    ..Our data imply changes in AKT phosphorylation as a therapeutic target for the prevention of exaggerated fear memories...
  26. pmc Intranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons
    Irina A Ionescu
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 37:1323-37. 2012
    ....
  27. pmc Stable isotope metabolic labeling with a novel N-enriched bacteria diet for improved proteomic analyses of mouse models for psychopathologies
    Elisabeth Frank
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e7821. 2009
    ..The newly developed (15)N bacteria diet provides researchers a novel tool to discover disease-relevant protein expression differences in mouse models using quantitative mass spectrometry...
  28. pmc Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein
    Amalia Tsolakidou
    Max Planck Institute of Psychiatry, Munich, Germany
    BMC Genomics 11:546. 2010
    ..Gene expression and regulation was determined by microarray analyses and further evaluated by bioinformatics tools including pathway and cluster analyses...
  29. ncbi request reprint Repetitive transcranial magnetic stimulation induces active coping strategies and attenuates the neuroendocrine stress response in rats
    M E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804, Munich, Germany
    J Psychiatr Res 34:265-76. 2000
    ....
  30. ncbi request reprint ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder
    Marianne B Muller
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neuropsychopharmacology 28:1991-9. 2003
    ....
  31. doi request reprint Methylglyoxal-mediated anxiolysis involves increased protein modification and elevated expression of glyoxalase 1 in the brain
    Boris Hambsch
    Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    J Neurochem 113:1240-51. 2010
    ..Thereby, we identified a novel molecular mechanism for anxiety-related behavior in mice that may help to elucidate genesis of psychiatric disorders in humans...
  32. ncbi request reprint Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice
    Rudolph Marsch
    Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    J Neurosci 27:832-9. 2007
    ..Our data provide first evidence for fear-promoting effects of TRPV1 with respect to both innate and conditioned fear and for a decisive role of this receptor in synaptic plasticity...
  33. doi request reprint Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism
    Alana Knapman
    Research Group of Psychoneuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Neurosci 35:412-22. 2012
    ..Thus, our results provide further support for the involvement of a dysregulated HPA axis and mitochondrial dysfunction in the etiology and pathophysiology of affective disorders...
  34. pmc Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice
    Ludwig Czibere
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 6:e23604. 2011
    ..Altogether, our results suggest that Ctsb has significant effects on emotionality, irrespective of the tested mouse strain, making it a promising target for future pharmacotherapy...
  35. ncbi request reprint Emotional stress triggers intrahypothalamic but not peripheral release of oxytocin in male rats
    M Engelmann
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neuroendocrinol 11:867-72. 1999
    ....
  36. pmc Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression
    Thomas Fenzl
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    BMC Neurosci 12:29. 2011
    ..Eight adult males of each of the three breeding lines were equipped with epidural EEG and intramuscular electromyogram (EMG) electrodes. After recovery, EEG and EMG recordings were performed for two days...
  37. ncbi request reprint Forced swimming triggers vasopressin release within the amygdala to modulate stress-coping strategies in rats
    Karl Ebner
    Max Planck Institut fur Psychiatrie, Munchen, Germany
    Eur J Neurosci 15:384-8. 2002
    ..Taken together with previous findings the results of the present study suggest that AVP is released within septum and amygdala to balance the behavioural response during forced swimming...
  38. ncbi request reprint High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats
    Raffael Kalisch
    NMR Study Group, Max Planck Institute of Psychiatry, Munich, Germany
    Neuroimage 23:382-91. 2004
    ..In the context of an anxiety-inhibiting role of the dmPFC, we propose that failure to sufficiently activate this region in stressful situations may contribute to high trait anxiety...
  39. doi request reprint Listening to neuropeptides by microdialysis: echoes and new sounds?
    Carsten T Wotjak
    Max Planck Institut fur Psychiatrie, Kraepelinstr 2, D 80804 München, Germany
    Pharmacol Biochem Behav 90:125-34. 2008
    ....
  40. doi request reprint Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders
    A Knapman
    Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 44:566-75. 2010
    ....
  41. ncbi request reprint Anxiolytic and anti-stress effects of brain prolactin: improved efficacy of antisense targeting of the prolactin receptor by molecular modeling
    L Torner
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 21:3207-14. 2001
    ..05, not significant; adjustment of target position after mRNA modeling, 72%; p < 0.05). Taken together, prolactin acting at brain level has to be considered as a novel regulator of both emotionality and HPA axis reactivity...
  42. ncbi request reprint Hyper-reactive hypothalamo-pituitary-adrenocortical axis in rats bred for high anxiety-related behaviour
    R Landgraf
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neuroendocrinol 11:405-7. 1999
    ....
  43. doi request reprint ¹⁵N metabolic labeling: evidence for a stable isotope effect on plasma protein levels and peptide chromatographic retention times
    Christian Webhofer
    Proteomics and Biomarkers, Max Planck Institute of Psychiatry, Munich, Germany
    J Proteomics 88:27-33. 2013
    ..Our data point toward a systemic effect of the introduction of heavy isotopes in vivo...
  44. pmc Identification of a role for the ventral hippocampus in neuropeptide S-elicited anxiolysis
    Julien Dine
    RG Neuronal Network Dynamics, Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 8:e60219. 2013
    ..Thus, our study provides, for the first time, strong experimental evidence for a direct involvement of the VH in NPS-induced anxiolysis and furthermore presents a novel mechanism of NPS action...
  45. pmc Sleep phenotyping in a mouse model of extreme trait anxiety
    Vladimira Jakubcakova
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 7:e40625. 2012
    ..Sleep profiling in an animal model with extremely high vs. low levels of trait anxiety might serve to further define sleep patterns associated with this psychopathology...
  46. ncbi request reprint Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders
    Martin E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
    Neuropsychopharmacology 26:94-105. 2002
    ....
  47. ncbi request reprint Anxiety and hippocampus volume in the rat
    Raffael Kalisch
    NMR Study Group, Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 31:925-32. 2006
    ....
  48. ncbi request reprint Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids
    M B Müller
    Max Planck Institute of Psychiatry, Munich, Germany
    Endocrinology 141:4262-9. 2000
    ..Taken together, our data reveal a selective compensatory activation of the hypothalamic vasopressinergic, but not the oxytocinergic system, to maintain basal ACTH secretion and HPA system activity in Crhr1-/- mutants...
  49. ncbi request reprint Cognitive performance in rats differing in their inborn anxiety
    Frauke Ohl
    Behavioral Phenotyping, Max Planck Institute of Psychiatry, Munich, Germany
    Behav Neurosci 116:464-71. 2002
    ....
  50. ncbi request reprint The CRH1 receptor antagonist R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety
    Marike Lancel
    Max Planck Institute of Psychiatry, Section Neurophysiology, Kraepelinstr 2 10, D 80804, Munich, Germany
    J Psychiatr Res 36:197-208. 2002
    ..e. CRH hypersecretion) condition only...
  51. doi request reprint Maternal care differs in mice bred for high vs. low trait anxiety: impact of brain vasopressin and cross-fostering
    Melanie S Kessler
    Max Planck Institute of Psychiatry, Munich, Germany
    Soc Neurosci 6:156-68. 2011
    ..The seemingly rigid genetic predisposition to hyperanxiety can only be moderately attenuated by the received nurturing...
  52. ncbi request reprint Cross-fostering and cross-breeding of HAB and LAB rats: a genetic rat model of anxiety
    A Wigger
    Max Planck Institute of Psychiatry, Munich, Germany
    Behav Genet 31:371-82. 2001
    ..These findings may be important for further studies on the genetic basis of emotionality...
  53. doi request reprint The vasopressin system--from antidiuresis to psychopathology
    Elisabeth Frank
    Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
    Eur J Pharmacol 583:226-42. 2008
    ..The capability of both responding to stressful stimuli and mediating genetic polymorphisms makes the vasopressin system a key mediator for converging (i.e., environmentally and genetically driven) behavioral regulation...
  54. ncbi request reprint Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior
    Markus S H Henniger
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 26:729-36. 2002
    ..It is concluded that, although such a relationship might exist in some individuals, increased levels of inborn anxiety and alcohol consumption are not necessarily related...
  55. doi request reprint Intrahippocampal corticosterone response in mice selectively bred for extremes in stress reactivity: a microdialysis study
    J M Heinzmann
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neuroendocrinol 22:1187-97. 2010
    ....
  56. ncbi request reprint Oxytocin released within the supraoptic nucleus of the rat brain by positive feedback action is involved in parturition-related events
    I Neumann
    Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany
    J Neuroendocrinol 8:227-33. 1996
    ....
  57. ncbi request reprint Brain oxytocin inhibits basal and stress-induced activity of the hypothalamo-pituitary-adrenal axis in male and female rats: partial action within the paraventricular nucleus
    I D Neumann
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neuroendocrinol 12:235-43. 2000
    ..Under basal conditions, the inhibition of the HPA axis occurs, at least in part, within the paraventricular nucleus...
  58. ncbi request reprint Ageing alters intrahypothalamic release patterns of vasopressin and oxytocin in rats
    M E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 Munich, Germany
    Eur J Neurosci 12:1487-94. 2000
    ..The increased basal release of AVP within the PVN suggests a role of intracerebral AVP in age-associated alterations of HPA axis regulation...
  59. ncbi request reprint Unconditioned anxiety and social behaviour in two rat lines selectively bred for high and low anxiety-related behaviour
    M S Henniger
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804, Munich, Germany
    Behav Brain Res 111:153-63. 2000
    ....
  60. ncbi request reprint Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain
    M E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Neurosci 12:3713-20. 2000
    ..Taken together, these data provide the first in vivo evidence that acute rTMS of frontal brain regions has a differentiated modulatory effect on selected neurotransmitter/neuromodulator systems in distinct brain areas...
  61. ncbi request reprint Dimensions of emotionality in a rat model of innate anxiety
    F Ohl
    Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    Behav Neurosci 115:429-36. 2001
    ..The approach used might help to develop specific treatment strategies for anxiety disorders...
  62. ncbi request reprint The anxiolytic effect of the CRH(1) receptor antagonist R121919 depends on innate emotionality in rats
    M E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 Munich, Germany
    Eur J Neurosci 13:373-80. 2001
    ....
  63. ncbi request reprint Neuropeptides and anxiety-related behavior
    R Landgraf
    Max Planck Institute of Psychiatry, Munich, Germany
    Endocr J 48:517-33. 2001
    ....
  64. ncbi request reprint The modified hole board as a differential screen for behavior in rodents
    F Ohl
    Max Planck Institute of Psychiatry, Kraepelinstr 2, D 80804 Munich, Germany
    Behav Res Methods Instrum Comput 33:392-7. 2001
    ..Therefore, the mHB represents an alternative to the common practice of using a series of more specific tests...
  65. ncbi request reprint The high-affinity non-peptide CRH1 receptor antagonist R121919 attenuates stress-induced alterations in plasma oxytocin, prolactin, and testosterone secretion in rats
    M E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacopsychiatry 36:27-31. 2003
    ..Moreover, the decrease in plasma testosterone following exposure to stress is abolished by R121919. Our data indicate that antagonism of CRH 1 receptors may prevent stress-associated endocrine alterations...
  66. ncbi request reprint Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects
    M E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 24:337-49. 2001
    ..Interestingly, in the psychopathological animal model repetitive transcranial magnetic stimulation induced changes in stress coping abilities in the high-anxiety line only...
  67. ncbi request reprint Endocrine and behavioral effects of airpuff-startle in rats
    M Engelmann
    Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany
    Psychoneuroendocrinology 21:391-400. 1996
    ....
  68. ncbi request reprint Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers
    U Zimmermann
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    J Psychiatr Res 38:385-93. 2004
    ..This might imply some short-term positive alcohol effect in sons of alcoholics, but also constitute a mechanism by which their risk to develop alcohol use disorders is increased...
  69. ncbi request reprint Increased stress-induced adrenocorticotropin response after long-term intracerebroventricular treatment of rats with antisense mineralocorticoid receptor oligodeoxynucleotides
    J M Reul
    Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany
    Neuroendocrinology 65:189-99. 1997
    ..In conclusion, down-regulation of the brain MR produces an enhanced responsiveness of ACTH to stressful situations which appears to be accompanied by a reduced sensitivity of the adrenal gland to ACTH...
  70. ncbi request reprint Central administration of IL-1 reduces anxiety and induces sickness behaviour in rats
    A Montkowski
    Clinical Institute, Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacol Biochem Behav 58:329-36. 1997
    ..Taken together, our data indicate that central administration of IL-1 has anxiolytic-like properties...
  71. pmc Attenuated neuroendocrine responses to emotional and physical stressors in pregnant rats involve adenohypophysial changes
    I D Neumann
    Max Planck Institute of Psychiatry, Munich, Germany
    J Physiol 508:289-300. 1998
    ..However, alterations in stressor perception at higher brain levels with the progression of pregnancy may also be involved...
  72. ncbi request reprint Endogenous oxytocin is involved in short-term olfactory memory in female rats
    M Engelmann
    Max Planck Institute of Psychiatry, Munich, Germany
    Behav Brain Res 90:89-94. 1998
    ..These data are discussed in the light of sexual dimorphic brain development...
  73. ncbi request reprint Swim stress triggers the release of vasopressin within the suprachiasmatic nucleus of male rats
    M Engelmann
    Max Planck Institute of Psychiatry, Munich, Germany
    Brain Res 792:343-7. 1998
    ..In this way, the neuropeptide may contribute to the regulation of endocrine and behavioral rhythms particularly in challenging situations associated with resettings of the endogenous clock...
  74. ncbi request reprint Increased basal activity of the hypothalamo-pituitary-adrenal axis during pregnancy in rats bred for high anxiety-related behaviour
    I D Neumann
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychoneuroendocrinology 23:449-63. 1998
    ..Thus, the passing-on of maternal behavioural characteristics via prenatal, hormonal 'imprinting' has to be considered as a possible contribution to emotional maturation during an individual's development...
  75. ncbi request reprint Long-term ethanol self-administration with repeated ethanol deprivation episodes changes ethanol drinking pattern and increases anxiety-related behaviour during ethanol deprivation in rats
    S M Hölter
    Max Planck Institute of Psychiatry, Munich, Germany
    Behav Pharmacol 9:41-8. 1998
    ..The possibility that anxiety during ethanol deprivation might contribute to the 'relapse'-like drinking behaviour is discussed...
  76. ncbi request reprint Vasopressin in CSF and plasma in depressed suicide attempters: preliminary results
    Jurgen Brunner
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
    Eur Neuropsychopharmacol 12:489-94. 2002
    ..Suicide attempters did not differ from nonattempters. In depressed patients, plasma AVP correlated positively with cortisol. There was no relationship between CSF AVP and monoamine metabolites in CSF...
  77. ncbi request reprint Oxytocin induces preservation of social recognition in male rats by activating alpha-adrenoceptors of the olfactory bulb
    D E Dluzen
    Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Neurosci 12:760-6. 2000
    ..Accordingly, this model affords the opportunity to study neuropeptide-catecholamine interactions, link these interactions with a specific behavioural outcome and identify a novel function/site of action for oxytocin in the male...
  78. doi request reprint Modeling psychotic and cognitive symptoms of affective disorders: Disrupted latent inhibition and reversal learning deficits in highly stress reactive mice
    A Knapman
    Research Group of Psychoneuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neurobiol Learn Mem 94:145-52. 2010
    ....
  79. doi request reprint Proteomic-based genotyping in a mouse model of trait anxiety exposes disease-relevant pathways
    C Ditzen
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 15:702-11. 2010
    ..The study shows that proteomic analysis can reveal genotypic differences relevant for the phenotype. The identified protein alterations, in turn, can expose metabolic pathways pertinent to the behavioral phenotype...
  80. ncbi request reprint The effects of infusion of arginine vasopressin, oxytocin, or their antagonists into the olfactory bulb upon social recognition responses in male rats
    D E Dluzen
    Max Planck Institute of Psychiatry, Munich, Germany
    Peptides 19:999-1005. 1998
    ..Moreover, our results suggest that the underlying mechanisms by which peptides function within the olfactory bulb differ as a function of whether they are involved with the display versus preservation of recognition responses...
  81. ncbi request reprint Olfactory bulb norepinephrine depletion abolishes vasopressin and oxytocin preservation of social recognition responses in rats
    D E Dluzen
    Max Planck Institute of Psychiatry, Munich, Germany
    Neurosci Lett 254:161-4. 1998
    ..These results suggest that this capacity for these neuropeptides to preserve social recognition responses is mediated through the norepinephrine system of the olfactory bulb...
  82. ncbi request reprint Human intestinal trefoil factor is expressed in human hypothalamus and pituitary: evidence for a novel neuropeptide
    J C Probst
    Max Planck Institute of Psychiatry, Clinical Institute, Department of Neuroendocrinology, Munich, Germany
    FASEB J 10:1518-23. 1996
    ..It is likely that hITF represents a novel neuropeptide of yet unknown function...
  83. ncbi request reprint Expression of the trefoil polypeptide ITF in PC12 cells
    J C Probst
    Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany
    Biochem Mol Biol Int 42:425-32. 1997
    ....
  84. ncbi request reprint Neurobiological correlates of high (HAB) versus low anxiety-related behavior (LAB): differential Fos expression in HAB and LAB rats
    Nicolas Salome
    Laboratoire de Stress Périnatal, Universite de Lille 1, Villeneuve d Ascq, France
    Biol Psychiatry 55:715-23. 2004
    ..Two Wistar rat lines selectively bred for either high (HAB) or low (LAB) anxiety-related behavior were used to identify neurobiological correlates of trait anxiety...
  85. pmc Regulation of activity-dependent dendritic vasopressin release from rat supraoptic neurones
    Mike Ludwig
    Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    J Physiol 564:515-22. 2005
    ..Vasopressin itself is effective in inducing dendritic vasopressin release, but it is ineffective in producing priming...
  86. ncbi request reprint GABA selectively controls the secretory activity of oxytocin neurons in the rat supraoptic nucleus
    Mario Engelmann
    Otto von Guericke Universitat Magdeburg, Institut für Medizinische Neurobiologie, Leipziger Str 44, D 39120 Magdeburg, Germany
    Eur J Neurosci 19:601-8. 2004
    ..Taken together, our data demonstrate that GABA is released within the SON during emotional stress to act as a selective inhibitor of both central and peripheral OXT secretion...
  87. ncbi request reprint Taurine regulates corticotropin secretion at the level of the supraoptic nucleus during stress in rats
    Mario Engelmann
    Otto von Guericke Universitat, Institut für Medizinische Neurobiologie, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    Neurosci Lett 348:120-2. 2003
    ..05, analysis of variance). This finding supports the hypothesis that the hypothalamic-neurohypophysial system is a potent regulator of the hormonal stress response and suggests an important role for taurine in this context...
  88. ncbi request reprint The hypothalamic-neurohypophysial system regulates the hypothalamic-pituitary-adrenal axis under stress: an old concept revisited
    Mario Engelmann
    Institut für Medizinische Neurobiologie, Otto von Guericke Universitat Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Front Neuroendocrinol 25:132-49. 2004
    ..This review presents data supporting the concept of HNS effects on HPA axis activity and outlines their possible impact on some aspects of behavioural regulation and psychopathology...
  89. ncbi request reprint Airjet and FG-7142-induced Fos expression differs in rats selectively bred for high and low anxiety-related behavior
    Peter Salchner
    Department of Pharmacology and Toxicology, Institute of Pharmacy and Center of Molecular Biosciences Innsbruck, University of Innsbruck, Peter Mayr Strasse 1, A 6020 Innsbruck, Austria
    Neuropharmacology 50:1048-58. 2006
    ....
  90. ncbi request reprint Neuroendocrine and behavioral response to social confrontation: residents versus intruders, active versus passive coping styles
    Karl Ebner
    Leopold Franzens Universitat, Institut fur Pharmakologie und Toxikologie, Peter Mayr Str 1, A 6020 Innsbruck, Austria
    Horm Behav 47:14-21. 2005
    ..The data of the present study suggest that the different interpretation of an aversive encounter results in differences in the neuroendocrine response and intrahypothalamic vasopressinergic signaling in intruders versus residents...
  91. ncbi request reprint Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites
    Mike Ludwig
    Department of Biomedical Sciences, University of Edinburgh Medical School, George Square, Edinburgh EH8 9XD, UK
    Nature 418:85-9. 2002
    ..This priming action makes dendritic oxytocin available for release in response to subsequent spike activity. Priming persists for a prolonged period, changing the nature of interactions between oxytocin neurons and their neighbours...
  92. ncbi request reprint Decreased sensitivity to thermal pain in rats bred for high anxiety-related behaviour is attenuated by citalopram or diazepam treatment
    Thomas Jochum
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07743 Jena, Federal Republic of Germany
    Behav Brain Res 183:18-24. 2007
    ....
  93. ncbi request reprint Reliability of high and low anxiety-related behaviour: influence of laboratory environment and multifactorial analysis
    Nicolas Salome
    Laboratoire de Neurosciences du Comportement, Universite de Lille 1, SN4, 59655 Villeneuve d Ascq cedex, France
    Behav Brain Res 136:227-37. 2002
    ..Finally, the principal component analysis again confirmed that the selection of HAB and LAB rats is based on anxiety-related behaviour rather than locomotor activity...
  94. ncbi request reprint Vasopressin from hypothalamic magnocellular neurons has opposite actions at the adenohypophysis and in the supraoptic nucleus on ACTH secretion
    Carsten T Wotjak
    Max Planck Institut fur Psychiatrie, Kraepelinstr 2, D 80804 München, Germany
    Eur J Neurosci 16:477-85. 2002
    ..We conclude from these findings that vasopressin from the hypothalamic-neurohypophysial system participates in the regulation of the hormonal stress response in a counterbalanced manner at the level of the SON and the adenohypophysis...
  95. ncbi request reprint Altered brain activation pattern associated with drug-induced attenuation of enhanced depression-like behavior in rats bred for high anxiety
    Patrik Muigg
    Department of Pharmacology and Toxicology, University of Innsbruck, Innsbruck, Austria
    Biol Psychiatry 61:782-96. 2007
    ..The aim of the present study was to identify neuronal substrates underlying this treatment response in HABs...
  96. ncbi request reprint Steroid synthesis inhibition with ketoconazole and its effect upon the regulation of the hypothalamus-pituitary-adrenal system in healthy humans
    Michael Deuschle
    Central Institute of Mental Health, Mannheim, Germany
    Neuropsychopharmacology 28:379-83. 2003
    ..7+/-4.6 nmol/l), but not in the young subgroup (pre: 15.6+/-11.3; post: 27.7+/-9.4 nmol/l). We thus conclude that the treatment of healthy controls with steroid-synthesis inhibitors does not lead to a major increase in CRH secretion...
  97. ncbi request reprint Effects of Morris water maze testing on the neuroendocrine stress response and intrahypothalamic release of vasopressin and oxytocin in the rat
    Mario Engelmann
    Otto von Guericke Universitat Magdeburg, Institut für Medizinische Neurobiologie, Leipziger Str 44, D 39120 Magdeburg, Germany
    Horm Behav 50:496-501. 2006
    ....
  98. ncbi request reprint Altered hypothalamo-pituitary-adrenal and sympatho-adrenomedullary activities in rats bred for high anxiety: central and peripheral correlates
    Nicolas Salome
    Unité de Neurosciences et de Physiologie Adaptatives, Laboratoire de Stress Périnatal, Universite de Lille 1, 59655 Villeneuve d Ascq, France
    Psychoneuroendocrinology 31:724-35. 2006
    ..In conclusion, HABs can be considered as an useful model to study the etiology and pathophysiology of stress-related disorders and their neuroendocrine substrates...
  99. ncbi request reprint Animal models of anxiety
    Rainer Landgraf
    Stress 6:73-5. 2003