Kazuhisa Kinoshita

Summary

Affiliation: Max Planck Institute of Molecular Cell Biology and Genetics
Country: Germany

Publications

  1. ncbi request reprint Reconstitution of physiological microtubule dynamics using purified components
    K Kinoshita
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307, Dresden, Germany
    Science 294:1340-3. 2001
  2. ncbi request reprint XMAP215: a key component of the dynamic microtubule cytoskeleton
    Kazuhisa Kinoshita
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Trends Cell Biol 12:267-73. 2002
  3. ncbi request reprint [From spindle fibers to microtubule dynamics in mitosis]
    Kazuhisa Kinoshita
    Max Planck Institute of Molecular Cell Biology and Genetics
    Tanpakushitsu Kakusan Koso 51:197-205. 2006
  4. ncbi request reprint Global and local control of microtubule destabilization promoted by a catastrophe kinesin MCAK/XKCM1
    Kazuhisa Kinoshita
    Max Planck Institute of Molecular Cell Biology and Genetics MPI CBG, Pfotenhauerstrasse 108, 01307, Dresden, Germany
    J Muscle Res Cell Motil 27:107-14. 2006
  5. pmc Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis
    Kazuhisa Kinoshita
    Max Planck Institute of Molecular Cell Biology and Genetics MPI CBG, 01307 Dresden, Germany
    J Cell Biol 170:1047-55. 2005
  6. pmc XMAP215 is a processive microtubule polymerase
    Gary J Brouhard
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Cell 132:79-88. 2008
  7. ncbi request reprint An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles
    Nurhan Ozlu
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden 01307, Germany
    Dev Cell 9:237-48. 2005
  8. pmc A comparison of the ability of XMAP215 and tau to inhibit the microtubule destabilizing activity of XKCM1
    Tim L Noetzel
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Philos Trans R Soc Lond B Biol Sci 360:591-4. 2005
  9. ncbi request reprint Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons
    Bruce T Schaar
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 41:203-13. 2004
  10. ncbi request reprint [Dynamics of mitotic spindle]
    Kazuhisa Kinoshita
    Tanpakushitsu Kakusan Koso 51:761-6. 2006

Detail Information

Publications13

  1. ncbi request reprint Reconstitution of physiological microtubule dynamics using purified components
    K Kinoshita
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307, Dresden, Germany
    Science 294:1340-3. 2001
    ..This represents an essential first step in the reconstitution of complex microtubule dynamics-dependent processes, such as chromosome segregation, from purified components...
  2. ncbi request reprint XMAP215: a key component of the dynamic microtubule cytoskeleton
    Kazuhisa Kinoshita
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Trends Cell Biol 12:267-73. 2002
    ..Together with members of the Kin I family of kinesins, XMAP215 and its orthologues form an essential circuit for generating dynamic microtubules in vivo...
  3. ncbi request reprint [From spindle fibers to microtubule dynamics in mitosis]
    Kazuhisa Kinoshita
    Max Planck Institute of Molecular Cell Biology and Genetics
    Tanpakushitsu Kakusan Koso 51:197-205. 2006
  4. ncbi request reprint Global and local control of microtubule destabilization promoted by a catastrophe kinesin MCAK/XKCM1
    Kazuhisa Kinoshita
    Max Planck Institute of Molecular Cell Biology and Genetics MPI CBG, Pfotenhauerstrasse 108, 01307, Dresden, Germany
    J Muscle Res Cell Motil 27:107-14. 2006
    ..Here we give an overview of the studies that have focused on the global and local control of microtubule destabilization promoted by MCAK/XKCM1...
  5. pmc Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis
    Kazuhisa Kinoshita
    Max Planck Institute of Molecular Cell Biology and Genetics MPI CBG, 01307 Dresden, Germany
    J Cell Biol 170:1047-55. 2005
    ..We propose that Aurora A regulation of TACC3 activity defines a centrosome-specific mechanism for regulation of microtubule polymerization in mitosis...
  6. pmc XMAP215 is a processive microtubule polymerase
    Gary J Brouhard
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Cell 132:79-88. 2008
    ..The similarities between XMAP215 and formins, actin polymerases, suggest that processive tip tracking is a common mechanism for stimulating the growth of cytoskeletal polymers...
  7. ncbi request reprint An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles
    Nurhan Ozlu
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden 01307, Germany
    Dev Cell 9:237-48. 2005
    ..Thus, activation and targeting of Aurora A appears to be an ancient and conserved function of TPX2 that plays a central role in mitotic spindle assembly...
  8. pmc A comparison of the ability of XMAP215 and tau to inhibit the microtubule destabilizing activity of XKCM1
    Tim L Noetzel
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Philos Trans R Soc Lond B Biol Sci 360:591-4. 2005
    ..We show that tau is a much more potent inhibitor of XKCM1 than XMAP215. Because tau completely suppresses XKCM1 activity, even at low concentrations, the combination of tau and XKCM1 is unable to generate mitotic microtubule dynamics...
  9. ncbi request reprint Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons
    Bruce T Schaar
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 41:203-13. 2004
    ....
  10. ncbi request reprint [Dynamics of mitotic spindle]
    Kazuhisa Kinoshita
    Tanpakushitsu Kakusan Koso 51:761-6. 2006
  11. ncbi request reprint CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation
    Keita Aoki
    Core Research for Evolutional Science and Technology Research Program of Japan Science and Technology Corporation, Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Curr Biol 16:1627-35. 2006
    ..Cdc2 thus directly phosphorylates Dis1, and this phosphorylation regulates Dis1 localization in both metaphase and anaphase and ensures high-fidelity segregation...
  12. pmc NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment
    Daisuke Mori
    Osaka City University Graduate School of Medicine, Genetic Disease Research, Asahi machi 1 4 3 Abeno, Osaka 545 8586, Japan
    Mol Cell Biol 27:352-67. 2007
    ..Our findings suggest that Aurora-A-mediated phosphorylation of NDEL1 is essential for centrosomal separation and centrosomal maturation and for mitotic entry...
  13. pmc Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules
    Teresa P Barros
    The Wellcome Trust Cancer Research UK Gurdon Institute, Department of Genetics, Cambridge CB2 1QN, England, UK
    J Cell Biol 170:1039-46. 2005
    ..This may explain why centrosomes are such dominant sites of MT assembly during mitosis...