Richard E Green

Summary

Affiliation: Max Planck Institute for Evolutionary Anthropology
Country: Germany

Publications

  1. pmc A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Cell 134:416-26. 2008
  2. doi request reprint A draft sequence of the Neandertal genome
    Richard E Green
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:710-22. 2010
  3. ncbi request reprint Analysis of one million base pairs of Neanderthal DNA
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nature 444:330-6. 2006
  4. pmc The Neandertal genome and ancient DNA authenticity
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    EMBO J 28:2494-502. 2009
  5. pmc Targeted investigation of the Neandertal genome by array-based sequence capture
    Hernán A Burbano
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:723-5. 2010
  6. doi request reprint Targeted retrieval and analysis of five Neandertal mtDNA genomes
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 325:318-21. 2009
  7. pmc Patterns of damage in genomic DNA sequences from a Neandertal
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 104:14616-21. 2007
  8. doi request reprint The complete genome sequence of a Neanderthal from the Altai Mountains
    Kay Prüfer
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
    Nature 505:43-9. 2014
  9. pmc Analysis of human accelerated DNA regions using archaic hominin genomes
    Hernán A Burbano
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS ONE 7:e32877. 2012
  10. pmc Computational challenges in the analysis of ancient DNA
    Kay Prüfer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Genome Biol 11:R47. 2010

Detail Information

Publications22

  1. pmc A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Cell 134:416-26. 2008
    ..There is evidence that purifying selection in the Neandertal mtDNA was reduced compared with other primate lineages, suggesting that the effective population size of Neandertals was small...
  2. doi request reprint A draft sequence of the Neandertal genome
    Richard E Green
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:710-22. 2010
    ....
  3. ncbi request reprint Analysis of one million base pairs of Neanderthal DNA
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nature 444:330-6. 2006
    ..Existing technology and fossil resources are now sufficient to initiate a Neanderthal genome-sequencing effort...
  4. pmc The Neandertal genome and ancient DNA authenticity
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    EMBO J 28:2494-502. 2009
    ..For analyses of other fossil hominins, which may become possible in the future, we suggest a similar 'boot-strap' approach in which interim approaches are applied until sufficient data for more definitive direct assays are acquired...
  5. pmc Targeted investigation of the Neandertal genome by array-based sequence capture
    Hernán A Burbano
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:723-5. 2010
    ..By generating the sequence of one Neandertal and 50 present-day humans at these positions, we have identified 88 amino acid substitutions that have become fixed in humans since our divergence from the Neandertals...
  6. doi request reprint Targeted retrieval and analysis of five Neandertal mtDNA genomes
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 325:318-21. 2009
    ..Together with analyses of mtDNA protein evolution, these data suggest that the long-term effective population size of Neandertals was smaller than that of modern humans and extant great apes...
  7. pmc Patterns of damage in genomic DNA sequences from a Neandertal
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 104:14616-21. 2007
    ..The results suggest that reliable genome sequences can be obtained from Pleistocene organisms...
  8. doi request reprint The complete genome sequence of a Neanderthal from the Altai Mountains
    Kay Prüfer
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
    Nature 505:43-9. 2014
    ..In addition, the high-quality Neanderthal genome allows us to establish a definitive list of substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans. ..
  9. pmc Analysis of human accelerated DNA regions using archaic hominin genomes
    Hernán A Burbano
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS ONE 7:e32877. 2012
    ..Our catalog of sequence changes in HARs will help prioritize them for functional studies of genomic elements potentially responsible for modern human adaptations...
  10. pmc Computational challenges in the analysis of ancient DNA
    Kay Prüfer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Genome Biol 11:R47. 2010
    ..We show that more accurate genome divergence estimates from ancient DNA sequence can be attained using at least two outgroup genomes and appropriate filtering...
  11. pmc PatMaN: rapid alignment of short sequences to large databases
    Kay Prüfer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Bioinformatics 24:1530-1. 2008
    ..Both queries with and without ambiguity codes can be searched. Search time is short for perfect matches, and retrieval time rises exponentially with the number of edits allowed...
  12. doi request reprint Comparative population genomics of the ejaculate in humans and the great apes
    Jeffrey M Good
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 30:964-76. 2013
    ..Thus, general patterns of male reproductive protein evolution among apes and humans depend strongly on gene function but not on inferred differences in the intensity of sperm competition among extant species...
  13. pmc A high-coverage genome sequence from an archaic Denisovan individual
    Matthias Meyer
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 338:222-6. 2012
    ....
  14. ncbi request reprint The derived FOXP2 variant of modern humans was shared with Neandertals
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Curr Biol 17:1908-12. 2007
    ..Thus, these results illustrate the usefulness of retrieving direct genetic information from ancient remains for understanding recent human evolution...
  15. pmc Functionality of intergenic transcription: an evolutionary comparison
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Genet 2:e171. 2006
    ..Further, we find that about half of the expression differences between humans and chimpanzees are due to intergenic transcripts...
  16. pmc The joint allele-frequency spectrum in closely related species
    Hua Chen
    Department of Integrative Biology, University of California, Berkeley, California 94720, USA
    Genetics 177:387-98. 2007
    ....
  17. ncbi request reprint Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements
    Liana F Lareau
    Department of Molecular and Cell Biology and, University of California, Berkeley, California 94720, USA
    Nature 446:926-9. 2007
    ..We find that unproductive splicing associated with conserved regions has arisen independently in different SR genes, suggesting that splicing factors may readily acquire this form of regulation...
  18. ncbi request reprint Pairwise alignment incorporating dipeptide covariation
    Gavin E Crooks
    Department of Plant and Microbial Biology 111 Koshland Hall 3102 University of California, Berkeley, CA 94720 3102, USA
    Bioinformatics 21:3704-10. 2005
    ....
  19. ncbi request reprint Genome-wide analysis reveals an unexpected function for the Drosophila splicing factor U2AF50 in the nuclear export of intronless mRNAs
    Marco Blanchette
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 14:775-86. 2004
    ..Immunopurification of nuclear RNP complexes showed that dU2AF50 associates with intronless mRNAs. These results reveal an unexpected role for the splicing factor dU2AF50 in the nuclear export of intronless mRNAs...
  20. ncbi request reprint The evolving roles of alternative splicing
    Liana F Lareau
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Curr Opin Struct Biol 14:273-82. 2004
    ..Evolutionary conservation of splicing patterns suggests functional importance and provides insight into the evolutionary history of alternative splicing...
  21. ncbi request reprint Statistical evaluation of pairwise protein sequence comparison with the Bayesian bootstrap
    Gavin A Price
    Department of Bioengineering, University of California, Berkeley, 94720, USA
    Bioinformatics 21:3824-31. 2005
    ..We have developed, as an alternative, an unbiased statistical evaluation based on the Bayesian bootstrap, a resampling method operationally similar to the standard bootstrap...
  22. ncbi request reprint Sulfotransferases and sulfatases in mycobacteria
    Joseph D Mougous
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Chem Biol 9:767-76. 2002
    ..As sulfated molecules are common mediators of cell-cell interactions, the sulfotransferases and sulfatases may be involved in regulating host-pathogen interactions...