Affiliation: Max Planck Institute for Biological Cybernetics
Raisch T, Bhandari D, Sabath K, Helms S, Valkov E, Weichenrieder O, et al
. Distinct modes of recruitment of the CCR4-NOT complex by Drosophila and vertebrate Nanos. EMBO J. 2016;35:974-90 pubmed publisher
..Thus, despite the absence of sequence conservation, the N-terminal regions of Nanos proteins recruit CCR4-NOT to assemble analogous repressive complexes. ..
Chen Y, Boland A, Kuzuoğlu Öztürk D, Bawankar P, Loh B, Chang C, et al
. A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing. Mol Cell. 2014;54:737-50 pubmed publisher
..Together, our data provide the missing physical links in a molecular pathway that connects miRNA target recognition with translational repression, deadenylation, and decapping. ..
Peter D, Igreja C, Weber R, Wohlbold L, Weiler C, Ebertsch L, et al
. Molecular architecture of 4E-BP translational inhibitors bound to eIF4E. Mol Cell. 2015;57:1074-87 pubmed publisher
..Our studies pave the way for the rational design of 4E-BP mimics as therapeutic tools to decrease translation during oncogenic transformation. ..
KuzuoÄŸlu Ã–ztÃ¼rk D, Bhandari D, Huntzinger E, Fauser M, Helms S, Izaurralde E. miRISC and the CCR4-NOT complex silence mRNA targets independently of 43S ribosomal scanning. EMBO J. 2016;35:1186-203 pubmed publisher
..This and additional observations indicate a common mechanism used by these proteins and miRNAs to mediate silencing. This mechanism does not require eIF4A function during ribosomal scanning. ..
Grüner S, Peter D, Weber R, Wohlbold L, Chung M, Weichenrieder O, et al
. The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation. Mol Cell. 2016;64:467-479 pubmed publisher
..Our studies provide a molecular model of the eIF4E-eIF4G complex, shed light on the competition mechanism of 4E-BPs, and enable the rational design of selective eIF4G inhibitors to dampen dysregulated translation in disease. ..
Sgromo A, Raisch T, Backhaus C, Keskeny C, Alva V, Weichenrieder O, et al
. Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets. RNA. 2017;: pubmed publisher
..Thus, Bam regulates the expression of its mRNA targets by recruiting the CCR4-NOT complex through interaction with CAF40. ..