Martin E Keck

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. ncbi request reprint rTMS as treatment strategy in psychiatric disorders--neurobiological concepts
    Martin E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 Munich, Germany
    Suppl Clin Neurophysiol 56:100-16. 2003
  2. ncbi request reprint The high-affinity non-peptide CRH1 receptor antagonist R121919 attenuates stress-induced alterations in plasma oxytocin, prolactin, and testosterone secretion in rats
    M E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacopsychiatry 36:27-31. 2003
  3. ncbi request reprint Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 28:235-43. 2003
  4. ncbi request reprint Mouse mutants for the study of corticotropin-releasing hormone receptor function: development of novel treatment strategies for mood disorders
    Martin E Keck
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Ann N Y Acad Sci 1018:445-57. 2004
  5. ncbi request reprint Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neurochem 92:1170-9. 2005
  6. ncbi request reprint [Repetitive transcranial magnetic stimulation (rTMS). Application to depression]
    Martin E Keck
    Max Planck Institut fur Psychiatrie, Kraepelinstr 2 10, 80804 München
    Med Monatsschr Pharm 26:227-31. 2003
  7. ncbi request reprint Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system
    M E Keck
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804, Munich, Germany
    Neuropharmacology 43:101-9. 2002
  8. ncbi request reprint Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders
    Martin E Keck
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neurosci Biobehav Rev 29:867-89. 2005
  9. ncbi request reprint Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders
    Martin E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
    Neuropsychopharmacology 26:94-105. 2002
  10. ncbi request reprint Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects
    M E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 24:337-49. 2001

Detail Information

Publications44

  1. ncbi request reprint rTMS as treatment strategy in psychiatric disorders--neurobiological concepts
    Martin E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 Munich, Germany
    Suppl Clin Neurophysiol 56:100-16. 2003
  2. ncbi request reprint The high-affinity non-peptide CRH1 receptor antagonist R121919 attenuates stress-induced alterations in plasma oxytocin, prolactin, and testosterone secretion in rats
    M E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacopsychiatry 36:27-31. 2003
    ..Moreover, the decrease in plasma testosterone following exposure to stress is abolished by R121919. Our data indicate that antagonism of CRH 1 receptors may prevent stress-associated endocrine alterations...
  3. ncbi request reprint Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 28:235-43. 2003
    ..This novel mechanism of action of paroxetine on vasopressin gene regulation renders vasopressinergic neuronal circuits a promising target for the development of more causal antidepressant treatment strategies...
  4. ncbi request reprint Mouse mutants for the study of corticotropin-releasing hormone receptor function: development of novel treatment strategies for mood disorders
    Martin E Keck
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Ann N Y Acad Sci 1018:445-57. 2004
    ..Moreover, beyond the encouraging preclinical studies, the first clinical open trial supports the notion that CRH type 1 receptors can be safely and effectively antagonized...
  5. ncbi request reprint Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neurochem 92:1170-9. 2005
    ..Chronic paroxetine enhanced the presynaptic responsivity in HAB rats, but not LAB rats, pointing to a preferential efficacy of paroxetine in rats with enhanced anxiety/depression-related behaviour...
  6. ncbi request reprint [Repetitive transcranial magnetic stimulation (rTMS). Application to depression]
    Martin E Keck
    Max Planck Institut fur Psychiatrie, Kraepelinstr 2 10, 80804 München
    Med Monatsschr Pharm 26:227-31. 2003
  7. ncbi request reprint Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system
    M E Keck
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804, Munich, Germany
    Neuropharmacology 43:101-9. 2002
    ..This increase in dopaminergic neurotransmission may contribute to the beneficial effects of rTMS in the treatment of affective disorders and Parkinson's disease...
  8. ncbi request reprint Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders
    Martin E Keck
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neurosci Biobehav Rev 29:867-89. 2005
    ....
  9. ncbi request reprint Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders
    Martin E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
    Neuropsychopharmacology 26:94-105. 2002
    ....
  10. ncbi request reprint Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects
    M E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 24:337-49. 2001
    ..Interestingly, in the psychopathological animal model repetitive transcranial magnetic stimulation induced changes in stress coping abilities in the high-anxiety line only...
  11. ncbi request reprint Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain
    M E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Neurosci 12:3713-20. 2000
    ..Taken together, these data provide the first in vivo evidence that acute rTMS of frontal brain regions has a differentiated modulatory effect on selected neurotransmitter/neuromodulator systems in distinct brain areas...
  12. ncbi request reprint Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders
    M E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
    Peptides 22:835-44. 2001
    ..Recent clinical observations support this possibility...
  13. ncbi request reprint Ageing alters intrahypothalamic release patterns of vasopressin and oxytocin in rats
    M E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 Munich, Germany
    Eur J Neurosci 12:1487-94. 2000
    ..The increased basal release of AVP within the PVN suggests a role of intracerebral AVP in age-associated alterations of HPA axis regulation...
  14. ncbi request reprint The anxiolytic effect of the CRH(1) receptor antagonist R121919 depends on innate emotionality in rats
    M E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 Munich, Germany
    Eur J Neurosci 13:373-80. 2001
    ....
  15. ncbi request reprint The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: an in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice
    Christoph K Thoeringer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 32:746-57. 2007
    ..In addition, our study highlights the use of in vivo microdialysis to assess the neuroendocrine endophenotype of animal models via profiling of stimulus-response patterns of stress hormones...
  16. ncbi request reprint Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress
    Tobias Welt
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 31:2573-9. 2006
    ..An increasingly released AVP of magnocellular origin seems to provide a negative tonus on ACTH secretion most probably via inhibiting the release of ACTH secretagogues from the median eminence into hypophyseal portal blood...
  17. doi request reprint Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:1196-204. 2008
    ..These data suggest that polymorphisms in the AVPR1B and the CRHR1 genes alter the susceptibility to panic disorder...
  18. ncbi request reprint Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders
    Angelika Erhardt
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 München, Germany
    J Affect Disord 101:159-68. 2007
    ..This region contains two candidate genes for purinergic ligand-gated ion channels, P2RX7 and P2RX4, and one gene coding for calmodulin-dependent protein kinase kinase b (CaMKKb)...
  19. ncbi request reprint Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 München, Germany
    J Affect Disord 105:177-84. 2008
    ..Furthermore, GAL is involved in hypothalamic-hypophysiotropic signalling and cosecreted with luteinizing hormone-releasing hormone (LHRH), possibly acting as a mediator of estrogen action...
  20. ncbi request reprint Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:424-9. 2007
    ..These results further underline a possible important role of genetic variations within the system controlling serotonergic neurotransmission for the development and course of disease in PD...
  21. ncbi request reprint Hypothalamic-pituitary-adrenocortical system and mood disorders: highlights from mutant mice
    Marianne B Muller
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuroendocrinology 79:1-12. 2004
    ..The identification and detailed characterization of these molecular pathways will ultimately lead to the development of novel neuropharmacological intervention strategies...
  22. ncbi request reprint Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder
    Angelika Erhardt
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 31:2515-22. 2006
    ..However, differences in the suppression effects and psychopathological correlation patterns between depressed and panic patients suggest different biological mechanisms of HPA system dysregulation in both disorders...
  23. ncbi request reprint Repetitive transcranial magnetic stimulation induces active coping strategies and attenuates the neuroendocrine stress response in rats
    M E Keck
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804, Munich, Germany
    J Psychiatr Res 34:265-76. 2000
    ....
  24. ncbi request reprint ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder
    Marianne B Muller
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neuropsychopharmacology 28:1991-9. 2003
    ....
  25. ncbi request reprint Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks
    Christoph K Thoeringer
    Max Planck Institute of Psychiatry, Munich 80804, Germany
    J Psychiatr Res 41:579-84. 2007
    ..43; 95% CI: 0.19-0.95). In conclusion, these results suggest a central role of DBI genetic variants in the susceptibility for the development of anxiety disorders that are characterized by the occurrence of panic attacks...
  26. ncbi request reprint Genetic modification of corticosteroid receptor signalling: novel insights into pathophysiology and treatment strategies of human affective disorders
    Marianne Müller
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804, Munich, Germany
    Neuropeptides 36:117-31. 2002
    ....
  27. ncbi request reprint Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids
    M B Müller
    Max Planck Institute of Psychiatry, Munich, Germany
    Endocrinology 141:4262-9. 2000
    ..Taken together, our data reveal a selective compensatory activation of the hypothalamic vasopressinergic, but not the oxytocinergic system, to maintain basal ACTH secretion and HPA system activity in Crhr1-/- mutants...
  28. ncbi request reprint Vasopressin in CSF and plasma in depressed suicide attempters: preliminary results
    Jurgen Brunner
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
    Eur Neuropsychopharmacol 12:489-94. 2002
    ..Suicide attempters did not differ from nonattempters. In depressed patients, plasma AVP correlated positively with cortisol. There was no relationship between CSF AVP and monoamine metabolites in CSF...
  29. ncbi request reprint Genetically engineered mice for studies of stress-related clinical conditions
    Marianne B Muller
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 36:53-76. 2002
    ....
  30. ncbi request reprint Behavioural screening in mutagenised mice--in search for novel animal models of psychiatric disorders
    Frauke Ohl
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804, Munich, Germany
    Eur J Pharmacol 480:219-28. 2003
    ..Different strategies are being introduced, which are used in ENU-mutagenesis screens to identify behavioural mutants representing possible endophenotypes of psychiatric diseases...
  31. pmc The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders
    C K Thoeringer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Neural Transm 116:649-57. 2009
    ..These data indicate a high load of genetic variance within SLC6A1 on pathological anxiety and highlight GAT-1 as a promising target for treatment of anxiety disorders with panic symptoms...
  32. doi request reprint Consequences of chronic social stress on behaviour and vasopressin gene expression in the PVN of DBA/2OlaHsd mice--influence of treatment with the CRHR1-antagonist R121919/NBI 30775
    A Erhardt
    MD Max Planck Institute of Psychiatry, Munich, Germany
    J Psychopharmacol 23:31-9. 2009
    ....
  33. ncbi request reprint Repetitive transcranial magnetic stimulation in rats: evidence for a neuroprotective effect in vitro and in vivo
    A Post
    Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Neurosci 11:3247-54. 1999
    ..These findings suggest that neurochemical effects induced by rTMS do not lead to reduced neuronal viability, and may even reduce the detrimental effects of oxidative stress in neurons...
  34. doi request reprint Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice
    C K Thoeringer
    Max Planck Institute of Psychiatry, Munich, Germany
    J Psychopharmacol 24:733-43. 2010
    ..This data indicate that both acute and long-term anxiolytic and antidepressant-like properties of brain GAT-1 inhibition coincide with a reduction in HPA system activity in mice...
  35. ncbi request reprint Endocrine disturbances in depression
    M A Tichomirowa
    Max Planck Institute of Psychiatry, Munich, Germany
    J Endocrinol Invest 28:89-99. 2005
    ..Alterations in the reproductive system may also play a role in the pathology of depression. In addition, there is increasing evidence that leptin and neurosteroids, such as DHEA, are implicated in mood disorders...
  36. ncbi request reprint Repetitive transcranial magnetic stimulation (rTMS) in major depression: relation between efficacy and stimulation intensity
    Frank Padberg
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neuropsychopharmacology 27:638-45. 2002
    ..These findings support the hypothesis of a relationship between stimulation intensity of rTMS and its antidepressant efficacy...
  37. ncbi request reprint Transcranial magnetic stimulation as a therapeutic tool in psychiatry: what do we know about the neurobiological mechanisms?
    A Post
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    J Psychiatr Res 35:193-215. 2001
    ..Together, these changes are, in part, reminiscent of those accompanying antidepressant drugs...
  38. ncbi request reprint Differential analysis of behavior and diazepam-induced alterations in C57BL/6N and BALB/c mice using the modified hole board test
    F Ohl
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 Munich, Germany
    J Psychiatr Res 35:147-54. 2001
    ..Therefore, this new strategy allows to reduce the number of experimental animals and the time needed, thus, representing an effective screening-tool for behavioral investigations...
  39. ncbi request reprint Expression of CRHR1 and CRHR2 in mouse pituitary and adrenal gland: implications for HPA system regulation
    M B Müller
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Endocrinology 142:4150-3. 2001
    ..The existence of an intra-adrenal CRH/CRHR1 regulatory system which contributes to the corticosteroid secretory activity adds to the complexity of HPA system regulation and stress hormone homeostasis...
  40. ncbi request reprint Disruption of feeding behavior in CRH receptor 1-deficient mice is dependent on glucocorticoids
    M B Müller
    Max Planck Institute of Psychiatry, Molecular Neurogenetics, Munich, Germany
    Neuroreport 11:1963-6. 2000
    ....
  41. ncbi request reprint Repetitive transcranial magnetic stimulation increases the release of dopamine in the nucleus accumbens shell of morphine-sensitized rats during abstinence
    A Erhardt
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 29:2074-80. 2004
    ..The DA release in morphine-sensitized rats was significantly higher than in controls. rTMS, therefore, might gain a potential therapeutic role in the treatment of dysphoric and anhedonic states during drug withdrawal in humans...
  42. ncbi request reprint Conditional CRF receptor 1 knockout mice show altered neuronal activation pattern to mild anxiogenic challenge
    Ngoc Khoi Nguyen
    Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Peter Mayrstr 1, 6020, Innsbruck, Austria
    Psychopharmacology (Berl) 188:374-85. 2006
    ..Nat Neurosci 6:1100-1107, 2003)...
  43. ncbi request reprint Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: effects on stress hormone levels and adult hippocampal neurogenesis
    Boldizsar Czeh
    The German Primate Center, Division of Neurobiology, Gottingen, Germany
    Biol Psychiatry 52:1057-65. 2002
    ..The present study investigated the effect of chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation treatment on stress hormone regulation and hippocampal neurogenesis...
  44. ncbi request reprint Occurrence of delusions during repetitive transcranial magnetic stimulation (rTMS) in major depression
    Peter Zwanzger
    Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Biol Psychiatry 51:602-3. 2002
    ..Repetitive transcranial magnetic stimulation (rTMS) has been suggested as a potentially useful treatment for major depression. Nonpsychotic depressed patients appear to have a better outcome than those with psychotic symptoms...