Research Topics
Species | Richard E GreenSummaryAffiliation: Max Planck Institute for Evolutionary Anthropology Country: Germany Publications
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Detail Information
Publications
A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencingRichard E Green
Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
Cell 134:416-26. 2008..There is evidence that purifying selection in the Neandertal mtDNA was reduced compared with other primate lineages, suggesting that the effective population size of Neandertals was small...
A draft sequence of the Neandertal genomeRichard E Green
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
Science 328:710-22. 2010....
Analysis of one million base pairs of Neanderthal DNARichard E Green
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
Nature 444:330-6. 2006..Existing technology and fossil resources are now sufficient to initiate a Neanderthal genome-sequencing effort...- The Neandertal genome and ancient DNA authenticityRichard E Green
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
EMBO J 28:2494-502. 2009..For analyses of other fossil hominins, which may become possible in the future, we suggest a similar 'boot-strap' approach in which interim approaches are applied until sufficient data for more definitive direct assays are acquired... - Targeted investigation of the Neandertal genome by array-based sequence captureHernán A Burbano
Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
Science 328:723-5. 2010..By generating the sequence of one Neandertal and 50 present-day humans at these positions, we have identified 88 amino acid substitutions that have become fixed in humans since our divergence from the Neandertals... - Targeted retrieval and analysis of five Neandertal mtDNA genomesAdrian W Briggs
Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
Science 325:318-21. 2009..Together with analyses of mtDNA protein evolution, these data suggest that the long-term effective population size of Neandertals was smaller than that of modern humans and extant great apes... - Patterns of damage in genomic DNA sequences from a NeandertalAdrian W Briggs
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
Proc Natl Acad Sci U S A 104:14616-21. 2007..The results suggest that reliable genome sequences can be obtained from Pleistocene organisms... - Analysis of human accelerated DNA regions using archaic hominin genomesHernán A Burbano
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
PLoS ONE 7:e32877. 2012..Our catalog of sequence changes in HARs will help prioritize them for functional studies of genomic elements potentially responsible for modern human adaptations... - Computational challenges in the analysis of ancient DNAKay Prüfer
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
Genome Biol 11:R47. 2010..We show that more accurate genome divergence estimates from ancient DNA sequence can be attained using at least two outgroup genomes and appropriate filtering... - PatMaN: rapid alignment of short sequences to large databasesKay Prüfer
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
Bioinformatics 24:1530-1. 2008..It is available from http://bioinf.eva.mpg.de/patman. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online... - A high-coverage genome sequence from an archaic Denisovan individualMatthias Meyer
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
Science 338:222-6. 2012.... - The derived FOXP2 variant of modern humans was shared with NeandertalsJohannes Krause
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
Curr Biol 17:1908-12. 2007..Thus, these results illustrate the usefulness of retrieving direct genetic information from ancient remains for understanding recent human evolution... - Functionality of intergenic transcription: an evolutionary comparisonPhilipp Khaitovich
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
PLoS Genet 2:e171. 2006..Further, we find that about half of the expression differences between humans and chimpanzees are due to intergenic transcripts... - The joint allele-frequency spectrum in closely related speciesHua Chen
Department of Integrative Biology, University of California, Berkeley, California 94720, USA
Genetics 177:387-98. 2007.... - Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elementsLiana F Lareau
Department of Molecular and Cell Biology and, University of California, Berkeley, California 94720, USA
Nature 446:926-9. 2007..We find that unproductive splicing associated with conserved regions has arisen independently in different SR genes, suggesting that splicing factors may readily acquire this form of regulation... - Pairwise alignment incorporating dipeptide covariationGavin E Crooks
Department of Plant and Microbial Biology 111 Koshland Hall 3102 University of California, Berkeley, CA 94720 3102, USA
Bioinformatics 21:3704-10. 2005..Therefore, the standard assumption that individual residues within protein sequences evolve independently of neighboring positions appears to be an efficient and appropriate approximation... - Genome-wide analysis reveals an unexpected function for the Drosophila splicing factor U2AF50 in the nuclear export of intronless mRNAsMarco Blanchette
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
Mol Cell 14:775-86. 2004..Immunopurification of nuclear RNP complexes showed that dU2AF50 associates with intronless mRNAs. These results reveal an unexpected role for the splicing factor dU2AF50 in the nuclear export of intronless mRNAs... - Statistical evaluation of pairwise protein sequence comparison with the Bayesian bootstrapGavin A Price
Department of Bioengineering, University of California, Berkeley, 94720, USA
Bioinformatics 21:3824-31. 2005..AVAILABILITY: The sequence sets and code for performing these analyses are available from http://compbio.berkeley.edu/. Contact: ... - The evolving roles of alternative splicingLiana F Lareau
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Curr Opin Struct Biol 14:273-82. 2004..Evolutionary conservation of splicing patterns suggests functional importance and provides insight into the evolutionary history of alternative splicing... - Sulfotransferases and sulfatases in mycobacteriaJoseph D Mougous
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Chem Biol 9:767-76. 2002..As sulfated molecules are common mediators of cell-cell interactions, the sulfotransferases and sulfatases may be involved in regulating host-pathogen interactions...