Manfred Kayser

Summary

Affiliation: Max Planck Institute for Evolutionary Anthropology
Country: Germany

Publications

  1. pmc Characteristics and frequency of germline mutations at microsatellite loci from the human Y chromosome, as revealed by direct observation in father/son pairs
    M Kayser
    Max Planck Institut für evolutionäre Anthropologie, D 04103 Leipzig, Germany
    Am J Hum Genet 66:1580-8. 2000
  2. pmc Y chromosome STR haplotypes and the genetic structure of U.S. populations of African, European, and Hispanic ancestry
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 13:624-34. 2003
  3. ncbi Online Y-chromosomal short tandem repeat haplotype reference database (YHRD) for U.S. populations
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    J Forensic Sci 47:513-9. 2002
  4. pmc Reduced Y-chromosome, but not mitochondrial DNA, diversity in human populations from West New Guinea
    Manfred Kayser
    Department for Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 72:281-302. 2003
  5. ncbi Mutations at Y-STR loci: implications for paternity testing and forensic analysis
    M Kayser
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103, Leipzig, Germany
    Forensic Sci Int 118:116-21. 2001
  6. pmc Independent histories of human Y chromosomes from Melanesia and Australia
    M Kayser
    Max Planck Institute for Evolutionary Anthropology, Department for Evolutionary Genetics, D 04103 Leipzig, Germany
    Am J Hum Genet 68:173-190. 2001
  7. pmc Extent and distribution of linkage disequilibrium in three genomic regions
    G R Abecasis
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England OX3 7BN
    Am J Hum Genet 68:191-197. 2001
  8. ncbi Melanesian origin of Polynesian Y chromosomes
    M Kayser
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Curr Biol 10:1237-46. 2000
  9. pmc A comprehensive survey of human Y-chromosomal microsatellites
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 74:1183-97. 2004
  10. ncbi Apparent intrachromosomal exchange on the human Y chromosome explained by population history
    Ralf Kittler
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Eur J Hum Genet 11:304-14. 2003

Detail Information

Publications39

  1. pmc Characteristics and frequency of germline mutations at microsatellite loci from the human Y chromosome, as revealed by direct observation in father/son pairs
    M Kayser
    Max Planck Institut für evolutionäre Anthropologie, D 04103 Leipzig, Germany
    Am J Hum Genet 66:1580-8. 2000
    ..This indicates that the general mutational mechanism of microsatellites is independent of recombination...
  2. pmc Y chromosome STR haplotypes and the genetic structure of U.S. populations of African, European, and Hispanic ancestry
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 13:624-34. 2003
    ....
  3. ncbi Online Y-chromosomal short tandem repeat haplotype reference database (YHRD) for U.S. populations
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    J Forensic Sci 47:513-9. 2002
    ....
  4. pmc Reduced Y-chromosome, but not mitochondrial DNA, diversity in human populations from West New Guinea
    Manfred Kayser
    Department for Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 72:281-302. 2003
    ..Our data further provide evidence for primarily female-mediated gene flow within the highlands of New Guinea but primarily male-mediated gene flow between highland and lowland/coastal regions...
  5. ncbi Mutations at Y-STR loci: implications for paternity testing and forensic analysis
    M Kayser
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103, Leipzig, Germany
    Forensic Sci Int 118:116-21. 2001
    ..In order to further enrich our knowledge of Y-STR mutations we suggest the establishment of a Y-STR mutation database and ask the forensic community for data contribution...
  6. pmc Independent histories of human Y chromosomes from Melanesia and Australia
    M Kayser
    Max Planck Institute for Evolutionary Anthropology, Department for Evolutionary Genetics, D 04103 Leipzig, Germany
    Am J Hum Genet 68:173-190. 2001
    ....
  7. pmc Extent and distribution of linkage disequilibrium in three genomic regions
    G R Abecasis
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England OX3 7BN
    Am J Hum Genet 68:191-197. 2001
    ..Although these findings are encouraging for the prospects of a genomewide LD map, they suggest caution in interpreting localization due to allelic association...
  8. ncbi Melanesian origin of Polynesian Y chromosomes
    M Kayser
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Curr Biol 10:1237-46. 2000
    ..Here, we used Y-chromosome polymorphisms to investigate the origins of Polynesians...
  9. pmc A comprehensive survey of human Y-chromosomal microsatellites
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 74:1183-97. 2004
    ..As a result of this work, a large number of new, highly polymorphic Y-chromosomal microsatellites are now available for population-genetic, evolutionary, genealogical, and forensic investigations...
  10. ncbi Apparent intrachromosomal exchange on the human Y chromosome explained by population history
    Ralf Kittler
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Eur J Hum Genet 11:304-14. 2003
    ..Thus, we demonstrate here that allele frequency distributions at duplicate loci that are suggestive of intrachromosomal recombination can be explained solely by population history...
  11. ncbi Melanesian and Asian origins of Polynesians: mtDNA and Y chromosome gradients across the Pacific
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 23:2234-44. 2006
    ..We also demonstrate that Fiji played a pivotal role in the history of Polynesia: humans probably first migrated to Fiji, and subsequent settlement of Polynesia probably came from Fiji...
  12. pmc Genome-wide data substantiate Holocene gene flow from India to Australia
    Irina Pugach
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 110:1803-8. 2013
    ..This is also approximately when changes in tool technology, food processing, and the dingo appear in the Australian archaeological record, suggesting that these may be related to the migration from India...
  13. ncbi Y-chromosome analysis confirms highly sex-biased dispersal and suggests a low male effective population size in bonobos (Pan paniscus)
    Jonas Eriksson
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Mol Ecol 15:939-49. 2006
    ..40,000-45,000). For humans the difference is merely a factor of two, suggesting a more stable demographic history in bonobos in comparison to humans...
  14. ncbi Development of Y-chromosomal microsatellite markers for nonhuman primates
    Axel Erler
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Mol Ecol 13:2921-30. 2004
    ....
  15. ncbi Identification of a candidate genetic variant for the high prevalence of type II diabetes in Polynesians
    Sean Myles
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Eur J Hum Genet 15:584-9. 2007
    ..703, P=0.007) and we therefore suggest that this allele may play a role in the large difference in type II diabetes prevalence between Polynesians and neighboring populations...
  16. ncbi Asian online Y-STR Haplotype Reference Database
    Ruediger Lessig
    Institute of Legal Medicine, University of Leipzig, Johannisallee 28, D 04103 Leipzig, Germany
    Leg Med (Tokyo) 5:S160-3. 2003
    ..All databases are maintained and curated at the Institute of Legal Medicine, Humboldt-University, Berlin and will soon be fused to a global repository including populations from all continents...
  17. doi Bridging near and remote Oceania: mtDNA and NRY variation in the Solomon Islands
    Frederick Delfin
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 29:545-64. 2012
    ..Our results fill an important lacuna in human genetic studies of Oceania and aid in understanding the colonization and genetic history of this region...
  18. ncbi Molecular evolution of Pediculus humanus and the origin of clothing
    Ralf Kittler
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Curr Biol 13:1414-7. 2003
    ..These results suggest that clothing was a surprisingly recent innovation in human evolution...
  19. pmc Dating the age of admixture via wavelet transform analysis of genome-wide data
    Irina Pugach
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, D 04103, Germany
    Genome Biol 12:R19. 2011
    ..The wavelet transform method offers better resolution than existing methods for dating admixture, and can be applied to either SNP or sequence data from humans or other species...
  20. ncbi A genome scan to detect candidate regions influenced by local natural selection in human populations
    Manfred Kayser
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 20:893-900. 2003
    ..Our results demonstrate that genome scans are a promising means of identifying candidate regions that have been subjected to local selection...
  21. ncbi Y-chromosomal evidence for a strong reduction in male population size of Yakuts
    Brigitte Pakendorf
    Institute of Human Biology, University of Hamburg, Germany
    Hum Genet 110:198-200. 2002
  22. ncbi A whole genome amplification method to generate long fragments from low quantities of genomic DNA
    Ralf Kittler
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Anal Biochem 300:237-44. 2002
    ..LL-DOP-PCR provides significantly better coverage for microsatellites and unique sequences in comparison to a conventional DOP-PCR method...
  23. ncbi Evaluation of saliva as a source of human DNA for population and association studies
    Dominique Quinque
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103, Leipzig, Germany
    Anal Biochem 353:272-7. 2006
    ..Thus, saliva can be considered a reliable source of DNA for a wide variety of genetic studies...
  24. pmc Maternal history of Oceania from complete mtDNA genomes: contrasting ancient diversity with recent homogenization due to the Austronesian expansion
    Ana T Duggan
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
    Am J Hum Genet 94:721-33. 2014
    ....
  25. ncbi Homogeneity and distinctiveness of Polish paternal lineages revealed by Y chromosome microsatellite haplotype analysis
    Rafal Ploski
    Human Molecular Genetics Lab, Department of Forensic Medicine, Warsaw Medical Academy, Poland
    Hum Genet 110:592-600. 2002
    ..Electronic supplementary material to this paper can be obtained by using the Springer LINK server located at http://dx.doi.org/10.1007/s00439-002-0728-0...
  26. pmc The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time
    Lev A Zhivotovsky
    N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
    Am J Hum Genet 74:50-61. 2004
    ..This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria...
  27. ncbi Evaluation of haplotype discrimination capacity of 35 Y-chromosomal short tandem repeat loci
    Heike Rodig
    Biotype AG, Moritzburger Weg 67, 01109 Dresden, Germany
    Forensic Sci Int 174:182-8. 2008
    ..Complete resolution of the pooled population was achieved by the additional genotyping of two further loci, DYS446 or DYS505 and DYF406S1 or DYS522...
  28. pmc A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population
    Fan Liu
    Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics and Clinical Genetics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Hum Genet 81:17-31. 2007
    ..For this region, our analysis identified the NMNAT3 and CLSTN2 genes. Our findings confirm linkage to chromosome 11q25. We were unable to confirm SORL1; instead, our analysis points to the OPCML and HNT genes...
  29. ncbi Signature of recent historical events in the European Y-chromosomal STR haplotype distribution
    Lutz Roewer
    Institute of Legal Medicine, Humboldt University, Berlin, Germany
    Hum Genet 116:279-91. 2005
    ..We conclude that Y-STRs may be capable of resolving male genealogies to an unparalleled degree and could therefore provide a useful means to study local population structure and recent demographic history...
  30. ncbi Correlation between genetic and geographic structure in Europe
    Oscar Lao
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Curr Biol 18:1241-8. 2008
    ..By including the widely used CEPH from Utah (CEU) samples into our analysis, we could show that these individuals represent northern and western Europeans reasonably well, thereby confirming their assumed regional ancestry...
  31. ncbi The impact of the Austronesian expansion: evidence from mtDNA and Y chromosome diversity in the Admiralty Islands of Melanesia
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Mol Biol Evol 25:1362-74. 2008
    ..These results significantly advance our understanding of the impact of the Austronesian expansion and human history in the Pacific region...
  32. pmc Proportioning whole-genome single-nucleotide-polymorphism diversity for the identification of geographic population structure and genetic ancestry
    Oscar Lao
    Department of Forensic Molecular Biology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Am J Hum Genet 78:680-90. 2006
    ....
  33. pmc Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:411-23. 2008
    ..Testing markers in the HERC2-OCA2 region may be useful in forensic applications to predict eye color phenotypes of unknown persons of European genetic origin...
  34. pmc Genome-wide analysis indicates more Asian than Melanesian ancestry of Polynesians
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:194-8. 2008
    ....
  35. ncbi Patterns of Y-chromosome diversity intersect with the Trans-New Guinea hypothesis
    Stefano Mona
    Department of Genetics and Microbiology, University of Bari, Bari, Italy
    Mol Biol Evol 24:2546-55. 2007
    ....
  36. pmc Stable RNA markers for identification of blood and saliva stains revealed from whole genome expression analysis of time-wise degraded samples
    Dmitry Zubakov
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, P O Box 2040, 3000 Rotterdam, The Netherlands
    Int J Legal Med 122:135-42. 2008
    ..We propose the use of these 14 stable mRNA markers for identification of blood and saliva stains in future forensic practice...
  37. ncbi Determining restriction digest efficiency using the SNaPshot single-base extension method and CE
    Kaye N Ballantyne
    Victoria Police Forensic Services Department, Macleod, Victoria, Australia
    Electrophoresis 28:1514-7. 2007
    ..Across two different restriction enzymes, the amount remaining undigested was found to be dependent on the amount of DNA, ranging from 0.08% with 200 ng to 1.25% with 600 ng...
  38. ncbi A counter-clockwise northern route of the Y-chromosome haplogroup N from Southeast Asia towards Europe
    Siiri Rootsi
    Department of Evolutionary Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    Eur J Hum Genet 15:204-11. 2007
    ..These phylogeographic patterns provide evidence consistent with male-mediated counter-clockwise late Pleistocene-Holocene migratory trajectories toward Northwestern Europe from an ancestral East Asian source of Paleolithic heritage...
  39. ncbi Significant genetic differentiation between Poland and Germany follows present-day political borders, as revealed by Y-chromosome analysis
    Manfred Kayser
    Department of Forensic Molecular Biology, Medical Genetic Cluster, Erasmus University Medical Center Rotterdam, PO Box 1738, 3000, DR Rotterdam, The Netherlands
    Hum Genet 117:428-43. 2005
    ....