S Kloiber

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. ncbi request reprint Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment
    Hubertus Himmerich
    Max Planck Institut fur Psychiatrie, Munchen, Deutschland
    Neuropsychobiology 55:28-35. 2007
  2. doi request reprint Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels
    Stefan Kloiber
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Eur Neuropsychopharmacol 23:653-62. 2013
  3. doi request reprint ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples
    Stefan Kloiber
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, Germany
    J Psychiatr Res 46:973-9. 2012
  4. doi request reprint Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression
    S Kloiber
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 15:736-47. 2010
  5. ncbi request reprint Overweight and obesity affect treatment response in major depression
    Stefan Kloiber
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:321-6. 2007
  6. doi request reprint Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project
    Johannes M Hennings
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    J Psychiatr Res 43:215-29. 2009
  7. doi request reprint A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich 80804, Germany
    Arch Gen Psychiatry 66:966-75. 2009
  8. doi request reprint TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies
    A Erhardt
    Max Planck Institute of Psychiatry, Munchen, Germany
    Mol Psychiatry 16:647-63. 2011
  9. ncbi request reprint Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:424-9. 2007
  10. doi request reprint Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression
    Manfred Uhr
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Neuron 57:203-9. 2008

Detail Information

Publications23

  1. ncbi request reprint Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment
    Hubertus Himmerich
    Max Planck Institut fur Psychiatrie, Munchen, Deutschland
    Neuropsychobiology 55:28-35. 2007
    ..Glucocorticoids themselves are reported to increase leptin synthesis and secretion in humans...
  2. doi request reprint Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels
    Stefan Kloiber
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Eur Neuropsychopharmacol 23:653-62. 2013
    ....
  3. doi request reprint ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples
    Stefan Kloiber
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, Germany
    J Psychiatr Res 46:973-9. 2012
    ..By analyzing the LD-structure, our highest associated SNPs could not be linked to the SNPs previously reported in BPD. Regarding ANK3 and CACNA1C, our findings do not support a strong genetic link between BPD and MDD for these two genes...
  4. doi request reprint Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression
    S Kloiber
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 15:736-47. 2010
    ..Identifying depressed patients at high risk for MetS using genetic variants could have direct clinical impact on individualized disease management and prevention strategies...
  5. ncbi request reprint Overweight and obesity affect treatment response in major depression
    Stefan Kloiber
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:321-6. 2007
    ..To elucidate the impact of weight on the course of depression beyond comorbidity, we investigated psychopathology, attention, neuroendocrinology, weight change, and treatment response in MDD patients, depending on their weight...
  6. doi request reprint Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project
    Johannes M Hennings
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    J Psychiatr Res 43:215-29. 2009
    ..We demonstrated that this subgroup can be characterized by a set of demographic, clinical and neuroendocrine variables allowing to predict unfavorable outcome at an early stage of treatment...
  7. doi request reprint A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich 80804, Germany
    Arch Gen Psychiatry 66:966-75. 2009
    ..Genetic factors and clinical characteristics contribute to the failure of a favorable treatment outcome...
  8. doi request reprint TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies
    A Erhardt
    Max Planck Institute of Psychiatry, Munchen, Germany
    Mol Psychiatry 16:647-63. 2011
    ..TMEM132D may thus be an important new candidate gene for PD as well as more generally for anxiety-related behavior...
  9. ncbi request reprint Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:424-9. 2007
    ..These results further underline a possible important role of genetic variations within the system controlling serotonergic neurotransmission for the development and course of disease in PD...
  10. doi request reprint Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression
    Manfred Uhr
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Neuron 57:203-9. 2008
    ..This finding can be viewed as a further step into personalized antidepressant treatment...
  11. pmc Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Neuropsychopharmacology 35:1583-92. 2010
    ..The reported associations in independent samples of AD and MDD support an estrogen-dependent function of GAL in pathophysiology of anxiety and depression, affecting response to antidepressant treatment...
  12. pmc Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients
    Martin A Kohli
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Arch Gen Psychiatry 67:348-59. 2010
    ..Especially in suicide victims, lower postmortem brain messenger RNA and protein levels of neurotrophins and their receptors have been reported...
  13. ncbi request reprint Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:47-54. 2007
    ..In the present study, we examined whether change in HPA system function during the first weeks of hospitalization predicts response to antidepressant treatment in major depression and thus constitutes a potential biomarker...
  14. doi request reprint Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:1100-9. 2009
    ..However, data from expression studies imply that these polymorphisms could tag functional effects on the neighboring gene MYO3A, which is also expressed in the brain, including the cingulate cortex and the amygdala...
  15. ncbi request reprint Persistent cognitive impairment in depression: the role of psychopathology and altered hypothalamic-pituitary-adrenocortical (HPA) system regulation
    Simone Reppermund
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:400-6. 2007
    ..This study examines the associations between HPA system regulation, cognitive functioning, and psychopathology in depressed inpatients on admission and at discharge...
  16. doi request reprint Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action
    Sonja Horstmann
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 34:238-48. 2009
    ..Our results confirm that dex/CRH tests can be used as predictors of clinical course also under mirtazapine treatment...
  17. doi request reprint Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Eur J Neurosci 28:389-98. 2008
    ..This reaction pattern suggests that subjects carrying these variants are at risk of displaying chronically elevated cortisol levels after repeated stress constituting a risk factor for stress-related diseases...
  18. ncbi request reprint Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 München, Germany
    J Affect Disord 105:177-84. 2008
    ..Furthermore, GAL is involved in hypothalamic-hypophysiotropic signalling and cosecreted with luteinizing hormone-releasing hormone (LHRH), possibly acting as a mediator of estrogen action...
  19. doi request reprint Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients
    Angela Heck
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:104-14. 2009
    ..These results suggest that the ACE gene is involved in the development of coping strategies...
  20. doi request reprint Plasma fibrinogen: now also an antidepressant response marker?
    D Martins-de-Souza
    1 Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Munich, Germany 2 Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
    Transl Psychiatry 4:e352. 2014
    ..These results were replicated in a second set of patients. Our findings lend further support to a recently identified association between MDD and fibrinogen levels from a large-scale study. ..
  21. doi request reprint Depression, comorbidities and the TNF-alpha system
    H Himmerich
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804, Munich, Germany
    Eur Psychiatry 23:421-9. 2008
    ..These results confirm earlier studies regarding the comorbidities of depression and support the hypothesis that activation of the TNF-alpha system may contribute to the development of a depressive disorder...
  22. doi request reprint Genetic markers within glutamate receptors associated with antidepressant treatment-emergent suicidal ideation
    Andreas Menke
    Am J Psychiatry 165:917-8. 2008
  23. ncbi request reprint [Familial plaque-only Alzheimer's disease in the Rottal-Inn and Passau counties]
    Hans H Klünemann
    Klinik und Poliklinik für Psychiatrie der Universität Regensburg am Bezirksklinikum
    Psychiatr Prax 31:S61-3. 2004
    ..We conclude, that there is a familial predisposition to dementia with variable age of onset between 36 and 80 years of age in the kindred of Johann F...