Genomes and Genes
Martin A Kohli
Affiliation: Max Planck Institute of Psychiatry
- Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccoloP F Sullivan
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
Mol Psychiatry 14:359-75. 2009..With the integrated replication effort, we present a specific hypothesis for further studies...
- Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patientsMartin A Kohli
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
Arch Gen Psychiatry 67:348-59. 2010..Especially in suicide victims, lower postmortem brain messenger RNA and protein levels of neurotrophins and their receptors have been reported...
- Polymorphisms within the metabotropic glutamate receptor 1 gene are associated with depression phenotypesAndreas Menke
Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
Psychoneuroendocrinology 37:565-75. 2012....
- A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depressionMarcus Ising
Max Planck Institute of Psychiatry, Munich 80804, Germany
Arch Gen Psychiatry 66:966-75. 2009..Genetic factors and clinical characteristics contribute to the failure of a favorable treatment outcome...
- The neuronal transporter gene SLC6A15 confers risk to major depressionMartin A Kohli
Max Planck Institute of Psychiatry, D 80804 Munich, Germany
Neuron 70:252-65. 2011..Our convergent data from human genetics, expression studies, brain imaging, and animal models suggest a pathophysiological mechanism for MD that may be accessible to drug targeting...
- Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatmentElisabeth B Binder
Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
Nat Genet 36:1319-25. 2004..These findings support a central role of genes regulating the HPA axis in the causality of depression and the mechanism of action of antidepressant drugs...
- Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levelsStefan Kloiber
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Eur Neuropsychopharmacol 23:653-62. 2013....
- Possible associations of NTRK2 polymorphisms with antidepressant treatment outcome: findings from an extended tag SNP approachJohannes M Hennings
Max Planck Institute of Psychiatry, Munich, Germany
PLoS ONE 8:e64947. 2013..Genetic variations within the genes coding for the brain-derived neurotrophic factor (BDNF) and its key receptor Trkb (NTRK2) may therefore influence the response to antidepressant treatment...