A R Fernie

Summary

Affiliation: Max Planck Institute of Molecular Plant Physiology
Country: Germany

Publications

  1. ncbi request reprint Antisense repression of cytosolic phosphoglucomutase in potato (Solanum tuberosum) results in severe growth retardation, reduction in tuber number and altered carbon metabolism
    Alisdair R Fernie
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Golm, Germany
    Planta 214:510-20. 2002
  2. doi request reprint Increasing amino acid supply in pea embryos reveals specific interactions of N and C metabolism, and highlights the importance of mitochondrial metabolism
    Kathleen Weigelt
    Leibniz Institut für Pflanzengenetik und Kulturpflanzenforschung, Gatersleben, Germany
    Plant J 55:909-26. 2008
  3. pmc Mild reductions in mitochondrial NAD-dependent isocitrate dehydrogenase activity result in altered nitrate assimilation and pigmentation but do not impact growth
    Agata Sienkiewicz-Porzucek
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Potsdam Golm, Germany
    Mol Plant 3:156-73. 2010
  4. pmc Metabolic characterization of loci affecting sensory attributes in tomato allows an assessment of the influence of the levels of primary metabolites and volatile organic contents
    Maria Ines Zanor
    Max Planck Institute for Molecular Plant Physiology, Am Muhlenberg 1, D 14476 Potsdam Golm, Germany
    J Exp Bot 60:2139-54. 2009
  5. pmc Phosphonate analogs of 2-oxoglutarate perturb metabolism and gene expression in illuminated Arabidopsis leaves
    Wagner L Araujo
    Max Planck Institut für Molekulare Pflanzenphysiologie Potsdam Golm, Germany
    Front Plant Sci 3:114. 2012
  6. pmc The genetic architecture of branched-chain amino acid accumulation in tomato fruits
    Andrej Kochevenko
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, D 14476 Potsdam Golm, Germany
    J Exp Bot 62:3895-906. 2011
  7. pmc The use of natural genetic diversity in the understanding of metabolic organization and regulation
    Alisdair R Fernie
    Max Planck Institute of Molecular Plant Physiology Potsdam Golm, Germany
    Front Plant Sci 2:59. 2011
  8. doi request reprint Analysis of metabolic flux using dynamic labelling and metabolic modelling
    A R Fernie
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Plant Cell Environ 36:1738-50. 2013
  9. pmc The use of metabolomics to dissect plant responses to abiotic stresses
    Toshihiro Obata
    Max Planck Institute of Molecular Plant Physiology, Potsdam Golm, Germany
    Cell Mol Life Sci 69:3225-43. 2012
  10. pmc OPTIMAS-DW: a comprehensive transcriptomics, metabolomics, ionomics, proteomics and phenomics data resource for maize
    Christian Colmsee
    Leibniz Institute of Plant Genetics and Crop Plant Research IPK, 06466 Stadt Seeland, Corrensstr 3, 06466 Stadt Seeland, OT Gatersleben, Germany
    BMC Plant Biol 12:245. 2012

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint Antisense repression of cytosolic phosphoglucomutase in potato (Solanum tuberosum) results in severe growth retardation, reduction in tuber number and altered carbon metabolism
    Alisdair R Fernie
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Golm, Germany
    Planta 214:510-20. 2002
    ..In summary, we conclude that cytosolic PGM plays a crucial role in the sucrose synthetic pathway within the leaf and in starch accumulation within the tuber, and as such is important in the maintenance of sink-source relationships...
  2. doi request reprint Increasing amino acid supply in pea embryos reveals specific interactions of N and C metabolism, and highlights the importance of mitochondrial metabolism
    Kathleen Weigelt
    Leibniz Institut für Pflanzengenetik und Kulturpflanzenforschung, Gatersleben, Germany
    Plant J 55:909-26. 2008
    ..These results demonstrate that legume seeds have a high capacity to regulate N:C ratios, and highlight the importance of mitochondria in the control of N-C balance and amino acid homeostasis...
  3. pmc Mild reductions in mitochondrial NAD-dependent isocitrate dehydrogenase activity result in altered nitrate assimilation and pigmentation but do not impact growth
    Agata Sienkiewicz-Porzucek
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Potsdam Golm, Germany
    Mol Plant 3:156-73. 2010
    ....
  4. pmc Metabolic characterization of loci affecting sensory attributes in tomato allows an assessment of the influence of the levels of primary metabolites and volatile organic contents
    Maria Ines Zanor
    Max Planck Institute for Molecular Plant Physiology, Am Muhlenberg 1, D 14476 Potsdam Golm, Germany
    J Exp Bot 60:2139-54. 2009
    ..The combined data presented here are thus discussed both with respect to those obtained recently from wide interspecific crosses of tomato and within the framework of current understanding of the chemical basis of fruit taste...
  5. pmc Phosphonate analogs of 2-oxoglutarate perturb metabolism and gene expression in illuminated Arabidopsis leaves
    Wagner L Araujo
    Max Planck Institut für Molekulare Pflanzenphysiologie Potsdam Golm, Germany
    Front Plant Sci 3:114. 2012
    ..Our results indicate that the TCA cycle activity is clearly working in a non-cyclic manner upon 2-OGDHC inhibition during the light period...
  6. pmc The genetic architecture of branched-chain amino acid accumulation in tomato fruits
    Andrej Kochevenko
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, D 14476 Potsdam Golm, Germany
    J Exp Bot 62:3895-906. 2011
    ..The results are discussed both with respect to the roles of these specific enzymes within plant amino acid metabolism and within the context of current understanding of the regulation of plant branched-chain amino acid metabolism...
  7. pmc The use of natural genetic diversity in the understanding of metabolic organization and regulation
    Alisdair R Fernie
    Max Planck Institute of Molecular Plant Physiology Potsdam Golm, Germany
    Front Plant Sci 2:59. 2011
    ..In addition to highlighting examples in which this genetic diversity approach has proven promising, we will discuss the challenges associated with this approach and provide a perspective for its future utility...
  8. doi request reprint Analysis of metabolic flux using dynamic labelling and metabolic modelling
    A R Fernie
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Plant Cell Environ 36:1738-50. 2013
    ..Finally, current limitations and future perspectives of kinetic modelling of plant metabolism are discussed. ..
  9. pmc The use of metabolomics to dissect plant responses to abiotic stresses
    Toshihiro Obata
    Max Planck Institute of Molecular Plant Physiology, Potsdam Golm, Germany
    Cell Mol Life Sci 69:3225-43. 2012
    ..Finally, where possible, mechanistic insights into metabolic regulatory processes are discussed...
  10. pmc OPTIMAS-DW: a comprehensive transcriptomics, metabolomics, ionomics, proteomics and phenomics data resource for maize
    Christian Colmsee
    Leibniz Institute of Plant Genetics and Crop Plant Research IPK, 06466 Stadt Seeland, Corrensstr 3, 06466 Stadt Seeland, OT Gatersleben, Germany
    BMC Plant Biol 12:245. 2012
    ..A data warehouse was developed to store experimental data as well as analysis results of the performed experiments...
  11. doi request reprint Perspectives on plant photorespiratory metabolism
    A R Fernie
    Max Planck Institute of Molecular Plant Physiology, Potsdam Golm, Germany
    Plant Biol (Stuttg) 15:748-53. 2013
    ....
  12. doi request reprint Leveraging metabolomics for functional investigations in sequenced marine diatoms
    Alisdair R Fernie
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Potsdam Golm, Germany
    Trends Plant Sci 17:395-403. 2012
    ....
  13. pmc Yield quantitative trait loci from wild tomato are predominately expressed by the shoot
    Amit Gur
    The Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agriculture, The Hebrew University of Jerusalem, P O Box 12, 76100, Rehovot, Israel
    Theor Appl Genet 122:405-20. 2011
    ..The results presented here suggest that genetic variation for root traits, in comparison to that present in the shoot, represents only a minor component in the determination of tomato fruit yield...
  14. pmc hi2-1, a QTL which improves harvest index, earliness and alters metabolite accumulation of processing tomatoes
    Amit Gur
    The Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agriculture, The Hebrew University of Jerusalem, P O Box 12, Rehovot, 76100, Israel
    Theor Appl Genet 121:1587-99. 2010
    ..Analysis of the flowering pattern of these lines revealed induced flowering at IL2-1 plants, suggest that hi2-1 may also affect harvest index and early ripening by changing plant architecture and flowering rate...
  15. pmc Application of GC-MS for the detection of lipophilic compounds in diverse plant tissues
    Anna Lytovchenko
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam Golm, Germany
    Plant Methods 5:4. 2009
    ..However, studies are generally confined to polar compounds alone. Here we describe a simple method for lipophilic compounds analysis in various plant tissues...
  16. pmc miSolRNA: A tomato micro RNA relational database
    Ariel A Bazzini
    Instituto de Biotecnologia, Instituto Nacional de Tecnología Agropecuaria Partner group of Institution 5, Castelar, Argentina
    BMC Plant Biol 10:240. 2010
    ..The economic importance of Solanaceae plant species is well documented and tomato has become a model for functional genomics studies. In plants, important processes are regulated by microRNAs (miRNA)...
  17. pmc PageMan: an interactive ontology tool to generate, display, and annotate overview graphs for profiling experiments
    Bjorn Usadel
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam, Germany
    BMC Bioinformatics 7:535. 2006
    ..Currently, most tools focus on a few limited biological aspects, rather than offering a holistic, integrated analysis...
  18. pmc Mild reductions in cytosolic NADP-dependent isocitrate dehydrogenase activity result in lower amino acid contents and pigmentation without impacting growth
    Ronan Sulpice
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Potsdam Golm, Germany
    Amino Acids 39:1055-66. 2010
    ..These data are discussed within the context of current models for the role of the various isoforms of isocitrate dehydrogenase within plant amino acid metabolism...
  19. ncbi request reprint Malate. Jack of all trades or master of a few?
    Alisdair R Fernie
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Phytochemistry 70:828-32. 2009
    ..Here we attempt to provide a synthesis of research in this field as well as re-evaluating the role of this metabolite in mediating guard cell function...
  20. ncbi request reprint The future of metabolic phytochemistry: larger numbers of metabolites, higher resolution, greater understanding
    Alisdair R Fernie
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Phytochemistry 68:2861-80. 2007
    ..This review attempts to provide both an overview of the current state of the art and a perspective of the major challenges that remain...
  21. ncbi request reprint The contribution of plastidial phosphoglucomutase to the control of starch synthesis within the potato tuber
    A R Fernie
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Golm, Germany
    Planta 213:418-26. 2001
    ..In tuber discs the control coefficient of plastidial PGM over starch synthesis was estimated as 0.36, indicating that this enzyme exerts considerable control over starch synthesis within the potato tuber...
  22. doi request reprint Metabolomics-assisted breeding: a viable option for crop improvement?
    Alisdair R Fernie
    Max Planck Institute für Molekulare Pfanzenphysiologie, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Trends Genet 25:39-48. 2009
    ..Metabolomics represents an important addition to the tools currently employed in genomics-assisted selection for crop improvement...
  23. ncbi request reprint Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport
    Alisdair R Fernie
    Department of Lothar Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Curr Opin Plant Biol 7:254-61. 2004
    ..Recently, a wide range of molecular and biochemical strategies have been adopted to elucidate the functional significance of these interactions...
  24. ncbi request reprint Metabolite profiling: from diagnostics to systems biology
    Alisdair R Fernie
    Department of Molecular Physiology, Max Planck Institute for Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Nat Rev Mol Cell Biol 5:763-9. 2004
    ..As a result, the power of metabolite profiling as a technology platform for diagnostics, and the research areas of gene-function analysis and systems biology, is now beginning to be fully realized...
  25. pmc Mild reductions in mitochondrial citrate synthase activity result in a compromised nitrate assimilation and reduced leaf pigmentation but have no effect on photosynthetic performance or growth
    Agata Sienkiewicz-Porzucek
    Max Planck Institut fur Molekulare Pflanzenphysiologie, 14476 Golm, Germany
    Plant Physiol 147:115-27. 2008
    ..The results are discussed in the context of carbon-nitrogen interaction and interorganellar coordination of metabolism...
  26. ncbi request reprint Deficiency of mitochondrial fumarase activity in tomato plants impairs photosynthesis via an effect on stomatal function
    Adriano Nunes-Nesi
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Plant J 50:1093-106. 2007
    ..Analysis of the response of the rate of photosynthesis to variation in the concentration of CO(2) confirmed that this restriction was due to a deficiency in stomatal function...
  27. ncbi request reprint Sucrose to starch: a transition in molecular plant physiology
    Alisdair R Fernie
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476, Golm, Germany
    Trends Plant Sci 7:35-41. 2002
    ..The investigation of the sucrose-to-starch transition in potato tubers is an excellent example of how the discipline of molecular plant physiology is evolving at both the scientific and technical levels...
  28. ncbi request reprint Carbon assimilation and metabolism in potato leaves deficient in plastidial phosphoglucomutase
    Anna Lytovchenko
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Planta 215:802-11. 2002
    ....
  29. ncbi request reprint The influence of cytosolic phosphoglucomutase on photosynthetic carbohydrate metabolism
    Anna Lytovchenko
    Dept Willnitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Planta 215:1013-21. 2002
    ..We conclude that these lines exhibit only moderate changes in sucrose synthesis but more complex changes on a range of diverse metabolic pathways...
  30. pmc Reduced expression of succinyl-coenzyme A ligase can be compensated for by up-regulation of the gamma-aminobutyrate shunt in illuminated tomato leaves
    Claudia Studart-Guimaraes
    Department Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, 14476 Golm, Germany
    Plant Physiol 145:626-39. 2007
    ..The results are discussed in the context of current models of plant respiration in mitochondrial and cellular metabolism of the illuminated leaf...
  31. doi request reprint New insights into photorespiration obtained from metabolomics
    A Florian
    Max Planck Institut für Molekular Pflanzenphysiologie, Potsdam Golm, Germany
    Plant Biol (Stuttg) 15:656-66. 2013
    ..Here we review recent progress into photorespiration and its interaction with other metabolic processes, paying particular attention to data emanating from metabolic profiling studies...
  32. pmc High-resolution metabolic phenotyping of genetically and environmentally diverse potato tuber systems. Identification of phenocopies
    U Roessner
    , , 14476 Golm, Germany
    Plant Physiol 127:749-64. 2001
    ..These comparisons highlight the importance of such an approach in the functional and qualitative assessment of diverse systems to gain insights into important mediators of metabolism...
  33. pmc The sucrose analog palatinose leads to a stimulation of sucrose degradation and starch synthesis when supplied to discs of growing potato tubers
    A R Fernie
    , , 14476 Golm, Germany
    Plant Physiol 125:1967-77. 2001
    ..These results suggest that supplying palatinose to potato tubers represents a novel way to increase starch synthesis...
  34. ncbi request reprint Tuber-specific cytosolic expression of a bacterial phosphoglucomutase in potato (Solanum tuberosum L.) dramatically alters carbon partitioning
    Anna Lytovchenko
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, D 14476 Golm, Germany
    Plant Cell Physiol 46:588-97. 2005
    ..These results are discussed with respect to current models of the regulation of central plant metabolism and tuber dormancy...
  35. pmc Enhanced photosynthetic performance and growth as a consequence of decreasing mitochondrial malate dehydrogenase activity in transgenic tomato plants
    Adriano Nunes-Nesi
    Max Planck Institut fur Molekulare Pflanzenphysiologie, 14476 Golm, Germany
    Plant Physiol 137:611-22. 2005
    ..This report thus shows that the repression of this mitochondrially localized enzyme improves both carbon assimilation and aerial growth in a crop species...
  36. ncbi request reprint Expression of a yeast acetyl CoA hydrolase in the mitochondrion of tobacco plants inhibits growth and restricts photosynthesis
    Lilia Bender-Machado
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Mol Biol 55:645-62. 2004
    ..In summary these results suggest that the content of acetyl CoA is under tight control and that alterations in the level of this central metabolite have severe metabolic and developmental consequences in tobacco...
  37. ncbi request reprint Conversion of MapMan to allow the analysis of transcript data from Solanaceous species: effects of genetic and environmental alterations in energy metabolism in the leaf
    Ewa Urbanczyk-Wochniak
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, Golm, 14476, Germany
    Plant Mol Biol 60:773-92. 2006
    ..Since the Solanaceous MapMan is intended to be a community resource it will be regularly updated on improvements in tomato gene annotation and transcript profiling resources...
  38. pmc Metabolic profiling of transgenic tomato plants overexpressing hexokinase reveals that the influence of hexose phosphorylation diminishes during fruit development
    Ute Roessner-Tunali
    Department of Lothar Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Physiol 133:84-99. 2003
    ..In summary, the data presented in this paper demonstrate that the influence of hexose phosphorylation diminishes during fruit development and highlights the importance of greater temporal resolution of metabolism...
  39. ncbi request reprint Metabolic profiling of leaves and fruit of wild species tomato: a survey of the Solanum lycopersicum complex
    Nicolas Schauer
    Department of Lothar Willmitzer, Max Planck Institut für Molekular Pflanzenphysiologie, Am Muhlenberg 1, D 14476 Golm, Germany
    J Exp Bot 56:297-307. 2005
    ..The significance of these changes is discussed with respect to the use of the various wild species for metabolic engineering within wide breeding strategies...
  40. ncbi request reprint Metabolic profiling reveals altered nitrogen nutrient regimes have diverse effects on the metabolism of hydroponically-grown tomato (Solanum lycopersicum) plants
    Ewa Urbanczyk-Wochniak
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, D 14476 Golm, Germany
    J Exp Bot 56:309-21. 2005
    ..These results are compared with previously reported transcript profiles of altered nitrogen regimes and discussed within the context of current models of carbon nitrogen interaction...
  41. ncbi request reprint Overexpression of the sucrose transporter SoSUT1 in potato results in alterations in leaf carbon partitioning and in tuber metabolism but has little impact on tuber morphology
    Georg Leggewie
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476, Golm, Germany
    Planta 217:158-67. 2003
    ....
  42. pmc De novo amino acid biosynthesis in potato tubers is regulated by sucrose levels
    Ute Roessner-Tunali
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Physiol 133:683-92. 2003
    ..Taken together, these data strongly suggest that Suc regulates amino acid biosynthesis in storage tissues such as potato tubers, most probably at the level of transcription...
  43. ncbi request reprint Enhancing vacuolar sucrose cleavage within the developing potato tuber has only minor effects on metabolism
    Bjoern H Junker
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, D 14476 Golm, Germany
    Plant Cell Physiol 47:277-89. 2006
    ..Finally, the results of this study are compared with those from other plant species and the relative roles of the vacuolar isoform of the enzyme are contrasted...
  44. ncbi request reprint Temporally regulated expression of a yeast invertase in potato tubers allows dissection of the complex metabolic phenotype obtained following its constitutive expression
    Björn H Junker
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, Golm, 14476, Germany
    Plant Mol Biol 56:91-110. 2004
    ....
  45. pmc Robin: an intuitive wizard application for R-based expression microarray quality assessment and analysis
    Marc Lohse
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Plant Physiol 153:642-51. 2010
    ....
  46. pmc Enzyme activity profiles during fruit development in tomato cultivars and Solanum pennellii
    Marie Caroline Steinhauser
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Plant Physiol 153:80-98. 2010
    ..We discuss the concept that the metabolite profile is an emergent property that is generated by complex network interactions...
  47. pmc Tricarboxylic acid cycle activity regulates tomato root growth via effects on secondary cell wall production
    Margaretha J van der Merwe
    Max Planck Institut fur Molekulare Pflanzenphysiologie, 14476 Potsdam Golm, Germany
    Plant Physiol 153:611-21. 2010
    ..Taken together, the combined results suggest that restriction of root respiration leads to a deficit in secondary cell wall synthesis. These data are discussed in the context of current models of biomass partitioning and plant growth...
  48. doi request reprint The enigmatic contribution of mitochondrial function in photosynthesis
    Adriano Nunes-Nesi
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, D 14476 Potsdam Golm, Germany
    J Exp Bot 59:1675-84. 2008
    ....
  49. ncbi request reprint GMD@CSB.DB: the Golm Metabolome Database
    Joachim Kopka
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Bioinformatics 21:1635-8. 2005
    ..AVAILABILITY: http://csbdb.mpimp-golm.mpg.de/gmd.html CONTACT: Steinhauser@mpimp-golm.mpg.de SUPPLEMENTARY INFORMATION: http://csbdb.mpimp-golm.mpg.de/..
  50. ncbi request reprint Expression of an Escherichia coli phosphoglucomutase in potato (Solanum tuberosum L.) results in minor changes in tuber metabolism and a considerable delay in tuber sprouting
    Anna Lytovchenko
    Department Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476, Golm, Germany
    Planta 221:915-27. 2005
    ..These results are discussed in the context of current understanding of the control of respiration and the breaking of tuber dormancy...
  51. ncbi request reprint Metabolic regulation of pathways of carbohydrate oxidation in potato (Solanum tuberosum) tubers
    Danilo C Centeno
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Physiol Plant 133:744-54. 2008
    ..Moreover these data suggest that the upregulation of respiration is a consequence of enhanced efficient mitochondrial metabolism...
  52. doi request reprint Web-based resources for mass-spectrometry-based metabolomics: a user's guide
    Takayuki Tohge
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Phytochemistry 70:450-6. 2009
    ....
  53. ncbi request reprint Potato hexokinase 2 complements transgenic Arabidopsis plants deficient in hexokinase 1 but does not play a key role in tuber carbohydrate metabolism
    Jon Veramendi
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Golm, Germany
    Plant Mol Biol 49:491-501. 2002
    ....
  54. pmc Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria
    Wagner L Araujo
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Golm, Germany
    Plant Cell 22:1549-63. 2010
    ....
  55. pmc Reduced expression of aconitase results in an enhanced rate of photosynthesis and marked shifts in carbon partitioning in illuminated leaves of wild species tomato
    Fernando Carrari
    Department Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Physiol 133:1322-35. 2003
    ..Therefore, we conclude that the Krebs cycle normally competes with the Suc synthetic pathway for carbon but is not essential for the supply of energy to fuel the operation of this pathway...
  56. ncbi request reprint Integrating profiling data: using linear correlation to reveal coregulation of transcript and metabolites
    Ewa Urbanczyk-Wochniak
    Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology, Potsdam Golm, Germany
    Methods Mol Biol 358:77-85. 2007
    ..In this chapter, we describe combined analysis of data obtained from transcript and metabolic profiling, and detail advantages of using both approaches in parallel...
  57. ncbi request reprint From measurements of metabolites to metabolomics: an 'on the fly' perspective illustrated by recent studies of carbon-nitrogen interactions
    Mark Stitt
    Departments of Metabolic Networks and Molecular Physiology, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476, Golm, Germany
    Curr Opin Biotechnol 14:136-44. 2003
    ..A major future challenge concerns the integration of the information gained from metabolite profiling into an accessible body of knowledge...
  58. ncbi request reprint Inhibition of chloroplastic fructose 1,6-bisphosphatase in tomato fruits leads to decreased fruit size, but only small changes in carbohydrate metabolism
    Hazem Obiadalla-Ali
    Willmitzer Department, Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476, Golm, Germany
    Planta 219:533-40. 2004
    ..One consequence of this reduction of in vivo activity of cp-FBPase was that the average weight of fully ripe fruits was significantly decreased by up to 20% in all transgenic lines in comparison with the control...
  59. ncbi request reprint Comprehensive metabolic profiling and phenotyping of interspecific introgression lines for tomato improvement
    Nicolas Schauer
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Nat Biotechnol 24:447-54. 2006
    ..The results of our genomic survey illustrate the power of genome-wide metabolic profiling and detailed morphological analysis for uncovering traits with potential for crop breeding...
  60. pmc RNA interference of LIN5 in tomato confirms its role in controlling Brix content, uncovers the influence of sugars on the levels of fruit hormones, and demonstrates the importance of sucrose cleavage for normal fruit development and fertility
    Maria Ines Zanor
    Max Planck Institut fur Molekulare Pflanzenphysiologie, 14476 Potsdam Golm, Germany
    Plant Physiol 150:1204-18. 2009
    ..These results are discussed in the context of current understanding of the role of sugar during the development of tomato fruit, with particular focus given to its impact on hormone levels and organ morphology...
  61. ncbi request reprint Enhancing crop yield in Solanaceous species through the genetic manipulation of energy metabolism
    A Nunes-Nesi
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Biochem Soc Trans 33:1430-4. 2005
    ..In this mini-review, we discuss metabolic engineering strategies specifically targeting energy metabolism as a strategy for yield enhancement...
  62. ncbi request reprint Profiling of diurnal patterns of metabolite and transcript abundance in potato (Solanum tuberosum) leaves
    Ewa Urbanczyk-Wochniak
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476, Golm, Germany
    Planta 221:891-903. 2005
    ....
  63. pmc Deficiency of a plastidial adenylate kinase in Arabidopsis results in elevated photosynthetic amino acid biosynthesis and enhanced growth
    Fernando Carrari
    Department Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, 14476 Golm, Germany
    Plant Physiol 137:70-82. 2005
    ..Taken together, these data suggest a role for the plastid stromal ADK in the coordination of metabolism and growth, but imply that the exact importance of this isoform is tissue dependent...
  64. ncbi request reprint Starch content and yield increase as a result of altering adenylate pools in transgenic plants
    Babette Regierer
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Nat Biotechnol 20:1256-60. 2002
    ..The modulation of the plastidial adenylate kinase activity in transgenic plants therefore represents a potentially very useful strategy for increasing formation of major storage compounds in heterotrophic tissues of higher plants...
  65. ncbi request reprint Combining genetic diversity, informatics and metabolomics to facilitate annotation of plant gene function
    Takayuki Tohge
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Potsdam Golm, Germany
    Nat Protoc 5:1210-27. 2010
    ..This approach can also be used as a tool to identify unknown mass-spectral peaks representing new or unusual secondary metabolites, which is currently the major challenge of this analytical research field...
  66. ncbi request reprint The metabolic response of Arabidopsis roots to oxidative stress is distinct from that of heterotrophic cells in culture and highlights a complex relationship between the levels of transcripts, metabolites, and flux
    Martin Lehmann
    Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 14476, Potsdam Golm, Germany
    Mol Plant 2:390-406. 2009
    ..Together, the results suggest that root tissues can recover metabolic activity after oxidative inhibition and highlight potentially important roles for glycolysis and the oxidative pentose phosphate pathway...
  67. ncbi request reprint Expression of a bacterial xylose isomerase in potato tubers results in an altered hexose composition and a consequent induction of metabolism
    Ewa Urbanczyk-Wochniak
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, D 14476 Golm, Germany
    Plant Cell Physiol 44:1359-67. 2003
    ..The consequences of altering hexose levels in the tuber are, however, not as severe as those observed following perturbation of the level of tuber sucrose...
  68. pmc The potato-specific apyrase is apoplastically localized and has influence on gene expression, growth, and development
    David Riewe
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Plant Physiol 147:1092-109. 2008
    ..We describe the evidence that underlies both this fact and that potato-specific apyrase has a crucial role in regulating growth and development...
  69. ncbi request reprint Plant metabolomics: towards biological function and mechanism
    Nicolas Schauer
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Trends Plant Sci 11:508-16. 2006
    ..Here, we assess the contribution of metabolite profiling to these areas...
  70. ncbi request reprint Subcellular pyrophosphate metabolism in developing tubers of potato (Solanum tuberosum)
    Eva M Farré
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Mol Biol 62:165-79. 2006
    ..These results are discussed both with respect to our previous hypotheses and to current models of the compartmentation of potato tuber metabolism...
  71. pmc Reconfiguration of the achene and receptacle metabolic networks during strawberry fruit development
    Aaron Fait
    Abteilung Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Potsdam Golm, Germany
    Plant Physiol 148:730-50. 2008
    ..The data are discussed within the context of current models both of the interaction of primary and secondary metabolism and of the metabolic interaction between the different plant organs...
  72. pmc Transcript and metabolite profiling of the adaptive response to mild decreases in oxygen concentration in the roots of arabidopsis plants
    Joost T van Dongen
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Ann Bot 103:269-80. 2009
    ..The aim of this study was to use transcript and metabolite profiling to investigate the genomic response of arabidopsis roots to a mild decrease in oxygen concentrations...
  73. pmc Parallel analysis of transcript and metabolic profiles: a new approach in systems biology
    Ewa Urbanczyk-Wochniak
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    EMBO Rep 4:989-93. 2003
    ..We believe this approach to be of high potential value in the identification of candidate genes for modifying the metabolite content of biological systems...
  74. ncbi request reprint Heard it through the grapevine? ABA and sugar cross-talk: the ASR story
    Fernando Carrari
    Max Planck Institut für Molekulare Pflanzenphysilogie, Golm, Germany
    Trends Plant Sci 9:57-9. 2004
    ..Taken together with the previously defined characteristics of ASP peptides, these findings should facilitate further dissection of the changing sugar and hormonal signal circuitry during fruit development...
  75. ncbi request reprint Nonsupervised construction and application of mass spectral and retention time index libraries from time-of-flight gas chromatography-mass spectrometry metabolite profiles
    Alexander Erban
    Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology, Potsdam Golm, Germany
    Methods Mol Biol 358:19-38. 2007
    ..Application of these libraries for automated identification by pure reference compounds and classification of hitherto unidentified MSTs from biological sources is demonstrated...
  76. pmc Inhibition of 2-oxoglutarate dehydrogenase in potato tuber suggests the enzyme is limiting for respiration and confirms its importance in nitrogen assimilation,
    Wagner L Araujo
    Max Planck Institut fur Molekulare Pflanzenphysiologie, 14476 Potsdam Golm, Germany
    Plant Physiol 148:1782-96. 2008
    ..The data obtained are discussed in the context of the roles of the 2-oxoglutarate dehydrogenase complex in respiration and carbon-nitrogen interactions...
  77. ncbi request reprint In plants the alc gene expression system responds more rapidly following induction with acetaldehyde than with ethanol
    Björn H Junker
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    FEBS Lett 535:136-40. 2003
    ..We propose that this system is therefore ideal for the temporal regulation of important metabolic enzyme activities...
  78. ncbi request reprint Highway or byway: the metabolic role of the GABA shunt in plants
    Aaron Fait
    Department Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Trends Plant Sci 13:14-9. 2008
    ..We further evaluate technological developments that will likely allow us to address the quantitative importance of this shunt within the biological processes to which it contributes...
  79. pmc Alterations in cytosolic glucose-phosphate metabolism affect structural features and biochemical properties of starch-related heteroglycans
    Joerg Fettke
    Department of Plant Physiology, University of Potsdam, 14476 Potsdam Golm, Germany
    Plant Physiol 148:1614-29. 2008
    ..Based on (14)C labeling experiments, we propose that in the cytosol, glucose and Glc-1-P are metabolized by largely separated paths...
  80. doi request reprint Decreased expression of plastidial adenylate kinase in potato tubers results in an enhanced rate of respiration and a stimulation of starch synthesis that is attributable to post-translational redox-activation of ADP-glucose pyrophosphorylase
    Sandra N Oliver
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, D 14476 Potsdam Golm, Germany
    J Exp Bot 59:315-25. 2008
    ..Results provide first evidence for a link between redox-activation of AGPase and adenine nucleotide levels in plants...
  81. pmc Mitochondrial uncoupling protein is required for efficient photosynthesis
    Lee J Sweetlove
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, United Kingdom
    Proc Natl Acad Sci U S A 103:19587-92. 2006
    ..Collectively, these results suggest that the main physiological role of UCP1 in Arabidopsis leaves is related to maintaining the redox poise of the mitochondrial electron transport chain to facilitate photosynthetic metabolism...
  82. pmc The metabolic response of heterotrophic Arabidopsis cells to oxidative stress
    Charles J Baxter
    Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom
    Plant Physiol 143:312-25. 2007
    ....
  83. pmc Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis
    Susan Wagner
    Angewandte Genetik, Freie Universitat Berlin, 14195 Berlin, Germany
    Plant Cell 18:1722-35. 2006
    ..In summary, our results demonstrate the critical function of the PDX1 protein family for metabolism, whole-plant development, and vitamin B6 biosynthesis in higher plants...
  84. ncbi request reprint Fruit carbohydrate metabolism in an introgression line of tomato with increased fruit soluble solids
    Charles J Baxter
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
    Plant Cell Physiol 46:425-37. 2005
    ..We conclude that the major factor that leads to increased fruit sugar in IL9-2-5 is an increase in the capacity to take up sucrose unloaded from the phloem...
  85. ncbi request reprint GC-MS libraries for the rapid identification of metabolites in complex biological samples
    Nicolas Schauer
    Max Planck Institute of Plant Molecular Physiology, Am Muehlenberg 1, D 14476 Golm, Germany
    FEBS Lett 579:1332-7. 2005
    ..csbdb.mpimp-golm.mpg.de/gmd.html). This resource should ameliorate many of the problems that each laboratory will face both for the initial establishment of metabolome analysis and for its maintenance at a constant sample throughput...
  86. pmc The sucrose transporter StSUT1 localizes to sieve elements in potato tuber phloem and influences tuber physiology and development
    Christina Kuhn
    Zentrum für Molekularbiologieder Pflanzen, Pflanzenphysiologie, Universitat Tubingen, Au der Morgenstelle, Germany
    Plant Physiol 131:102-13. 2003
    ....
  87. ncbi request reprint The influence of cytosolic phosphorylating glyceraldehyde 3-phosphate dehydrogenase (GAPC) on potato tuber metabolism
    Mohammad Reza Hajirezaei
    Institute of Plant Genetics and Crop Plant Research IPK, Corrensstrasse 3, D 06466 Gatersleben, Germany
    J Exp Bot 57:2363-77. 2006
    ..The results presented here are discussed in relation to current models regarding primary metabolism in the potato tuber parenchyma...
  88. ncbi request reprint From structure to dynamics of metabolic pathways: application to the plant mitochondrial TCA cycle
    Ralf Steuer
    University Potsdam, Institute for Biochemistry and Biology, Haus 20, Germany
    Bioinformatics 23:1378-85. 2007
    ..However, despite extensive knowledge about its stoichiometric properties, the function and the dynamical capabilities of the TCA cycle remain largely unknown. Methods and..
  89. ncbi request reprint Altered activity of the P2 isoform of plastidic glucose 6-phosphate dehydrogenase in tobacco (Nicotiana tabacum cv. Samsun) causes changes in carbohydrate metabolism and response to oxidative stress in leaves
    Phillip M Debnam
    College of Biological Science, University of Guelph, Gordon Street, Guelph, Ont, Canada N1G 2W1
    Plant J 38:49-59. 2004
    ..The results are discussed from the perspective of the role of G6PDH in carbohydrate metabolism and oxidative stress. It is suggested that the activity of P2-G6PDH may be crucial in balancing the redox poise in chloroplasts...
  90. ncbi request reprint Getting to grips with the plant metabolic network
    Lee J Sweetlove
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
    Biochem J 409:27-41. 2008
    ..In the present review we will appraise the current state of the art regarding plant metabolic network analysis and attempt to outline what the necessary steps are in order to further our understanding of network regulation...
  91. pmc Glycolytic enzymes associate dynamically with mitochondria in response to respiratory demand and support substrate channeling
    James W A Graham
    Department of Plant Sciences, University of Oxford, Oxford, OX1 3RB, United Kingdom
    Plant Cell 19:3723-38. 2007
    ..It appears that glycolytic enzymes associate dynamically with mitochondria to support respiration and that substrate channeling restricts the use of intermediates by competing metabolic pathways...
  92. pmc Silencing of the mitochondrial ascorbate synthesizing enzyme L-galactono-1,4-lactone dehydrogenase affects plant and fruit development in tomato
    Moftah Alhagdow
    Institut National de la Recherche Agronomique, Universite Bordeaux 1, Universite Victor Segalen Bordeaux 2, BP 81, 33883 Villenave d Ornon Cedex, France
    Plant Physiol 145:1408-22. 2007
    ..Moreover, it strongly suggests that, in addition to ascorbate synthesis, GalLDH could play an important role in the regulation of cell growth-related processes in plants...
  93. ncbi request reprint Modulation of fructokinase activity of potato (Solanum tuberosum) results in substantial shifts in tuber metabolism
    Howard V Davies
    Quality, Health and Nutrition Programme, Scottish Crop Research Institute, Dundee DD2 5DA, UK
    Plant Cell Physiol 46:1103-15. 2005
    ....
  94. pmc Alteration of organic acid metabolism in Arabidopsis overexpressing the maize C4 NADP-malic enzyme causes accelerated senescence during extended darkness
    Holger Fahnenstich
    Botanisches Institut, Universitat zu Koln, 50931 Cologne, Germany
    Plant Physiol 145:640-52. 2007
    ..In addition, the data revealed that both malate and fumarate are important forms of fixed carbon that can be rapidly metabolized under stress conditions in Arabidopsis...
  95. pmc Decrease in manganese superoxide dismutase leads to reduced root growth and affects tricarboxylic acid cycle flux and mitochondrial redox homeostasis
    Megan J Morgan
    Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom
    Plant Physiol 147:101-14. 2008
    ..The data also highlight the flexibility of plant metabolism with TCA cycle inhibition having little effect on overall respiratory rates...
  96. ncbi request reprint Functional analysis of the essential bifunctional tobacco enzyme 3-dehydroquinate dehydratase/shikimate dehydrogenase in transgenic tobacco plants
    Li Ding
    Institut für Pflanzengenetik und Kulturpflanzenforschung IPK, Corrensstrasse 3, 06466 Gatersleben, Germany
    J Exp Bot 58:2053-67. 2007
    ..These data are discussed in the context of current models of plant intermediary metabolism...