Research Topics
Genomes and GenesSpecies | Eckhard LammertSummaryAffiliation: Max Planck Institute of Molecular Cell Biology and Genetics Country: Germany Publications
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Detail Information
Publications
Role of endothelial cells in early pancreas and liver developmentEckhard Lammert
Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
Mech Dev 120:59-64. 2003..This review summarizes reports on EC signaling during organogenesis and cell differentiation...- Role of VEGF-A in vascularization of pancreatic isletsEckhard Lammert
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
Curr Biol 13:1070-4. 2003..The second step involves paracrine VEGF-A signaling to elaborate the interaction of islets with the circulatory system... 
The vascular trigger of type II diabetes mellitusE Lammert
Max Planck Institute of Molecular Cell Biology and Genetics and Institute of Animal Physiology, Heinrich Heine University, Dusseldorf, Germany
Exp Clin Endocrinol Diabetes 116:S21-5. 2008..Whereas vascular complications have been widely accepted as a result of type II diabetes, we suggest that changes within the vascular system may act at an earlier stage and trigger the onset of type II diabetes...- The vascular niche and its basement membraneGanka Nikolova
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, D 01307 Dresden, Germany
Trends Cell Biol 17:19-25. 2007..We further propose that these cells require a vascular niche when they retain a high degree of plasticity... - Vascular lumen formation from a cell biological perspectiveTomas Kucera
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, D 01307 Dresden, Germany
Novartis Found Symp 283:46-56; discussion 56-60, 238-41. 2007..In addition, we point to a number of questions that need to be addressed to understand better the cell biology that drives the formation of a vascular lumen... - The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferationGanka Nikolova
Max-Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
Dev Cell 10:397-405. 2006..The proposed mechanism explains why beta cells must interact with endothelial cells, and it may apply to other cellular processes in which endothelial signals are required... - Interdependent development of blood vessels and organsGanka Nikolova
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasssse 108, 01307, Dresden, Germany
Cell Tissue Res 314:33-42. 2003..Such signals give EC organ-specific features that the organ needs to interact with the circulatory system. This review provides the reader with specific examples of an interdependent development of organs and blood vessels... - EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic isletsIrena Konstantinova
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
Cell 129:359-70. 2007..Thus, we explain how beta cell communication in pancreatic islets conversely affects basal and glucose-stimulated insulin secretion to improve glucose homeostasis... 
Mechanoinduction of lymph vessel expansionLara Planas-Paz
Institute of Metabolic Physiology, Heinrich Heine University, Dusseldorf, Germany
EMBO J 31:788-804. 2012..Thus, we propose a new and physiologically relevant mode of VEGFR3 activation, which is based on mechanotransduction and is essential for normal development and fluid homeostasis in a mammalian embryo...- A new collagenase blend increases the number of islets isolated from mouse pancreasPinar Yesil
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Islets 1:185-90. 2009..Furthermore, this study also points to a possibility to increase the number and mass of islets isolated from human pancreases, for which only a limited donor pool exists... - Resolving cell-cell junctions: lumen formation in blood vesselsMartin Zeeb
Institute of Metabolic Physiology, Heinrich Heine University, Dusseldorf, Germany
Curr Opin Cell Biol 22:626-32. 2010..Here we review the role of EC junctions in vascular lumen formation within different vascular beds... - Vascular lumen formationJennifer Axnick
Institute of Metabolic Physiology, Heinrich Heine University, Dusseldorf, Germany
Curr Opin Hematol 19:192-8. 2012..Here, we discuss the molecular and cellular mechanisms underlying vascular lumen formation in invertebrates and vertebrates and highlight a new hypothesis describing oxygen transport in human malignant tumors... - Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetesDeepak Jain
Institute of Metabolic Physiology, Heinrich Heine University, D 40225 Dusseldorf, Germany
J Mol Cell Biol 4:221-30. 2012..Our data suggest that DJ-1 is more generally involved in age- and lifestyle-related human diseases and show for the first time that DJ-1 plays a key role in glucose homeostasis and might serve as a novel drug target for T2DM... - Islet dynamics: a glimpse at beta cell proliferationPinar Yesil
Max Planck Institute of Molecular Cell Biology and Genetics MPI CBG, Dresden, Germany
Histol Histopathol 23:883-95. 2008..Once established, these methods would have profound benefits for diabetic patients... - Microvascular development: learning from pancreatic isletsIrena Konstantinova
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden Germany
Bioessays 26:1069-75. 2004..At the end, we look at the islet microvasculature from a medical point of view, thus describing its critical role during type I diabetes and islet transplantation...