Research Topics
Genomes and GenesSpecies | Yoav GiladSummaryAffiliation: Max Planck Institute for Evolutionary Anthropology Country: Germany Publications
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Detail Information
Publications
Human specific loss of olfactory receptor genesYoav Gilad
Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, Leipzig D 04103, Germany
Proc Natl Acad Sci U S A 100:3324-7. 2003..As a consequence, the fraction of OR pseudogenes in humans is almost twice as high as in the non-human primates, suggesting a human-specific process of OR gene disruption, likely due to a reduced chemosensory dependence relative to apes...- Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primatesYoav Gilad
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
PLoS Biol 2:E5. 2004..Our findings suggest that the deterioration of the olfactory repertoire occurred concomitant with the acquisition of full trichromatic color vision in primates... - Natural selection on the olfactory receptor gene family in humans and chimpanzeesYoav Gilad
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Am J Hum Genet 73:489-501. 2003..These observations are likely due to differences in lifestyle, between humans and great apes, that have led to distinct sensory needs... - Absence of the TAP2 human recombination hotspot in chimpanzeesSusan E Ptak
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
PLoS Biol 2:e155. 2004.... 
Evolution of bitter taste receptors in humans and apesAnne Fischer
Max Plank Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
Mol Biol Evol 22:432-6. 2005..However, in contrast to the olfactory receptor gene repertoire, where humans have a higher proportion of pseudogenes than apes, there is no evidence that the rate of loss of bitter taste receptor genes varies among humans and apes...- Different noses for different peopleIdan Menashe
Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
Nat Genet 34:143-4. 2003..The results show an unprecedented prevalence of segregating pseudogenes, identifying one of the most pronounced cases of functional population diversity in the human genome... - Using DNA microarrays to study gene expression in closely related speciesAlicia Oshlack
Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia
Bioinformatics 23:1235-42. 2007..Here, we use data collected using a multi-primate cDNA array to evaluate the reliability of each approach... - Natural selection on gene expressionYoav Gilad
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Trends Genet 22:456-61. 2006..An important implication is that mutations affecting gene expression will often be deleterious and might underlie many human diseases... - Expression profiling in primates reveals a rapid evolution of human transcription factorsYoav Gilad
Department of Genetics, Yale University, New Haven, Connecticut 06510, USA
Nature 440:242-5. 2006..Among the gene set with a human-specific increase in expression, there is an excess of transcription factors; the same is not true for genes with increased expression in chimpanzee... - Multi-species microarrays reveal the effect of sequence divergence on gene expression profilesYoav Gilad
Yale University School of Medicine, Department of Genetics, Yale University, New Haven, CT 06520, USA
Genome Res 15:674-80. 2005..Our results indicate that naive use of single-species arrays in direct interspecies comparisons can yield spurious results... - A comparison of the human and chimpanzee olfactory receptor gene repertoiresYoav Gilad
Yale University School of Medicine, Department of Genetics, New Haven, Connecticut 06520, USA
Genome Res 15:224-30. 2005..Thus, although overall there is relaxed constraint on human olfaction relative to chimpanzee, species-specific sensory requirements appear to have shaped the evolution of the functional OR gene repertoires in both species... - Population differences in haplotype structure within a human olfactory receptor gene clusterIdan Menashe
Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
Hum Mol Genet 11:1381-90. 2002..Our data suggests that OR genes may have evolved to create different functional repertoires in distinct human populations... - Population differences in the human functional olfactory repertoireYoav Gilad
Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot, Israel
Mol Biol Evol 20:307-14. 2003..Our observations are unlikely to be accounted for by simple demographic models but may be explained by positive selection acting on OR loci in Caucasians... - Prediction of the odorant binding site of olfactory receptor proteins by human-mouse comparisonsOrna Man
Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
Protein Sci 13:240-54. 2004..This conclusion is supported by the observation that all but one of the predicted binding site residues correspond to ligand-contact positions in other rhodopsin-like GPCRs... - A combination of genomic approaches reveals the role of FOXO1a in regulating an oxidative stress response pathwayPaola de Candia
Department of Human Genetics, University of Chicago, Chicago, Illinois, USA
PLoS ONE 3:e1670. 2008..We concentrated on this gene because of its known role in the regulation of metabolism and in longevity... - Using reporter gene assays to identify cis regulatory differences between humans and chimpanzeesAdrien Chabot
Department of Human Genetics, University of Chicago, 920 E 58th Street, Chicago, IL 60637, USA
Genetics 176:2069-76. 2007..High-throughput application of this approach can provide a map of regulatory element differences between humans and our close evolutionary relatives... - Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarrayXiaohong Zhang
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Genome Biol 8:R86. 2007..To rectify this, we have developed a DNA microarray that contains probes for most predicted human OR loci and used that array to examine OR gene expression profiles in olfactory epithelium tissues from three individuals... - Evidence for positive selection and population structure at the human MAO-A geneYoav Gilad
Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
Proc Natl Acad Sci U S A 99:862-7. 2002.... - An evolutionarily conserved sexual signature in the primate brainBjörn Reinius
Department of Development and Genetics, Uppsala University, Uppsala, Sweden
PLoS Genet 4:e1000100. 2008..Genes within sexual expression profiles may underlie important functional differences between the sexes, with possible importance during primate evolution...