Bianca Habermann

Summary

Affiliation: Max Planck Institute of Molecular Cell Biology and Genetics
Country: Germany

Publications

  1. pmc The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent
    Eva Hannak
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    J Cell Biol 157:591-602. 2002
  2. pmc SeLOX--a locus of recombination site search tool for the detection and directed evolution of site-specific recombination systems
    Vineeth Surendranath
    Max Planck Institute for the Molecular Cell Biology and Genetics, Dresden, Germany
    Nucleic Acids Res 38:W293-8. 2010
  3. pmc From biomedicine to natural history research: EST resources for ambystomatid salamanders
    Srikrishna Putta
    Department of Biology, University of Kentucky, Lexington, KY 40506, USA
    BMC Genomics 5:54. 2004
  4. pmc Identification of the C. elegans anaphase promoting complex subunit Cdc26 by phenotypic profiling and functional rescue in yeast
    Yan Dong
    The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK
    BMC Dev Biol 7:19. 2007
  5. pmc A user-centred evaluation framework for the Sealife semantic web browsers
    Helen Oliver
    City eHealth Research Centre, City University, London, EC1V 0HB, UK
    BMC Bioinformatics 10:S14. 2009
  6. pmc An Ambystoma mexicanum EST sequencing project: analysis of 17,352 expressed sequence tags from embryonic and regenerating blastema cDNA libraries
    Bianca Habermann
    Scionics Computer Innovation GmbH, Pfotenhauerstrasse 110, Dresden 01307, Germany
    Genome Biol 5:R67. 2004
  7. pmc The BAR-domain family of proteins: a case of bending and binding?
    Bianca Habermann
    Scionics Computer Innovation, GmbH, c o Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    EMBO Rep 5:250-5. 2004
  8. ncbi request reprint The power and the limitations of cross-species protein identification by mass spectrometry-driven sequence similarity searches
    Bianca Habermann
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Mol Cell Proteomics 3:238-49. 2004
  9. ncbi request reprint An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles
    Nurhan Ozlu
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden 01307, Germany
    Dev Cell 9:237-48. 2005
  10. ncbi request reprint The Caenorhabditis elegans centrosomal protein SPD-2 is required for both pericentriolar material recruitment and centriole duplication
    Laurence Pelletier
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Curr Biol 14:863-73. 2004

Detail Information

Publications41

  1. pmc The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent
    Eva Hannak
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    J Cell Biol 157:591-602. 2002
    ..Thus, although unknown mechanisms can support partial assembly of mitotic centrosomal asters, gamma-tubulin is the kinetically dominant centrosomal MT nucleator...
  2. pmc SeLOX--a locus of recombination site search tool for the detection and directed evolution of site-specific recombination systems
    Vineeth Surendranath
    Max Planck Institute for the Molecular Cell Biology and Genetics, Dresden, Germany
    Nucleic Acids Res 38:W293-8. 2010
    ..SeLOX is freely available at http://selox.mpi-cbg.de/cgi-bin/selox/index...
  3. pmc From biomedicine to natural history research: EST resources for ambystomatid salamanders
    Srikrishna Putta
    Department of Biology, University of Kentucky, Lexington, KY 40506, USA
    BMC Genomics 5:54. 2004
    ..We developed ESTs for Mexican axolotl (Ambystoma mexicanum) and Eastern tiger salamander (A. tigrinum tigrinum), species with deep and diverse research histories...
  4. pmc Identification of the C. elegans anaphase promoting complex subunit Cdc26 by phenotypic profiling and functional rescue in yeast
    Yan Dong
    The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK
    BMC Dev Biol 7:19. 2007
    ..Here we present a functional analysis of the gene B0511.9, previously identified as a candidate cell polarity gene in an RNAi videorecording screen of chromosome I embryonic lethal genes...
  5. pmc A user-centred evaluation framework for the Sealife semantic web browsers
    Helen Oliver
    City eHealth Research Centre, City University, London, EC1V 0HB, UK
    BMC Bioinformatics 10:S14. 2009
    ..Sealife's main objective is to develop the notion of context-based information integration by extending three existing Semantic Web browsers (SWBs) to link the existing Web to the eScience infrastructure...
  6. pmc An Ambystoma mexicanum EST sequencing project: analysis of 17,352 expressed sequence tags from embryonic and regenerating blastema cDNA libraries
    Bianca Habermann
    Scionics Computer Innovation GmbH, Pfotenhauerstrasse 110, Dresden 01307, Germany
    Genome Biol 5:R67. 2004
    ..This is a major limitation for molecular studies on caudate development, regeneration and evolution. To address this lack of sequence information we have generated an expressed sequence tag (EST) database for A. mexicanum...
  7. pmc The BAR-domain family of proteins: a case of bending and binding?
    Bianca Habermann
    Scionics Computer Innovation, GmbH, c o Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    EMBO Rep 5:250-5. 2004
    ..However, data on Arfaptin 2 and now also on the Adaptor proteins APPL1 and 2 suggest that another function of the BAR domain is to bind to small GTPases...
  8. ncbi request reprint The power and the limitations of cross-species protein identification by mass spectrometry-driven sequence similarity searches
    Bianca Habermann
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Mol Cell Proteomics 3:238-49. 2004
    ..We also estimated phylogenetic distances between organisms under study and related reference organisms with completely sequenced genomes that allow substantial coverage of unknown proteomes...
  9. ncbi request reprint An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles
    Nurhan Ozlu
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden 01307, Germany
    Dev Cell 9:237-48. 2005
    ..Thus, activation and targeting of Aurora A appears to be an ancient and conserved function of TPX2 that plays a central role in mitotic spindle assembly...
  10. ncbi request reprint The Caenorhabditis elegans centrosomal protein SPD-2 is required for both pericentriolar material recruitment and centriole duplication
    Laurence Pelletier
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Curr Biol 14:863-73. 2004
    ..To date, however, the molecular mechanisms that govern these two processes still remain poorly understood...
  11. ncbi request reprint An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division
    Ralf Kittler
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Nature 432:1036-40. 2004
    ..Thus, our study uncovers new aspects of cell division and establishes esiRNA as a versatile approach for genomic RNAi screens in mammalian cells...
  12. ncbi request reprint Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies
    Ralf Kittler
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Nat Methods 4:337-44. 2007
    ..Hence, the presented esiRNA libraries offer an efficient, cost-effective and specific alternative to presently available mammalian RNAi resources...
  13. ncbi request reprint Genome-scale RNAi profiling of cell division in human tissue culture cells
    Ralf Kittler
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Nat Cell Biol 9:1401-12. 2007
    ..Our work provides an experimental framework from which the systematic analysis of novel genes necessary for cell division in human cells can begin...
  14. pmc The clathrin adaptor Gga2p is a phosphatidylinositol 4-phosphate effector at the Golgi exit
    Lars Demmel
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, D 01307, Germany
    Mol Biol Cell 19:1991-2002. 2008
    ..These data provide an explanation for the TGN-specific membrane recruitment of Gga2p...
  15. ncbi request reprint Homology-based functional proteomics by mass spectrometry: application to the Xenopus microtubule-associated proteome
    Adam J Liska
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Proteomics 4:2707-21. 2004
    ..These findings were made possible due to the application of sequence-similarity methods, which extended mass spectrometric protein identification capabilities by 2-fold compared to conventional methods...
  16. ncbi request reprint Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis
    Lucas Pelkmans
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Nature 436:78-86. 2005
    ..Our analysis demonstrates that signalling functions such as those controlling cell adhesion, growth and proliferation, are built into the machinery of endocytosis to a much higher degree than previously recognized...
  17. ncbi request reprint Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity
    Julia Franziska Winter
    Max Planck Institute of Molecular Cell Biology and Genetics, MPI CBG, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Nat Cell Biol 14:666-76. 2012
    ..Our data suggest that PAR-5 acts as a regulatory hub for a polarity-maintaining network required for apicobasal asymmetry of F-actin and proper Rab11-RE positioning...
  18. ncbi request reprint Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B
    Sebastian Hoepfner
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Cell 121:437-50. 2005
    ..We propose that this mechanism could have important implications for signaling...
  19. pmc Molecular strategies of the Caenorhabditis elegans dauer larva to survive extreme desiccation
    Cihan Erkut
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    PLoS ONE 8:e82473. 2013
    ..Remarkably, this response is specific and involves a small number of functional pathways, which represent the generic toolkit for anhydrobiosis in plants and animals. ..
  20. ncbi request reprint LET-767 is required for the production of branched chain and long chain fatty acids in Caenorhabditis elegans
    Eugeni V Entchev
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    J Biol Chem 283:17550-60. 2008
    ..elegans required for the bulk production of monomethyl branched and long chain fatty acids, and the developmental arrest in let-767 (RNAi) worms is caused by the deficiency of the former...
  21. pmc Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment
    Anna Shevchenko
    MPI of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Genome Biol 9:R167. 2008
    ..Because uncertainties remain regarding the accuracy of proteomic data, several issues need to be resolved before comparative proteomics can be fruitful...
  22. ncbi request reprint Interaction between Sec7p and Pik1p: the first clue for the regulation of a coincidence detection signal
    Yvonne Gloor
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden D 01307, Germany
    Eur J Cell Biol 89:575-83. 2010
    ....
  23. pmc ProFAT: a web-based tool for the functional annotation of protein sequences
    Charles Richard Bradshaw
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    BMC Bioinformatics 7:466. 2006
    ..However, few tools exist so far, that provide a means to include functional information in sequence database searches...
  24. ncbi request reprint Production of endoribonuclease-prepared short interfering RNAs for gene silencing in mammalian cells
    Ralf Kittler
    Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
    Nat Methods 2:779-84. 2005
  25. ncbi request reprint APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment
    Marta Miaczynska
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Cell 116:445-56. 2004
    ..Our findings identify an endosomal compartment bearing Rab5 and APPL proteins as an intermediate in signaling between the plasma membrane and the nucleus...
  26. ncbi request reprint XMAP215: a key component of the dynamic microtubule cytoskeleton
    Kazuhisa Kinoshita
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Trends Cell Biol 12:267-73. 2002
    ..Together with members of the Kin I family of kinesins, XMAP215 and its orthologues form an essential circuit for generating dynamic microtubules in vivo...
  27. pmc Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27
    Martin Schwickart
    Max Planck Institute of Molecular Cell Biology and Genetics Scionics Computer Innovation GmbH, Dresden, Germany
    Mol Cell Biol 24:3562-76. 2004
    ..Accordingly, Swm1/Apc13 is required for ubiquitin ligase activity in vitro and for the timely execution of APC/C-dependent cell cycle events in vivo...
  28. pmc Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline
    Jeremy N Pulvers
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 107:16595-600. 2010
    ..Our findings broaden the spectrum of phenotypic effects of ASPM mutations and raise the possibility that positive selection of ASPM during primate evolution reflects its function in the germline...
  29. ncbi request reprint The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development
    Annette Schenck
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Cell 133:486-97. 2008
    ..We propose that partitioning of Akt and selected effectors onto endosomal compartments represents a key mechanism contributing to the specificity of signal transduction in vertebrate development...
  30. pmc DEQOR: a web-based tool for the design and quality control of siRNAs
    Andreas Henschel
    Scionics Computer Innovation, GmbH, Pfotenhauerstrasse 110, 01307 Dresden, Germany
    Nucleic Acids Res 32:W113-20. 2004
    ..DEQOR is freely available at http://cluster-1.mpi-cbg.de/Deqor/deqor.html...
  31. ncbi request reprint Conformational adaptability of Redbeta during DNA annealing and implications for its structural relationship with Rad52
    Axel Erler
    Genomics, Biotechnology Center, Technische Universitat Dresden, 01307 Dresden, Germany
    J Mol Biol 391:586-98. 2009
    ..Hence, our findings have implications for a common mechanism of DNA annealing mediated by single-strand annealing proteins including Rad52...
  32. ncbi request reprint Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells
    Folker Spitzenberger
    Experimental Diabetology and the Department of Internal Medicine III, Carl Gustav Carus Medical School, University of Technology Dresden, 01307 Dresden, Germany
    J Biol Chem 278:26166-73. 2003
    ..ICA69 is therefore a novel arfaptin-related protein that is likely to play a role in membrane trafficking at the Golgi complex and immature secretory granules in neurosecretory cells...
  33. pmc Comparative transcriptional profiling of the axolotl limb identifies a tripartite regeneration-specific gene program
    Dunja Knapp
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    PLoS ONE 8:e61352. 2013
    ..In summary, we identified a set of genes that are expressed specifically during regeneration and are therefore, likely candidates for the regulation of blastema formation...
  34. ncbi request reprint PDZ-domain-binding sites are common among cadherins
    Fabio Demontis
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307, Dresden, Germany
    Dev Genes Evol 216:737-41. 2006
    ..This suggests that PDZ-domain-containing proteins are common cytoplasmic interacting partners for cadherins lacking catenin-binding sites...
  35. ncbi request reprint Centriole assembly requires both centriolar and pericentriolar material proteins
    Alexander Dammermann
    Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Dev Cell 7:815-29. 2004
    ..Thus, both centriolar and pericentriolar material proteins contribute to centriole assembly...
  36. ncbi request reprint Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins
    Toshiki Itoh
    Department of Cell Biology and Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Dev Cell 9:791-804. 2005
    ..These results suggest a close interplay between the mechanisms that control actin dynamics and those that mediate plasma membrane invagination and fission...
  37. ncbi request reprint Distinct roles for two C. elegans anillins in the gonad and early embryo
    Amy Shaub Maddox
    Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Development 132:2837-48. 2005
    ..Our results highlight specialization of divergent anillin family proteins in the C. elegans life cycle and reveal conserved roles for this protein family in organizing syncytial structures and cortical contractility...
  38. pmc The planarian Schmidtea mediterranea as a model for epigenetic germ cell specification: analysis of ESTs from the hermaphroditic strain
    Ricardo M Zayas
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 102:18491-6. 2005
    ..In addition to its utility for studying germ cell development, this EST collection will be an important resource for annotating the planarian genome and studying this animal's amazing regenerative abilities...
  39. ncbi request reprint Apoptosis protection by the Epo target Bcl-X(L) allows factor-independent differentiation of primary erythroblasts
    Helmut Dolznig
    Division of Molecular Biology, Institute of Medical Biochemistry, 1030 Vienna, Austria
    Curr Biol 12:1076-85. 2002
    ..Here we address whether Epo function during terminal maturation involves a cytokine-independent "default program," requiring only apoptosis inhibition through Epo-dependent upregulation of Bcl-X(L)...
  40. ncbi request reprint Translational control of putative protooncogene Nm23-M2 by cytokines via phosphoinositide 3-kinase signaling
    Marieke Joosten
    Department of Hematology, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Biol Chem 279:38169-76. 2004
    ..Taken together, nm23-m2 exemplifies that cytokine-dependent control of translation initiation is an important mechanism of gene expression regulation...
  41. ncbi request reprint Sealife: a semantic grid browser for the life sciences applied to the study of infectious diseases
    Michael Schroeder
    TU Dresden, Germany
    Stud Health Technol Inform 120:167-78. 2006
    ..For more information see http://www.biote.ctu-dresden.de/sealife...