Michael Hofreiter

Summary

Affiliation: Max Planck Institute for Evolutionary Anthropology
Country: Germany

Publications

  1. pmc Mitochondrial genomes reveal an explosive radiation of extinct and extant bears near the Miocene-Pliocene boundary
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    BMC Evol Biol 8:220. 2008
  2. pmc Lack of phylogeography in European mammals before the last glaciation
    Michael Hofreiter
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 101:12963-8. 2004
  3. ncbi request reprint Genetic analyses from ancient DNA
    Svante Paabo
    Max Planck Institute for Evolutionary Anthropology, D 04013 Leipzig, Germany
    Annu Rev Genet 38:645-79. 2004
  4. ncbi request reprint Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nature 439:724-7. 2006
  5. pmc Direct multiplex sequencing (DMPS)--a novel method for targeted high-throughput sequencing of ancient and highly degraded DNA
    Mathias Stiller
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Genome Res 19:1843-8. 2009
  6. doi request reprint First DNA sequences from Asian cave bear fossils reveal deep divergences and complex phylogeographic patterns
    Michael Knapp
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Ecol 18:1225-38. 2009
  7. pmc Proboscidean mitogenomics: chronology and mode of elephant evolution using mastodon as outgroup
    Nadin Rohland
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 5:e207. 2007
  8. pmc From micrograms to picograms: quantitative PCR reduces the material demands of high-throughput sequencing
    Matthias Meyer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nucleic Acids Res 36:e5. 2008
  9. pmc No evidence of Neandertal mtDNA contribution to early modern humans
    David Serre
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E57. 2004
  10. pmc Isotopic evidence for omnivory among European cave bears: Late Pleistocene Ursus spelaeus from the Peştera cu Oase, Romania
    Michael P Richards
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 105:600-4. 2008

Detail Information

Publications47

  1. pmc Mitochondrial genomes reveal an explosive radiation of extinct and extant bears near the Miocene-Pliocene boundary
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    BMC Evol Biol 8:220. 2008
    ..Widely divergent topologies have been suggested based on various data sets and methods...
  2. pmc Lack of phylogeography in European mammals before the last glaciation
    Michael Hofreiter
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 101:12963-8. 2004
    ....
  3. ncbi request reprint Genetic analyses from ancient DNA
    Svante Paabo
    Max Planck Institute for Evolutionary Anthropology, D 04013 Leipzig, Germany
    Annu Rev Genet 38:645-79. 2004
    ..We also highlight some significant results and areas of promising future research...
  4. ncbi request reprint Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nature 439:724-7. 2006
    ..However, the divergence of mammoth, African and Asian elephants occurred over a short time, corresponding to only about 7% of the total length of the phylogenetic tree for the three evolutionary lineages...
  5. pmc Direct multiplex sequencing (DMPS)--a novel method for targeted high-throughput sequencing of ancient and highly degraded DNA
    Mathias Stiller
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Genome Res 19:1843-8. 2009
    ..Embedded in our approach, we present a new protocol for the construction of barcoded sequencing libraries, which is compatible with all current high-throughput technologies and can be performed entirely in plate setup...
  6. doi request reprint First DNA sequences from Asian cave bear fossils reveal deep divergences and complex phylogeographic patterns
    Michael Knapp
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Ecol 18:1225-38. 2009
    ..They also agree with recent studies on other extinct and extant species, such as wolves, hyenas and steppe bison, which have also revealed higher genetic and ecological diversity in Pleistocene populations than previously known...
  7. pmc Proboscidean mitogenomics: chronology and mode of elephant evolution using mastodon as outgroup
    Nadin Rohland
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 5:e207. 2007
    ..0 mya, supporting the view that these two groups represent different species. Finally, we found the mitochondrial mutation rate of proboscideans to be roughly half of the rate in primates during at least the last 24 million years...
  8. pmc From micrograms to picograms: quantitative PCR reduces the material demands of high-throughput sequencing
    Matthias Meyer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nucleic Acids Res 36:e5. 2008
    ..The method should also apply to Illumina/Solexa and ABI/SOLiD sequencing, and should therefore help to widen the accessibility of all three platforms...
  9. pmc No evidence of Neandertal mtDNA contribution to early modern humans
    David Serre
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E57. 2004
    ..In combination with current mtDNA data, this excludes any large genetic contribution by Neandertals to early modern humans, but does not rule out the possibility of a smaller contribution...
  10. pmc Isotopic evidence for omnivory among European cave bears: Late Pleistocene Ursus spelaeus from the Peştera cu Oase, Romania
    Michael P Richards
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 105:600-4. 2008
    ..These data therefore broaden the dietary profile of U. spelaeus and raise questions about the nature of the carnivore guild in Pleistocene Europe...
  11. ncbi request reprint Evidence for reproductive isolation between cave bear populations
    Michael Hofreiter
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103, Leipzig, Germany
    Curr Biol 14:40-3. 2004
    ..We also find no evidence that the morphology of the bears in the two caves changed to become more similar over time. We suggest that the two cave bear forms may have represented two reproductively isolated subspecies or species...
  12. ncbi request reprint Comparison and optimization of ancient DNA extraction
    Nadin Rohland
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Biotechniques 42:343-52. 2007
    ..Finally, we observed a marked difference in the performance between different types of DNA polymerases, as measured by amplification success...
  13. ncbi request reprint The population history of extant and extinct hyenas
    Nadin Rohland
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 22:2435-43. 2005
    ..Both striped and brown hyenas show low amounts of genetic diversity, with the latter ones displaying just a single haplotype...
  14. ncbi request reprint Ancient DNA extraction from bones and teeth
    Nadin Rohland
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nat Protoc 2:1756-62. 2007
    ..The protocol presented here allows DNA extraction from ancient bone and teeth with a minimum of working steps and equipment and yields DNA extracts within 2 working days...
  15. ncbi request reprint Ancient DNA analyses reveal high mitochondrial DNA sequence diversity and parallel morphological evolution of late pleistocene cave bears
    Michael Hofreiter
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 19:1244-50. 2002
    ..This suggests that small size may have been an ancestral trait in cave bears and that large size evolved at least twice independently...
  16. pmc Vertebrate DNA in fecal samples from bonobos and gorillas: evidence for meat consumption or artefact?
    Michael Hofreiter
    Research Group Molecular Ecology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS ONE 5:e9419. 2010
    ..As a control we also attempted PCR amplifications from gorilla feces, a species assumed to be strictly herbivorous...
  17. pmc Influence of climate warming on arctic mammals? New insights from ancient DNA studies of the collared lemming Dicrostonyx torquatus
    Stefan Prost
    Research Group Molecular Ecology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS ONE 5:e10447. 2010
    ....
  18. ncbi request reprint Nondestructive DNA extraction method for mitochondrial DNA analyses of museum specimens
    Nadin Rohland
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Biotechniques 36:814-6, 818-21. 2004
    ..Thus this method opens up the possibility to repeatedly use museum collections for mtDNA analyses without damaging the specimens and thus without reducing the value of irreplaceable collections for morphological analyses...
  19. pmc Road blocks on paleogenomes--polymerase extension profiling reveals the frequency of blocking lesions in ancient DNA
    Patricia Heyn
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nucleic Acids Res 38:e161. 2010
    ....
  20. pmc Computational challenges in the analysis of ancient DNA
    Kay Prüfer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Genome Biol 11:R47. 2010
    ..We show that more accurate genome divergence estimates from ancient DNA sequence can be attained using at least two outgroup genomes and appropriate filtering...
  21. doi request reprint Effects of late quaternary climate change on Palearctic shrews
    Stefan Prost
    Research Group Molecular Ecology, Max Planck Institute for Evolutionary Anthropology, Leipzig, 04103, Germany
    Glob Chang Biol 19:1865-74. 2013
    ....
  22. doi request reprint Parallel tagged sequencing on the 454 platform
    Matthias Meyer
    Max Planck Institute for Evolutionary Anthropology, Department of Evolutionary Genetics, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nat Protoc 3:267-78. 2008
    ..Most of the reactions can be performed in a multichannel setup on 96-well reaction plates, allowing for processing up to several hundreds of samples in a few days...
  23. pmc A mitogenomic phylogeny of living primates
    Knut Finstermeier
    Research Group Molecular Ecology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS ONE 8:e69504. 2013
    ..Finally, we show that mt genomes are a useful tool for resolving primate phylogenetic relationships on various taxonomic levels. ..
  24. pmc Whole mitochondrial genome sequencing of domestic horses reveals incorporation of extensive wild horse diversity during domestication
    Sebastian Lippold
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    BMC Evol Biol 11:328. 2011
    ....
  25. ncbi request reprint Mammoths
    Michael Hofreiter
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Curr Biol 16:R347-8. 2006
  26. ncbi request reprint Mitochondrial DNA sequence from an enigmatic gorilla population (Gorilla gorilla uellensis)
    Michael Hofreiter
    Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
    Am J Phys Anthropol 121:361-8. 2003
    ....
  27. pmc Targeted high-throughput sequencing of tagged nucleic acid samples
    Matthias Meyer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nucleic Acids Res 35:e97. 2007
    ..PTS dramatically increases the sequencing throughput of samples in parallel and thus fully mobilizes the resources of the 454 technology for targeted sequencing...
  28. doi request reprint A rapid column-based ancient DNA extraction method for increased sample throughput
    Nadin Rohland
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA Department of Biology, University of York, YO10 5YW, York, UK
    Mol Ecol Resour 10:677-83. 2010
    ..Thus, this method is suited for harvesting the power of high-throughput sequencing using the DNA preserved in the millions of paleontological and museums specimens...
  29. doi request reprint Discovery of lost diversity of paternal horse lineages using ancient DNA
    Sebastian Lippold
    Research Group Molecular Ecology, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Nat Commun 2:450. 2011
    ..Our methodology establishes the feasibility of re-sequencing long ancient nuclear DNA fragments and demonstrates the power of ancient Y chromosome DNA sequence data to provide insights into the evolutionary history of populations...
  30. pmc Mitochondrial genomes reveal slow rates of molecular evolution and the timing of speciation in beavers (Castor), one of the largest rodent species
    Susanne Horn
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS ONE 6:e14622. 2011
    ..Little is known about their evolution and even their closest phylogenetic relatives have not yet been identified with certainty. Similarly, little is known about the timing of divergence events within the genus Castor...
  31. ncbi request reprint Pleistocene extinctions: haunting the survivors
    Michael Hofreiter
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Curr Biol 17:R609-11. 2007
    ..However, recent analyses show that the surviving species may also have experienced losses in terms of genetic and ecological diversity...
  32. ncbi request reprint Learning from the past: evolution of GPCR functions
    Torsten Schoneberg
    Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Trends Pharmacol Sci 28:117-21. 2007
    ....
  33. ncbi request reprint Multiplex amplification of ancient DNA
    Holger Römpler
    Molecular Biochemistry, Institute of Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Nat Protoc 1:720-8. 2006
    ..It thus combines optimal template usage with a high specificity and can be performed within a day...
  34. ncbi request reprint G protein-coupled time travel: evolutionary aspects of GPCR research
    Holger Römpler
    Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Mol Interv 7:17-25. 2007
    ..This review discusses recent advances and approaches aimed at developing a better understanding of GPCR biology based on evolutionary data...
  35. ncbi request reprint A melanocortin 1 receptor allele suggests varying pigmentation among Neanderthals
    Carles Lalueza-Fox
    Departament de Biologia Animal, Universitat de Barcelona, Spain
    Science 318:1453-5. 2007
    ..Our data suggest that inactive MC1R variants evolved independently in both modern humans and Neanderthals...
  36. pmc Molecular breeding of polymerases for amplification of ancient DNA
    Michael Hofreiter
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Biotechnol 25:939-43. 2007
    ..Our results demonstrate that engineered polymerases can expand the recovery of genetic information from Pleistocene specimens and may benefit genetic analysis in paleontology, archeology and forensic medicine...
  37. ncbi request reprint Molecular caving
    Michael Hofreiter
    Curr Biol 13:R693-5. 2003
  38. ncbi request reprint Ongoing controversy over Romanov remains
    Michael Hofreiter
    Science 306:407-10. 2004
  39. ncbi request reprint Pleistocene brown bears in the mid-continent of North America
    Paul Matheus
    Alaska Quaternary Center, University of Alaska Fairbanks, Fairbanks, AK, USA
    Science 306:1150. 2004
    ....
  40. ncbi request reprint Genomic sequencing of Pleistocene cave bears
    James P Noonan
    United States Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA
    Science 309:597-9. 2005
    ..Comparison of cave bear and modern bear sequences revealed the evolutionary relationship of these lineages. The metagenomic approach used here establishes the feasibility of ancient DNA genome sequencing programs...
  41. ncbi request reprint Tenrec phylogeny and the noninvasive extraction of nuclear DNA
    Robert J Asher
    Museum für Naturkunde, D 10115, Berlin, Germany
    Syst Biol 55:181-94. 2006
    ....
  42. ncbi request reprint Sudden replacement of cave bear mitochondrial DNA in the late Pleistocene
    Michael Hofreiter
    Curr Biol 17:R122-3. 2007
  43. doi request reprint DNA from pre-Clovis human coprolites in Oregon, North America
    M Thomas P Gilbert
    Centre for Ancient Genetics, University of Copenhagen, Universitetsparken 15, 2100 Copenhagen, Denmark
    Science 320:786-9. 2008
    ..The mtDNA corresponds to Native American founding haplogroups A2 and B2. The dates of the coprolites are >1000 14C years earlier than currently accepted dates for the Clovis complex...
  44. pmc A rapid loss of stripes: the evolutionary history of the extinct quagga
    Jennifer A Leonard
    Genetics Program, National Museum of Natural History, Smithsonian Institution, 3001 Connecticut Avenue, NW, Washington, DC 20008 0551, USA
    Biol Lett 1:291-5. 2005
    ..This emphasizes the importance of Pleistocene climate changes for phylogeographic patterns in African as well as Holarctic fauna...
  45. pmc Ancient biomolecules from deep ice cores reveal a forested southern Greenland
    Eske Willerslev
    Centre for Ancient Genetics, University of Copenhagen, Denmark
    Science 317:111-4. 2007
    ..The results provide direct evidence in support of a forested southern Greenland and suggest that many deep ice cores may contain genetic records of paleoenvironments in their basal sections...
  46. ncbi request reprint Nuclear gene indicates coat-color polymorphism in mammoths
    Holger Römpler
    Molecular Biochemistry, Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany
    Science 313:62. 2006
    ..This finding suggests that mammoths may have been polymorphic in coat color, with both dark- and light-haired individuals co-occurring...
  47. pmc Surprising migration and population size dynamics in ancient Iberian brown bears (Ursus arctos)
    Cristina E Valdiosera
    Centro Mixto, Universidad Complutense de Madrid Instituto de Salud Carlos III de Evolución y Comportamiento Humanos, c Sinesio Delgado 4 Pabellon 14, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 105:5123-8. 2008
    ..Thus, the current situation is highly unusual and the population may in fact be isolated for the first time in its history...