M Ising

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. ncbi request reprint Systemic growth hormone-releasing hormone (GHRH) impairs sleep in healthy young women
    Stefan Mathias
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 32:1021-7. 2007
  2. ncbi request reprint Stress response regulation in panic disorder
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Curr Pharm Des 18:5675-84. 2012
  3. ncbi request reprint The Munich vulnerability study on affective disorders: premorbid psychometric profile of affected individuals
    M Ising
    Max Planck Institute of Psychiatry, Munich, Germany
    Acta Psychiatr Scand 109:332-8. 2004
  4. ncbi request reprint The Munich vulnerability study on affective disorders: premorbid neuroendocrine profile of affected high-risk probands
    M Ising
    Max Planck Institute of Psychiatry, Kraeplinstrasse 10, D 80804 München, Germany
    J Psychiatr Res 39:21-8. 2005
  5. ncbi request reprint Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Eur J Neurosci 28:389-98. 2008
  6. ncbi request reprint The combined dexamethasone/CRH test as a potential surrogate marker in depression
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1085-93. 2005
  7. doi request reprint CRH-sub-1 receptor antagonists for the treatment of depression and anxiety
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich, Germany
    Exp Clin Psychopharmacol 15:519-28. 2007
  8. pmc Genetics of stress response and stress-related disorders
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 Munich, Germany
    Dialogues Clin Neurosci 8:433-44. 2006
  9. ncbi request reprint High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neuropsychopharmacology 32:1941-9. 2007
  10. ncbi request reprint Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:47-54. 2007

Detail Information

Publications87

  1. ncbi request reprint Systemic growth hormone-releasing hormone (GHRH) impairs sleep in healthy young women
    Stefan Mathias
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 32:1021-7. 2007
    ..After both dosages GH increased whereas ACTH and cortisol remained unchanged. This study confirms that systemic GHRH impairs sleep in women...
  2. ncbi request reprint Stress response regulation in panic disorder
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Curr Pharm Des 18:5675-84. 2012
    ....
  3. ncbi request reprint The Munich vulnerability study on affective disorders: premorbid psychometric profile of affected individuals
    M Ising
    Max Planck Institute of Psychiatry, Munich, Germany
    Acta Psychiatr Scand 109:332-8. 2004
    ..We conducted a longitudinal high-risk study to identify psychometric vulnerability markers for affective disorders...
  4. ncbi request reprint The Munich vulnerability study on affective disorders: premorbid neuroendocrine profile of affected high-risk probands
    M Ising
    Max Planck Institute of Psychiatry, Kraeplinstrasse 10, D 80804 München, Germany
    J Psychiatr Res 39:21-8. 2005
    ..Our results suggest that a dysregulated HPA system indicated by this function test can rather be regarded as a neurobiological scar developing during the course of affective disorders...
  5. ncbi request reprint Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Eur J Neurosci 28:389-98. 2008
    ..This reaction pattern suggests that subjects carrying these variants are at risk of displaying chronically elevated cortisol levels after repeated stress constituting a risk factor for stress-related diseases...
  6. ncbi request reprint The combined dexamethasone/CRH test as a potential surrogate marker in depression
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1085-93. 2005
    ..Further systematic research is required and already ongoing to confirm the suitability of the combined dex/CRH test as a surrogate marker in depression...
  7. doi request reprint CRH-sub-1 receptor antagonists for the treatment of depression and anxiety
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich, Germany
    Exp Clin Psychopharmacol 15:519-28. 2007
    ..The psychotropic effects observed in the clinical studies underscore that CRH1 antagonists constitute a novel treatment of depression and anxiety but may also serve to prevent negative sequelae of severe stressors...
  8. pmc Genetics of stress response and stress-related disorders
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 Munich, Germany
    Dialogues Clin Neurosci 8:433-44. 2006
    ..This, together with the use of new text--and information-mining tools, will bring us closer to integrating all the findings into sophisticated models delineating the pathways from genes to stress response and stress-related disorders...
  9. ncbi request reprint High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neuropsychopharmacology 32:1941-9. 2007
    ..NBI-34041 demonstrates that inhibition of the CRF system is a promising target for drug development against depression and anxiety disorders...
  10. ncbi request reprint Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:47-54. 2007
    ..In the present study, we examined whether change in HPA system function during the first weeks of hospitalization predicts response to antidepressant treatment in major depression and thus constitutes a potential biomarker...
  11. doi request reprint HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients
    E B Binder
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D80804 Munich, Germany
    Psychoneuroendocrinology 34:99-109. 2009
    ..In male patients, a single measure of HPA-axis dysregulation at admission may serve as a predictor of response to antidepressant treatment in addition to the previously reported repeated measure of the Dex-CRH test...
  12. doi request reprint Somatization in major depression--clinical features and genetic associations
    T Klengel
    Max Planck Institute of Psychiatry, Kraepelinstrasse, Munich, Germany
    Acta Psychiatr Scand 124:317-28. 2011
    ..To identify clinical variables and genetic variations within monoaminergic genes known to be implicated in pain perception that are associated with the occurrence of somatization symptoms in patients with major depression...
  13. ncbi request reprint Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. a prospective study
    A W Zobel
    Max Planck Institute of Psychiatry, Kraepelinstr 2-10, 80804 Munich, Germany
    J Psychiatr Res 35:83-94. 2001
    ..Hence, an exaggerated cortisol response in the combined DEX/CRH test predicts the recurrence of depressive psychopathology. The test performance can be further optimized if gender and age are taken into account...
  14. doi request reprint TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies
    A Erhardt
    Max Planck Institute of Psychiatry, Munchen, Germany
    Mol Psychiatry 16:647-63. 2011
    ..TMEM132D may thus be an important new candidate gene for PD as well as more generally for anxiety-related behavior...
  15. doi request reprint Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression
    S Kloiber
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 15:736-47. 2010
    ..Identifying depressed patients at high risk for MetS using genetic variants could have direct clinical impact on individualized disease management and prevention strategies...
  16. ncbi request reprint P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder
    Susanne Lucae
    The Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Hum Mol Genet 15:2438-45. 2006
    ..This polymorphism results in an amino acid exchange in the C-terminal cytosolic domain of the P2RX7 channel protein, suggesting that the observed P2RX7 polymorphism might play a causal role in the development of depression...
  17. ncbi request reprint Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Nat Genet 36:1319-25. 2004
    ..These findings support a central role of genes regulating the HPA axis in the causality of depression and the mechanism of action of antidepressant drugs...
  18. doi request reprint Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial
    Heike E Kunzel
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    J Psychiatr Res 43:702-10. 2009
    ..In delusional depression HPA overactivity is more distinct than in other subtypes of depression. HPA suppression is thought to contribute to the action of trimipramine...
  19. ncbi request reprint Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin, and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazapine
    Dagmar A Schmid
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 31:832-44. 2006
    ..A weight gain of approximately 3 kg was observed. This unique profile of changes is compatible with the action of mirtazapine at 5-HT-2 receptors, at presynaptic adrenergic alpha 2 receptors, at the HPA system, and on ghrelin and leptin...
  20. doi request reprint Variants within the GABA transaminase (ABAT) gene region are associated with somatosensory evoked EEG potentials in families at high risk for affective disorders
    M Wegerer
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychol Med 43:1207-17. 2013
    ..The sample was composed of high-risk families participating in the Munich Vulnerability Study and genetic association analyses were calculated using qfam (family-based association tests for quantitative traits) implemented in PLINK 1.05...
  21. ncbi request reprint Impaired divided attention predicts delayed response and risk to relapse in subjects with depressive disorders
    M Majer
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychol Med 34:1453-63. 2004
    ..This study addresses the complex relationship between cognitive function and the course of depression...
  22. ncbi request reprint The Munich vulnerability study on affective disorders: premorbid polysomnographic profile of affected high-risk probands
    Sieglinde Modell
    Max Planck Institute of Psychiatry, Munich
    Biol Psychiatry 58:694-9. 2005
    ..To identify vulnerability markers, we investigated premorbid sleep EEG parameters in healthy high-risk probands (HRPs) with a positive family history of affective disorders...
  23. doi request reprint HTR2A gene variation is involved in antidepressant treatment response
    Susanne Lucae
    Max Planck Institute of Psychiatry, Munich, Germany
    Eur Neuropsychopharmacol 20:65-8. 2010
    ....
  24. doi request reprint Increased prevalence of anxiety-associated personality traits in patients with Cushing's disease: a cross-sectional study
    C Dimopoulou
    Department of Endocrinology, Max Planck Institute of Psychiatry, Munich, Germany dimopoulou mpipsykl mpg de
    Neuroendocrinology 97:139-45. 2013
    ..We aimed to test this hypothesis and attempted to determine the effects of disease- and treatment-related factors that might moderate an altered personality in CD...
  25. doi request reprint Distinct dopaminergic personality patterns in patients with prolactinomas: a comparison with nonfunctioning pituitary adenoma patients and age- and gender-matched controls
    A P Athanasoulia
    Department of Internal Medicine, Endocrinology and Clinical Chemistry, Max Planck Institute of Psychiatry, Munich, Germany
    Neuroendocrinology 96:204-11. 2012
    ..Hence, we aimed at examining whether patients with prolactinomas exhibit modified personality patterns compared to patients with nonfunctioning pituitary adenomas and healthy controls...
  26. ncbi request reprint Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks
    Christoph K Thoeringer
    Max Planck Institute of Psychiatry, Munich 80804, Germany
    J Psychiatr Res 41:579-84. 2007
    ..43; 95% CI: 0.19-0.95). In conclusion, these results suggest a central role of DBI genetic variants in the susceptibility for the development of anxiety disorders that are characterized by the occurrence of panic attacks...
  27. doi request reprint Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project
    Johannes M Hennings
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    J Psychiatr Res 43:215-29. 2009
    ..We demonstrated that this subgroup can be characterized by a set of demographic, clinical and neuroendocrine variables allowing to predict unfavorable outcome at an early stage of treatment...
  28. doi request reprint A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich 80804, Germany
    Arch Gen Psychiatry 66:966-75. 2009
    ..Genetic factors and clinical characteristics contribute to the failure of a favorable treatment outcome...
  29. ncbi request reprint Impaired hypothalamic-pituitary-adrenocortical (HPA) system is related to severity of benzodiazepine withdrawal in patients with depression
    Adam Wichniak
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Psychoneuroendocrinology 29:1101-8. 2004
    ..In view of the GABAergic inhibition of HPA system activity and the anxiogenic effect of CRH, benzodiazepine withdrawal symptoms may be partly due to a disinhibition of the HPA system during discontinuation of benzodiazepines...
  30. ncbi request reprint Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism
    T C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Mol Psychiatry 11:1003-15. 2006
    ..We could show that SNP rs4291 influences ACE activity and HPA-axis hyperactivity and might therefore represent a common pathophysiologic link for unipolar depression and cardiovascular disease...
  31. pmc The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders
    C K Thoeringer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Neural Transm 116:649-57. 2009
    ..These data indicate a high load of genetic variance within SLC6A1 on pathological anxiety and highlight GAT-1 as a promising target for treatment of anxiety disorders with panic symptoms...
  32. doi request reprint More CLEC16A gene variants associated with multiple sclerosis
    S Nischwitz
    Max Planck Institute of Psychiatry, Munich, Germany
    Acta Neurol Scand 123:400-6. 2011
    ..Recently, associations of several single-nucleotide polymorphisms (SNPs) within the CLEC16A gene with multiple sclerosis (MS), type-I diabetes, and primary adrenal insufficiency were reported...
  33. ncbi request reprint Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:424-9. 2007
    ..These results further underline a possible important role of genetic variations within the system controlling serotonergic neurotransmission for the development and course of disease in PD...
  34. ncbi request reprint Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder
    Angelika Erhardt
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 31:2515-22. 2006
    ..However, differences in the suppression effects and psychopathological correlation patterns between depressed and panic patients suggest different biological mechanisms of HPA system dysregulation in both disorders...
  35. ncbi request reprint Hypothalamus-pituitary-adrenal system regulation and suicidal behavior in depression
    Andrea Pfennig
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 57:336-42. 2005
    ..So far data on the involvement of the HPA axis in the pathophysiology of suicidal behavior in depressed patients are controversial...
  36. ncbi request reprint Cognitive impairment in unipolar depression is persistent and non-specific: further evidence for the final common pathway disorder hypothesis
    S Reppermund
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychol Med 39:603-14. 2009
    ....
  37. ncbi request reprint The effect of the ANKK1/DRD2 Taq1A polymorphism on weight changes of dopaminergic treatment in prolactinomas
    A P Athanasoulia
    Department of Internal Medicine, Endocrinology and Clinical Chemistry, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804, Munich, Germany
    Pituitary 17:240-5. 2014
    ..However, there was no association to the A1 allele of Taq1A, observation that needs to be analysed in larger cohorts. ..
  38. ncbi request reprint Treatment with the CRH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression
    K Held
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804, Munich, Germany
    J Psychiatr Res 38:129-36. 2004
    ....
  39. ncbi request reprint Nocturnal ghrelin, ACTH, GH and cortisol secretion after sleep deprivation in humans
    P Schussler
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychoneuroendocrinology 31:915-23. 2006
    ..Whereas the effects of SD on ghrelin levels were relatively weak, our findings are in line with the hypothesis that ghrelin is a sleep-promoting factor in humans. Ghrelin may be involved in sleep promotion after SD...
  40. ncbi request reprint Pharmacological and nonpharmacological factors influencing hypothalamic-pituitary-adrenocortical axis reactivity in acutely depressed psychiatric in-patients, measured by the Dex-CRH test
    H E Künzel
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 28:2169-78. 2003
    ..Finally, more severe vegetative symptoms are associated with an enhanced HPA-axis activity...
  41. ncbi request reprint Polymorphisms of the drug transporter gene ABCB1 predict side effects of treatment with cabergoline in patients with PRL adenomas
    A P Athanasoulia
    Department of Internal Medicine, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Eur J Endocrinol 167:327-35. 2012
    ..Central side effects may depend on a substance's ability to pass the blood-brain barrier, which can be actively controlled by transporter molecules such as the P-glycoprotein (P-gp) encoded by the ABCB1 gene...
  42. ncbi request reprint Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking
    A Heck
    Max Planck Institute of Psychiatry, Munich, Germany
    Genes Brain Behav 8:464-72. 2009
    ..Our results show that HTR2A polymorphisms modulate facets of novelty seeking behaviour in healthy adults suggesting that serotonergic neurotransmission is involved in this phenotype...
  43. doi request reprint Depression, comorbidities and the TNF-alpha system
    H Himmerich
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804, Munich, Germany
    Eur Psychiatry 23:421-9. 2008
    ..These results confirm earlier studies regarding the comorbidities of depression and support the hypothesis that activation of the TNF-alpha system may contribute to the development of a depressive disorder...
  44. doi request reprint Personality in patients with pituitary adenomas is characterized by increased anxiety-related traits: comparison of 70 acromegalic patients with patients with non-functioning pituitary adenomas and age- and gender-matched controls
    C Sievers
    Department of Endocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Endocrinol 160:367-73. 2009
    ..We examined whether patients with acromegaly showed an altered personality profile compared with patients with non-functioning pituitary adenomas and healthy controls...
  45. doi request reprint Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:1196-204. 2008
    ..These data suggest that polymorphisms in the AVPR1B and the CRHR1 genes alter the susceptibility to panic disorder...
  46. ncbi request reprint Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects
    Heike E Kunzel
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
    J Psychiatr Res 37:525-33. 2003
    ..No effects of R121919 on clinical laboratory parameters including liver enzymes, EEG and ECG were observed. These results encourage the development of other CRH-1-R antagonists as a novel class of antidepressive drugs...
  47. ncbi request reprint The Munich Vulnerability Study on Affective Disorders: stability of polysomnographic findings over time
    Sieglinde Modell
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 52:430-7. 2002
    ..In the present study, we re-investigated a subsample of these HRPs to evaluate the stability of these findings over time...
  48. ncbi request reprint Clinical and neurobiological effects of tianeptine and paroxetine in major depression
    Thomas Nickel
    Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Psychopharmacol 23:155-68. 2003
    ..The normalization of the HPA system as a common mode of action of different antidepressants seems to be of special interest...
  49. ncbi request reprint Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders
    Angelika Erhardt
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 München, Germany
    J Affect Disord 101:159-68. 2007
    ..This region contains two candidate genes for purinergic ligand-gated ion channels, P2RX7 and P2RX4, and one gene coding for calmodulin-dependent protein kinase kinase b (CaMKKb)...
  50. doi request reprint Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action
    Sonja Horstmann
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 34:238-48. 2009
    ..Our results confirm that dex/CRH tests can be used as predictors of clinical course also under mirtazapine treatment...
  51. ncbi request reprint Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease
    Nibal Ackl
    Department of Psychiatry, Memory Clinic, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80802 Munich, Germany
    Neurosci Lett 384:23-8. 2005
    ..Moreover, multivoxel 1H MRS may enable an objective staging of the neurodegenerative process underlying the age-dependent cognitive deficits eventually leading to dementia...
  52. doi request reprint Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients
    Angela Heck
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:104-14. 2009
    ..These results suggest that the ACE gene is involved in the development of coping strategies...
  53. ncbi request reprint Prevalence of mental disorders in acromegaly: a cross-sectional study in 81 acromegalic patients
    Caroline Sievers
    Departments of Endocrinology and Molecular Psychology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, Germany
    Clin Endocrinol (Oxf) 71:691-701. 2009
    ....
  54. doi request reprint Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:1100-9. 2009
    ..However, data from expression studies imply that these polymorphisms could tag functional effects on the neighboring gene MYO3A, which is also expressed in the brain, including the cingulate cortex and the amygdala...
  55. pmc Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Neuropsychopharmacology 35:1583-92. 2010
    ..The reported associations in independent samples of AD and MDD support an estrogen-dependent function of GAL in pathophysiology of anxiety and depression, affecting response to antidepressant treatment...
  56. pmc Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment
    Sonja Horstmann
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 35:727-40. 2010
    ....
  57. doi request reprint Stress hormone regulation: biological role and translation into therapy
    Florian Holsboer
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Annu Rev Psychol 61:81-109, C1-11. 2010
    ..These could be a first step into personalized medicine using treatments tailored to the specific pathology of the patients...
  58. pmc The Munich vulnerability study on affective disorders: microstructure of sleep in high-risk subjects
    Elisabeth Friess
    Max Planck Institute of Psychiatry, 80804, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:285-91. 2008
    ..Ongoing follow up investigations of HRPs will clarify whether the observed increase in sigma EEG activity during nonREM sleep is of clinical relevance with respect to the likelihood to develop an affective disorder...
  59. ncbi request reprint The interplay of familial depression liability and adverse events in predicting the first onset of depression during a 10-year follow-up
    Petra Zimmermann
    Molecular Psychology Unit, Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 63:406-14. 2008
    ....
  60. ncbi request reprint Nocturnal ghrelin levels--relationship to sleep EEG, the levels of growth hormone, ACTH and cortisol--and gender differences
    Petra Schuessler
    Max Planck Institute of Psychiatry, Munich, Germany
    J Sleep Res 14:329-36. 2005
    ..No peak in plasma ghrelin levels resembling the GH surge was observed. We suggest that under naturalistic conditions plasma ghrelin levels show no distinct interaction with sleep...
  61. ncbi request reprint Persistent cognitive impairment in depression: the role of psychopathology and altered hypothalamic-pituitary-adrenocortical (HPA) system regulation
    Simone Reppermund
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:400-6. 2007
    ..This study examines the associations between HPA system regulation, cognitive functioning, and psychopathology in depressed inpatients on admission and at discharge...
  62. ncbi request reprint Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 München, Germany
    J Affect Disord 105:177-84. 2008
    ..Furthermore, GAL is involved in hypothalamic-hypophysiotropic signalling and cosecreted with luteinizing hormone-releasing hormone (LHRH), possibly acting as a mediator of estrogen action...
  63. ncbi request reprint Overweight and obesity affect treatment response in major depression
    Stefan Kloiber
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:321-6. 2007
    ..To elucidate the impact of weight on the course of depression beyond comorbidity, we investigated psychopathology, attention, neuroendocrinology, weight change, and treatment response in MDD patients, depending on their weight...
  64. doi request reprint Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression
    Manfred Uhr
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Neuron 57:203-9. 2008
    ..This finding can be viewed as a further step into personalized antidepressant treatment...
  65. ncbi request reprint Successful antidepressant therapy restores the disturbed interplay between TNF-alpha system and HPA axis
    Hubertus Himmerich
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 60:882-8. 2006
    ....
  66. doi request reprint Central CRH system in depression and anxiety--evidence from clinical studies with CRH1 receptor antagonists
    Florian Holsboer
    Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Pharmacol 583:350-7. 2008
    ..The results of the clinical studies underscore that CRH(1) receptor antagonists represent promising novel therapeutics in the psychopharmacology of depression and anxiety...
  67. ncbi request reprint Paroxetine treatment improves motor symptoms in patients with multiple system atrophy
    Elisabeth Friess
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Parkinsonism Relat Disord 12:432-7. 2006
    ..In addition, we assessed the effects on the psychopathological status of the patients...
  68. doi request reprint Dex/CRH-test response and sleep in depressed patients and healthy controls with and without vulnerability for affective disorders
    Elisabeth Friess
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    J Psychiatr Res 42:1154-62. 2008
    ..These associations, however, are not unidimensional, but dependent on the kind of sleep parameters as well as on the selection of the subjects...
  69. ncbi request reprint Plasma fibrinogen: now also an antidepressant response marker?
    D Martins-de-Souza
    1 Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Munich, Germany 2 Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
    Transl Psychiatry 4:e352. 2014
    ..These results were replicated in a second set of patients. Our findings lend further support to a recently identified association between MDD and fibrinogen levels from a large-scale study. ..
  70. doi request reprint Glucose tolerance in depressed inpatients, under treatment with mirtazapine and in healthy controls
    J M Hennings
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Exp Clin Endocrinol Diabetes 118:98-100. 2010
    ..Although glucose tolerance improved under mirtazapine treatment, insulin sensitivity was still impaired and remained significantly lower in patients compared to controls...
  71. doi request reprint IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations
    F Weber
    Max Planck Institute of Psychiatry, Munich, Germany
    Genes Immun 9:259-63. 2008
    ..1 to 1.5. The discovery and validation of new genetic risk factors in independent populations may help toward the understanding of MS pathogenesis by providing valuable information on biological pathways to be investigated...
  72. ncbi request reprint Ghrelin promotes slow-wave sleep in humans
    J C Weikel
    Max Planck Institute of Psychiatry, Department of Psychiatry, 80804 Munich, Germany
    Am J Physiol Endocrinol Metab 284:E407-15. 2003
    ..Furthermore, ghrelin appears to be a common stimulus of the somatotropic and hypothalamo-pituitary-adrenocortical systems. It appears that ghrelin is a sleep-promoting factor in humans...
  73. ncbi request reprint Toward a reliable distinction between patients with mild cognitive impairment and Alzheimer-type dementia versus major depression
    Anke Post
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 59:858-62. 2006
    ....
  74. doi request reprint Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis
    Sandra Nischwitz
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neuroimmunol 227:162-6. 2010
    ..No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433...
  75. ncbi request reprint Ghrelin stimulates appetite, imagination of food, GH, ACTH, and cortisol, but does not affect leptin in normal controls
    Dagmar A Schmid
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 30:1187-92. 2005
    ..Our data suggest that i.v. ghrelin stimulates appetite and images of food in young women and men. Obviously, leptin is not involved in these effects...
  76. ncbi request reprint Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression
    Heike E Kunzel
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 Munich, Germany
    J Psychiatr Res 39:173-7. 2005
    ..Together with previous findings indicating safety, tolerability, and clinical efficacy CRH1R antagonists are highly promising as a new treatment option in depression...
  77. ncbi request reprint Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters
    Jurgen Brunner
    Facharzt für Psychiatrie und Psychotherapie, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 255:438-40. 2005
    ..2. Proteomic analysis of the CSF is a promising non hypothesis-driven screening method for the detection of new candidate genes in neurobiological suicide research...
  78. ncbi request reprint Lithium augmentation increases the ACTH and cortisol response in the combined DEX/CRH test in unipolar major depression
    Tom Bschor
    Department of Psychiatry, Technische Universitat Dresden, Dresden, Germany
    Neuropsychopharmacology 27:470-8. 2002
    ..This effect might be explained by the serotonergic effects of lithium...
  79. ncbi request reprint Polymorphisms of the glucocorticoid receptor gene and major depression
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Biol Psychiatry 59:681-8. 2006
    ..The N363S and BclI polymorphisms have been associated with hypersensitivity to glucocorticoids, whereas the ER22/23EK polymorphism is related to glucocorticoid resistance...
  80. ncbi request reprint Association between response to lithium augmentation and the combined DEX/CRH test in major depressive disorder
    Tom Bschor
    Department of Psychiatry, Technische Universitat Dresden, Fetscherstrasse 74, D 01307, Dresden, Germany
    J Psychiatr Res 37:135-43. 2003
    ..Results of this study should be confirmed in a larger study group...
  81. ncbi request reprint Platelet 5-HT2A receptor binding and tryptophan availability in depression are not associated with recent history of suicide attempts but with personality traits characteristic for suicidal behavior
    Erik Lauterbach
    University of Schleswig Holstein, Campus Luebeck, Department of Psychiatry and Psychotherapy, Ratzeburger Allee 160, 23538 Luebeck, Germany
    J Affect Disord 91:57-62. 2006
    ..A number of personality traits were assessed in order to provide a basis for a psychobiological model of suicidal behavior...
  82. ncbi request reprint Long-latency somatosensory potentials in high risk probands for affective disorders
    Marcus Ising
    J Psychiatr Res 38:219-21. 2004
  83. ncbi request reprint Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment
    Hubertus Himmerich
    Max Planck Institut fur Psychiatrie, Munchen, Deutschland
    Neuropsychobiology 55:28-35. 2007
    ..Glucocorticoids themselves are reported to increase leptin synthesis and secretion in humans...
  84. ncbi request reprint Electroencephalographic sleep profiles in treatment course and long-term outcome of major depression: association with DEX/CRH-test response
    Martin Hatzinger
    Psychiatric University Hospital, Depression Research Unit, Wilhelm Klein Str 27, CH 4025 Basel, Switzerland
    J Psychiatr Res 38:453-65. 2004
    ..These disturbances may reflect important mechanisms responsible of causing and maintaining the disease process of depression...
  85. doi request reprint Genetic markers within glutamate receptors associated with antidepressant treatment-emergent suicidal ideation
    Andreas Menke
    Am J Psychiatry 165:917-8. 2008
  86. ncbi request reprint Lithium augmentation increases post-dexamethasone cortisol in the dexamethasone suppression test in unipolar major depression
    Tom Bschor
    Department of Psychiatry, Technische Universitat Dresden, Germany
    Depress Anxiety 17:43-8. 2003
    ..This is in contrast to the established decline of HPA system activity during treatment with tricyclic antidepressants...
  87. ncbi request reprint Bringing basic and clinical research together to an integrated understanding of psychiatric disorders
    Marcus Ising
    J Psychiatr Res 41:1-2. 2007