Florian Holsboer

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
  2. pmc Deducing corticotropin-releasing hormone receptor type 1 signaling networks from gene expression data by usage of genetic algorithms and graphical Gaussian models
    Dietrich Trumbach
    Max Planck Institute of Psychiatry, Kraepelinstr, 2 10, 80804 Munich, Germany
    BMC Syst Biol 4:159. 2010
  3. pmc Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression
    Thomas Fenzl
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    BMC Neurosci 12:29. 2011
  4. pmc Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations
    Florian Then Bergh
    Section of Neurology, Max Planck Institut fur Psychiatrie, Munchen, Germany
    BMC Neurol 6:19. 2006
  5. ncbi request reprint Prospects for antidepressant drug discovery
    F Holsboer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804, Munich, Germany
    Biol Psychol 57:47-65. 2001
  6. ncbi request reprint Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy
    F Holsboer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804, Munich, Germany
    J Affect Disord 62:77-91. 2001
  7. doi request reprint How can we realize the promise of personalized antidepressant medicines?
    Florian Holsboer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Nat Rev Neurosci 9:638-46. 2008
  8. doi request reprint Central CRH system in depression and anxiety--evidence from clinical studies with CRH1 receptor antagonists
    Florian Holsboer
    Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Pharmacol 583:350-7. 2008
  9. ncbi request reprint [Detlev Ploog (1920 through 2005)]
    F Holsboer
    Max Planck Institut fur Psychiatrie, Kraepelinstrasse 10, 80804 München
    Nervenarzt 77:852-3. 2006
  10. ncbi request reprint Corticotropin-releasing hormone modulators and depression
    Florian Holsboer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    Curr Opin Investig Drugs 4:46-50. 2003

Collaborators

Detail Information

Publications179 found, 100 shown here

  1. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
    ..With the integrated replication effort, we present a specific hypothesis for further studies...
  2. pmc Deducing corticotropin-releasing hormone receptor type 1 signaling networks from gene expression data by usage of genetic algorithms and graphical Gaussian models
    Dietrich Trumbach
    Max Planck Institute of Psychiatry, Kraepelinstr, 2 10, 80804 Munich, Germany
    BMC Syst Biol 4:159. 2010
    ..To extract significantly regulated genes from a genome-wide microarray data set and to deduce underlying CRHR1-dependent signaling networks, we combined supervised and unsupervised algorithms...
  3. pmc Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression
    Thomas Fenzl
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    BMC Neurosci 12:29. 2011
    ..Eight adult males of each of the three breeding lines were equipped with epidural EEG and intramuscular electromyogram (EMG) electrodes. After recovery, EEG and EMG recordings were performed for two days...
  4. pmc Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations
    Florian Then Bergh
    Section of Neurology, Max Planck Institut fur Psychiatrie, Munchen, Germany
    BMC Neurol 6:19. 2006
    ..Intermittent IV-MP, alone or with immunomodulators, has been suggested but insufficiently studied as a strategy to prevent relapses...
  5. ncbi request reprint Prospects for antidepressant drug discovery
    F Holsboer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804, Munich, Germany
    Biol Psychol 57:47-65. 2001
    ..In this sense, biotechnology opens up new chances for drug development through serendipity by providing new data bases on which systematic biological research in psychiatry and psychology can be conducted...
  6. ncbi request reprint Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy
    F Holsboer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804, Munich, Germany
    J Affect Disord 62:77-91. 2001
    ..Furthermore, the potential of drugs that interfere more directly with stress hormone regulation, such as corticosteroid receptor antagonists and corticotropin-releasing hormone receptor antagonists, is discussed...
  7. doi request reprint How can we realize the promise of personalized antidepressant medicines?
    Florian Holsboer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Nat Rev Neurosci 9:638-46. 2008
    ..This process will require many further steps and collaboration between basic and clinical neuroscience...
  8. doi request reprint Central CRH system in depression and anxiety--evidence from clinical studies with CRH1 receptor antagonists
    Florian Holsboer
    Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Pharmacol 583:350-7. 2008
    ..The results of the clinical studies underscore that CRH(1) receptor antagonists represent promising novel therapeutics in the psychopharmacology of depression and anxiety...
  9. ncbi request reprint [Detlev Ploog (1920 through 2005)]
    F Holsboer
    Max Planck Institut fur Psychiatrie, Kraepelinstrasse 10, 80804 München
    Nervenarzt 77:852-3. 2006
  10. ncbi request reprint Corticotropin-releasing hormone modulators and depression
    Florian Holsboer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    Curr Opin Investig Drugs 4:46-50. 2003
    ....
  11. ncbi request reprint Unipolar versus bipolar disorder: a distinction not helpful for studies of causality
    Florian Holsboer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Curr Psychiatry Rep 7:405-7. 2005
  12. ncbi request reprint The future of antidepressant pharmacogenetics is arriving. Introduction
    Florian Holsboer
    Max Planck Institute Psychiatry, Kraepelinstrasse 2 10, Munich 8 80806, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:996-8. 2005
  13. ncbi request reprint Antidepressant drug discovery in the postgenomic era
    F Holsboer
    Max Planck Institute of Psychiatry Kraepelinstr 2 10 80804 Munich, Germany
    World J Biol Psychiatry 2:165-77. 2001
    ..Once these goals are achieved notorious undertreatment of depression may come to an end...
  14. ncbi request reprint High-quality antidepressant discovery by understanding stress hormone physiology
    Florian Holsboer
    Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    Ann N Y Acad Sci 1007:394-404. 2003
    ..All these strategies are not yet fully clinically developed, but preliminary data from basic and clinical research strongly underscore that such strategies may lead to innovative treatment modalities...
  15. doi request reprint Stress hormone regulation: biological role and translation into therapy
    Florian Holsboer
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Annu Rev Psychol 61:81-109, C1-11. 2010
    ..These could be a first step into personalized medicine using treatments tailored to the specific pathology of the patients...
  16. doi request reprint CRH signaling. Molecular specificity for drug targeting in the CNS
    Damian Refojo
    Max Planck Institute of Psychiatry, Munich, Germany
    Ann N Y Acad Sci 1179:106-19. 2009
    ..Recent findings obtained with this mouse model and its usefulness in the context of the CRH-dependent, region-specific changes in depression will be discussed...
  17. ncbi request reprint The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety
    F Holsboer
    Max Planck Institute of Psychiatry, Munich, Germany
    J Psychiatr Res 33:181-214. 1999
    ..Thus, patients with clinical conditions that are causally related to HPA hyperactivity may profit from treatment with a CRH1 receptor antagonist...
  18. doi request reprint [The future of depression research]
    F Holsboer
    Max Planck Institut fur Psychiatrie, Kraepelinstr 2 10, 80804, Munchen, Deutschland
    Nervenarzt 81:1306, 1308,1309-12, Passim. 2010
    ..The application of a personalized depression therapy supported by genetic testing and biomarkers raises the possibility of early recognition of the risk of disease and a targeted intervention before the symptoms of disease emerge...
  19. pmc Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Neuropsychopharmacology 35:1583-92. 2010
    ..The reported associations in independent samples of AD and MDD support an estrogen-dependent function of GAL in pathophysiology of anxiety and depression, affecting response to antidepressant treatment...
  20. ncbi request reprint Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neurochem 92:1170-9. 2005
    ..Chronic paroxetine enhanced the presynaptic responsivity in HAB rats, but not LAB rats, pointing to a preferential efficacy of paroxetine in rats with enhanced anxiety/depression-related behaviour...
  21. doi request reprint Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2
    Jan M Deussing
    Max Planck Institut fur Psychiatrie, Munich, Germany
    J Neurosci 30:9103-16. 2010
    ..In conclusion, our results suggest a novel role for UCN3 and CRH-R2 related to the processing of social cues and to the establishment of social memories...
  22. ncbi request reprint Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin
    Alexandra Wigger
    Max Planck Institute of Psychiatry, Behavioural Neuroendocrinology, Munich, Germany
    Neuropsychopharmacology 29:1-14. 2004
    ....
  23. ncbi request reprint Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety
    Chris Murgatroyd
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 24:7762-70. 2004
    ..Taken together, our results demonstrate a role for an AVP gene polymorphism and CBF-A in elevated AVP expression in the PVN of HAB rats likely to contribute to their behavioral and neuroendocrine phenotype...
  24. doi request reprint Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions
    Torsten Klengel
    Max Planck Institute of Psychiatry, Munich, Germany
    Nat Neurosci 16:33-41. 2013
    ..This identification of molecular mechanisms of genotype-directed long-term environmental reactivity will be useful for designing more effective treatment strategies for stress-related disorders...
  25. doi request reprint Dex/CRH-test response and sleep in depressed patients and healthy controls with and without vulnerability for affective disorders
    Elisabeth Friess
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    J Psychiatr Res 42:1154-62. 2008
    ..These associations, however, are not unidimensional, but dependent on the kind of sleep parameters as well as on the selection of the subjects...
  26. ncbi request reprint The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: an in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice
    Christoph K Thoeringer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 32:746-57. 2007
    ..In addition, our study highlights the use of in vivo microdialysis to assess the neuroendocrine endophenotype of animal models via profiling of stimulus-response patterns of stress hormones...
  27. doi request reprint Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine
    Inge Sillaber
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Psychopharmacology (Berl) 200:557-72. 2008
    ..Monoamine-based antidepressants inhibit neurotransmitter reuptake within short time. However, it commonly takes several weeks until clinical symptoms start to resolve--indicating the involvement of effects distant from reuptake inhibition...
  28. ncbi request reprint FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells
    Gabriela M Wochnik
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    J Biol Chem 280:4609-16. 2005
    ..In addition, differential regulation of dynein association and nuclear translocation contributes to the effects of the two immunophilins on the glucocorticoid receptor in mammals...
  29. doi request reprint Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression
    Manfred Uhr
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Neuron 57:203-9. 2008
    ..This finding can be viewed as a further step into personalized antidepressant treatment...
  30. ncbi request reprint Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders
    Angelika Erhardt
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 München, Germany
    J Affect Disord 101:159-68. 2007
    ..This region contains two candidate genes for purinergic ligand-gated ion channels, P2RX7 and P2RX4, and one gene coding for calmodulin-dependent protein kinase kinase b (CaMKKb)...
  31. doi request reprint Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences
    Mathias V Schmidt
    Max Planck Institute of Psychiatry, Munich, Germany
    Endocrinology 150:2709-16. 2009
    ..Postnatal glucocorticoid excess results in an altered stress-coping behavior in adult animals, with no effects on anxiety like behavior or cognition...
  32. pmc A hypomorphic vasopressin allele prevents anxiety-related behavior
    Mirjam Bunck
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e5129. 2009
    ....
  33. doi request reprint Homer1 mediates acute stress-induced cognitive deficits in the dorsal hippocampus
    Klaus V Wagner
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 33:3857-64. 2013
    ..These findings help to reveal the underlying effects of cognitive impairments in patients suffering from stress-related psychiatric disorders...
  34. ncbi request reprint Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress
    Marianne B Muller
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, Munich 80804, Germany
    Nat Neurosci 6:1100-7. 2003
    ..Furthermore, we provide evidence for a new role of limbic Crhr1 in neuroendocrine adaptation to stress...
  35. ncbi request reprint Altered serotonergic neurotransmission but normal hypothalamic-pituitary-adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775
    Akihiko Oshima
    Max Planck Institute of Psychiatry, Sections of Neurochemistry and Neuropsychopharmacology, Munich, Germany
    Neuropsychopharmacology 28:2148-59. 2003
    ..Owing to the important role of 5-HT in the pathophysiology of mood and anxiety disorders, the latter observation may contribute to the therapeutical efficacy of CRH-R1 antagonists in these illnesses...
  36. ncbi request reprint Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 München, Germany
    J Affect Disord 105:177-84. 2008
    ..Furthermore, GAL is involved in hypothalamic-hypophysiotropic signalling and cosecreted with luteinizing hormone-releasing hormone (LHRH), possibly acting as a mediator of estrogen action...
  37. doi request reprint A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich 80804, Germany
    Arch Gen Psychiatry 66:966-75. 2009
    ..Genetic factors and clinical characteristics contribute to the failure of a favorable treatment outcome...
  38. doi request reprint Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Eur J Neurosci 28:389-98. 2008
    ..This reaction pattern suggests that subjects carrying these variants are at risk of displaying chronically elevated cortisol levels after repeated stress constituting a risk factor for stress-related diseases...
  39. pmc Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice
    Christoph P N Romanowski
    Max Planck Institute of Psychiatry, Munich, Germany
    Sleep 33:427-36. 2010
    ..Therefore, we investigated in CNS-specific CRH receptor type 1 deficient mice whether centrally administered CRH could induce its sleep-wake modulatory effects without peripheral induction of HPA activity...
  40. pmc Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression
    Chadi Touma
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e4325. 2009
    ..This so-called 'stress reactivity' (SR) mouse model consists of three separate breeding lines selected for either high (HR), intermediate (IR), or low (LR) corticosterone increase in response to stressors...
  41. doi request reprint Dynamic DNA methylation programs persistent adverse effects of early-life stress
    Chris Murgatroyd
    Max Planck Institute of Psychiatry, Munich, Germany
    Nat Neurosci 12:1559-66. 2009
    ..Thus, ELS can dynamically control DNA methylation in postmitotic neurons to generate stable changes in Avp expression that trigger neuroendocrine and behavioral alterations that are frequent features in depression...
  42. doi request reprint The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress
    Jakob Hartmann
    Max Planck Institute of Psychiatry, RG Neurobiology of Stress, Kraepelinstr 2 10, 80804 Munich, Germany
    Neuropharmacology 62:332-9. 2012
    ..These results suggest an enhanced negative glucocorticoid feedback within the HPA axis of 51KO mice, possibly modulated by an increased sensitivity of the GR. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  43. doi request reprint Polymorphisms within the metabotropic glutamate receptor 1 gene are associated with depression phenotypes
    Andreas Menke
    Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
    Psychoneuroendocrinology 37:565-75. 2012
    ....
  44. ncbi request reprint Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment
    Hubertus Himmerich
    Max Planck Institut fur Psychiatrie, Munchen, Deutschland
    Neuropsychobiology 55:28-35. 2007
    ..Glucocorticoids themselves are reported to increase leptin synthesis and secretion in humans...
  45. pmc Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment
    Sonja Horstmann
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 35:727-40. 2010
    ....
  46. pmc Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients
    Martin A Kohli
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Arch Gen Psychiatry 67:348-59. 2010
    ..Especially in suicide victims, lower postmortem brain messenger RNA and protein levels of neurotrophins and their receptors have been reported...
  47. doi request reprint Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project
    Johannes M Hennings
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    J Psychiatr Res 43:215-29. 2009
    ..We demonstrated that this subgroup can be characterized by a set of demographic, clinical and neuroendocrine variables allowing to predict unfavorable outcome at an early stage of treatment...
  48. ncbi request reprint Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety
    Simone A Krömer
    Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    J Neurosci 25:4375-84. 2005
    ..Additional studies will examine whether glyoxalase-I has an impact beyond that of a biomarker to predict the genetic predisposition to anxiety- and depression-like behavior...
  49. doi request reprint Development of the brain's default mode network from wakefulness to slow wave sleep
    Philipp G Sämann
    Max Planck Institute of Psychiatry, Neuroimaging Research Group, 80804 Munich, Germany
    Cereb Cortex 21:2082-93. 2011
    ..Results resonate with a role of the PCC/RspC for the regulation of consciousness. We further submit that preserved corticocortical synchronization could represent a prerequisite for maintaining internal and external awareness...
  50. pmc The Munich vulnerability study on affective disorders: microstructure of sleep in high-risk subjects
    Elisabeth Friess
    Max Planck Institute of Psychiatry, 80804, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:285-91. 2008
    ..Ongoing follow up investigations of HRPs will clarify whether the observed increase in sigma EEG activity during nonREM sleep is of clinical relevance with respect to the likelihood to develop an affective disorder...
  51. doi request reprint Acute cortisol administration increases sleep depth and growth hormone release in patients with major depression
    Dagmar A Schmid
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Psychiatr Res 42:991-9. 2008
    ..Our results suggest that non-REM and REM sleep abnormalities during the acute state of the disease are differentially linked to the activity of the HPA axis...
  52. doi request reprint Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial
    Heike E Kunzel
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    J Psychiatr Res 43:702-10. 2009
    ..In delusional depression HPA overactivity is more distinct than in other subtypes of depression. HPA suppression is thought to contribute to the action of trimipramine...
  53. ncbi request reprint Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity
    Jan M Deussing
    Max Planck Institute of Psychiatry, Munich, Germany
    J Cereb Blood Flow Metab 27:1476-95. 2007
    ..In conclusion, these data suggest a novel, previously unknown role of the CRH/CRH-R1 system in modulating neurovascular gene expression and function...
  54. ncbi request reprint Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress
    Tobias Welt
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 31:2573-9. 2006
    ..An increasingly released AVP of magnocellular origin seems to provide a negative tonus on ACTH secretion most probably via inhibiting the release of ACTH secretagogues from the median eminence into hypophyseal portal blood...
  55. doi request reprint Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss
    Xiao Dong Wang
    Max Planck Institute of Psychiatry, Munich, Germany
    Nat Neurosci 16:706-13. 2013
    ..Our findings suggest that hippocampal nectin-3 is necessary for the effects of stress on memory and structural plasticity and indicate that the CRH-CRHR1 system interacts with the nectin-afadin complex to mediate such effects...
  56. pmc The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety
    Mariya Gonik
    Max Planck Institute of Psychiatry, Munich, Germany
    BMC Genomics 13:579. 2012
    ..Its dysfunction is related to several mental disorders, including anxiety and depression. The aim of this study was to identify genetic loci underlying the endocrine regulation of the HPA axis...
  57. pmc Intranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons
    Irina A Ionescu
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 37:1323-37. 2012
    ....
  58. pmc Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways
    Yaoyang Zhang
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Cell Proteomics 10:M111.008110. 2011
    ..Our data demonstrate that the high anxiety-related behavior and low anxiety-related behavior mouse model is a valuable tool for anxiety disorder drug discovery efforts...
  59. pmc Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein
    Amalia Tsolakidou
    Max Planck Institute of Psychiatry, Munich, Germany
    BMC Genomics 11:546. 2010
    ..Gene expression and regulation was determined by microarray analyses and further evaluated by bioinformatics tools including pathway and cluster analyses...
  60. ncbi request reprint Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects
    Heike E Kunzel
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
    J Psychiatr Res 37:525-33. 2003
    ..No effects of R121919 on clinical laboratory parameters including liver enzymes, EEG and ECG were observed. These results encourage the development of other CRH-1-R antagonists as a novel class of antidepressive drugs...
  61. ncbi request reprint Psychological stress increases hippocampal mineralocorticoid receptor levels: involvement of corticotropin-releasing hormone
    A Gesing
    Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, 80804 Munich, Germany
    J Neurosci 21:4822-9. 2001
    ..We conclude that the interaction between CRH and MR presents a novel mechanism involved in the adaptation of the brain to psychologically stressful events...
  62. doi request reprint Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:1196-204. 2008
    ..These data suggest that polymorphisms in the AVPR1B and the CRHR1 genes alter the susceptibility to panic disorder...
  63. doi request reprint Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels
    Nicole Zimmermann
    Chaperone Research Group, Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Biochem J 448:93-102. 2012
    ..In conclusion, the present study presents a model where distinct ADs affect DNMT1 activity via G9a with important repercussions for possible novel treatment regimes...
  64. pmc Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients
    Andreas Menke
    Moleculargenetics of Affective Disorders, Max Planck Institute of Psychiatry, Kraepelinstr, Munich, Germany
    Neuropsychopharmacology 37:1455-64. 2012
    ....
  65. ncbi request reprint Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919)
    Anke Post
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    Psychopharmacology (Berl) 180:150-8. 2005
    ..Despite its therapeutic efficacy, there is only little information about its mechanisms of action on cellular and molecular targets...
  66. doi request reprint Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1
    Damian Refojo
    Max Planck Institute of Psychiatry, Munich, Germany
    Science 333:1903-7. 2011
    ..These results define a bidirectional model for the role of CRHR1 in anxiety and suggest that an imbalance between CRHR1-controlled anxiogenic glutamatergic and anxiolytic dopaminergic systems might lead to emotional disorders...
  67. ncbi request reprint Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:424-9. 2007
    ..These results further underline a possible important role of genetic variations within the system controlling serotonergic neurotransmission for the development and course of disease in PD...
  68. ncbi request reprint Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers
    Ulrich Zimmermann
    Max Planck Institute of Psychiatry, Kraepelinstrasse, Munich, Germany
    Neuropsychopharmacology 29:1156-65. 2004
    ....
  69. ncbi request reprint Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders
    Martin E Keck
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neurosci Biobehav Rev 29:867-89. 2005
    ....
  70. ncbi request reprint Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice
    Melanie S Kessler
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Eur J Neurosci 26:2857-64. 2007
    ..Thus, the SNP-associated deficit in plasma and central AVP contributes to signs of cDI and, at least partially, to low trait anxiety, both features being typical of LAB animals...
  71. ncbi request reprint Successful antidepressant therapy restores the disturbed interplay between TNF-alpha system and HPA axis
    Hubertus Himmerich
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 60:882-8. 2006
    ....
  72. doi request reprint Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior
    A Lu
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 13:1028-42. 2008
    ..Thus, these transgenic mouse lines may serve as animal models for stress-elicited pathologies and treatments that target the central CRH system...
  73. pmc Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies
    Divya Mehta
    Max Planck Institute of Psychiatry, Kraepelinstrasse, Munich, Germany
    Arch Gen Psychiatry 68:901-10. 2011
    ..Polymorphisms in the gene encoding the glucocorticoid receptor (GR) regulating co-chaperone FKBP5 have been shown to alter GR sensitivity and are associated with an increased risk to develop posttraumatic stress disorder (PTSD)...
  74. ncbi request reprint Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Nat Genet 36:1319-25. 2004
    ..These findings support a central role of genes regulating the HPA axis in the causality of depression and the mechanism of action of antidepressant drugs...
  75. ncbi request reprint Overweight and obesity affect treatment response in major depression
    Stefan Kloiber
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:321-6. 2007
    ..To elucidate the impact of weight on the course of depression beyond comorbidity, we investigated psychopathology, attention, neuroendocrinology, weight change, and treatment response in MDD patients, depending on their weight...
  76. ncbi request reprint Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90
    Gabriela M Wochnik
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    FEBS Lett 560:35-8. 2004
    ..Importantly, similar results were obtained with a constitutively active GR. Thus, the action of p23 on the nuclear stage of GR regulation requires its Hsp90 co-chaperone function, but not its chaperone activity...
  77. doi request reprint Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:1100-9. 2009
    ..However, data from expression studies imply that these polymorphisms could tag functional effects on the neighboring gene MYO3A, which is also expressed in the brain, including the cingulate cortex and the amygdala...
  78. pmc Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits
    Xiao Dong Wang
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 31:13625-34. 2011
    ....
  79. ncbi request reprint High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats
    Raffael Kalisch
    NMR Study Group, Max Planck Institute of Psychiatry, Munich, Germany
    Neuroimage 23:382-91. 2004
    ..In the context of an anxiety-inhibiting role of the dmPFC, we propose that failure to sufficiently activate this region in stressful situations may contribute to high trait anxiety...
  80. doi request reprint Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action
    Sonja Horstmann
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 34:238-48. 2009
    ..Our results confirm that dex/CRH tests can be used as predictors of clinical course also under mirtazapine treatment...
  81. doi request reprint HTR2A gene variation is involved in antidepressant treatment response
    Susanne Lucae
    Max Planck Institute of Psychiatry, Munich, Germany
    Eur Neuropsychopharmacol 20:65-8. 2010
    ....
  82. ncbi request reprint Effects of transgenic overproduction of CRH on anxiety-like behaviour
    Marcel M van Gaalen
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Eur J Neurosci 15:2007-15. 2002
    ....
  83. ncbi request reprint Trimipramine and imipramine exert different effects on the sleep EEG and on nocturnal hormone secretion during treatment of major depression
    A Sonntag
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Depression 4:1-13. 1996
    ..We conclude that trimipramine is an antidepressant with sleep-improving qualities that possibly acts through inhibition of hypothalamic-pituitary-adrenocortical system activity by a yet unknown mechanism...
  84. ncbi request reprint Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: an in vivo microdialysis study in mutant mice
    R G Peñalva
    Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Sections of Neurochemistry and Neuropsychopharmacology, Kraepelinstrasse 2, D 80804 Munich, Germany
    Neuroscience 109:253-66. 2002
    ..These data provide further evidence for the intricate relationship between corticotropin-releasing hormone and serotonin and the important role of the CRH-R1 herein...
  85. ncbi request reprint Intact spatial learning and memory in transgenic mice with reduced BDNF
    A Montkowski
    Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany
    Neuroreport 8:779-82. 1997
    ..This indicates that extrapolation from LTP in a single brain structure to complex behaviours such as learning and memory may not be justified...
  86. ncbi request reprint Dose-dependent effects of endotoxin on human sleep
    J Mullington
    Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany
    Am J Physiol Regul Integr Comp Physiol 278:R947-55. 2000
    ..Whereas it is well established that the endocrine and thermoregulatory systems are very sensitive to endotoxin, this study shows that human sleep-wake behavior is even more sensitive to activation of host defense mechanisms...
  87. ncbi request reprint Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids
    M B Müller
    Max Planck Institute of Psychiatry, Munich, Germany
    Endocrinology 141:4262-9. 2000
    ..Taken together, our data reveal a selective compensatory activation of the hypothalamic vasopressinergic, but not the oxytocinergic system, to maintain basal ACTH secretion and HPA system activity in Crhr1-/- mutants...
  88. doi request reprint Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders
    A Knapman
    Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 44:566-75. 2010
    ....
  89. ncbi request reprint P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder
    Susanne Lucae
    The Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Hum Mol Genet 15:2438-45. 2006
    ..This polymorphism results in an amino acid exchange in the C-terminal cytosolic domain of the P2RX7 channel protein, suggesting that the observed P2RX7 polymorphism might play a causal role in the development of depression...
  90. pmc Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice
    Michel A Steiner
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 33:54-67. 2008
    ..We conclude that pharmacological blockade of CB1 signaling shares antidepressant-like behavioral effects with desipramine, but reveals opposite effects on HPA axis activity...
  91. ncbi request reprint Pharmacological and nonpharmacological factors influencing hypothalamic-pituitary-adrenocortical axis reactivity in acutely depressed psychiatric in-patients, measured by the Dex-CRH test
    H E Künzel
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 28:2169-78. 2003
    ..Finally, more severe vegetative symptoms are associated with an enhanced HPA-axis activity...
  92. ncbi request reprint Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2
    J Preil
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Endocrinology 142:4946-55. 2001
    ..Within the intraadrenal CRH/ACTH system, our data suggest different roles for CRHR1 and CRHR2 in fine-tuning of adrenocortical corticosterone release...
  93. ncbi request reprint Neuroendocrine, polysomnographic and psychometric observations in healthy subjects at high familial risk for affective disorders: the current state of the 'Munich vulnerability study'
    J C Krieg
    Max Planck Institute of Psychiatry, Munich, Germany
    J Affect Disord 62:33-7. 2001
    ..Whether the relatives with the neurobiological and psychometric abnormalities we identified have a higher risk for developing an affective disorder than those without has to be answered by the still ongoing prospective part of the study...
  94. doi request reprint Blunted ACTH response to dexamethasone suppression-CRH stimulation in posttraumatic stress disorder
    Andreas Strohle
    Max Planck Institute of Psychiatry, Munich, Germany
    J Psychiatr Res 42:1185-8. 2008
    ..Our results give further evidence for a central role of the pituitary in reflecting changes of the negative feedback sensitivity of the HPA system in patients with PTSD...
  95. ncbi request reprint The Munich Vulnerability Study on Affective Disorders: risk factors for unipolarity versus bipolarity
    Sieglinde Modell
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    J Affect Disord 74:173-84. 2003
    ..The aim of this study was to differentiate between healthy members of unipolar and bipolar families without a previous history of any psychiatric disorder according to the neurobiological and psychometric findings...
  96. ncbi request reprint Impaired hypothalamic-pituitary-adrenocortical (HPA) system is related to severity of benzodiazepine withdrawal in patients with depression
    Adam Wichniak
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Psychoneuroendocrinology 29:1101-8. 2004
    ..In view of the GABAergic inhibition of HPA system activity and the anxiogenic effect of CRH, benzodiazepine withdrawal symptoms may be partly due to a disinhibition of the HPA system during discontinuation of benzodiazepines...
  97. ncbi request reprint The CRH1 receptor antagonist R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety
    Marike Lancel
    Max Planck Institute of Psychiatry, Section Neurophysiology, Kraepelinstr 2 10, D 80804, Munich, Germany
    J Psychiatr Res 36:197-208. 2002
    ..e. CRH hypersecretion) condition only...
  98. ncbi request reprint Effect of sleep and sleep deprivation on serotonergic neurotransmission in the hippocampus: a combined in vivo microdialysis/EEG study in rats
    Rosana G Peñalva
    Max Planck Institute of Psychiatry, Section of Neurochemistry, Kraepelinstrasse 2, D 80804 Munich, Germany
    Eur J Neurosci 17:1896-906. 2003
    ..We hypothesize that the elevated hippocampal 5-HT levels during SD may participate in the transient mood enhancing properties of forced wakefulness observed in depressed patients...
  99. ncbi request reprint Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks
    Christoph K Thoeringer
    Max Planck Institute of Psychiatry, Munich 80804, Germany
    J Psychiatr Res 41:579-84. 2007
    ..43; 95% CI: 0.19-0.95). In conclusion, these results suggest a central role of DBI genetic variants in the susceptibility for the development of anxiety disorders that are characterized by the occurrence of panic attacks...
  100. ncbi request reprint ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder
    Marianne B Muller
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neuropsychopharmacology 28:1991-9. 2003
    ....
  101. ncbi request reprint Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption
    Manfred Uhr
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    Biol Psychiatry 54:840-6. 2003
    ....