Affiliation: Max Planck Institute for Evolutionary Anthropology
- Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimersMatthias Gralle
Laboratory for Molecular and Cellular Systems, Department of Neurophysiology and Sensory Physiology, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
J Biol Chem 284:15016-25. 2009..These findings suggest a potentially beneficial effect of increasing sAPPalpha production or disrupting APP dimers for neuronal survival...
- Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neuronsAnja Schneider
Centre for Biochemistry and Molecular Cell Biology, Department of Psychiatry and Psychotherapy, University of Gottingen, 37073 Gottingen, Germany
J Neurosci 28:2874-82. 2008..Together, our data suggest that cholesterol/flotillin-dependent clustering of APP may stimulate the internalization into a specialized clathrin-dependent endocytosis pathway to promote amyloidogenic processing...
- pHlameleons: a family of FRET-based protein sensors for quantitative pH imagingAlessandro Esposito
Laboratory for Molecular and Cellular Systems, Department of Neuro and Sensory Physiology, University Medicine Gottingen, Humboldtalee 23, 37073 Gottingen, Germany
Biochemistry 47:13115-26. 2008..The principle is demonstrated in the existing high-efficiency FRET fusion Cy11.5, and tunability of the platform design is demonstrated by genetic alteration of the pH sensitivity of the acceptor moiety...