Research Topics
Genomes and Genes
| Bianca HabermannSummaryAffiliation: Max Planck Institute of Molecular Cell Biology and Genetics Country: Germany Publications
| Collaborators
|
Detail Information
Publications
The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependentEva Hannak
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
J Cell Biol 157:591-602. 2002..Thus, although unknown mechanisms can support partial assembly of mitotic centrosomal asters, gamma-tubulin is the kinetically dominant centrosomal MT nucleator...- From biomedicine to natural history research: EST resources for ambystomatid salamandersSrikrishna Putta
Department of Biology, University of Kentucky, Lexington, KY 40506, USA
BMC Genomics 5:54. 2004..We developed ESTs for Mexican axolotl (Ambystoma mexicanum) and Eastern tiger salamander (A. tigrinum tigrinum), species with deep and diverse research histories... - Identification of the C. elegans anaphase promoting complex subunit Cdc26 by phenotypic profiling and functional rescue in yeastYan Dong
The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK
BMC Dev Biol 7:19. 2007..Here we present a functional analysis of the gene B0511.9, previously identified as a candidate cell polarity gene in an RNAi videorecording screen of chromosome I embryonic lethal genes... 
A user-centred evaluation framework for the Sealife semantic web browsersHelen Oliver
City eHealth Research Centre, City University, London, EC1V 0HB, UK
BMC Bioinformatics 10:S14. 2009..Sealife's main objective is to develop the notion of context-based information integration by extending three existing Semantic Web browsers (SWBs) to link the existing Web to the eScience infrastructure...- An Ambystoma mexicanum EST sequencing project: analysis of 17,352 expressed sequence tags from embryonic and regenerating blastema cDNA librariesBianca Habermann
Scionics Computer Innovation GmbH, Pfotenhauerstrasse 110, Dresden 01307, Germany
Genome Biol 5:R67. 2004..This is a major limitation for molecular studies on caudate development, regeneration and evolution. To address this lack of sequence information we have generated an expressed sequence tag (EST) database for A. mexicanum... - The BAR-domain family of proteins: a case of bending and binding?Bianca Habermann
Scionics Computer Innovation, GmbH, c o Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
EMBO Rep 5:250-5. 2004..However, data on Arfaptin 2 and now also on the Adaptor proteins APPL1 and 2 suggest that another function of the BAR domain is to bind to small GTPases... 
The power and the limitations of cross-species protein identification by mass spectrometry-driven sequence similarity searchesBianca Habermann
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Mol Cell Proteomics 3:238-49. 2004..We also estimated phylogenetic distances between organisms under study and related reference organisms with completely sequenced genomes that allow substantial coverage of unknown proteomes...- An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindlesNurhan Ozlu
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden 01307, Germany
Dev Cell 9:237-48. 2005..Thus, activation and targeting of Aurora A appears to be an ancient and conserved function of TPX2 that plays a central role in mitotic spindle assembly... - The Caenorhabditis elegans centrosomal protein SPD-2 is required for both pericentriolar material recruitment and centriole duplicationLaurence Pelletier
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Curr Biol 14:863-73. 2004..To date, however, the molecular mechanisms that govern these two processes still remain poorly understood... - Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studiesRalf Kittler
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
Nat Methods 4:337-44. 2007..Hence, the presented esiRNA libraries offer an efficient, cost-effective and specific alternative to presently available mammalian RNAi resources... 
Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarityJulia Franziska Winter
Max Planck Institute of Molecular Cell Biology and Genetics, MPI CBG, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Nat Cell Biol 14:666-76. 2012..Our data suggest that PAR-5 acts as a regulatory hub for a polarity-maintaining network required for apicobasal asymmetry of F-actin and proper Rab11-RE positioning...- Genome-scale RNAi profiling of cell division in human tissue culture cellsRalf Kittler
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
Nat Cell Biol 9:1401-12. 2007..Our work provides an experimental framework from which the systematic analysis of novel genes necessary for cell division in human cells can begin... - Modulation of receptor recycling and degradation by the endosomal kinesin KIF16BSebastian Hoepfner
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
Cell 121:437-50. 2005..We propose that this mechanism could have important implications for signaling... - Homology-based functional proteomics by mass spectrometry: application to the Xenopus microtubule-associated proteomeAdam J Liska
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Proteomics 4:2707-21. 2004..These findings were made possible due to the application of sequence-similarity methods, which extended mass spectrometric protein identification capabilities by 2-fold compared to conventional methods... - The clathrin adaptor Gga2p is a phosphatidylinositol 4-phosphate effector at the Golgi exitLars Demmel
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, D 01307, Germany
Mol Biol Cell 19:1991-2002. 2008..These data provide an explanation for the TGN-specific membrane recruitment of Gga2p... - An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell divisionRalf Kittler
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
Nature 432:1036-40. 2004..Thus, our study uncovers new aspects of cell division and establishes esiRNA as a versatile approach for genomic RNAi screens in mammalian cells... - Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosisLucas Pelkmans
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Nature 436:78-86. 2005..Our analysis demonstrates that signalling functions such as those controlling cell adhesion, growth and proliferation, are built into the machinery of endocytosis to a much higher degree than previously recognized... - Interaction between Sec7p and Pik1p: the first clue for the regulation of a coincidence detection signalYvonne Gloor
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden D 01307, Germany
Eur J Cell Biol 89:575-83. 2010.... - LET-767 is required for the production of branched chain and long chain fatty acids in Caenorhabditis elegansEugeni V Entchev
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
J Biol Chem 283:17550-60. 2008..elegans required for the bulk production of monomethyl branched and long chain fatty acids, and the developmental arrest in let-767 (RNAi) worms is caused by the deficiency of the former... - Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environmentAnna Shevchenko
MPI of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Genome Biol 9:R167. 2008..Because uncertainties remain regarding the accuracy of proteomic data, several issues need to be resolved before comparative proteomics can be fruitful... - ProFAT: a web-based tool for the functional annotation of protein sequencesCharles Richard Bradshaw
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
BMC Bioinformatics 7:466. 2006..However, few tools exist so far, that provide a means to include functional information in sequence database searches... - XMAP215: a key component of the dynamic microtubule cytoskeletonKazuhisa Kinoshita
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Trends Cell Biol 12:267-73. 2002..Together with members of the Kin I family of kinesins, XMAP215 and its orthologues form an essential circuit for generating dynamic microtubules in vivo... - Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germlineJeremy N Pulvers
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
Proc Natl Acad Sci U S A 107:16595-600. 2010..Our findings broaden the spectrum of phenotypic effects of ASPM mutations and raise the possibility that positive selection of ASPM during primate evolution reflects its function in the germline... - The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate developmentAnnette Schenck
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Cell 133:486-97. 2008..We propose that partitioning of Akt and selected effectors onto endosomal compartments represents a key mechanism contributing to the specificity of signal transduction in vertebrate development... - APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartmentMarta Miaczynska
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Cell 116:445-56. 2004..Our findings identify an endosomal compartment bearing Rab5 and APPL proteins as an intermediate in signaling between the plasma membrane and the nucleus... - Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cellsFolker Spitzenberger
Experimental Diabetology and the Department of Internal Medicine III, Carl Gustav Carus Medical School, University of Technology Dresden, 01307 Dresden, Germany
J Biol Chem 278:26166-73. 2003..ICA69 is therefore a novel arfaptin-related protein that is likely to play a role in membrane trafficking at the Golgi complex and immature secretory granules in neurosecretory cells... - Conformational adaptability of Redbeta during DNA annealing and implications for its structural relationship with Rad52Axel Erler
Genomics, Biotechnology Center, Technische Universitat Dresden, 01307 Dresden, Germany
J Mol Biol 391:586-98. 2009..Hence, our findings have implications for a common mechanism of DNA annealing mediated by single-strand annealing proteins including Rad52... - PDZ-domain-binding sites are common among cadherinsFabio Demontis
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307, Dresden, Germany
Dev Genes Evol 216:737-41. 2006..This suggests that PDZ-domain-containing proteins are common cytoplasmic interacting partners for cadherins lacking catenin-binding sites... - DEQOR: a web-based tool for the design and quality control of siRNAsAndreas Henschel
Scionics Computer Innovation, GmbH, Pfotenhauerstrasse 110, 01307 Dresden, Germany
Nucleic Acids Res 32:W113-20. 2004..DEQOR is freely available at http://cluster-1.mpi-cbg.de/Deqor/deqor.html... - Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27Martin Schwickart
Max Planck Institute of Molecular Cell Biology and Genetics Scionics Computer Innovation GmbH, Dresden, Germany
Mol Cell Biol 24:3562-76. 2004..Accordingly, Swm1/Apc13 is required for ubiquitin ligase activity in vitro and for the timely execution of APC/C-dependent cell cycle events in vivo... - Centriole assembly requires both centriolar and pericentriolar material proteinsAlexander Dammermann
Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Dev Cell 7:815-29. 2004..Thus, both centriolar and pericentriolar material proteins contribute to centriole assembly... - Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteinsToshiki Itoh
Department of Cell Biology and Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Dev Cell 9:791-804. 2005..These results suggest a close interplay between the mechanisms that control actin dynamics and those that mediate plasma membrane invagination and fission... - Distinct roles for two C. elegans anillins in the gonad and early embryoAmy Shaub Maddox
Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Development 132:2837-48. 2005..Our results highlight specialization of divergent anillin family proteins in the C. elegans life cycle and reveal conserved roles for this protein family in organizing syncytial structures and cortical contractility... - Translational control of putative protooncogene Nm23-M2 by cytokines via phosphoinositide 3-kinase signalingMarieke Joosten
Department of Hematology, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
J Biol Chem 279:38169-76. 2004..Taken together, nm23-m2 exemplifies that cytokine-dependent control of translation initiation is an important mechanism of gene expression regulation... - The planarian Schmidtea mediterranea as a model for epigenetic germ cell specification: analysis of ESTs from the hermaphroditic strainRicardo M Zayas
Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Proc Natl Acad Sci U S A 102:18491-6. 2005..In addition to its utility for studying germ cell development, this EST collection will be an important resource for annotating the planarian genome and studying this animal's amazing regenerative abilities... - Sealife: a semantic grid browser for the life sciences applied to the study of infectious diseasesMichael Schroeder
TU Dresden, Germany
Stud Health Technol Inform 120:167-78. 2006..For more information see http://www.biote.ctu-dresden.de/sealife... - Apoptosis protection by the Epo target Bcl-X(L) allows factor-independent differentiation of primary erythroblastsHelmut Dolznig
Division of Molecular Biology, Institute of Medical Biochemistry, 1030 Vienna, Austria
Curr Biol 12:1076-85. 2002..Here we address whether Epo function during terminal maturation involves a cytokine-independent "default program," requiring only apoptosis inhibition through Epo-dependent upregulation of Bcl-X(L)...