Wolfgang Enard

Summary

Affiliation: Max Planck Institute for Evolutionary Anthropology
Country: Germany

Publications

  1. doi request reprint Functional primate genomics--leveraging the medical potential
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    J Mol Med (Berl) 90:471-80. 2012
  2. doi request reprint FOXP2 and the role of cortico-basal ganglia circuits in speech and language evolution
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Curr Opin Neurobiol 21:415-24. 2011
  3. doi request reprint A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Cell 137:961-71. 2009
  4. ncbi request reprint Comparative primate genomics
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Annu Rev Genomics Hum Genet 5:351-78. 2004
  5. ncbi request reprint Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Science 309:1850-4. 2005
  6. ncbi request reprint Evolution of primate gene expression
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nat Rev Genet 7:693-702. 2006
  7. pmc FUNC: a package for detecting significant associations between gene sets and ontological annotations
    Kay Prüfer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    BMC Bioinformatics 8:41. 2007
  8. ncbi request reprint Molecular evolution of FOXP2, a gene involved in speech and language
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nature 418:869-72. 2002
  9. pmc A neutral model of transcriptome evolution
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E132. 2004
  10. pmc Functional analysis of human and chimpanzee promoters
    Florian Heissig
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Genome Biol 6:R57. 2005

Detail Information

Publications20

  1. doi request reprint Functional primate genomics--leveraging the medical potential
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    J Mol Med (Berl) 90:471-80. 2012
    ..Especially the possibility to generate pluripotent stem cells from primates should allow extending the comparative approach to many medically relevant questions...
  2. doi request reprint FOXP2 and the role of cortico-basal ganglia circuits in speech and language evolution
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Curr Opin Neurobiol 21:415-24. 2011
    ..Here I review recent studies investigating the functional consequences of these two substitutions and discuss how these first endeavors to study human brain evolution can be interpreted in the context of speech and language evolution...
  3. doi request reprint A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Cell 137:961-71. 2009
    ..Since mice carrying one nonfunctional Foxp2 allele show opposite effects, this suggests that alterations in cortico-basal ganglia circuits might have been important for the evolution of speech and language in humans...
  4. ncbi request reprint Comparative primate genomics
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Annu Rev Genomics Hum Genet 5:351-78. 2004
    ..In this article, we review recent progress in these areas with an emphasis on how comparative approaches may be used to identify functionally relevant features unique to the human genome...
  5. ncbi request reprint Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Science 309:1850-4. 2005
    ....
  6. ncbi request reprint Evolution of primate gene expression
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nat Rev Genet 7:693-702. 2006
    ....
  7. pmc FUNC: a package for detecting significant associations between gene sets and ontological annotations
    Kay Prüfer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    BMC Bioinformatics 8:41. 2007
    ..However, it is often difficult to assess the statistical significance of such analyses since many inter-dependent categories are tested simultaneously...
  8. ncbi request reprint Molecular evolution of FOXP2, a gene involved in speech and language
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nature 418:869-72. 2002
    ..Here we show that human FOXP2 contains changes in amino-acid coding and a pattern of nucleotide polymorphism, which strongly suggest that this gene has been the target of selection during recent human evolution...
  9. pmc A neutral model of transcriptome evolution
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E132. 2004
    ..Furthermore, it may be possible to apply a molecular clock based on expression differences to infer the evolutionary history of tissues...
  10. pmc Functional analysis of human and chimpanzee promoters
    Florian Heissig
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Genome Biol 6:R57. 2005
    ....
  11. doi request reprint A recent evolutionary change affects a regulatory element in the human FOXP2 gene
    Tomislav Maricic
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 30:844-52. 2013
    ....
  12. pmc Regional patterns of gene expression in human and chimpanzee brains
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 14:1462-73. 2004
    ..Furthermore, genes that show an elevated expression level in humans are statistically significantly enriched in regions that are recently duplicated in humans...
  13. pmc Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates
    Claudia Stäubert
    Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    PLoS ONE 5:e11133. 2010
    ..More generally, our study points out how analyses in an evolutionary context can help to interpret functional data generated in single species...
  14. pmc Selection on human genes as revealed by comparisons to chimpanzee cDNA
    Ines Hellmann
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 13:831-7. 2003
    ..This indicates that positive selection may have had a considerable influence on 5'UTRs. The dinucleotide CG (CpG) also exhibits a different substitution pattern within 5'UTRs as compared with other parts of the genome...
  15. ncbi request reprint The derived FOXP2 variant of modern humans was shared with Neandertals
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Curr Biol 17:1908-12. 2007
    ..Thus, these results illustrate the usefulness of retrieving direct genetic information from ancient remains for understanding recent human evolution...
  16. ncbi request reprint Identification of large-scale human-specific copy number differences by inter-species array comparative genomic hybridization
    Violaine Goidts
    Department of Human Genetics, University of Ulm, Albert Einstein Allee, 11, 89081 Ulm, Germany
    Hum Genet 119:185-98. 2006
    ..The association of human-specific copy number gains with chromosomal breakpoints emphasizes their potential importance in mediating karyotypic evolution as well as in promoting human genomic diversity...
  17. ncbi request reprint Differences in DNA methylation patterns between humans and chimpanzees
    Wolfgang Enard
    Curr Biol 14:R148-9. 2004
  18. ncbi request reprint Intra- and interspecific variation in primate gene expression patterns
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Science 296:340-3. 2002
    ..We identified species-specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain...
  19. ncbi request reprint Positive selection on gene expression in the human brain
    Philipp Khaitovich
    Curr Biol 16:R356-8. 2006
  20. pmc Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings
    C Geoffrey Woods
    Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge, United Kingdom
    Am J Hum Genet 76:717-28. 2005
    ..So an understanding of this rare genetic disorder may offer us significant insights into neurogenic mitosis and the evolution of the most striking differences between us and our closest living relatives: brain size and cognitive ability...